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Increased size of nasopharyngeal adenoids

MedGen UID:
628857
Concept ID:
C0455938
Finding
Synonym: Adenoid hypertrophy
SNOMED CT: Large adenoids (276442006)
 
HPO: HP:0040261
Monarch Initiative: MONDO:0000740

Definition

An abnormal increase in the size of nasopharyngeal adenoids. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased size of nasopharyngeal adenoids

Conditions with this feature

Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin
MedGen UID:
1802903
Concept ID:
C5676928
Disease or Syndrome
Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin (MNDLFH) is characterized by clinically significant pharyngeal lymphoid hypertrophy, with adenoid overgrowth, frequent upper airway infections, and sleep apnea. Macrocephaly without structural brain abnormalities is present, and patients exhibit increased weight for height as well as delayed gross motor and impaired intellectual development; autistic features and attention-deficit hyperactivity disorder have also been reported. An increased fraction of fetal hemoglobin has been observed in some patients (Ohishi et al., 2020; von der Lippe et al., 2022).

Professional guidelines

PubMed

Pavoni C, Cretella Lombardo E, Franchi L, Lione R, Cozza P
Int J Pediatr Otorhinolaryngol 2017 Oct;101:47-50. Epub 2017 Jul 24 doi: 10.1016/j.ijporl.2017.07.032. PMID: 28964309

Recent clinical studies

Etiology

Berkiten G, Şengiz Erhan S, Çelik C, Tutar B, Atar Y, Aksungur E, Sari H, Uyar Y
Int J Pediatr Otorhinolaryngol 2023 Nov;174:111718. Epub 2023 Sep 14 doi: 10.1016/j.ijporl.2023.111718. PMID: 37722297
Li H, Wang H, Hao H, An H, Geng H
Comput Math Methods Med 2022;2022:5096406. Epub 2022 Aug 30 doi: 10.1155/2022/5096406. PMID: 36081428Free PMC Article
Yoon A, Abdelwahab M, Bockow R, Vakili A, Lovell K, Chang I, Ganguly R, Liu SY, Kushida C, Hong C
Sleep Med 2022 Apr;92:96-102. Epub 2022 Feb 19 doi: 10.1016/j.sleep.2022.02.011. PMID: 35390750Free PMC Article
Windfuhr JP, Chen YS
HNO 2020 Jan;68(Suppl 1):50-55. doi: 10.1007/s00106-019-00797-w. PMID: 31970445
Surov A, Ryl I, Bartel-Friedrich S, Wienke A, Kösling S
Neuroradiol J 2016 Oct;29(5):408-12. Epub 2016 Aug 16 doi: 10.1177/1971400916665386. PMID: 27531860Free PMC Article

Diagnosis

Berkiten G, Şengiz Erhan S, Çelik C, Tutar B, Atar Y, Aksungur E, Sari H, Uyar Y
Int J Pediatr Otorhinolaryngol 2023 Nov;174:111718. Epub 2023 Sep 14 doi: 10.1016/j.ijporl.2023.111718. PMID: 37722297
Yoon A, Abdelwahab M, Bockow R, Vakili A, Lovell K, Chang I, Ganguly R, Liu SY, Kushida C, Hong C
Sleep Med 2022 Apr;92:96-102. Epub 2022 Feb 19 doi: 10.1016/j.sleep.2022.02.011. PMID: 35390750Free PMC Article
Iwasaki T, Sugiyama T, Yanagisawa-Minami A, Oku Y, Yokura A, Yamasaki Y
J Clin Sleep Med 2020 Dec 15;16(12):2021-2028. doi: 10.5664/jcsm.8736. PMID: 32780013Free PMC Article
Thompson LD, Penner C, Ho NJ, Foss RD, Miettinen M, Wieneke JA, Moskaluk CA, Stelow EB
Head Neck Pathol 2014 Mar;8(1):88-109. Epub 2013 Sep 15 doi: 10.1007/s12105-013-0487-3. PMID: 24037641Free PMC Article
Cho JH, Lee DH, Lee NS, Won YS, Yoon HR, Suh BD
J Laryngol Otol 1999 Oct;113(10):899-905. doi: 10.1017/s0022215100145530. PMID: 10664704

Therapy

Schwab RJ, Kim C, Bagchi S, Keenan BT, Comyn FL, Wang S, Tapia IE, Huang S, Traylor J, Torigian DA, Bradford RM, Marcus CL
Am J Respir Crit Care Med 2015 Jun 1;191(11):1295-309. doi: 10.1164/rccm.201501-0169OC. PMID: 25835282Free PMC Article
Berini J, Spica Russotto V, Castelnuovo P, Di Candia S, Gargantini L, Grugni G, Iughetti L, Nespoli L, Nosetti L, Padoan G, Pilotta A, Trifirò G, Chiumello G, Salvatoni A; Genetic Obesity Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
J Clin Endocrinol Metab 2013 Sep;98(9):E1516-23. Epub 2013 Jul 26 doi: 10.1210/jc.2013-1831. PMID: 23894156
Reid D, Morton R, Salkeld L, Bartley J
Int J Pediatr Otorhinolaryngol 2011 Feb;75(2):261-4. Epub 2010 Dec 4 doi: 10.1016/j.ijporl.2010.11.012. PMID: 21131064
Kheirandish-Gozal L, Serpero LD, Dayyat E, Kim J, Goldman JL, Snow A, Bhattacharjee R, Gozal D
Eur Respir J 2009 May;33(5):1077-84. Epub 2008 Dec 1 doi: 10.1183/09031936.00130608. PMID: 19047310
Al-Ghamdi SA, Manoukian JJ, Morielli A, Oudjhane K, Ducharme FM, Brouillette RT
Laryngoscope 1997 Oct;107(10):1382-7. doi: 10.1097/00005537-199710000-00017. PMID: 9331318

Prognosis

Abdel Tawab HM, Tabook SMS
Ear Nose Throat J 2021 Mar;100(3):NP141-NP146. Epub 2019 Sep 23 doi: 10.1177/0145561319875438. PMID: 31547716
Narang I, Al-Saleh S, Amin R, Propst EJ, Bin-Hasan S, Campisi P, Ryan C, Kendzerska T
Otolaryngol Head Neck Surg 2018 Apr;158(4):745-751. Epub 2017 Nov 7 doi: 10.1177/0194599817740349. PMID: 29110575
Ant A, Kemaloglu YK, Yilmaz M, Dilci A
J Craniofac Surg 2017 May;28(3):625-628. doi: 10.1097/SCS.0000000000003409. PMID: 28468136
Orji FT, Adiele DK, Umedum NG, Akpeh JO, Ofoegbu VC, Nwosu JN
Eur Arch Otorhinolaryngol 2017 Mar;274(3):1237-1243. Epub 2016 Jul 18 doi: 10.1007/s00405-016-4207-y. PMID: 27430227
Reid D, Morton R, Salkeld L, Bartley J
Int J Pediatr Otorhinolaryngol 2011 Feb;75(2):261-4. Epub 2010 Dec 4 doi: 10.1016/j.ijporl.2010.11.012. PMID: 21131064

Clinical prediction guides

Berkiten G, Şengiz Erhan S, Çelik C, Tutar B, Atar Y, Aksungur E, Sari H, Uyar Y
Int J Pediatr Otorhinolaryngol 2023 Nov;174:111718. Epub 2023 Sep 14 doi: 10.1016/j.ijporl.2023.111718. PMID: 37722297
Yoon A, Abdelwahab M, Bockow R, Vakili A, Lovell K, Chang I, Ganguly R, Liu SY, Kushida C, Hong C
Sleep Med 2022 Apr;92:96-102. Epub 2022 Feb 19 doi: 10.1016/j.sleep.2022.02.011. PMID: 35390750Free PMC Article
Ant A, Kemaloglu YK, Yilmaz M, Dilci A
J Craniofac Surg 2017 May;28(3):625-628. doi: 10.1097/SCS.0000000000003409. PMID: 28468136
Orji FT, Adiele DK, Umedum NG, Akpeh JO, Ofoegbu VC, Nwosu JN
Eur Arch Otorhinolaryngol 2017 Mar;274(3):1237-1243. Epub 2016 Jul 18 doi: 10.1007/s00405-016-4207-y. PMID: 27430227
Cho JH, Lee DH, Lee NS, Won YS, Yoon HR, Suh BD
J Laryngol Otol 1999 Oct;113(10):899-905. doi: 10.1017/s0022215100145530. PMID: 10664704

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