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Macroscopic hematuria

MedGen UID:
633103
Concept ID:
C0473237
Finding
Synonyms: Gross hematuria; Hematuria, gross
SNOMED CT: Gross hematuria (197941005); Frank hematuria (197941005); Macroscopic hematuria (197941005)
 
HPO: HP:0012587

Definition

Hematuria that is visible upon inspection of the urine. [from HPO]

Term Hierarchy

Conditions with this feature

Primary hypomagnesemia
MedGen UID:
120640
Concept ID:
C0268448
Disease or Syndrome
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is a progressive renal disorder characterized by excessive urinary Ca(2+) and Mg(2+) excretion. There is progressive loss of kidney function, and in about 50% of cases, the need for renal replacement therapy arises as early as the second decade of life (summary by Muller et al., 2006). Amelogenesis imperfecta may also be present in some patients (Bardet et al., 2016). A similar disorder with renal magnesium wasting, renal failure, and nephrocalcinosis (HOMG5; 248190) is caused by mutations in another tight-junction gene, CLDN19 (610036), and is distinguished by the association of severe ocular involvement. For a discussion of phenotypic and genetic heterogeneity of familial hypomagnesemia, see HOMG1 (602014).
Anti-glomerular basement membrane disease
MedGen UID:
140788
Concept ID:
C0403529
Disease or Syndrome
A rare, fulminant small vessel vasculitis that affects the capillary beds of the kidneys and lungs and characterized by the presence of anti-glomerular basement membrane (GBM) and, in its full-blown form, anti-alveolar basement membrane (ABM) antibodies. Consequently, it may manifest as a rapidly progressive, isolated glomerulonephritis (anti-GBM nephritis) or as a pulmonary-renal syndrome with severe lung hemorrhage.
Immunodeficiency, common variable, 6
MedGen UID:
462091
Concept ID:
C3150741
Disease or Syndrome
Any common variable immunodeficiency in which the cause of the disease is a mutation in the CD81 gene.

Professional guidelines

PubMed

Noh SY, Shin JH, Yang WJ, Chu HH, Park S, Chen C, Lee WH
Minim Invasive Ther Allied Technol 2022 Feb;31(2):197-205. Epub 2020 Jul 17 doi: 10.1080/13645706.2020.1782939. PMID: 32678715
Vedula R, Iyengar AA
Indian J Pediatr 2020 Aug;87(8):618-624. Epub 2020 Feb 6 doi: 10.1007/s12098-020-03184-4. PMID: 32026313
Expert Panel on Pediatric Imaging:, Dillman JR, Rigsby CK, Iyer RS, Alazraki AL, Anupindi SA, Brown BP, Chan SS, Dorfman SR, Falcone RA Jr, Garber MD, Nguyen JC, Peters CA, Safdar NM, Trout AT, Karmazyn BK
J Am Coll Radiol 2018 May;15(5S):S91-S103. doi: 10.1016/j.jacr.2018.03.022. PMID: 29724430

Recent clinical studies

Etiology

Poggio ED, McClelland RL, Blank KN, Hansen S, Bansal S, Bomback AS, Canetta PA, Khairallah P, Kiryluk K, Lecker SH, McMahon GM, Palevsky PM, Parikh S, Rosas SE, Tuttle K, Vazquez MA, Vijayan A, Rovin BH; Kidney Precision Medicine Project
Clin J Am Soc Nephrol 2020 Nov 6;15(11):1595-1602. Epub 2020 Oct 15 doi: 10.2215/CJN.04710420. PMID: 33060160Free PMC Article
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Duan ZY, Cai GY, Li JJ, Bu R, Chen XM
Kidney Blood Press Res 2017;42(4):738-748. Epub 2017 Oct 19 doi: 10.1159/000481970. PMID: 29050002
Barratt J, Feehally J
Kidney Int 2006 Jun;69(11):1934-8. doi: 10.1038/sj.ki.5000419. PMID: 16641928
Morin JP, Fillastre JP, Olier B
Chemioterapia 1984 Feb;3(1):33-40. PMID: 6100174

Diagnosis

Poggio ED, McClelland RL, Blank KN, Hansen S, Bansal S, Bomback AS, Canetta PA, Khairallah P, Kiryluk K, Lecker SH, McMahon GM, Palevsky PM, Parikh S, Rosas SE, Tuttle K, Vazquez MA, Vijayan A, Rovin BH; Kidney Precision Medicine Project
Clin J Am Soc Nephrol 2020 Nov 6;15(11):1595-1602. Epub 2020 Oct 15 doi: 10.2215/CJN.04710420. PMID: 33060160Free PMC Article
Vedula R, Iyengar AA
Indian J Pediatr 2020 Aug;87(8):618-624. Epub 2020 Feb 6 doi: 10.1007/s12098-020-03184-4. PMID: 32026313
Kincaid-Smith P, Fairley K
Semin Nephrol 2005 May;25(3):127-35. doi: 10.1016/j.semnephrol.2005.01.002. PMID: 15880321
Lau KK, Wyatt RJ
Adolesc Med Clin 2005 Feb;16(1):67-85. doi: 10.1016/j.admecli.2004.09.008. PMID: 15844384
Galla JH
Kidney Int 1995 Feb;47(2):377-87. doi: 10.1038/ki.1995.50. PMID: 7723227

Therapy

Pfeiffer T, Tzannou I, Wu M, Ramos C, Sasa G, Martinez C, Lulla P, Krance RA, Scherer L, Ruderfer D, Naik S, Bocchini C, Fraser IP, Patel B, Ward D, Wang T, Heslop HE, Leen AM, Omer B
Clin Cancer Res 2023 Jan 17;29(2):324-330. doi: 10.1158/1078-0432.CCR-22-2415. PMID: 36628536Free PMC Article
Poggio ED, McClelland RL, Blank KN, Hansen S, Bansal S, Bomback AS, Canetta PA, Khairallah P, Kiryluk K, Lecker SH, McMahon GM, Palevsky PM, Parikh S, Rosas SE, Tuttle K, Vazquez MA, Vijayan A, Rovin BH; Kidney Precision Medicine Project
Clin J Am Soc Nephrol 2020 Nov 6;15(11):1595-1602. Epub 2020 Oct 15 doi: 10.2215/CJN.04710420. PMID: 33060160Free PMC Article
Resontoc LP, Yap HK
Pediatr Nephrol 2016 Jun;31(6):907-15. Epub 2015 Jul 15 doi: 10.1007/s00467-015-3160-0. PMID: 26173707
Moreno JA, Martín-Cleary C, Gutiérrez E, Toldos O, Blanco-Colio LM, Praga M, Ortiz A, Egido J
Clin J Am Soc Nephrol 2012 Jan;7(1):175-84. Epub 2011 Nov 17 doi: 10.2215/CJN.01970211. PMID: 22096039
Morin JP, Fillastre JP, Olier B
Chemioterapia 1984 Feb;3(1):33-40. PMID: 6100174

Prognosis

Paranhos RM, De Souza Figueiredo GA, De Abreu GR, Ferreira GC, Fonseca GG, Simões E Silva AC
Nephrology (Carlton) 2022 Apr;27(4):307-317. Epub 2021 Oct 29 doi: 10.1111/nep.13987. PMID: 34676611
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Duan ZY, Cai GY, Li JJ, Bu R, Chen XM
Kidney Blood Press Res 2017;42(4):738-748. Epub 2017 Oct 19 doi: 10.1159/000481970. PMID: 29050002
Galla JH
Kidney Int 1995 Feb;47(2):377-87. doi: 10.1038/ki.1995.50. PMID: 7723227
Morin JP, Fillastre JP, Olier B
Chemioterapia 1984 Feb;3(1):33-40. PMID: 6100174

Clinical prediction guides

Paranhos RM, De Souza Figueiredo GA, De Abreu GR, Ferreira GC, Fonseca GG, Simões E Silva AC
Nephrology (Carlton) 2022 Apr;27(4):307-317. Epub 2021 Oct 29 doi: 10.1111/nep.13987. PMID: 34676611
Vianello FA, Mazzoni MB, Peeters GG, Fossali EF, Camozzi P, Bianchetti MG, Milani GP
Pediatr Nephrol 2016 Feb;31(2):175-84. Epub 2015 Jan 28 doi: 10.1007/s00467-015-3045-2. PMID: 25627663
Tomino Y
Kaohsiung J Med Sci 2012 Oct;28(10):517-20. Epub 2012 Sep 25 doi: 10.1016/j.kjms.2012.04.012. PMID: 23089315
Kincaid-Smith P, Fairley K
Semin Nephrol 2005 May;25(3):127-35. doi: 10.1016/j.semnephrol.2005.01.002. PMID: 15880321
Morin JP, Fillastre JP, Olier B
Chemioterapia 1984 Feb;3(1):33-40. PMID: 6100174

Recent systematic reviews

He P, Wang H, Huang C, He L
Ren Fail 2021 Dec;43(1):488-499. doi: 10.1080/0886022X.2021.1879852. PMID: 33685345Free PMC Article
Poggio ED, McClelland RL, Blank KN, Hansen S, Bansal S, Bomback AS, Canetta PA, Khairallah P, Kiryluk K, Lecker SH, McMahon GM, Palevsky PM, Parikh S, Rosas SE, Tuttle K, Vazquez MA, Vijayan A, Rovin BH; Kidney Precision Medicine Project
Clin J Am Soc Nephrol 2020 Nov 6;15(11):1595-1602. Epub 2020 Oct 15 doi: 10.2215/CJN.04710420. PMID: 33060160Free PMC Article
Ahn T, Roberts MJ, Navaratnam A, Chung E, Wood S
Int Urol Nephrol 2017 Nov;49(11):1897-1905. Epub 2017 Sep 4 doi: 10.1007/s11255-017-1694-8. PMID: 28871505
Vianello FA, Mazzoni MB, Peeters GG, Fossali EF, Camozzi P, Bianchetti MG, Milani GP
Pediatr Nephrol 2016 Feb;31(2):175-84. Epub 2015 Jan 28 doi: 10.1007/s00467-015-3045-2. PMID: 25627663
Corapi KM, Chen JL, Balk EM, Gordon CE
Am J Kidney Dis 2012 Jul;60(1):62-73. Epub 2012 Apr 24 doi: 10.1053/j.ajkd.2012.02.330. PMID: 22537423

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