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Intraventricular Hemorrhage of the Newborn with Ventricular Dilatation

MedGen UID:
634837
•Concept ID:
C0475591
•
Pathologic Function
Synonym: Grade 3 Intraventricular Hemorrhage of the Newborn

Definition

Bleeding into the lateral cerebral ventricles of a newborn infant with ventricular dilatation directly attributable to the acute bleeding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraventricular Hemorrhage of the Newborn with Ventricular Dilatation

Professional guidelines

PubMed

Neonatal ventriculomegaly: Pathophysiology and management guided with cranial ultrasonography.
Bravo MC, Lubian S, Horsch S, Cabañas F, de Vries LS; EurUS.Brain group
Dev Med Child Neurol 2024 Nov;66(11):1419-1431. Epub 2024 May 15 doi: 10.1111/dmcn.15955. PMID: 38747316
Treatment of Posthemorrhagic Hydrocephalus.
Cohen S, Flibotte J
Clin Perinatol 2022 Mar;49(1):15-25. Epub 2022 Jan 21 doi: 10.1016/j.clp.2021.11.002. PMID: 35209998
Management of posthaemorrhagic ventricular dilatation.
Whitelaw A, Aquilina K
Arch Dis Child Fetal Neonatal Ed 2012 May;97(3):F229-3. Epub 2011 Feb 2 doi: 10.1136/adc.2010.190173. PMID: 21289015

Recent clinical studies

Etiology

Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
Neuroprotection Care Bundle Implementation to Decrease Acute Brain Injury in Preterm Infants.
Murthy P, Zein H, Thomas S, Scott JN, Abou Mehrem A, Esser MJ, Lodha A, Metcalfe C, Kowal D, Irvine L, Scotland J, Leijser L, Mohammad K
Pediatr Neurol 2020 Sep;110:42-48. Epub 2020 May 1 doi: 10.1016/j.pediatrneurol.2020.04.016. PMID: 32473764
State-of-the-art neonatal cerebral ultrasound: technique and reporting.
Dudink J, Jeanne Steggerda S, Horsch S; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):3-12. doi: 10.1038/s41390-020-0776-y. PMID: 32218539Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Preterm brain injury: Germinal matrix-intraventricular hemorrhage and post-hemorrhagic ventricular dilatation.
Leijser LM, de Vries LS
Handb Clin Neurol 2019;162:173-199. doi: 10.1016/B978-0-444-64029-1.00008-4. PMID: 31324310

Diagnosis

Intraventricular haemorrhage and posthaemorrhagic ventricular dilatation: moving beyond CSF diversion.
Chari A, Mallucci C, Whitelaw A, Aquilina K
Childs Nerv Syst 2021 Nov;37(11):3375-3383. Epub 2021 May 15 doi: 10.1007/s00381-021-05206-8. PMID: 33993367Free PMC Article
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
Management of posthaemorrhagic ventricular dilatation.
Whitelaw A, Aquilina K
Arch Dis Child Fetal Neonatal Ed 2012 May;97(3):F229-3. Epub 2011 Feb 2 doi: 10.1136/adc.2010.190173. PMID: 21289015
Posthemorrhagic hydrocephalus.
Holt PJ
J Child Neurol 1989;4 Suppl:S23-31. doi: 10.1177/0883073889004001s06. PMID: 2681374
Periventricular-intraventricular hemorrhage.
Allan WC, Volpe JJ
Pediatr Clin North Am 1986 Feb;33(1):47-63. doi: 10.1016/s0031-3955(16)34969-0. PMID: 3513102

Therapy

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Romantsik O, Smit E, Odd DE, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 16;3(3):CD001691. doi: 10.1002/14651858.CD001691.pub4. PMID: 36924438Free PMC Article
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
Prospective multicenter studies in pediatric hydrocephalus.
Kestle JRW, Riva-Cambrin J
J Neurosurg Pediatr 2019 Feb 1;23(2):135-141. doi: 10.3171/2018.10.PEDS18328. PMID: 30717034
Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Smit E, Odd D, Whitelaw A
Cochrane Database Syst Rev 2013 Aug 13;2013(8):CD001691. doi: 10.1002/14651858.CD001691.pub3. PMID: 23943189Free PMC Article
Management of posthaemorrhagic ventricular dilatation.
Whitelaw A, Aquilina K
Arch Dis Child Fetal Neonatal Ed 2012 May;97(3):F229-3. Epub 2011 Feb 2 doi: 10.1136/adc.2010.190173. PMID: 21289015

Prognosis

Predicting Outcomes of Preterm Neonates Post Intraventricular Hemorrhage.
Vignolle GA, Bauerstätter P, Schönthaler S, Nöhammer C, Olischar M, Berger A, Kasprian G, Langs G, Vierlinger K, Goeral K
Int J Mol Sci 2024 Sep 25;25(19) doi: 10.3390/ijms251910304. PMID: 39408633Free PMC Article
Cerebral gray matter injuries in infants with intraventricular hemorrhage.
Sharma DR, Agyemang A, Ballabh P
Semin Perinatol 2022 Aug;46(5):151595. Epub 2022 Mar 12 doi: 10.1016/j.semperi.2022.151595. PMID: 35418320Free PMC Article
Treatment of Posthemorrhagic Hydrocephalus.
Cohen S, Flibotte J
Clin Perinatol 2022 Mar;49(1):15-25. Epub 2022 Jan 21 doi: 10.1016/j.clp.2021.11.002. PMID: 35209998
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Prospective multicenter studies in pediatric hydrocephalus.
Kestle JRW, Riva-Cambrin J
J Neurosurg Pediatr 2019 Feb 1;23(2):135-141. doi: 10.3171/2018.10.PEDS18328. PMID: 30717034

Clinical prediction guides

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Romantsik O, Smit E, Odd DE, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 16;3(3):CD001691. doi: 10.1002/14651858.CD001691.pub4. PMID: 36924438Free PMC Article
Cerebral gray matter injuries in infants with intraventricular hemorrhage.
Sharma DR, Agyemang A, Ballabh P
Semin Perinatol 2022 Aug;46(5):151595. Epub 2022 Mar 12 doi: 10.1016/j.semperi.2022.151595. PMID: 35418320Free PMC Article
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation: Outcome at 2 Years.
Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernández I, van Straaten HLM, Steggerda S, Smit BJ, Whitelaw A, Woerdeman P, Heep A, de Vries LS; ELVIS study group
J Pediatr 2020 Nov;226:28-35.e3. Epub 2020 Aug 12 doi: 10.1016/j.jpeds.2020.08.014. PMID: 32800815
State-of-the-art neonatal cerebral ultrasound: technique and reporting.
Dudink J, Jeanne Steggerda S, Horsch S; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):3-12. doi: 10.1038/s41390-020-0776-y. PMID: 32218539Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article

Recent systematic reviews

Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Romantsik O, Smit E, Odd DE, Bruschettini M
Cochrane Database Syst Rev 2023 Mar 16;3(3):CD001691. doi: 10.1002/14651858.CD001691.pub4. PMID: 36924438Free PMC Article
Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis.
Dunbar MJ, Woodward K, Leijser LM, Kirton A
Dev Med Child Neurol 2021 Feb;63(2):144-155. Epub 2020 Oct 22 doi: 10.1111/dmcn.14713. PMID: 33094492
Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Smit E, Odd D, Whitelaw A
Cochrane Database Syst Rev 2013 Aug 13;2013(8):CD001691. doi: 10.1002/14651858.CD001691.pub3. PMID: 23943189Free PMC Article
Intraventricular streptokinase after intraventricular hemorrhage in newborn infants.
Whitelaw A, Odd DE
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD000498. doi: 10.1002/14651858.CD000498.pub2. PMID: 17943743Free PMC Article
Intraventricular streptokinase after intraventricular hemorrhage in newborn infants.
Whitelaw A
Cochrane Database Syst Rev 2000;(2):CD000498. doi: 10.1002/14651858.CD000498. PMID: 10796211

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