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Germinal Matrix Hemorrhage of the Newborn

MedGen UID:
634835
Concept ID:
C0475589
Pathologic Function
Synonym: Grade 1 Intraventricular Hemorrhage of the Newborn

Definition

Bleeding into the thick layer of immature cells under the ependymal lining at the ventrolateral aspect of the lateral cerebral ventricles of a newborn. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGerminal Matrix Hemorrhage of the Newborn

Professional guidelines

PubMed

Koutsouras GW, Koustov T, Zyck S, Krishnamurthy S
Childs Nerv Syst 2022 Mar;38(3):511-520. Epub 2022 Jan 4 doi: 10.1007/s00381-021-05427-x. PMID: 34981170
Robinson S
J Neurosurg Pediatr 2012 Mar;9(3):242-58. doi: 10.3171/2011.12.PEDS11136. PMID: 22380952Free PMC Article
Kenet G, Kuperman AA, Strauss T, Brenner B
Thromb Res 2011 Feb;127 Suppl 3:S120-2. doi: 10.1016/S0049-3848(11)70032-9. PMID: 21262430

Recent clinical studies

Etiology

Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
de Bijl-Marcus K, Brouwer AJ, De Vries LS, Groenendaal F, Wezel-Meijler GV
Arch Dis Child Fetal Neonatal Ed 2020 Jul;105(4):419-424. Epub 2019 Nov 15 doi: 10.1136/archdischild-2018-316692. PMID: 31732682
Leijser LM, de Vries LS
Handb Clin Neurol 2019;162:173-199. doi: 10.1016/B978-0-444-64029-1.00008-4. PMID: 31324310
Grant EG, White EM
J Child Neurol 1986 Oct;1(4):319-37. doi: 10.1177/088307388600100403. PMID: 3298401

Diagnosis

Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Langley EA, Blake SM, Coe KL
Neonatal Netw 2022 Mar 1;41(2):100-106. doi: 10.1891/11-T-722. PMID: 35260427
Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K
Eur J Paediatr Neurol 2018 Jul;22(4):690-717. Epub 2018 Apr 24 doi: 10.1016/j.ejpn.2018.04.008. PMID: 29731328
Maller VV, Cohen HL
Pediatr Radiol 2017 Aug;47(9):1031-1045. Epub 2017 Aug 4 doi: 10.1007/s00247-017-3884-z. PMID: 28779189
Grant EG, White EM
J Child Neurol 1986 Oct;1(4):319-37. doi: 10.1177/088307388600100403. PMID: 3298401

Therapy

Kim KY, Nowrangi R, McGehee A, Joshi N, Acharya PT
Pediatr Radiol 2022 Mar;52(3):533-538. Epub 2022 Jan 22 doi: 10.1007/s00247-021-05239-w. PMID: 35064324
Koutsouras GW, Koustov T, Zyck S, Krishnamurthy S
Childs Nerv Syst 2022 Mar;38(3):511-520. Epub 2022 Jan 4 doi: 10.1007/s00381-021-05427-x. PMID: 34981170
Ogihara T, Mino M
Free Radic Biol Med 2022 Feb 20;180:13-32. Epub 2021 Dec 4 doi: 10.1016/j.freeradbiomed.2021.11.037. PMID: 34871765
Ballabh P
Clin Perinatol 2014 Mar;41(1):47-67. Epub 2013 Dec 12 doi: 10.1016/j.clp.2013.09.007. PMID: 24524446Free PMC Article
Kenet G, Kuperman AA, Strauss T, Brenner B
Thromb Res 2011 Feb;127 Suppl 3:S120-2. doi: 10.1016/S0049-3848(11)70032-9. PMID: 21262430

Prognosis

Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Atienza-Navarro I, Alves-Martinez P, Lubian-Lopez S, Garcia-Alloza M
Int J Mol Sci 2020 Nov 6;21(21) doi: 10.3390/ijms21218343. PMID: 33172205Free PMC Article
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
de Bijl-Marcus K, Brouwer AJ, De Vries LS, Groenendaal F, Wezel-Meijler GV
Arch Dis Child Fetal Neonatal Ed 2020 Jul;105(4):419-424. Epub 2019 Nov 15 doi: 10.1136/archdischild-2018-316692. PMID: 31732682
Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K
Eur J Paediatr Neurol 2018 Jul;22(4):690-717. Epub 2018 Apr 24 doi: 10.1016/j.ejpn.2018.04.008. PMID: 29731328

Clinical prediction guides

Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Atienza-Navarro I, Alves-Martinez P, Lubian-Lopez S, Garcia-Alloza M
Int J Mol Sci 2020 Nov 6;21(21) doi: 10.3390/ijms21218343. PMID: 33172205Free PMC Article
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
de Bijl-Marcus K, Brouwer AJ, De Vries LS, Groenendaal F, Wezel-Meijler GV
Arch Dis Child Fetal Neonatal Ed 2020 Jul;105(4):419-424. Epub 2019 Nov 15 doi: 10.1136/archdischild-2018-316692. PMID: 31732682
Tan AP, Svrckova P, Cowan F, Chong WK, Mankad K
Eur J Paediatr Neurol 2018 Jul;22(4):690-717. Epub 2018 Apr 24 doi: 10.1016/j.ejpn.2018.04.008. PMID: 29731328

Recent systematic reviews

Koutsouras GW, Koustov T, Zyck S, Krishnamurthy S
Childs Nerv Syst 2022 Mar;38(3):511-520. Epub 2022 Jan 4 doi: 10.1007/s00381-021-05427-x. PMID: 34981170
Dunbar MJ, Woodward K, Leijser LM, Kirton A
Dev Med Child Neurol 2021 Feb;63(2):144-155. Epub 2020 Oct 22 doi: 10.1111/dmcn.14713. PMID: 33094492
Romantsik O, Calevo MG, Bruschettini M
Cochrane Database Syst Rev 2017 Jul 20;7(7):CD012362. doi: 10.1002/14651858.CD012362.pub2. PMID: 28727900Free PMC Article
Bruschettini M, Romantsik O, Zappettini S, Banzi R, Ramenghi LA, Calevo MG
Cochrane Database Syst Rev 2016 Mar 21;3:CD011636. doi: 10.1002/14651858.CD011636.pub2. PMID: 26998583
Brouwer MJ, de Vries LS, Pistorius L, Rademaker KJ, Groenendaal F, Benders MJ
Acta Paediatr 2010 Sep;99(9):1298-306. doi: 10.1111/j.1651-2227.2010.01830.x. PMID: 20394588

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