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Reproductive system neoplasm

MedGen UID:
64246
•Concept ID:
C0178830
•
Neoplastic Process
Synonyms: Neoplasm of Reproductive System; neoplasm of reproductive system; Neoplasm of the Reproductive System; neoplasm of the reproductive system; Reproductive Neoplasm; reproductive neoplasm; Reproductive System Neoplasm; reproductive system neoplasm; reproductive system neoplasm (disease); Reproductive System Tumor; reproductive system tumor; reproductive system tumour; Reproductive Tumor; reproductive tumor; reproductive tumour; Tumor of Reproductive System; tumor of reproductive system; Tumor of the Reproductive System; tumor of the reproductive system; tumour of reproductive system; tumour of the reproductive system
 
Monarch Initiative: MONDO:0006054

Definition

A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReproductive system neoplasm

Professional guidelines

PubMed

Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS Network
Eur J Endocrinol 2023 Aug 2;189(2):G43-G64. doi: 10.1093/ejendo/lvad096. PMID: 37580861
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE
J Clin Endocrinol Metab 2023 Sep 18;108(10):2447-2469. doi: 10.1210/clinem/dgad463. PMID: 37580314Free PMC Article
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
The Microbiome and Genitourinary Cancer: A Collaborative Review.
Markowski MC, Boorjian SA, Burton JP, Hahn NM, Ingersoll MA, Maleki Vareki S, Pal SK, Sfanos KS
Eur Urol 2019 Apr;75(4):637-646. Epub 2019 Jan 15 doi: 10.1016/j.eururo.2018.12.043. PMID: 30655087Free PMC Article
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Decision curve analysis: a novel method for evaluating prediction models.
Vickers AJ, Elkin EB
Med Decis Making 2006 Nov-Dec;26(6):565-74. doi: 10.1177/0272989X06295361. PMID: 17099194Free PMC Article

Diagnosis

Revolutionizing the female reproductive system research using microfluidic chip platform.
Yan J, Wu T, Zhang J, Gao Y, Wu JM, Wang S
J Nanobiotechnology 2023 Dec 19;21(1):490. doi: 10.1186/s12951-023-02258-7. PMID: 38111049Free PMC Article
Physiological and pharmacological overview of the gonadotropin releasing hormone.
Casati L, Ciceri S, Maggi R, Bottai D
Biochem Pharmacol 2023 Jun;212:115553. Epub 2023 Apr 17 doi: 10.1016/j.bcp.2023.115553. PMID: 37075816
Role of m6A modification in female infertility and reproductive system diseases.
Chen J, Fang Y, Xu Y, Sun H
Int J Biol Sci 2022;18(9):3592-3604. Epub 2022 May 16 doi: 10.7150/ijbs.69771. PMID: 35813486Free PMC Article
Radioproteomics in patients with ovarian cancer.
McCague C, Beer L
Br J Radiol 2021 Sep 1;94(1125):20201331. Epub 2021 Jun 11 doi: 10.1259/bjr.20201331. PMID: 34111953Free PMC Article
Reproductive system infections in women: lower genital tract syndromes.
Brunham RC, Paavonen J
Pathog Dis 2020 Jul 1;78(5) doi: 10.1093/femspd/ftaa022. PMID: 32463432

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Advanced Prostate Cancer: Treatment Advances and Future Directions.
Swami U, McFarland TR, Nussenzveig R, Agarwal N
Trends Cancer 2020 Aug;6(8):702-715. Epub 2020 Jun 10 doi: 10.1016/j.trecan.2020.04.010. PMID: 32534790
The microbiome and gynaecological cancer development, prevention and therapy.
Łaniewski P, Ilhan ZE, Herbst-Kralovetz MM
Nat Rev Urol 2020 Apr;17(4):232-250. Epub 2020 Feb 18 doi: 10.1038/s41585-020-0286-z. PMID: 32071434Free PMC Article
MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis.
Kasivisvanathan V, Rannikko AS, Borghi M, Panebianco V, Mynderse LA, Vaarala MH, Briganti A, Budäus L, Hellawell G, Hindley RG, Roobol MJ, Eggener S, Ghei M, Villers A, Bladou F, Villeirs GM, Virdi J, Boxler S, Robert G, Singh PB, Venderink W, Hadaschik BA, Ruffion A, Hu JC, Margolis D, Crouzet S, Klotz L, Taneja SS, Pinto P, Gill I, Allen C, Giganti F, Freeman A, Morris S, Punwani S, Williams NR, Brew-Graves C, Deeks J, Takwoingi Y, Emberton M, Moore CM; PRECISION Study Group Collaborators
N Engl J Med 2018 May 10;378(19):1767-1777. Epub 2018 Mar 18 doi: 10.1056/NEJMoa1801993. PMID: 29552975Free PMC Article
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Lancet 2005 May 14-20;365(9472):1687-717. doi: 10.1016/S0140-6736(05)66544-0. PMID: 15894097

Prognosis

Revolutionizing the female reproductive system research using microfluidic chip platform.
Yan J, Wu T, Zhang J, Gao Y, Wu JM, Wang S
J Nanobiotechnology 2023 Dec 19;21(1):490. doi: 10.1186/s12951-023-02258-7. PMID: 38111049Free PMC Article
Association between Alcohol Intake and Prostate Cancer Mortality and Survival.
D'Ecclesiis O, Pastore E, Gandini S, Caini S, Marvaso G, Jereczek-Fossa BA, Corrao G, Raimondi S, Bellerba F, Ciceri S, Latella M, Cavalcabò NB, Bendinelli B, Saieva C, Fontana M, Gnagnarella P
Nutrients 2023 Feb 12;15(4) doi: 10.3390/nu15040925. PMID: 36839283Free PMC Article
Trends in cervical cancer mortality in China from 1989 to 2018: an age-period-cohort study and Joinpoint analysis.
Guo M, Xu J, Du J
BMC Public Health 2021 Jul 6;21(1):1329. doi: 10.1186/s12889-021-11401-8. PMID: 34229639Free PMC Article
Cryptorchidism.
Hutson JM, Balic A, Nation T, Southwell B
Semin Pediatr Surg 2010 Aug;19(3):215-24. doi: 10.1053/j.sempedsurg.2010.04.001. PMID: 20610195
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Clinical prediction guides

Interobserver Agreement and Accuracy in Interpreting mpMRI of the Prostate: a Systematic Review.
Annamalai A, Fustok JN, Beltran-Perez J, Rashad AT, Krane LS, Triche BL
Curr Urol Rep 2022 Jan;23(1):1-10. Epub 2022 Feb 28 doi: 10.1007/s11934-022-01084-y. PMID: 35226257
Endocrine disruptors and the male reproductive system.
Stukenborg JB, Mitchell RT, Söder O
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101567. Epub 2021 Aug 14 doi: 10.1016/j.beem.2021.101567. PMID: 34426080
Positive Predictive Value of Prostate Imaging Reporting and Data System Version 2 for the Detection of Clinically Significant Prostate Cancer: A Systematic Review and Meta-analysis.
Mazzone E, Stabile A, Pellegrino F, Basile G, Cignoli D, Cirulli GO, Sorce G, Barletta F, Scuderi S, Bravi CA, Cucchiara V, Fossati N, Gandaglia G, Montorsi F, Briganti A
Eur Urol Oncol 2021 Oct;4(5):697-713. Epub 2020 Dec 25 doi: 10.1016/j.euo.2020.12.004. PMID: 33358543
Environmental factors and testicular function.
Giwercman A, Giwercman YL
Best Pract Res Clin Endocrinol Metab 2011 Apr;25(2):391-402. doi: 10.1016/j.beem.2010.09.011. PMID: 21397206
Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention.
Bełtowski J, Semczuk A
Pharmacol Rep 2010 Jan-Feb;62(1):15-27. doi: 10.1016/s1734-1140(10)70239-5. PMID: 20360612

Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.
Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314Free PMC Article
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review.
Wirtz C, Mohamed Y, Engel D, Sidibe A, Holloway M, Bloem P, Kumar S, Brotherton J, Reis V, Morgan C
Vaccine 2022 Mar 31;40 Suppl 1:A116-A123. Epub 2021 Dec 1 doi: 10.1016/j.vaccine.2021.11.013. PMID: 34863615
The Role of Zinc in Selected Female Reproductive System Disorders.
Nasiadek M, Stragierowicz J, Klimczak M, Kilanowicz A
Nutrients 2020 Aug 16;12(8) doi: 10.3390/nu12082464. PMID: 32824334Free PMC Article

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