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Asteroid hyalosis

MedGen UID:
636821
Concept ID:
C0521770
Disease or Syndrome
Synonyms: Asteroid hyalitis; Benson's disease
SNOMED CT: Asteroid hyalosis (95800001); Benson's disease (95800001); Asteroid hyalitis (95800001)
 
HPO: HP:0030672

Definition

The presence of small, white vitreous opacities consisting of calcium phosphate and complex, layered lipid deposits. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAsteroid hyalosis

Conditions with this feature

Retinitis pigmentosa 13
MedGen UID:
325486
Concept ID:
C1838702
Disease or Syndrome
Any retinitis pigmentosa in which the cause of the disease is a mutation in the PRPF8 gene.
Multiple epiphyseal dysplasia, Beighton type
MedGen UID:
377049
Concept ID:
C1851536
Disease or Syndrome
A rare primary bone dysplasia characterized by the association of multiple epiphyseal dysplasia, visual impairment (with early-onset progressive myopia, retinal thinning, and cataracts), and conductive hearing loss. Patients are of short stature and present brachydactyly, genu valgus deformity, and joint pain.
Leber congenital amaurosis 6
MedGen UID:
344245
Concept ID:
C1854260
Congenital Abnormality
Leber congenital amaurosis comprises a group of early-onset childhood retinal dystrophies characterized by vision loss, nystagmus, and severe retinal dysfunction. Patients usually present at birth with profound vision loss and pendular nystagmus. Electroretinogram (ERG) responses are usually nonrecordable. Other clinical findings may include high hypermetropia, photodysphoria, oculodigital sign, keratoconus, cataracts, and a variable appearance to the fundus (summary by Chung and Traboulsi, 2009). For a general description and a discussion of genetic heterogeneity of LCA, see 204000.
Retinitis pigmentosa 83
MedGen UID:
1648404
Concept ID:
C4748536
Disease or Syndrome
Retinitis pigmentosa-83 (RP83) is characterized by onset of night blindness in the first decade of life, with decreased central vision in the second decade of life in association with retinal degeneration. The retinal dystrophy is associated with cataract, and macular edema has also been reported in some patients (Holtan et al., 2019).

Professional guidelines

PubMed

Delaney YM, Oyinloye A, Benjamin L
Eye (Lond) 2002 Jan;16(1):21-6. doi: 10.1038/sj.eye.6700026. PMID: 11913884

Recent clinical studies

Etiology

Duong R, Cai X, Ambati N, Shildkrot Y, Sieburth R
Eye (Lond) 2023 Jun;37(8):1678-1682. Epub 2022 Aug 29 doi: 10.1038/s41433-022-02214-z. PMID: 36038722Free PMC Article
Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y
Acta Ophthalmol 2020 Dec;98(8):755-762. Epub 2020 May 15 doi: 10.1111/aos.14465. PMID: 32410360
Jabłońska A, Ciszewska J, Kęcik D
Klin Oczna 2014;116(4):272-6. PMID: 25906639
Kador PF, Wyman M
Eye (Lond) 2008 Oct;22(10):1278-85. Epub 2008 Mar 14 doi: 10.1038/eye.2008.35. PMID: 18344964
Yazar Z, Hanioglu S, Karakoç G, Gürsel E
Eur J Ophthalmol 2001 Jan-Mar;11(1):57-61. doi: 10.1177/112067210101100111. PMID: 11284486

Diagnosis

Khadia A, Gupta I, Thangaraju D, Assadi FA, Ghosh A, Veena K, Mouttapa F, Venkatesh R
Indian J Ophthalmol 2023 Jan;71(1):287-289. doi: 10.4103/ijo.IJO_1884_22. PMID: 36588253Free PMC Article
Khoshnevis M, Rosen S, Sebag J
Surv Ophthalmol 2019 Jul-Aug;64(4):452-462. Epub 2019 Jan 30 doi: 10.1016/j.survophthal.2019.01.008. PMID: 30707924
Gologorsky D, Spierer O
Eur J Intern Med 2018 Jan;47:e5-e6. Epub 2017 May 13 doi: 10.1016/j.ejim.2017.04.027. PMID: 28511850
McAlinden C, Skiadaresi E
Mayo Clin Proc 2015 Jul;90(7):992. doi: 10.1016/j.mayocp.2014.10.015. PMID: 26141340
Schmidt JC, Chofflet J, Hörle S, Mennel S, Meyer SH
Dev Ophthalmol 2008;42:35-42. doi: 10.1159/000138923. PMID: 18535379

Therapy

Renschler A, Kelkar N, Eid K, Hawn V, Bundogji N, Werner L, Mamalis N
J Cataract Refract Surg 2024 Apr 1;50(4):394-400. doi: 10.1097/j.jcrs.0000000000001371. PMID: 37994083
Doshi S, Pathengay A, Sane S, Saldanha M
BMJ Case Rep 2019 Apr 5;12(4) doi: 10.1136/bcr-2019-230076. PMID: 30954967Free PMC Article
Ochi R, Sato B, Morishita S, Imagawa Y, Mimura M, Fukumoto M, Sato T, Kobayashi T, Kida T, Ikeda T
BMC Ophthalmol 2017 May 15;17(1):68. doi: 10.1186/s12886-017-0467-6. PMID: 28506223Free PMC Article
Jabłońska A, Ciszewska J, Kęcik D
Klin Oczna 2014;116(4):272-6. PMID: 25906639
Kador PF, Wyman M
Eye (Lond) 2008 Oct;22(10):1278-85. Epub 2008 Mar 14 doi: 10.1038/eye.2008.35. PMID: 18344964

Prognosis

Ortega-Usobiaga J, Bilbao-Calabuig R, González-López F, Beltrán-Sanz J, Wang Y, Llovet-Osuna F, Figueroa MS
J Fr Ophtalmol 2024 Apr;47(4):104105. Epub 2024 Feb 29 doi: 10.1016/j.jfo.2024.104105. PMID: 38428321
Yellapragada B, Hornauer S, Snyder K, Yu S, Yiu G
Ophthalmol Retina 2022 Feb;6(2):116-129. Epub 2021 Jul 2 doi: 10.1016/j.oret.2021.06.010. PMID: 34217854Free PMC Article
Janetos TM, German O, Mirza R
J Med Case Rep 2021 Apr 2;15(1):145. doi: 10.1186/s13256-021-02774-w. PMID: 33794992Free PMC Article
Elbaz H, Schuster AK, Nickels S, Nagler M, Ponto KI, Münzel T, Wild PS, Beutel ME, Schmidtmann I, Lackner KJ, Pfeiffer N, Peto T
Ophthalmology 2021 Feb;128(2):328-330. Epub 2020 Jul 9 doi: 10.1016/j.ophtha.2020.07.008. PMID: 32652202
Moussa K, Leng T, Oatts JT, Bhisitkul RB, Hwang DG, Stewart JM
Ophthalmic Surg Lasers Imaging Retina 2017 May 1;48(5):422-426. doi: 10.3928/23258160-20170428-09. PMID: 28499054

Clinical prediction guides

Lee KH, Lee SC, Lee MW
Korean J Ophthalmol 2024 Apr;38(2):113-121. Epub 2024 Feb 14 doi: 10.3341/kjo.2023.0133. PMID: 38351484Free PMC Article
Yellapragada B, Hornauer S, Snyder K, Yu S, Yiu G
Ophthalmol Retina 2022 Feb;6(2):116-129. Epub 2021 Jul 2 doi: 10.1016/j.oret.2021.06.010. PMID: 34217854Free PMC Article
Ochi R, Sato B, Morishita S, Imagawa Y, Mimura M, Fukumoto M, Sato T, Kobayashi T, Kida T, Ikeda T
BMC Ophthalmol 2017 May 15;17(1):68. doi: 10.1186/s12886-017-0467-6. PMID: 28506223Free PMC Article
Zarifa R, Shaikh S, Kester E
Indian J Ophthalmol 2013 Apr;61(4):182-3. doi: 10.4103/0301-4738.112166. PMID: 23685493Free PMC Article
Zaharopoulos P, Schnadig V
Diagn Cytopathol 2003 Feb;28(2):88-91. doi: 10.1002/dc.10236. PMID: 12561028

Recent systematic reviews

Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y
Acta Ophthalmol 2020 Dec;98(8):755-762. Epub 2020 May 15 doi: 10.1111/aos.14465. PMID: 32410360

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