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Postpartum psychosis

MedGen UID:
636162
•Concept ID:
C0520678
•
Mental or Behavioral Dysfunction
Synonyms: Postnatal psychosis; postpartum psychosis; Puerperal psychosis; puerperal psychosis
SNOMED CT: Postnatal psychosis (18260003); Postpartum psychosis (18260003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018623
Orphanet: ORPHA443173

Definition

A rare gynecologic or obstetric disease characterized by an abrupt onset of psychiatric symptoms during the first weeks after childbirth. Clinical features include mood changes, depression, anxiety, delusions, and hallucinations, among others. The disease is associated with a risk of suicide or infanticide, as well as an increased risk for recurrence after the next pregnancy and future non-pregnancy related psychotic episodes. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostpartum psychosis

Professional guidelines

PubMed

Treatment and Management of Mental Health Conditions During Pregnancy and Postpartum: ACOG Clinical Practice Guideline No. 5.
Obstet Gynecol 2023 Jun 1;141(6):1262-1288. doi: 10.1097/AOG.0000000000005202. PMID: 37486661
Postpartum Depression: Screening and Collaborative Management.
Wells T
Prim Care 2023 Mar;50(1):127-142. Epub 2023 Jan 11 doi: 10.1016/j.pop.2022.10.011. PMID: 36822723
Treatment of Peripartum Bipolar Disorder.
Clark CT, Wisner KL
Obstet Gynecol Clin North Am 2018 Sep;45(3):403-417. doi: 10.1016/j.ogc.2018.05.002. PMID: 30092918Free PMC Article

Recent clinical studies

Etiology

Postpartum Psychosis.
Friedman SH, Reed E, Ross NE
Curr Psychiatry Rep 2023 Feb;25(2):65-72. Epub 2023 Jan 13 doi: 10.1007/s11920-022-01406-4. PMID: 36637712Free PMC Article
CE: Postpartum Depression: A Nurse's Guide.
Alba BM
Am J Nurs 2021 Jul 1;121(7):32-43. doi: 10.1097/01.NAJ.0000756516.95992.8e. PMID: 34117132
Postpartum psychiatric disorders.
Meltzer-Brody S, Howard LM, Bergink V, Vigod S, Jones I, Munk-Olsen T, Honikman S, Milgrom J
Nat Rev Dis Primers 2018 Apr 26;4:18022. doi: 10.1038/nrdp.2018.22. PMID: 29695824
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood.
Bergink V, Rasgon N, Wisner KL
Am J Psychiatry 2016 Dec 1;173(12):1179-1188. Epub 2016 Sep 9 doi: 10.1176/appi.ajp.2016.16040454. PMID: 27609245
Perinatal mental illness: definition, description and aetiology.
O'Hara MW, Wisner KL
Best Pract Res Clin Obstet Gynaecol 2014 Jan;28(1):3-12. Epub 2013 Oct 7 doi: 10.1016/j.bpobgyn.2013.09.002. PMID: 24140480Free PMC Article

Diagnosis

Treatment and Management of Mental Health Conditions During Pregnancy and Postpartum: ACOG Clinical Practice Guideline No. 5.
Obstet Gynecol 2023 Jun 1;141(6):1262-1288. doi: 10.1097/AOG.0000000000005202. PMID: 37486661
Postpartum Psychosis.
Friedman SH, Reed E, Ross NE
Curr Psychiatry Rep 2023 Feb;25(2):65-72. Epub 2023 Jan 13 doi: 10.1007/s11920-022-01406-4. PMID: 36637712Free PMC Article
CE: Postpartum Depression: A Nurse's Guide.
Alba BM
Am J Nurs 2021 Jul 1;121(7):32-43. doi: 10.1097/01.NAJ.0000756516.95992.8e. PMID: 34117132
Postpartum psychiatric disorders.
Meltzer-Brody S, Howard LM, Bergink V, Vigod S, Jones I, Munk-Olsen T, Honikman S, Milgrom J
Nat Rev Dis Primers 2018 Apr 26;4:18022. doi: 10.1038/nrdp.2018.22. PMID: 29695824
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood.
Bergink V, Rasgon N, Wisner KL
Am J Psychiatry 2016 Dec 1;173(12):1179-1188. Epub 2016 Sep 9 doi: 10.1176/appi.ajp.2016.16040454. PMID: 27609245

Therapy

Postpartum psychosis: A proposed treatment algorithm.
Jairaj C, Seneviratne G, Bergink V, Sommer IE, Dazzan P
J Psychopharmacol 2023 Oct;37(10):960-970. Epub 2023 Jul 29 doi: 10.1177/02698811231181573. PMID: 37515460Free PMC Article
Antipsychotics in Postpartum Psychosis.
Teodorescu A, Dima L, Popa MA, Moga MA, Bîgiu NF, Ifteni P
Am J Ther 2020 Jun 22;28(3):e341-e348. doi: 10.1097/MJT.0000000000001218. PMID: 32618591
Treatment of Peripartum Bipolar Disorder.
Clark CT, Wisner KL
Obstet Gynecol Clin North Am 2018 Sep;45(3):403-417. doi: 10.1016/j.ogc.2018.05.002. PMID: 30092918Free PMC Article
Postpartum psychiatric disorders.
Meltzer-Brody S, Howard LM, Bergink V, Vigod S, Jones I, Munk-Olsen T, Honikman S, Milgrom J
Nat Rev Dis Primers 2018 Apr 26;4:18022. doi: 10.1038/nrdp.2018.22. PMID: 29695824
Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood.
Bergink V, Rasgon N, Wisner KL
Am J Psychiatry 2016 Dec 1;173(12):1179-1188. Epub 2016 Sep 9 doi: 10.1176/appi.ajp.2016.16040454. PMID: 27609245

Prognosis

Postpartum psychosis: A proposed treatment algorithm.
Jairaj C, Seneviratne G, Bergink V, Sommer IE, Dazzan P
J Psychopharmacol 2023 Oct;37(10):960-970. Epub 2023 Jul 29 doi: 10.1177/02698811231181573. PMID: 37515460Free PMC Article
Long-Term Outcomes of Postpartum Psychosis: A Systematic Review and Meta-Analysis.
Gilden J, Kamperman AM, Munk-Olsen T, Hoogendijk WJG, Kushner SA, Bergink V
J Clin Psychiatry 2020 Mar 10;81(2) doi: 10.4088/JCP.19r12906. PMID: 32160423
Resurrecting melancholia.
Fink M, Taylor MA
Acta Psychiatr Scand Suppl 2007;(433):14-20. doi: 10.1111/j.1600-0447.2007.00958.x. PMID: 17280566
Pharmacotherapy of postpartum psychosis.
Sharma V
Expert Opin Pharmacother 2003 Oct;4(10):1651-8. doi: 10.1517/14656566.4.10.1651. PMID: 14521476
Prepartum psychosis.
Brockington IF, Oates M, Rose G
J Affect Disord 1990 May;19(1):31-5. doi: 10.1016/0165-0327(90)90006-t. PMID: 2140844

Clinical prediction guides

Postpartum Psychosis: The Role of Women's Health Care Providers and the Health Care System.
Stacy M, Schulkin J
Obstet Gynecol Surv 2022 Dec;77(12):763-777. doi: 10.1097/OGX.0000000000001093. PMID: 36477388
Antipsychotics in Postpartum Psychosis.
Teodorescu A, Dima L, Popa MA, Moga MA, Bîgiu NF, Ifteni P
Am J Ther 2020 Jun 22;28(3):e341-e348. doi: 10.1097/MJT.0000000000001218. PMID: 32618591
Long-Term Outcomes of Postpartum Psychosis: A Systematic Review and Meta-Analysis.
Gilden J, Kamperman AM, Munk-Olsen T, Hoogendijk WJG, Kushner SA, Bergink V
J Clin Psychiatry 2020 Mar 10;81(2) doi: 10.4088/JCP.19r12906. PMID: 32160423
Do Defective Immune System-Mediated Myelination Processes Increase Postpartum Psychosis Risk?
Dazzan P, Fusté M, Davies W
Trends Mol Med 2018 Nov;24(11):942-949. Epub 2018 Oct 19 doi: 10.1016/j.molmed.2018.09.002. PMID: 30348609Free PMC Article
Prenatal depression leading to postpartum psychosis.
Ebeid E, Nassif N, Sinha P
J Obstet Gynaecol 2010;30(5):435-8. doi: 10.3109/01443611003802321. PMID: 20604641

Recent systematic reviews

Long-Term Outcomes of Postpartum Psychosis: A Systematic Review and Meta-Analysis.
Gilden J, Kamperman AM, Munk-Olsen T, Hoogendijk WJG, Kushner SA, Bergink V
J Clin Psychiatry 2020 Mar 10;81(2) doi: 10.4088/JCP.19r12906. PMID: 32160423
Recovery from postpartum psychosis: a systematic review and metasynthesis of women's and families' experiences.
Forde R, Peters S, Wittkowski A
Arch Womens Ment Health 2020 Oct;23(5):597-612. Epub 2020 Feb 4 doi: 10.1007/s00737-020-01025-z. PMID: 32020314Free PMC Article
The global prevalence of postpartum psychosis: a systematic review.
VanderKruik R, Barreix M, Chou D, Allen T, Say L, Cohen LS; Maternal Morbidity Working Group
BMC Psychiatry 2017 Jul 28;17(1):272. doi: 10.1186/s12888-017-1427-7. PMID: 28754094Free PMC Article
Risk of Postpartum Relapse in Bipolar Disorder and Postpartum Psychosis: A Systematic Review and Meta-Analysis.
Wesseloo R, Kamperman AM, Munk-Olsen T, Pop VJ, Kushner SA, Bergink V
Am J Psychiatry 2016 Feb 1;173(2):117-27. Epub 2015 Oct 30 doi: 10.1176/appi.ajp.2015.15010124. PMID: 26514657
Interventions for the prevention and treatment of postpartum psychosis: a systematic review.
Doucet S, Jones I, Letourneau N, Dennis CL, Blackmore ER
Arch Womens Ment Health 2011 Apr;14(2):89-98. Epub 2010 Dec 3 doi: 10.1007/s00737-010-0199-6. PMID: 21128087

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