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High grade B-cell lymphoma

MedGen UID:
629622
•Concept ID:
C0456863
•
Neoplastic Process
Synonyms: HGBL; High Grade B-Cell Lymphoma; high grade B-cell lymphoma; High-Grade B-Cell Lymphoma; high-grade B-cell lymphoma
SNOMED CT: High grade B-cell lymphoma (277617004)
 
Monarch Initiative: MONDO:0044889

Definition

A term that refers to high grade B-cell lymphoma, not otherwise specified or high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements. [from NCI]

Professional guidelines

PubMed

Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107
Management of adults and children undergoing chimeric antigen receptor T-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE).
Yakoub-Agha I, Chabannon C, Bader P, Basak GW, Bonig H, Ciceri F, Corbacioglu S, Duarte RF, Einsele H, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Robinson S, Saccardi R, Sanchez-Guijo F, Snowden JA, Srour M, Styczynski J, Urbano-Ispizua A, Hayden PJ, Kröger N
Haematologica 2020;105(2):297-316. Epub 2020 Jan 31 doi: 10.3324/haematol.2019.229781. PMID: 31753925Free PMC Article
Burkitt's lymphoma: clinicopathologic features and differential diagnosis.
Ferry JA
Oncologist 2006 Apr;11(4):375-83. doi: 10.1634/theoncologist.11-4-375. PMID: 16614233

Recent clinical studies

Etiology

Double-hit lymphoma: optimizing therapy.
Dunleavy K
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):157-163. doi: 10.1182/hematology.2021000247. PMID: 34889402Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.
Ramis-Zaldivar JE, Gonzalez-Farré B, Balagué O, Celis V, Nadeu F, Salmerón-Villalobos J, Andrés M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Bárcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdú-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera P, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I
Blood 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699. PMID: 31738823Free PMC Article
Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.
Ennishi D, Jiang A, Boyle M, Collinge B, Grande BM, Ben-Neriah S, Rushton C, Tang J, Thomas N, Slack GW, Farinha P, Takata K, Miyata-Takata T, Craig J, Mottok A, Meissner B, Saberi S, Bashashati A, Villa D, Savage KJ, Sehn LH, Kridel R, Mungall AJ, Marra MA, Shah SP, Steidl C, Connors JM, Gascoyne RD, Morin RD, Scott DW
J Clin Oncol 2019 Jan 20;37(3):190-201. Epub 2018 Dec 3 doi: 10.1200/JCO.18.01583. PMID: 30523716Free PMC Article
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article

Diagnosis

Diagnostic approaches and future directions in Burkitt lymphoma and high-grade B-cell lymphoma.
King RL, Hsi ED, Chan WC, Piris MA, Cook JR, Scott DW, Swerdlow SH
Virchows Arch 2023 Jan;482(1):193-205. Epub 2022 Sep 3 doi: 10.1007/s00428-022-03404-6. PMID: 36057749
Defining and treating high-grade B-cell lymphoma, NOS.
Olszewski AJ, Kurt H, Evens AM
Blood 2022 Sep 1;140(9):943-954. doi: 10.1182/blood.2020008374. PMID: 34525177
High-grade B-cell lymphoma: how to diagnose and treat.
Novo M, Castellino A, Nicolosi M, Santambrogio E, Vassallo F, Chiappella A, Vitolo U
Expert Rev Hematol 2019 Jul;12(7):497-506. Epub 2019 Jun 19 doi: 10.1080/17474086.2019.1624157. PMID: 31150587
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article
Burkitt's lymphoma: clinicopathologic features and differential diagnosis.
Ferry JA
Oncologist 2006 Apr;11(4):375-83. doi: 10.1634/theoncologist.11-4-375. PMID: 16614233

Therapy

Engineered T Cells: CAR T Cell Therapy and Beyond.
Johnson PC, Abramson JS
Curr Oncol Rep 2022 Jan;24(1):23-31. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01161-4. PMID: 35059997
Double-hit lymphoma: optimizing therapy.
Dunleavy K
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):157-163. doi: 10.1182/hematology.2021000247. PMID: 34889402Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy.
Sha C, Barrans S, Cucco F, Bentley MA, Care MA, Cummin T, Kennedy H, Thompson JS, Uddin R, Worrillow L, Chalkley R, van Hoppe M, Ahmed S, Maishman T, Caddy J, Schuh A, Mamot C, Burton C, Tooze R, Davies A, Du MQ, Johnson PWM, Westhead DR
J Clin Oncol 2019 Jan 20;37(3):202-212. Epub 2018 Dec 3 doi: 10.1200/JCO.18.01314. PMID: 30523719Free PMC Article
A Review of Autologous Stem Cell Transplantation in Lymphoma.
Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F
Curr Hematol Malig Rep 2017 Jun;12(3):217-226. doi: 10.1007/s11899-017-0382-1. PMID: 28478586Free PMC Article

Prognosis

Defining and treating high-grade B-cell lymphoma, NOS.
Olszewski AJ, Kurt H, Evens AM
Blood 2022 Sep 1;140(9):943-954. doi: 10.1182/blood.2020008374. PMID: 34525177
Distinct molecular profile of IRF4-rearranged large B-cell lymphoma.
Ramis-Zaldivar JE, Gonzalez-Farré B, Balagué O, Celis V, Nadeu F, Salmerón-Villalobos J, Andrés M, Martin-Guerrero I, Garrido-Pontnou M, Gaafar A, Suñol M, Bárcena C, Garcia-Bragado F, Andión M, Azorín D, Astigarraga I, Sagaseta de Ilurdoz M, Sábado C, Gallego S, Verdú-Amorós J, Fernandez-Delgado R, Perez V, Tapia G, Mozos A, Torrent M, Solano-Páez P, Rivas-Delgado A, Dlouhy I, Clot G, Enjuanes A, López-Guillermo A, Galera P, Oberley MJ, Maguire A, Ramsower C, Rimsza LM, Quintanilla-Martinez L, Jaffe ES, Campo E, Salaverria I
Blood 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699. PMID: 31738823Free PMC Article
High-grade B-cell lymphoma: how to diagnose and treat.
Novo M, Castellino A, Nicolosi M, Santambrogio E, Vassallo F, Chiappella A, Vitolo U
Expert Rev Hematol 2019 Jul;12(7):497-506. Epub 2019 Jun 19 doi: 10.1080/17474086.2019.1624157. PMID: 31150587
Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.
Ennishi D, Jiang A, Boyle M, Collinge B, Grande BM, Ben-Neriah S, Rushton C, Tang J, Thomas N, Slack GW, Farinha P, Takata K, Miyata-Takata T, Craig J, Mottok A, Meissner B, Saberi S, Bashashati A, Villa D, Savage KJ, Sehn LH, Kridel R, Mungall AJ, Marra MA, Shah SP, Steidl C, Connors JM, Gascoyne RD, Morin RD, Scott DW
J Clin Oncol 2019 Jan 20;37(3):190-201. Epub 2018 Dec 3 doi: 10.1200/JCO.18.01583. PMID: 30523716Free PMC Article
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology.
Scott DW, King RL, Staiger AM, Ben-Neriah S, Jiang A, Horn H, Mottok A, Farinha P, Slack GW, Ennishi D, Schmitz N, Pfreundschuh M, Nowakowski GS, Kahl BS, Connors JM, Gascoyne RD, Ott G, Macon WR, Rosenwald A
Blood 2018 May 3;131(18):2060-2064. Epub 2018 Feb 23 doi: 10.1182/blood-2017-12-820605. PMID: 29475959Free PMC Article

Clinical prediction guides

Blastoid high-grade B-cell lymphoma initially presenting in bone marrow: a diagnostic challenge.
Khanlari M, Medeiros LJ, Lin P, Xu J, You MJ, Tang G, Yin CC, Wang W, Qiu L, Miranda RN, Bueso-Ramos CE, Li S
Mod Pathol 2022 Mar;35(3):419-426. Epub 2021 Oct 4 doi: 10.1038/s41379-021-00909-4. PMID: 34608246
Molecular classification of aggressive lymphomas-past, present, future.
Wienand K, Chapuy B
Hematol Oncol 2021 Jun;39 Suppl 1:24-30. doi: 10.1002/hon.2847. PMID: 34105819
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology.
Scott DW, King RL, Staiger AM, Ben-Neriah S, Jiang A, Horn H, Mottok A, Farinha P, Slack GW, Ennishi D, Schmitz N, Pfreundschuh M, Nowakowski GS, Kahl BS, Connors JM, Gascoyne RD, Ott G, Macon WR, Rosenwald A
Blood 2018 May 3;131(18):2060-2064. Epub 2018 Feb 23 doi: 10.1182/blood-2017-12-820605. PMID: 29475959Free PMC Article
Hematolymphoid lesions of the breast.
Hoffmann J, Ohgami RS
Semin Diagn Pathol 2017 Sep;34(5):462-469. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.007. PMID: 28662998
MYC/BCL2 double-hit high-grade B-cell lymphoma.
Li S, Lin P, Young KH, Kanagal-Shamanna R, Yin CC, Medeiros LJ
Adv Anat Pathol 2013 Sep;20(5):315-26. doi: 10.1097/PAP.0b013e3182a289f2. PMID: 23939148

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