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Acute pyelonephritis

MedGen UID:
636072
•Concept ID:
C0520575
•
Disease or Syndrome
Synonyms: Acute kidney infection; Acute PN - pyelonephritis; Acute Pyelonephritis; acute pyelonephritis; APN - Acute pyelonephritis; pyelonephritis, acute
SNOMED CT: Acute PN - pyelonephritis (36689008); APN - Acute pyelonephritis (36689008); Acute kidney infection (36689008); Acute pyelonephritis (36689008)
 
Monarch Initiative: MONDO:0003529

Definition

Sudden onset pyelonephritis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute pyelonephritis

Professional guidelines

PubMed

Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.
Hari P, Meena J, Kumar M, Sinha A, Thergaonkar RW, Iyengar A, Khandelwal P, Ekambaram S, Pais P, Sharma J, Kanitkar M, Bagga A; Indian Society of Pediatric Nephrology
Pediatr Nephrol 2024 May;39(5):1639-1668. Epub 2023 Oct 28 doi: 10.1007/s00467-023-06173-9. PMID: 37897526
Contemporary Management of Urinary Tract Infection in Children.
Mattoo TK, Shaikh N, Nelson CP
Pediatrics 2021 Feb;147(2) doi: 10.1542/peds.2020-012138. PMID: 33479164
Diagnosis and management of acute pyelonephritis in adults.
Ramakrishnan K, Scheid DC
Am Fam Physician 2005 Mar 1;71(5):933-42. PMID: 15768623

Recent clinical studies

Etiology

Urinary tract infections in pregnancy.
Ansaldi Y, Martinez de Tejada Weber B
Clin Microbiol Infect 2023 Oct;29(10):1249-1253. Epub 2022 Aug 27 doi: 10.1016/j.cmi.2022.08.015. PMID: 36031053
Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial.
Kaye KS, Belley A, Barth P, Lahlou O, Knechtle P, Motta P, Velicitat P
JAMA 2022 Oct 4;328(13):1304-1314. doi: 10.1001/jama.2022.17034. PMID: 36194218Free PMC Article
Contemporary Management of Urinary Tract Infection in Children.
Mattoo TK, Shaikh N, Nelson CP
Pediatrics 2021 Feb;147(2) doi: 10.1542/peds.2020-012138. PMID: 33479164
Acute Pyelonephritis in Adults.
Johnson JR, Russo TA
N Engl J Med 2018 Jan 4;378(1):48-59. doi: 10.1056/nejmcp1702758. PMID: 29298155
Acute pyelonephritis in children.
Morello W, La Scola C, Alberici I, Montini G
Pediatr Nephrol 2016 Aug;31(8):1253-65. Epub 2015 Aug 4 doi: 10.1007/s00467-015-3168-5. PMID: 26238274

Diagnosis

Contemporary Management of Urinary Tract Infection in Children.
Mattoo TK, Shaikh N, Nelson CP
Pediatrics 2021 Feb;147(2) doi: 10.1542/peds.2020-012138. PMID: 33479164
Acute Pyelonephritis in Adults: Rapid Evidence Review.
Herness J, Buttolph A, Hammer NC
Am Fam Physician 2020 Aug 1;102(3):173-180. PMID: 32735433
The diagnosis and management of a patient with acute pyelonephritis.
Hudson C, Mortimore G
Br J Nurs 2020 Feb 13;29(3):144-150. doi: 10.12968/bjon.2020.29.3.144. PMID: 32053436
Acute Pyelonephritis in Adults.
Johnson JR, Russo TA
N Engl J Med 2018 Jan 4;378(1):48-59. doi: 10.1056/nejmcp1702758. PMID: 29298155
Acute pyelonephritis in children.
Morello W, La Scola C, Alberici I, Montini G
Pediatr Nephrol 2016 Aug;31(8):1253-65. Epub 2015 Aug 4 doi: 10.1007/s00467-015-3168-5. PMID: 26238274

Therapy

Cefepime-Taniborbactam in Complicated Urinary Tract Infection.
Wagenlehner FM, Gasink LB, McGovern PC, Moeck G, McLeroth P, Dorr M, Dane A, Henkel T; CERTAIN-1 Study Team
N Engl J Med 2024 Feb 15;390(7):611-622. doi: 10.1056/NEJMoa2304748. PMID: 38354140
Urinary tract infections in pregnancy.
Ansaldi Y, Martinez de Tejada Weber B
Clin Microbiol Infect 2023 Oct;29(10):1249-1253. Epub 2022 Aug 27 doi: 10.1016/j.cmi.2022.08.015. PMID: 36031053
Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial.
Kaye KS, Belley A, Barth P, Lahlou O, Knechtle P, Motta P, Velicitat P
JAMA 2022 Oct 4;328(13):1304-1314. doi: 10.1001/jama.2022.17034. PMID: 36194218Free PMC Article
Contemporary Management of Urinary Tract Infection in Children.
Mattoo TK, Shaikh N, Nelson CP
Pediatrics 2021 Feb;147(2) doi: 10.1542/peds.2020-012138. PMID: 33479164
Acute Pyelonephritis in Adults.
Johnson JR, Russo TA
N Engl J Med 2018 Jan 4;378(1):48-59. doi: 10.1056/nejmcp1702758. PMID: 29298155

Prognosis

Urinary tract infections in pregnancy.
Ansaldi Y, Martinez de Tejada Weber B
Clin Microbiol Infect 2023 Oct;29(10):1249-1253. Epub 2022 Aug 27 doi: 10.1016/j.cmi.2022.08.015. PMID: 36031053
Contemporary Management of Urinary Tract Infection in Children.
Mattoo TK, Shaikh N, Nelson CP
Pediatrics 2021 Feb;147(2) doi: 10.1542/peds.2020-012138. PMID: 33479164
Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial.
Kyriazopoulou E, Liaskou-Antoniou L, Adamis G, Panagaki A, Melachroinopoulos N, Drakou E, Marousis K, Chrysos G, Spyrou A, Alexiou N, Symbardi S, Alexiou Z, Lagou S, Kolonia V, Gkavogianni T, Kyprianou M, Anagnostopoulos I, Poulakou G, Lada M, Makina A, Roulia E, Koupetori M, Apostolopoulos V, Petrou D, Nitsotolis T, Antoniadou A, Giamarellos-Bourboulis EJ
Am J Respir Crit Care Med 2021 Jan 15;203(2):202-210. doi: 10.1164/rccm.202004-1201OC. PMID: 32757963Free PMC Article
Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent.
Zhanel GG, Esquivel J, Zelenitsky S, Lawrence CK, Adam HJ, Golden A, Hink R, Berry L, Schweizer F, Zhanel MA, Bay D, Lagacé-Wiens PRS, Walkty AJ, Lynch JP 3rd, Karlowsky JA
Drugs 2020 Feb;80(3):285-313. doi: 10.1007/s40265-020-01257-4. PMID: 31970713
Updates on urinary tract infections in kidney transplantation.
Fiorentino M, Pesce F, Schena A, Simone S, Castellano G, Gesualdo L
J Nephrol 2019 Oct;32(5):751-761. Epub 2019 Jan 28 doi: 10.1007/s40620-019-00585-3. PMID: 30689126

Clinical prediction guides

Sulopenem for the Treatment of Complicated Urinary Tract Infections Including Pyelonephritis: A Phase 3, Randomized Trial.
Dunne MW, Aronin SI, Das AF, Akinapelli K, Breen J, Zelasky MT, Puttagunta S
Clin Infect Dis 2023 Jan 6;76(1):78-88. doi: 10.1093/cid/ciac704. PMID: 36068705Free PMC Article
Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial.
Rius-Gordillo N, Ferré N, González JD, Ibars Z, Parada-Ricart E, Fraga MG, Chocron S, Samper M, Vicente C, Fuertes J, Escribano J; DEXCAR Study Group
Pediatr Nephrol 2022 Sep;37(9):2109-2118. Epub 2022 Jan 18 doi: 10.1007/s00467-021-05398-w. PMID: 35041042Free PMC Article
Acute Pyelonephritis in Adults: Rapid Evidence Review.
Herness J, Buttolph A, Hammer NC
Am Fam Physician 2020 Aug 1;102(3):173-180. PMID: 32735433
Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent.
Zhanel GG, Esquivel J, Zelenitsky S, Lawrence CK, Adam HJ, Golden A, Hink R, Berry L, Schweizer F, Zhanel MA, Bay D, Lagacé-Wiens PRS, Walkty AJ, Lynch JP 3rd, Karlowsky JA
Drugs 2020 Feb;80(3):285-313. doi: 10.1007/s40265-020-01257-4. PMID: 31970713
Efficacy of Tocilizumab in Patients With Moderate-to-Severe Corticosteroid-Resistant Graves Orbitopathy: A Randomized Clinical Trial.
Perez-Moreiras JV, Gomez-Reino JJ, Maneiro JR, Perez-Pampin E, Romo Lopez A, Rodríguez Alvarez FM, Castillo Laguarta JM, Del Estad Cabello A, Gessa Sorroche M, España Gregori E, Sales-Sanz M; Tocilizumab in Graves Orbitopathy Study Group
Am J Ophthalmol 2018 Nov;195:181-190. Epub 2018 Aug 4 doi: 10.1016/j.ajo.2018.07.038. PMID: 30081019

Recent systematic reviews

Cephalosporins for the treatment of uncomplicated pyelonephritis: A systematic review.
Zimmerman DE, Tomas M, Miller D, Tomcsanyi L, Signorella C, Montepara CA, Covvey JR, Guarascio AJ
J Am Pharm Assoc (2003) 2023 Sep-Oct;63(5):1461-1471. Epub 2023 Jul 4 doi: 10.1016/j.japh.2023.06.028. PMID: 37414282
Antibiotics for asymptomatic bacteriuria in pregnancy.
Smaill FM, Vazquez JC
Cochrane Database Syst Rev 2019 Nov 25;2019(11) doi: 10.1002/14651858.CD000490.pub4. PMID: 31765489Free PMC Article
Pyelonephritis (acute) in non-pregnant women.
Neumann I, Moore P
BMJ Clin Evid 2014 Nov 4;2014 PMID: 25373019Free PMC Article
Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection-- 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials.
Eliakim-Raz N, Yahav D, Paul M, Leibovici L
J Antimicrob Chemother 2013 Oct;68(10):2183-91. Epub 2013 May 21 doi: 10.1093/jac/dkt177. PMID: 23696620
Pyelonephritis (acute) in non-pregnant women.
Neumann I, Moore P
BMJ Clin Evid 2011 Jan 13;2011 PMID: 21477395Free PMC Article

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