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Perinatal asphyxia

MedGen UID:
644043
•Concept ID:
C0559477
•
Pathologic Function
Synonym: Perinatal Depression
SNOMED CT: Perinatal asphyxia (281578009)

Definition

A condition characterized by cardiorespiratory and neurological depression following birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPerinatal asphyxia

Professional guidelines

PubMed

Risk Factors for Periventricular Leukomalacia in Preterm Infants: A Systematic Review, Meta-analysis, and GRADE-Based Assessment of Certainty of Evidence.
Abiramalatha T, Bandyopadhyay T, Ramaswamy VV, Shaik NB, Thanigainathan S, Pullattayil AK, Amboiram P
Pediatr Neurol 2021 Nov;124:51-71. Epub 2021 Aug 17 doi: 10.1016/j.pediatrneurol.2021.08.003. PMID: 34537463
Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Erythropoietin Alone, and Erythropoietin Combined with Hypothermia: History, Current Status, and Future Research.
Oorschot DE, Sizemore RJ, Amer AR
Int J Mol Sci 2020 Feb 21;21(4) doi: 10.3390/ijms21041487. PMID: 32098276Free PMC Article
Neonatal management of pregnancy complicated by diabetes.
Mohsin F, Khan S, Baki MA, Zabeen B, Azad K
J Pak Med Assoc 2016 Sep;66(9 Suppl 1):S81-4. PMID: 27582162

Recent clinical studies

Etiology

Neonatal multiple organ failure after perinatal asphyxia.
Iribarren I, Hilario E, Álvarez A, Alonso-Alconada D
An Pediatr (Engl Ed) 2022 Oct;97(4):280.e1-280.e8. Epub 2022 Sep 14 doi: 10.1016/j.anpede.2022.08.010. PMID: 36115781
Special consideration in neonatal resuscitation.
Ali N, Sawyer T
Semin Perinatol 2022 Oct;46(6):151626. Epub 2022 May 25 doi: 10.1016/j.semperi.2022.151626. PMID: 35738945
Is perinatal asphyxia predictable?
Locatelli A, Lambicchi L, Incerti M, Bonati F, Ferdico M, Malguzzi S, Torcasio F, Calzi P, Varisco T, Paterlini G
BMC Pregnancy Childbirth 2020 Mar 30;20(1):186. doi: 10.1186/s12884-020-02876-1. PMID: 32228514Free PMC Article
Neonatal management of pregnancy complicated by diabetes.
Mohsin F, Khan S, Baki MA, Zabeen B, Azad K
J Pak Med Assoc 2016 Sep;66(9 Suppl 1):S81-4. PMID: 27582162
Perinatal Asphyxia from the Obstetric Standpoint: Diagnosis and Interventions.
Herrera CA, Silver RM
Clin Perinatol 2016 Sep;43(3):423-38. Epub 2016 Jun 17 doi: 10.1016/j.clp.2016.04.003. PMID: 27524445

Diagnosis

Neonatal Encephalopathy: Beyond Hypoxic-Ischemic Encephalopathy.
Russ JB, Simmons R, Glass HC
Neoreviews 2021 Mar;22(3):e148-e162. doi: 10.1542/neo.22-3-e148. PMID: 33649088
Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Is perinatal asphyxia predictable?
Locatelli A, Lambicchi L, Incerti M, Bonati F, Ferdico M, Malguzzi S, Torcasio F, Calzi P, Varisco T, Paterlini G
BMC Pregnancy Childbirth 2020 Mar 30;20(1):186. doi: 10.1186/s12884-020-02876-1. PMID: 32228514Free PMC Article
Neonatal management of pregnancy complicated by diabetes.
Mohsin F, Khan S, Baki MA, Zabeen B, Azad K
J Pak Med Assoc 2016 Sep;66(9 Suppl 1):S81-4. PMID: 27582162
Perinatal Asphyxia from the Obstetric Standpoint: Diagnosis and Interventions.
Herrera CA, Silver RM
Clin Perinatol 2016 Sep;43(3):423-38. Epub 2016 Jun 17 doi: 10.1016/j.clp.2016.04.003. PMID: 27524445

Therapy

Preventing Brain Injury in the Preterm Infant-Current Controversies and Potential Therapies.
Yates N, Gunn AJ, Bennet L, Dhillon SK, Davidson JO
Int J Mol Sci 2021 Feb 7;22(4) doi: 10.3390/ijms22041671. PMID: 33562339Free PMC Article
Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.
Finder M, Boylan GB, Twomey D, Ahearne C, Murray DM, Hallberg B
JAMA Pediatr 2020 Jan 1;174(1):48-55. doi: 10.1001/jamapediatrics.2019.4011. PMID: 31710357Free PMC Article
Birth Asphyxia and Hypoxic-Ischemic Brain Injury in the Preterm Infant.
Laptook AR
Clin Perinatol 2016 Sep;43(3):529-45. Epub 2016 Jun 10 doi: 10.1016/j.clp.2016.04.010. PMID: 27524452
Hypothermia therapy for newborns with hypoxic ischemic encephalopathy.
Silveira RC, Procianoy RS
J Pediatr (Rio J) 2015 Nov-Dec;91(6 Suppl 1):S78-83. Epub 2015 Sep 4 doi: 10.1016/j.jped.2015.07.004. PMID: 26354871
Perinatal asphyxia.
McGuire W
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450354Free PMC Article

Prognosis

Neonatal mortality associated with perinatal asphyxia: a population-based study in a middle-income country.
Kawakami MD, Sanudo A, Teixeira MLP, Andreoni S, de Castro JQX, Waldvogel B, Guinsburg R, de Almeida MF
BMC Pregnancy Childbirth 2021 Feb 27;21(1):169. doi: 10.1186/s12884-021-03652-5. PMID: 33639885Free PMC Article
Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Is perinatal asphyxia predictable?
Locatelli A, Lambicchi L, Incerti M, Bonati F, Ferdico M, Malguzzi S, Torcasio F, Calzi P, Varisco T, Paterlini G
BMC Pregnancy Childbirth 2020 Mar 30;20(1):186. doi: 10.1186/s12884-020-02876-1. PMID: 32228514Free PMC Article
Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy.
Chiang MC, Jong YJ, Lin CH
Pediatr Neonatol 2017 Dec;58(6):475-483. Epub 2017 Mar 27 doi: 10.1016/j.pedneo.2016.11.001. PMID: 28416250
Perinatal asphyxia.
McGuire W
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450354Free PMC Article

Clinical prediction guides

Neonatal mortality associated with perinatal asphyxia: a population-based study in a middle-income country.
Kawakami MD, Sanudo A, Teixeira MLP, Andreoni S, de Castro JQX, Waldvogel B, Guinsburg R, de Almeida MF
BMC Pregnancy Childbirth 2021 Feb 27;21(1):169. doi: 10.1186/s12884-021-03652-5. PMID: 33639885Free PMC Article
Methods for assessing the severity of perinatal asphyxia and early prognostic tools in neonates with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia.
Walas W, Wilińska M, Bekiesińska-Figatowska M, Halaba Z, Śmigiel R
Adv Clin Exp Med 2020 Aug;29(8):1011-1016. doi: 10.17219/acem/124437. PMID: 32820870
Is perinatal asphyxia predictable?
Locatelli A, Lambicchi L, Incerti M, Bonati F, Ferdico M, Malguzzi S, Torcasio F, Calzi P, Varisco T, Paterlini G
BMC Pregnancy Childbirth 2020 Mar 30;20(1):186. doi: 10.1186/s12884-020-02876-1. PMID: 32228514Free PMC Article
Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.
Finder M, Boylan GB, Twomey D, Ahearne C, Murray DM, Hallberg B
JAMA Pediatr 2020 Jan 1;174(1):48-55. doi: 10.1001/jamapediatrics.2019.4011. PMID: 31710357Free PMC Article
Perinatal asphyxia.
McGuire W
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450354Free PMC Article

Recent systematic reviews

Biomarkers of hypoxic-ischemic encephalopathy: a systematic review.
Caramelo I, Coelho M, Rosado M, Cardoso CMP, Dinis A, Duarte CB, Grãos M, Manadas B
World J Pediatr 2023 Jun;19(6):505-548. Epub 2023 Apr 21 doi: 10.1007/s12519-023-00698-7. PMID: 37084165Free PMC Article
Therapeutic hypothermia in neonatal hypoxic encephalopathy: A systematic review and meta-analysis.
Mathew JL, Kaur N, Dsouza JM
J Glob Health 2022;12:04030. Epub 2022 Apr 9 doi: 10.7189/jogh.12.04030. PMID: 35444799Free PMC Article
Perinatal asphyxia and its associated factors in Ethiopia: a systematic review and meta-analysis.
Sendeku FW, Azeze GG, Fenta SL
BMC Pediatr 2020 Mar 24;20(1):135. doi: 10.1186/s12887-020-02039-3. PMID: 32209083Free PMC Article
Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews.
Shepherd E, Salam RA, Middleton P, Han S, Makrides M, McIntyre S, Badawi N, Crowther CA
Cochrane Database Syst Rev 2018 Jun 20;6(6):CD012409. doi: 10.1002/14651858.CD012409.pub2. PMID: 29926474Free PMC Article
Perinatal asphyxia.
McGuire W
BMJ Clin Evid 2007 Nov 7;2007 PMID: 19450354Free PMC Article

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