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Infant death

MedGen UID:
639821
•Concept ID:
C0549159
•
Finding
Synonyms: Death, Infant; Deaths, Infant; Infant Death; Infant Deaths
SNOMED CT: Infant death (240297000)

Definition

The death of a live-born INFANT within its first year of life. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant death

Professional guidelines

PubMed

Interventions for Tobacco Smoking Cessation in Adults, Including Pregnant Persons: US Preventive Services Task Force Recommendation Statement.
US Preventive Services Task Force, Krist AH, Davidson KW, Mangione CM, Barry MJ, Cabana M, Caughey AB, Donahue K, Doubeni CA, Epling JW Jr, Kubik M, Ogedegbe G, Pbert L, Silverstein M, Simon MA, Tseng CW, Wong JB
JAMA 2021 Jan 19;325(3):265-279. doi: 10.1001/jama.2020.25019. PMID: 33464343
Emerging Implications of Genetic Testing in Inherited Primary Arrhythmia Syndromes.
Asatryan B, Medeiros-Domingo A
Cardiol Rev 2019 Jan/Feb;27(1):23-33. doi: 10.1097/CRD.0000000000000203. PMID: 29528859
Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management.
Meng L, Pammi M, Saronwala A, Magoulas P, Ghazi AR, Vetrini F, Zhang J, He W, Dharmadhikari AV, Qu C, Ward P, Braxton A, Narayanan S, Ge X, Tokita MJ, Santiago-Sim T, Dai H, Chiang T, Smith H, Azamian MS, Robak L, Bostwick BL, Schaaf CP, Potocki L, Scaglia F, Bacino CA, Hanchard NA, Wangler MF, Scott D, Brown C, Hu J, Belmont JW, Burrage LC, Graham BH, Sutton VR, Craigen WJ, Plon SE, Lupski JR, Beaudet AL, Gibbs RA, Muzny DM, Miller MJ, Wang X, Leduc MS, Xiao R, Liu P, Shaw C, Walkiewicz M, Bi W, Xia F, Lee B, Eng CM, Yang Y, Lalani SR
JAMA Pediatr 2017 Dec 4;171(12):e173438. doi: 10.1001/jamapediatrics.2017.3438. PMID: 28973083Free PMC Article

Recent clinical studies

Etiology

Sudden infant death syndrome prevention.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):320. doi: 10.1186/s12887-021-02536-z. PMID: 34496779Free PMC Article
Manifestation and Pathogenesis of Sudden Infant Death Syndrome: A Review.
Kaler J, Hussain A, Lee S
Crit Rev Eukaryot Gene Expr 2020;30(2):111-120. doi: 10.1615/CritRevEukaryotGeneExpr.2020033009. PMID: 32558490
SIDS, BRUE, and Safe Sleep Guidelines.
Behnam-Terneus M, Clemente M
Pediatr Rev 2019 Sep;40(9):443-455. doi: 10.1542/pir.2017-0259. PMID: 31477587
Sudden Infant Death Syndrome: A Review.
Goldberg N, Rodriguez-Prado Y, Tillery R, Chua C
Pediatr Ann 2018 Mar 1;47(3):e118-e123. doi: 10.3928/19382359-20180221-03. PMID: 29538785
Sudden infant death syndrome.
Adams SM, Ward CE, Garcia KL
Am Fam Physician 2015 Jun 1;91(11):778-83. PMID: 26034855

Diagnosis

Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome.
Harrington CT, Hafid NA, Waters KA
EBioMedicine 2022 Jun;80:104041. Epub 2022 May 6 doi: 10.1016/j.ebiom.2022.104041. PMID: 35533499Free PMC Article
SIDS, BRUE, and Safe Sleep Guidelines.
Behnam-Terneus M, Clemente M
Pediatr Rev 2019 Sep;40(9):443-455. doi: 10.1542/pir.2017-0259. PMID: 31477587
Impaired CO(2)-Induced Arousal in SIDS and SUDEP.
Buchanan GF
Trends Neurosci 2019 Apr;42(4):242-250. doi: 10.1016/j.tins.2019.02.002. PMID: 30905388Free PMC Article
Sudden infant death syndrome and inherited cardiac conditions.
Baruteau AE, Tester DJ, Kapplinger JD, Ackerman MJ, Behr ER
Nat Rev Cardiol 2017 Dec;14(12):715-726. Epub 2017 Sep 7 doi: 10.1038/nrcardio.2017.129. PMID: 28880023
Infant mortality.
Lancet 1988 Nov 12;2(8620):1117-8. PMID: 2903329

Therapy

Vosoritide therapy in children with achondroplasia aged 3-59 months: a multinational, randomised, double-blind, placebo-controlled, phase 2 trial.
Savarirayan R, Wilcox WR, Harmatz P, Phillips J 3rd, Polgreen LE, Tofts L, Ozono K, Arundel P, Irving M, Bacino CA, Basel D, Bober MB, Charrow J, Mochizuki H, Kotani Y, Saal HM, Army C, Jeha G, Qi Y, Han L, Fisheleva E, Huntsman-Labed A, Day J
Lancet Child Adolesc Health 2024 Jan;8(1):40-50. Epub 2023 Nov 18 doi: 10.1016/S2352-4642(23)00265-1. PMID: 37984383
Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix: The TOPS Randomized Clinical Trial.
Hoffman MK, Clifton RG, Biggio JR, Saade GR, Ugwu LG, Longo M, Bousleiman SZ, Clark K, Grobman WA, Frey HA, Chauhan SP, Dugoff L, Manuck TA, Chien EK, Rouse DJ, Simhan HN, Esplin MS, Macones GA; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network
JAMA 2023 Jul 25;330(4):340-348. doi: 10.1001/jama.2023.10812. PMID: 37490086Free PMC Article
17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG Study): A Multicenter, International, Randomized Double-Blind Trial.
Blackwell SC, Gyamfi-Bannerman C, Biggio JR Jr, Chauhan SP, Hughes BL, Louis JM, Manuck TA, Miller HS, Das AF, Saade GR, Nielsen P, Baker J, Yuzko OM, Reznichenko GI, Reznichenko NY, Pekarev O, Tatarova N, Gudeman J, Birch R, Jozwiakowski MJ, Duncan M, Williams L, Krop J
Am J Perinatol 2020 Jan;37(2):127-136. Epub 2019 Oct 25 doi: 10.1055/s-0039-3400227. PMID: 31652479
Parent-infant co-sleeping and the implications for sudden infant death syndrome.
Straw J, Jones P
Nurs Child Young People 2017 Dec 5;29(10):24-29. doi: 10.7748/ncyp.2017.e945. PMID: 29206359
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes.
Brown J, Ceysens G, Boulvain M
Cochrane Database Syst Rev 2017 Jun 22;6(6):CD012202. doi: 10.1002/14651858.CD012202.pub2. PMID: 28639706Free PMC Article

Prognosis

Deaths: Leading Causes for 2020.
Curtin SC, Tejada-Vera B, Bastian BA
Natl Vital Stat Rep 2023 Dec;72(13):1-115. PMID: 38085308
Sudden Unexpected Infant Deaths: 2015-2020.
Shapiro-Mendoza CK, Woodworth KR, Cottengim CR, Erck Lambert AB, Harvey EM, Monsour M, Parks SE, Barfield WD
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-058820. PMID: 36911916Free PMC Article
Mortality in the United States, 2021.
Xu J, Murphy SL, Kochanek KD, Arias E
NCHS Data Brief 2022 Dec;(456):1-8. PMID: 36598387
Mortality in the United States, 2020.
Murphy SL, Kochanek KD, Xu J, Arias E
NCHS Data Brief 2021 Dec;(427):1-8. PMID: 34978528
Sudden infant death syndrome.
Adams SM, Ward CE, Garcia KL
Am Fam Physician 2015 Jun 1;91(11):778-83. PMID: 26034855

Clinical prediction guides

Early Newborn Metabolic Patterning and Sudden Infant Death Syndrome.
Oltman SP, Rogers EE, Baer RJ, Amsalu R, Bandoli G, Chambers CD, Cho H, Dagle JM, Karvonen KL, Kingsmore SF, McKenzie-Sampson S, Momany A, Ontiveros E, Protopsaltis LD, Rand L, Kobayashi ES, Steurer MA, Ryckman KK, Jelliffe-Pawlowski LL
JAMA Pediatr 2024 Nov 1;178(11):1183-1191. doi: 10.1001/jamapediatrics.2024.3033. PMID: 39250160Free PMC Article
Infant death prediction using machine learning: A population-based retrospective study.
Zhang Z, Xiao Q, Luo J
Comput Biol Med 2023 Oct;165:107423. Epub 2023 Sep 1 doi: 10.1016/j.compbiomed.2023.107423. PMID: 37672926
Sudden infant death syndrome prevention.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):320. doi: 10.1186/s12887-021-02536-z. PMID: 34496779Free PMC Article
Long QT syndrome and sudden unexpected infant death.
Van Niekerk C, Van Deventer BS, du Toit-Prinsloo L
J Clin Pathol 2017 Sep;70(9):808-813. Epub 2017 Jun 29 doi: 10.1136/jclinpath-2016-204199. PMID: 28663329
Carnitine palmitoyltransferase 1A P479L and infant death: policy implications of emerging data.
Fohner AE, Garrison NA, Austin MA, Burke W
Genet Med 2017 Aug;19(8):851-857. Epub 2017 Jan 26 doi: 10.1038/gim.2016.202. PMID: 28125087Free PMC Article

Recent systematic reviews

Mirror syndrome: a systematic literature review.
Biswas S, Gomez J, Horgan R, Sibai BM, Saad A, Powel JE, Al-Kouatly HB
Am J Obstet Gynecol MFM 2023 Sep;5(9):101067. Epub 2023 Jun 28 doi: 10.1016/j.ajogmf.2023.101067. PMID: 37385374
Burden of disease attributable to second-hand smoke exposure: A systematic review.
Carreras G, Lugo A, Gallus S, Cortini B, Fernández E, López MJ, Soriano JB, López-Nicolás A, Semple S, Gorini G; TackSHS Project Investigators
Prev Med 2019 Dec;129:105833. Epub 2019 Sep 7 doi: 10.1016/j.ypmed.2019.105833. PMID: 31505203
Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes.
Brown J, Ceysens G, Boulvain M
Cochrane Database Syst Rev 2017 Jun 22;6(6):CD012202. doi: 10.1002/14651858.CD012202.pub2. PMID: 28639706Free PMC Article
Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.
Downes KL, Grantz KL, Shenassa ED
Am J Perinatol 2017 Aug;34(10):935-957. Epub 2017 Mar 22 doi: 10.1055/s-0037-1599149. PMID: 28329897Free PMC Article
Swaddling: a systematic review.
van Sleuwen BE, Engelberts AC, Boere-Boonekamp MM, Kuis W, Schulpen TW, L'Hoir MP
Pediatrics 2007 Oct;120(4):e1097-106. doi: 10.1542/peds.2006-2083. PMID: 17908730

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