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Platypnea

MedGen UID:
636259
•Concept ID:
C0520825
•
Sign or Symptom
SNOMED CT: Platypnea (30744009)
 
HPO: HP:0033368

Definition

A type of dyspnea that occurs when the affected person changes from a recumbent to an upright position. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlatypnea

Professional guidelines

PubMed

Importance of platypnea orthodeoxia in the differential diagnosis of dyspnea.
Takase B, Tanaka Y, Hattori H, Ishihara M
Intern Med 2012;51(13):1651-2. Epub 2012 Jul 1 doi: 10.2169/internalmedicine.51.7720. PMID: 22790121
Patent foramen ovale--assessment and treatment.
Irwin B, Ray S
Cardiovasc Ther 2012 Jun;30(3):e128-35. Epub 2011 Feb 15 doi: 10.1111/j.1755-5922.2010.00250.x. PMID: 21883994
Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management.
Cheng TO
Catheter Cardiovasc Interv 1999 May;47(1):64-6. doi: 10.1002/(SICI)1522-726X(199905)47:1<64::AID-CCD15>3.0.CO;2-6. PMID: 10385164

Recent clinical studies

Etiology

Patent foramen ovale closure for secondary prevention of cryptogenic stroke.
Kolte D, Palacios IF
Expert Rev Cardiovasc Ther 2021 Mar;19(3):211-220. Epub 2021 Feb 19 doi: 10.1080/14779072.2021.1878026. PMID: 33605829
Cardiac platypnea-orthodeoxia syndrome: an often unrecognized malady.
Knapper JT, Schultz J, Das G, Sperling LS
Clin Cardiol 2014 Oct;37(10):645-9. Epub 2014 Jun 9 doi: 10.1002/clc.22301. PMID: 24912004Free PMC Article
Current status of percutaneous PFO closure.
Rohrhoff N, Vavalle JP, Halim S, Kiefer TL, Harrison JK
Curr Cardiol Rep 2014 May;16(5):477. doi: 10.1007/s11886-014-0477-4. PMID: 24633647
Platypnea-orthodeoxia syndrome in review: defining a new disease?
Rodrigues P, Palma P, Sousa-Pereira L
Cardiology 2012;123(1):15-23. Epub 2012 Aug 31 doi: 10.1159/000339872. PMID: 22948714
Patent foramen ovale--assessment and treatment.
Irwin B, Ray S
Cardiovasc Ther 2012 Jun;30(3):e128-35. Epub 2011 Feb 15 doi: 10.1111/j.1755-5922.2010.00250.x. PMID: 21883994

Diagnosis

The multiple dimensions of Platypnea-Orthodeoxia syndrome: A review.
Agrawal A, Palkar A, Talwar A
Respir Med 2017 Aug;129:31-38. Epub 2017 May 31 doi: 10.1016/j.rmed.2017.05.016. PMID: 28732833
Platypnea-orthodeoxia syndrome : Orthostatic dyspnea and possible pathophysiological substrates.
De Vecchis R, Baldi C, Ariano C, Giasi A, Cioppa C
Herz 2017 Jun;42(4):384-389. Epub 2016 Sep 12 doi: 10.1007/s00059-016-4479-4. PMID: 27622245
The platypnea-orthodeoxia syndrome.
Akin E, Krüger U, Braun P, Stroh E, Janicke I, Rezwanian R, Akin I, Schöls WH
Eur Rev Med Pharmacol Sci 2014;18(18):2599-604. PMID: 25317791
Platypnea-orthodeoxia syndrome in review: defining a new disease?
Rodrigues P, Palma P, Sousa-Pereira L
Cardiology 2012;123(1):15-23. Epub 2012 Aug 31 doi: 10.1159/000339872. PMID: 22948714
The hepatopulmonary syndrome.
Lange PA, Stoller JK
Ann Intern Med 1995 Apr 1;122(7):521-9. doi: 10.7326/0003-4819-122-7-199504010-00008. PMID: 7872588

Therapy

Patent foramen ovale closure for secondary prevention of cryptogenic stroke.
Kolte D, Palacios IF
Expert Rev Cardiovasc Ther 2021 Mar;19(3):211-220. Epub 2021 Feb 19 doi: 10.1080/14779072.2021.1878026. PMID: 33605829
To close or not to close: contemporary indications for patent foramen ovale closure.
Zier LS, Sievert H, Mahadevan VS
Expert Rev Cardiovasc Ther 2016 Nov;14(11):1235-1244. Epub 2016 Sep 10 doi: 10.1080/14779072.2016.1224178. PMID: 27616622
Patent foramen ovale: Unanswered questions.
Mojadidi MK, Christia P, Salamon J, Liebelt J, Zaman T, Gevorgyan R, Nezami N, Mojaddedi S, Elgendy IY, Tobis JM, Faillace R
Eur J Intern Med 2015 Dec;26(10):743-51. Epub 2015 Oct 17 doi: 10.1016/j.ejim.2015.09.017. PMID: 26489724
Patent foramen ovale--assessment and treatment.
Irwin B, Ray S
Cardiovasc Ther 2012 Jun;30(3):e128-35. Epub 2011 Feb 15 doi: 10.1111/j.1755-5922.2010.00250.x. PMID: 21883994
Patent foramen ovale and stroke.
Horton SC, Bunch TJ
Mayo Clin Proc 2004 Jan;79(1):79-88. doi: 10.4065/79.1.79. PMID: 14708951

Prognosis

Platypnoea-orthodeoxia syndrome in COVID-19 pneumonia patients: An observational study.
Hanada M, Ishimatsu Y, Sakamoto N, Ashizawa N, Yamanashi H, Sekino M, Izumikawa K, Mukae H, Ariyoshi K, Maeda T, Hara T, Sato S, Kozu R
Respir Investig 2024 Mar;62(2):291-294. Epub 2024 Jan 28 doi: 10.1016/j.resinv.2024.01.006. PMID: 38281397
Current status of percutaneous PFO closure.
Rohrhoff N, Vavalle JP, Halim S, Kiefer TL, Harrison JK
Curr Cardiol Rep 2014 May;16(5):477. doi: 10.1007/s11886-014-0477-4. PMID: 24633647
Platypnea-orthodeoxia syndrome in review: defining a new disease?
Rodrigues P, Palma P, Sousa-Pereira L
Cardiology 2012;123(1):15-23. Epub 2012 Aug 31 doi: 10.1159/000339872. PMID: 22948714
Patent foramen ovale and stroke.
Horton SC, Bunch TJ
Mayo Clin Proc 2004 Jan;79(1):79-88. doi: 10.4065/79.1.79. PMID: 14708951
The hepatopulmonary syndrome.
Lange PA, Stoller JK
Ann Intern Med 1995 Apr 1;122(7):521-9. doi: 10.7326/0003-4819-122-7-199504010-00008. PMID: 7872588

Clinical prediction guides

Reversible platypnoea-orthodeoxia syndrome.
Joseph TJ, Isaac BT, James P, Thangakunam B
BMJ Case Rep 2023 Oct 31;16(10) doi: 10.1136/bcr-2023-255587. PMID: 37907322Free PMC Article
Patent foramen ovale closure for secondary prevention of cryptogenic stroke.
Kolte D, Palacios IF
Expert Rev Cardiovasc Ther 2021 Mar;19(3):211-220. Epub 2021 Feb 19 doi: 10.1080/14779072.2021.1878026. PMID: 33605829
Patent Foramen Ovale and Hypoxemia.
Mojadidi MK, Ruiz JC, Chertoff J, Zaman MO, Elgendy IY, Mahmoud AN, Al-Ani M, Elgendy AY, Patel NK, Shantha G, Tobis JM, Meier B
Cardiol Rev 2019 Jan/Feb;27(1):34-40. doi: 10.1097/CRD.0000000000000205. PMID: 29570476
Patent foramen ovale: Unanswered questions.
Mojadidi MK, Christia P, Salamon J, Liebelt J, Zaman T, Gevorgyan R, Nezami N, Mojaddedi S, Elgendy IY, Tobis JM, Faillace R
Eur J Intern Med 2015 Dec;26(10):743-51. Epub 2015 Oct 17 doi: 10.1016/j.ejim.2015.09.017. PMID: 26489724
The hepatopulmonary syndrome.
Lange PA, Stoller JK
Ann Intern Med 1995 Apr 1;122(7):521-9. doi: 10.7326/0003-4819-122-7-199504010-00008. PMID: 7872588

Supplemental Content

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