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Threatened Preterm Labor

MedGen UID:
633206
•Concept ID:
C0473390
•
Pathologic Function
Synonym: Threatened Premature Labor

Definition

Frequent painful contractions prior to 37 weeks of gestation without cervical change. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThreatened Preterm Labor

Professional guidelines

PubMed

Effectiveness and safety of atosiban versus conventional treatment in the management of preterm labor.
Yu Y, Yang Z, Wu L, Zhu Y, Guo F
Taiwan J Obstet Gynecol 2020 Sep;59(5):682-685. doi: 10.1016/j.tjog.2020.07.010. PMID: 32917318
Listeriosis in pregnancy: under-diagnosis despite over-treatment.
Fouks Y, Amit S, Many A, Haham A, Mandel D, Shinar S
J Perinatol 2018 Jan;38(1):26-30. Epub 2017 Oct 12 doi: 10.1038/jp.2017.145. PMID: 29022924
An algorithm for risk assessment and intervention of mother to child transmission of hepatitis B virus.
Pan CQ, Duan ZP, Bhamidimarri KR, Zou HB, Liang XF, Li J, Tong MJ
Clin Gastroenterol Hepatol 2012 May;10(5):452-9. Epub 2011 Nov 9 doi: 10.1016/j.cgh.2011.10.041. PMID: 22079509

Recent clinical studies

Etiology

Prevention of preterm birth in multiples.
Dom AM, Mather A, Seligman NS
Curr Opin Obstet Gynecol 2021 Apr 1;33(2):72-77. doi: 10.1097/GCO.0000000000000686. PMID: 33427762
Maintaining and repeating tocolysis: A reflection on evidence.
Dehaene I, Bergman L, Turtiainen P, Ridout A, Mol BW, Lorthe E; from the International Spontaneous Preterm birth Young Investigators group (I-SPY)
Semin Perinatol 2017 Dec;41(8):468-476. Epub 2017 Sep 22 doi: 10.1053/j.semperi.2017.08.005. PMID: 28943054
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.
Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G
Ultrasound Obstet Gynecol 2017 Mar;49(3):322-329. Epub 2017 Feb 8 doi: 10.1002/uog.17388. PMID: 27997053
Multiple gestations and preterm birth.
Fuchs F, Senat MV
Semin Fetal Neonatal Med 2016 Apr;21(2):113-20. Epub 2016 Jan 13 doi: 10.1016/j.siny.2015.12.010. PMID: 26795885
Ethanol for preventing preterm birth in threatened preterm labor.
Haas DM, Morgan AM, Deans SJ, Schubert FP
Cochrane Database Syst Rev 2015 Nov 5;2015(11):CD011445. doi: 10.1002/14651858.CD011445.pub2. PMID: 26544539Free PMC Article

Diagnosis

Assessment of uterine contractions in labor and delivery.
Rosen H, Yogev Y
Am J Obstet Gynecol 2023 May;228(5S):S1209-S1221. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.09.003. PMID: 37164494
Serum Copeptin Levels in Threatened Preterm Labor.
Tulmac OB, Sayan CD, Dag ZO, Oguz Y, Gencosmanoglu G, Caglar T, Kisa U
Fetal Pediatr Pathol 2021 Oct;40(5):414-422. Epub 2020 Feb 12 doi: 10.1080/15513815.2020.1721626. PMID: 32050829
Economic consequences of over-diagnosis of threatened preterm labor.
Coloma M, Kang F, Vallejo-Torres L, Díaz P, Méndez Y, Álvarez de la Rosa M
Int J Gynaecol Obstet 2018 May;141(2):200-205. Epub 2018 Feb 14 doi: 10.1002/ijgo.12450. PMID: 29369336
Multiple gestations and preterm birth.
Fuchs F, Senat MV
Semin Fetal Neonatal Med 2016 Apr;21(2):113-20. Epub 2016 Jan 13 doi: 10.1016/j.siny.2015.12.010. PMID: 26795885
Ethanol for preventing preterm birth in threatened preterm labor.
Haas DM, Morgan AM, Deans SJ, Schubert FP
Cochrane Database Syst Rev 2015 Nov 5;2015(11):CD011445. doi: 10.1002/14651858.CD011445.pub2. PMID: 26544539Free PMC Article

Therapy

Assessment of uterine contractions in labor and delivery.
Rosen H, Yogev Y
Am J Obstet Gynecol 2023 May;228(5S):S1209-S1221. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.09.003. PMID: 37164494
Maintaining and repeating tocolysis: A reflection on evidence.
Dehaene I, Bergman L, Turtiainen P, Ridout A, Mol BW, Lorthe E; from the International Spontaneous Preterm birth Young Investigators group (I-SPY)
Semin Perinatol 2017 Dec;41(8):468-476. Epub 2017 Sep 22 doi: 10.1053/j.semperi.2017.08.005. PMID: 28943054
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.
Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G
Ultrasound Obstet Gynecol 2017 Mar;49(3):322-329. Epub 2017 Feb 8 doi: 10.1002/uog.17388. PMID: 27997053
Ethanol for preventing preterm birth in threatened preterm labor.
Haas DM, Morgan AM, Deans SJ, Schubert FP
Cochrane Database Syst Rev 2015 Nov 5;2015(11):CD011445. doi: 10.1002/14651858.CD011445.pub2. PMID: 26544539Free PMC Article
Terbutaline pump maintenance therapy after threatened preterm labor for preventing preterm birth.
Nanda K, Cook LA, Gallo MF, Grimes DA
Cochrane Database Syst Rev 2002;(4):CD003933. doi: 10.1002/14651858.CD003933. PMID: 12519621

Prognosis

Vaginal Ureaplasma urealyticum or Mycoplasma hominis and preterm delivery in women with threatened preterm labor.
Miyoshi Y, Suga S, Sugimi S, Kurata N, Yamashita H, Yasuhi I
J Matern Fetal Neonatal Med 2022 Mar;35(5):878-883. Epub 2020 Mar 4 doi: 10.1080/14767058.2020.1733517. PMID: 32131651
Serum Copeptin Levels in Threatened Preterm Labor.
Tulmac OB, Sayan CD, Dag ZO, Oguz Y, Gencosmanoglu G, Caglar T, Kisa U
Fetal Pediatr Pathol 2021 Oct;40(5):414-422. Epub 2020 Feb 12 doi: 10.1080/15513815.2020.1721626. PMID: 32050829
Single and repeat cervical-length measurement in twin gestation with threatened preterm labor.
Prodan N, Wagner P, Sonek J, Abele H, Hoopmann M, Kagan KO
Ultrasound Obstet Gynecol 2020 Apr;55(4):496-501. doi: 10.1002/uog.20306. PMID: 31066097
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.
Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G
Ultrasound Obstet Gynecol 2017 Mar;49(3):322-329. Epub 2017 Feb 8 doi: 10.1002/uog.17388. PMID: 27997053
Multiple gestations and preterm birth.
Fuchs F, Senat MV
Semin Fetal Neonatal Med 2016 Apr;21(2):113-20. Epub 2016 Jan 13 doi: 10.1016/j.siny.2015.12.010. PMID: 26795885

Clinical prediction guides

Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes.
Vargas M, Yañez F, Elias A, Bernabeu A, Goya M, Xie Z, Farrás A, Sánchez O, Soler Z, Blasquez C, Valle L, Olivella A, Muñoz B, Brik M, Carreras E, Manichanh C
Acta Obstet Gynecol Scand 2022 Dec;101(12):1403-1413. Epub 2022 Sep 28 doi: 10.1111/aogs.14460. PMID: 36168933Free PMC Article
Serum Copeptin Levels in Threatened Preterm Labor.
Tulmac OB, Sayan CD, Dag ZO, Oguz Y, Gencosmanoglu G, Caglar T, Kisa U
Fetal Pediatr Pathol 2021 Oct;40(5):414-422. Epub 2020 Feb 12 doi: 10.1080/15513815.2020.1721626. PMID: 32050829
Single and repeat cervical-length measurement in twin gestation with threatened preterm labor.
Prodan N, Wagner P, Sonek J, Abele H, Hoopmann M, Kagan KO
Ultrasound Obstet Gynecol 2020 Apr;55(4):496-501. doi: 10.1002/uog.20306. PMID: 31066097
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.
Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G
Ultrasound Obstet Gynecol 2017 Mar;49(3):322-329. Epub 2017 Feb 8 doi: 10.1002/uog.17388. PMID: 27997053
Multiple gestations and preterm birth.
Fuchs F, Senat MV
Semin Fetal Neonatal Med 2016 Apr;21(2):113-20. Epub 2016 Jan 13 doi: 10.1016/j.siny.2015.12.010. PMID: 26795885

Recent systematic reviews

Uterine fibroids and preterm birth risk: A systematic review and meta-analysis.
Pérez-Roncero GR, López-Baena MT, Ornat L, Cuerva MJ, Garcia-Casarrubios P, Chedraui P, Pérez-López FR
J Obstet Gynaecol Res 2020 Sep;46(9):1711-1727. Epub 2020 Jul 6 doi: 10.1111/jog.14343. PMID: 32633025
Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data.
Berghella V, Palacio M, Ness A, Alfirevic Z, Nicolaides KH, Saccone G
Ultrasound Obstet Gynecol 2017 Mar;49(3):322-329. Epub 2017 Feb 8 doi: 10.1002/uog.17388. PMID: 27997053
Fetal fibronectin testing for prevention of preterm birth in singleton pregnancies with threatened preterm labor: a systematic review and metaanalysis of randomized controlled trials.
Berghella V, Saccone G
Am J Obstet Gynecol 2016 Oct;215(4):431-8. Epub 2016 Apr 29 doi: 10.1016/j.ajog.2016.04.038. PMID: 27133012
Ethanol for preventing preterm birth in threatened preterm labor.
Haas DM, Morgan AM, Deans SJ, Schubert FP
Cochrane Database Syst Rev 2015 Nov 5;2015(11):CD011445. doi: 10.1002/14651858.CD011445.pub2. PMID: 26544539Free PMC Article
Terbutaline pump maintenance therapy after threatened preterm labor for preventing preterm birth.
Nanda K, Cook LA, Gallo MF, Grimes DA
Cochrane Database Syst Rev 2002;(4):CD003933. doi: 10.1002/14651858.CD003933. PMID: 12519621

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