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Physiological hyperbilirubinemia

MedGen UID:
633012
•Concept ID:
C0473118
•
Disease or Syndrome
Synonym: Physiologic Hyperbilirubinemia
SNOMED CT: Physiological hyperbilirubinemia (235905008)

Definition

Elevated bilirubin levels in the blood of a newborn infant. It is a normal response due to the limited ability to excrete bilirubin until the maturation of the neonatal liver is complete. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhysiological hyperbilirubinemia

Professional guidelines

PubMed

Diagnostic criteria and contributors to Gilbert's syndrome.
Wagner KH, Shiels RG, Lang CA, Seyed Khoei N, Bulmer AC
Crit Rev Clin Lab Sci 2018 Mar;55(2):129-139. Epub 2018 Feb 1 doi: 10.1080/10408363.2018.1428526. PMID: 29390925
Neonatal jaundice: aetiology, diagnosis and treatment.
Mitra S, Rennie J
Br J Hosp Med (Lond) 2017 Dec 2;78(12):699-704. doi: 10.12968/hmed.2017.78.12.699. PMID: 29240507
Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Fawaz R, Baumann U, Ekong U, Fischler B, Hadzic N, Mack CL, McLin VA, Molleston JP, Neimark E, Ng VL, Karpen SJ
J Pediatr Gastroenterol Nutr 2017 Jan;64(1):154-168. doi: 10.1097/MPG.0000000000001334. PMID: 27429428

Recent clinical studies

Etiology

Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn.
Hansen TWR, Wong RJ, Stevenson DK
Physiol Rev 2020 Jul 1;100(3):1291-1346. doi: 10.1152/physrev.00004.2019. PMID: 32401177
Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia.
Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M
Hepatology 2018 Apr;67(4):1609-1619. Epub 2018 Mar 2 doi: 10.1002/hep.29599. PMID: 29059457
Quantitative trait analysis of polymorphisms in two bilirubin metabolism enzymes to physiologic bilirubin levels in Chinese newborns.
Zhou Y, Wang SN, Li H, Zha W, Peng Q, Li S, Chen Y, Jin L
J Pediatr 2014 Dec;165(6):1154-1160.e1. Epub 2014 Sep 26 doi: 10.1016/j.jpeds.2014.08.041. PMID: 25262300

Prognosis

Quantitative trait analysis of polymorphisms in two bilirubin metabolism enzymes to physiologic bilirubin levels in Chinese newborns.
Zhou Y, Wang SN, Li H, Zha W, Peng Q, Li S, Chen Y, Jin L
J Pediatr 2014 Dec;165(6):1154-1160.e1. Epub 2014 Sep 26 doi: 10.1016/j.jpeds.2014.08.041. PMID: 25262300

Clinical prediction guides

Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.
Fujiwara R, Maruo Y, Chen S, Tukey RH
Toxicol Appl Pharmacol 2015 Nov 15;289(1):124-32. Epub 2015 Sep 2 doi: 10.1016/j.taap.2015.08.018. PMID: 26342858Free PMC Article
Quantitative trait analysis of polymorphisms in two bilirubin metabolism enzymes to physiologic bilirubin levels in Chinese newborns.
Zhou Y, Wang SN, Li H, Zha W, Peng Q, Li S, Chen Y, Jin L
J Pediatr 2014 Dec;165(6):1154-1160.e1. Epub 2014 Sep 26 doi: 10.1016/j.jpeds.2014.08.041. PMID: 25262300

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