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Asteroid hyalosis

MedGen UID:
636821
Concept ID:
C0521770
Disease or Syndrome
Synonyms: Asteroid hyalitis; Benson's disease
SNOMED CT: Asteroid hyalosis (95800001); Benson's disease (95800001); Asteroid hyalitis (95800001)
 
HPO: HP:0030672

Definition

The presence of small, white vitreous opacities consisting of calcium phosphate and complex, layered lipid deposits. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAsteroid hyalosis

Conditions with this feature

Retinitis pigmentosa 13
MedGen UID:
325486
Concept ID:
C1838702
Disease or Syndrome
Any retinitis pigmentosa in which the cause of the disease is a mutation in the PRPF8 gene.
Multiple epiphyseal dysplasia, Beighton type
MedGen UID:
377049
Concept ID:
C1851536
Disease or Syndrome
A rare primary bone dysplasia characterized by the association of multiple epiphyseal dysplasia, visual impairment (with early-onset progressive myopia, retinal thinning, and cataracts), and conductive hearing loss. Patients are of short stature and present brachydactyly, genu valgus deformity, and joint pain.
Retinitis pigmentosa 83
MedGen UID:
1648404
Concept ID:
C4748536
Disease or Syndrome
Retinitis pigmentosa-83 (RP83) is characterized by onset of night blindness in the first decade of life, with decreased central vision in the second decade of life in association with retinal degeneration. The retinal dystrophy is associated with cataract, and macular edema has also been reported in some patients (Holtan et al., 2019).

Professional guidelines

PubMed

Delaney YM, Oyinloye A, Benjamin L
Eye (Lond) 2002 Jan;16(1):21-6. doi: 10.1038/sj.eye.6700026. PMID: 11913884

Recent clinical studies

Etiology

Duong R, Cai X, Ambati N, Shildkrot Y, Sieburth R
Eye (Lond) 2023 Jun;37(8):1678-1682. Epub 2022 Aug 29 doi: 10.1038/s41433-022-02214-z. PMID: 36038722Free PMC Article
Zhang C, Shao L, Dong L, Da Zhou W, Zhang RH, Wei WB
BMC Ophthalmol 2022 Sep 6;22(1):360. doi: 10.1186/s12886-022-02586-6. PMID: 36068511Free PMC Article
Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y
Acta Ophthalmol 2020 Dec;98(8):755-762. Epub 2020 May 15 doi: 10.1111/aos.14465. PMID: 32410360
Jabłońska A, Ciszewska J, Kęcik D
Klin Oczna 2014;116(4):272-6. PMID: 25906639
Yazar Z, Hanioglu S, Karakoç G, Gürsel E
Eur J Ophthalmol 2001 Jan-Mar;11(1):57-61. doi: 10.1177/112067210101100111. PMID: 11284486

Diagnosis

Duong R, Cai X, Ambati N, Shildkrot Y, Sieburth R
Eye (Lond) 2023 Jun;37(8):1678-1682. Epub 2022 Aug 29 doi: 10.1038/s41433-022-02214-z. PMID: 36038722Free PMC Article
Zhang C, Shao L, Dong L, Da Zhou W, Zhang RH, Wei WB
BMC Ophthalmol 2022 Sep 6;22(1):360. doi: 10.1186/s12886-022-02586-6. PMID: 36068511Free PMC Article
Khoshnevis M, Rosen S, Sebag J
Surv Ophthalmol 2019 Jul-Aug;64(4):452-462. Epub 2019 Jan 30 doi: 10.1016/j.survophthal.2019.01.008. PMID: 30707924
Gologorsky D, Spierer O
Eur J Intern Med 2018 Jan;47:e5-e6. Epub 2017 May 13 doi: 10.1016/j.ejim.2017.04.027. PMID: 28511850
McAlinden C, Skiadaresi E
Mayo Clin Proc 2015 Jul;90(7):992. doi: 10.1016/j.mayocp.2014.10.015. PMID: 26141340

Therapy

Yellapragada B, Hornauer S, Snyder K, Yu S, Yiu G
Ophthalmol Retina 2022 Feb;6(2):116-129. Epub 2021 Jul 2 doi: 10.1016/j.oret.2021.06.010. PMID: 34217854Free PMC Article
John M, Ipe A, Jacob I
Indian J Ophthalmol 2015 Jun;63(6):524-7. doi: 10.4103/0301-4738.99867. PMID: 23571244Free PMC Article
Jabłońska A, Ciszewska J, Kęcik D
Klin Oczna 2014;116(4):272-6. PMID: 25906639
Kador PF, Wyman M
Eye (Lond) 2008 Oct;22(10):1278-85. Epub 2008 Mar 14 doi: 10.1038/eye.2008.35. PMID: 18344964
Allison KL, Price J, Odin L
J Cataract Refract Surg 1991 Mar;17(2):181-6. doi: 10.1016/s0886-3350(13)80248-9. PMID: 2040975

Prognosis

Yellapragada B, Hornauer S, Snyder K, Yu S, Yiu G
Ophthalmol Retina 2022 Feb;6(2):116-129. Epub 2021 Jul 2 doi: 10.1016/j.oret.2021.06.010. PMID: 34217854Free PMC Article
Janetos TM, German O, Mirza R
J Med Case Rep 2021 Apr 2;15(1):145. doi: 10.1186/s13256-021-02774-w. PMID: 33794992Free PMC Article
Elbaz H, Schuster AK, Nickels S, Nagler M, Ponto KI, Münzel T, Wild PS, Beutel ME, Schmidtmann I, Lackner KJ, Pfeiffer N, Peto T
Ophthalmology 2021 Feb;128(2):328-330. Epub 2020 Jul 9 doi: 10.1016/j.ophtha.2020.07.008. PMID: 32652202
Mouna A, Berrod JP, Conart JB
Ophthalmic Res 2017;58(1):35-39. Epub 2017 May 3 doi: 10.1159/000468990. PMID: 28463846
Ikeda T, Sawa H, Koizumi K, Yasuhara T, Kinoshita S, Tano Y
Retina 1998;18(5):410-4. doi: 10.1097/00006982-199805000-00004. PMID: 9801034

Clinical prediction guides

Yellapragada B, Hornauer S, Snyder K, Yu S, Yiu G
Ophthalmol Retina 2022 Feb;6(2):116-129. Epub 2021 Jul 2 doi: 10.1016/j.oret.2021.06.010. PMID: 34217854Free PMC Article
Motiani MV, McCannel CA, Almanzor R, McCannel TA
Semin Ophthalmol 2017;32(2):257-259. Epub 2016 Apr 8 doi: 10.3109/08820538.2015.1053627. PMID: 27058861
Mitchell P, Wang MY, Wang JJ
Ophthalmic Epidemiol 2003 Dec;10(5):331-5. doi: 10.1076/opep.10.5.331.17324. PMID: 14566634
Moss SE, Klein R, Klein BE
Am J Ophthalmol 2001 Jul;132(1):70-5. doi: 10.1016/s0002-9394(01)00936-9. PMID: 11438056
Ikeda T, Sawa H, Koizumi K, Yasuhara T, Kinoshita S, Tano Y
Retina 1998;18(5):410-4. doi: 10.1097/00006982-199805000-00004. PMID: 9801034

Recent systematic reviews

Møller-Lorentzen TB, Eckmann-Hansen C, Faber C, Larsen M, Subhi Y
Acta Ophthalmol 2020 Dec;98(8):755-762. Epub 2020 May 15 doi: 10.1111/aos.14465. PMID: 32410360

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