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Hilar lymph node enlargement

MedGen UID:
629708
Concept ID:
C0456973
Disease or Syndrome
Synonym: Hilar lymphadenopathy
SNOMED CT: Hilar lymphadenopathy (87500009); Bronchopulmonary lymphadenopathy (87500009)
 
HPO: HP:0034388

Definition

Hilar lymphadenopathy is swelling or enlargement of lymph nodes localised in hila, wedge-shaped anatomical structures containing pulmonary vessels, major bronchi, nerves and lymph nodes. Hilar lymph nodes are not visible on chest X-ray if they are not enlarged. Hilar lymph node enlargement can be caused by benign and malignant conditions and can be symmetrical (bilateral) or asymmetrical (unilateral). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHilar lymph node enlargement

Conditions with this feature

Respiratory infections, recurrent, and failure to thrive with or without diarrhea
MedGen UID:
1824079
Concept ID:
C5774306
Disease or Syndrome
Recurrent respiratory infections and failure to thrive with or without diarrhea (RIFTD) is characterized by neonatal onset of chronic cough, episodic wheezing, recurrent lower respiratory tract infections, chronic diarrhea, and failure to thrive. Despite the resemblance to cystic fibrosis (CF; 219700), these patients have normal sweat chloride and pancreatic elastase tests (Bertoli-Avella et al., 2022).

Professional guidelines

PubMed

Koh WJ, Jeong YJ, Kwon OJ, Kim HJ, Cho EH, Lew WJ, Lee KS
Korean J Radiol 2010 Nov-Dec;11(6):612-7. Epub 2010 Oct 29 doi: 10.3348/kjr.2010.11.6.612. PMID: 21076586Free PMC Article
Yilmaz U, Polat G, Sahin N, Soy O, Gülay U
Monaldi Arch Chest Dis 2005 Mar;63(1):17-22. doi: 10.4081/monaldi.2005.653. PMID: 16035560

Recent clinical studies

Etiology

Kulkarni S, Bhimaniya S, Chi L, Tica S, Alghamdi S, Stoll J, Caudill K, Fleckenstein J
Clin Imaging 2023 May;97:7-13. Epub 2023 Feb 4 doi: 10.1016/j.clinimag.2023.01.012. PMID: 36868034
Demirdöğen E, Ursavaş A, Aydın Güçlü Ö, Acet Öztürk NA, Özkaya G, Karadağ M
Tuberk Toraks 2020 Sep;68(3):285-292. doi: 10.5578/tt.70045. PMID: 33295727
Erturk SM, Durak G, Ayyildiz H, Comert RG, Medetalibeyoglu A, Senkal N, Uysal E, Tunaci A
J Comput Assist Tomogr 2020 Sep/Oct;44(5):633-639. doi: 10.1097/RCT.0000000000001073. PMID: 32842068
Xu Y, Lin J, Chen M, Zheng H, Feng J
BMC Pulm Med 2020 May 15;20(1):140. doi: 10.1186/s12890-020-01183-x. PMID: 32414358Free PMC Article
Christe A, Walti L, Charimo J, Rauch A, Furrer H, Meyer A, Huynh-Do U, Heverhagen JT, Mueller NJ, Cavassini M, Mombelli M, van Delden C, Frauenfelder T, Montet X, Beigelman-Aubry C, Arampatzis S, Ebner L
Swiss Med Wkly 2019 Sep 23;149:w20130. Epub 2019 Oct 3 doi: 10.4414/smw.2019.20130. PMID: 31580472

Diagnosis

Ugurlu E, Metin M, Cetin N, Kilicarslan E, Degirmencioglu S, Sengoz T, Akbudak IH, Gokoz Dogu G, Aydogmus U
Medicine (Baltimore) 2023 Sep 1;102(35):e34928. doi: 10.1097/MD.0000000000034928. PMID: 37657039Free PMC Article
Kang Q, Haibo L, Gang L, Yanyan H, Lin N, Janhua Z, Bing W, Jian L
Acta Chir Belg 2023 Jun;123(3):313-316. Epub 2021 Nov 9 doi: 10.1080/00015458.2021.2001900. PMID: 34753409
Yan X, Fang S, Wang T, Wu H, Jiang Z, Fang L, Fan X, Zhang Y, Wang J
Clin Lab 2021 Feb 1;67(2) doi: 10.7754/Clin.Lab.2020.200632. PMID: 33616320
Demirdöğen E, Ursavaş A, Aydın Güçlü Ö, Acet Öztürk NA, Özkaya G, Karadağ M
Tuberk Toraks 2020 Sep;68(3):285-292. doi: 10.5578/tt.70045. PMID: 33295727
Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, Xaubet A
Radiographics 2010 Oct;30(6):1567-86. doi: 10.1148/rg.306105512. PMID: 21071376

Therapy

Du Z, Yu Y, Wu D, Zhang G, Wang Y, He L, Meng R
Medicine (Baltimore) 2018 Nov;97(45):e13105. doi: 10.1097/MD.0000000000013105. PMID: 30407323Free PMC Article
Kabara M, Nakagawa N, Matsuki M, Chinda J, Fujino T, Hasebe N
Mod Rheumatol 2013 Jan;23(1):146-50. Epub 2012 Feb 19 doi: 10.1007/s10165-012-0614-0. PMID: 22350640
da Silva RM, da Rosa L, Lemos RN
J Bras Pneumol 2006 May-Jun;32(3):228-33. PMID: 17273612
Wolfensberger TJ, Herbort CP
Ophthalmology 1999 Feb;106(2):285-9. doi: 10.1016/S0161-6420(99)90067-2. PMID: 9951478
Kikawada M, Ichinose Y, Kunisawa A, Yanagisawa N, Minemura K, Kasuga I, Yonemaru M, Kawanishi K, Takasaki M, Toyama K
Respirology 1998 Mar;3(1):41-4. doi: 10.1046/j.1440-1843.1998.d01-1.x. PMID: 9657659

Prognosis

Demirdöğen E, Ursavaş A, Aydın Güçlü Ö, Acet Öztürk NA, Özkaya G, Karadağ M
Tuberk Toraks 2020 Sep;68(3):285-292. doi: 10.5578/tt.70045. PMID: 33295727
Erturk SM, Durak G, Ayyildiz H, Comert RG, Medetalibeyoglu A, Senkal N, Uysal E, Tunaci A
J Comput Assist Tomogr 2020 Sep/Oct;44(5):633-639. doi: 10.1097/RCT.0000000000001073. PMID: 32842068
Xu Y, Lin J, Chen M, Zheng H, Feng J
BMC Pulm Med 2020 May 15;20(1):140. doi: 10.1186/s12890-020-01183-x. PMID: 32414358Free PMC Article
Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, Xaubet A
Radiographics 2010 Oct;30(6):1567-86. doi: 10.1148/rg.306105512. PMID: 21071376
Hunsaker AR, Munden RF, Pugatch RD, Mentzer SJ
Radiology 1996 Jul;200(1):255-61. doi: 10.1148/radiology.200.1.8657922. PMID: 8657922

Clinical prediction guides

Demirdöğen E, Ursavaş A, Aydın Güçlü Ö, Acet Öztürk NA, Özkaya G, Karadağ M
Tuberk Toraks 2020 Sep;68(3):285-292. doi: 10.5578/tt.70045. PMID: 33295727
Erturk SM, Durak G, Ayyildiz H, Comert RG, Medetalibeyoglu A, Senkal N, Uysal E, Tunaci A
J Comput Assist Tomogr 2020 Sep/Oct;44(5):633-639. doi: 10.1097/RCT.0000000000001073. PMID: 32842068
Xu Y, Lin J, Chen M, Zheng H, Feng J
BMC Pulm Med 2020 May 15;20(1):140. doi: 10.1186/s12890-020-01183-x. PMID: 32414358Free PMC Article
Okada F, Ando Y, Nakayama T, Tanoue S, Ishii R, Ono A, Watanabe M, Takaki H, Maeda T, Mori H
Br J Radiol 2011 Dec;84(1008):1109-14. Epub 2010 Dec 1 doi: 10.1259/bjr/42762966. PMID: 21123308Free PMC Article
Scadding JG
Postgrad Med J 1970 Aug;46(538):530-6. doi: 10.1136/pgmj.46.538.530. PMID: 5481107Free PMC Article

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