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Microcystic adenoma

MedGen UID:
64420
•Concept ID:
C0205648
•
Neoplastic Process
Synonyms: Adenoma, Microcystic; Adenomas, Microcystic; Microcystic Adenoma; Microcystic Adenomas
SNOMED CT: Microcystic adenoma (79494009)
 
Monarch Initiative: MONDO:0003435

Definition

A benign epithelial neoplasm characterized by a microcystic pattern. The cystic spaces are lined by small cuboidal cells without evidence of significant cytologic atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicrocystic adenoma

Professional guidelines

PubMed

Magnetic resonance imaging of cystic pancreatic lesions in adults: an update in current diagnostic features and management.
Barral M, Soyer P, Dohan A, Laurent V, Hoeffel C, Fishman EK, Boudiaf M
Abdom Imaging 2014 Feb;39(1):48-65. doi: 10.1007/s00261-013-0048-y. PMID: 24263208
Comments and illustrations regarding the guidelines and good clinical practice recommendations for contrast-enhanced ultrasound (CEUS)--update 2008.
Dietrich CF
Ultraschall Med 2008 Sep;29 Suppl 4:S188-202. Epub 2008 Oct 2 doi: 10.1055/s-2008-1027799. PMID: 18833497

Recent clinical studies

Etiology

Cystic tumors of the pancreas: ultrasound, computed tomography, and magnetic resonance imaging features.
Sidden CR, Mortele KJ
Semin Ultrasound CT MR 2007 Oct;28(5):339-56. doi: 10.1053/j.sult.2007.07.001. PMID: 17970551
A giant pancreatic serous microcystic adenoma with 20 years follow-up.
Schulz HU, Kellner U, Kahl S, Effenberger O, Asperger W, Lippert H, Röcken C
Langenbecks Arch Surg 2007 Mar;392(2):209-13. Epub 2007 Jan 19 doi: 10.1007/s00423-006-0146-1. PMID: 17235583
Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features.
Lal A, Bourtsos EP, DeFrias DV, Nemcek AA, Nayar R
Cancer 2004 Oct 25;102(5):288-94. doi: 10.1002/cncr.20487. PMID: 15559952
Microcystic features at US: a nonspecific sign for microcystic adenomas of the pancreas.
Yeh HC, Stancato-Pasik A, Shapiro RS
Radiographics 2001 Nov-Dec;21(6):1455-61. doi: 10.1148/radiographics.21.6.g01nv251455. PMID: 11706216
Pancreatic cystic neoplasms.
Mathieu D, Guigui B, Valette PJ, Dao TH, Bruneton JN, Bruel JM, Pringot J, Vasile N
Radiol Clin North Am 1989 Jan;27(1):163-76. PMID: 2642272

Diagnosis

Cystic tumors of the pancreas: imaging and management.
Dewhurst CE, Mortele KJ
Radiol Clin North Am 2012 May;50(3):467-86. Epub 2012 Mar 28 doi: 10.1016/j.rcl.2012.03.001. PMID: 22560692
Solid serous adenoma of the pancreas: an uncommon but important entity.
Machado MC, Machado MA
Eur J Surg Oncol 2008 Jul;34(7):730-3. Epub 2008 Apr 25 doi: 10.1016/j.ejso.2008.03.009. PMID: 18440191
Microcystic adenoma of the pancreas: clinical, radiologic, and cytologic features.
Lal A, Bourtsos EP, DeFrias DV, Nemcek AA, Nayar R
Cancer 2004 Oct 25;102(5):288-94. doi: 10.1002/cncr.20487. PMID: 15559952
MR imaging of pancreatic diseases.
Ito K, Koike S, Matsunaga N
Eur J Radiol 2001 May;38(2):78-93. doi: 10.1016/s0720-048x(01)00293-5. PMID: 11335090
From the Archives of the AFIP. Microcystic adenoma of the pancreas.
Buck JL, Hayes WS
Radiographics 1990 Mar;10(2):313-22. doi: 10.1148/radiographics.10.2.2183300. PMID: 2183300

Therapy

Use of expandable metallic biliary stents in resectable pancreatic cancer.
Wasan SM, Ross WA, Staerkel GA, Lee JH
Am J Gastroenterol 2005 Sep;100(9):2056-61. doi: 10.1111/j.1572-0241.2005.42031.x. PMID: 16128952

Prognosis

Synchronous pancreatic cancer and pancreatic serous cystic neoplasm: A case report.
Zong Y, Xiao W, Ma Y, Wang B, Yu W
J Pak Med Assoc 2023 Apr;73(4):901-904. doi: 10.47391/JPMA.5496. PMID: 37052011
Solid serous microcystic adenoma of the pancreas.
Stern JR, Frankel WL, Ellison EC, Bloomston M
World J Surg Oncol 2007 Mar 5;5:26. doi: 10.1186/1477-7819-5-26. PMID: 17338818Free PMC Article
A giant pancreatic serous microcystic adenoma with 20 years follow-up.
Schulz HU, Kellner U, Kahl S, Effenberger O, Asperger W, Lippert H, Röcken C
Langenbecks Arch Surg 2007 Mar;392(2):209-13. Epub 2007 Jan 19 doi: 10.1007/s00423-006-0146-1. PMID: 17235583
Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
Adsay NV, Basturk O, Cheng JD, Andea AA
Semin Radiat Oncol 2005 Oct;15(4):254-64. doi: 10.1016/j.semradonc.2005.04.001. PMID: 16183479
Pancreatic cystic neoplasms.
Mathieu D, Guigui B, Valette PJ, Dao TH, Bruneton JN, Bruel JM, Pringot J, Vasile N
Radiol Clin North Am 1989 Jan;27(1):163-76. PMID: 2642272

Clinical prediction guides

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758
MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors.
Jiao LR, Frampton AE, Jacob J, Pellegrino L, Krell J, Giamas G, Tsim N, Vlavianos P, Cohen P, Ahmad R, Keller A, Habib NA, Stebbing J, Castellano L
PLoS One 2012;7(2):e32068. Epub 2012 Feb 22 doi: 10.1371/journal.pone.0032068. PMID: 22384141Free PMC Article
A von Hippel-Lindau disease-associated microcystic adenoma of the ethmoid sinus: case report.
Xu DS, Dirks MS, Quezado MM, Lubensky IA, Zhuang Z, Lonser RR, Asthagiri AR
Neurosurgery 2011 Oct;69(4):E1017-21; discussion E1021-2. doi: 10.1227/NEU.0b013e318223b7a7. PMID: 21572360Free PMC Article
Neuroendocrine tumours--analysis of own material--a nine--year retrospective study.
Krzysztof K, Wiktor B, Tadeusz Ł, Waldemar B, Magdalena K, Janusz D
Hepatogastroenterology 2010 Mar-Apr;57(98):236-41. PMID: 20583420
From the Archives of the AFIP. Microcystic adenoma of the pancreas.
Buck JL, Hayes WS
Radiographics 1990 Mar;10(2):313-22. doi: 10.1148/radiographics.10.2.2183300. PMID: 2183300

Recent systematic reviews

Multifocal/diffuse pancreatic serous cystic neoplasms: Systematic review with a new case.
Wu YHA, Samuels JM, Harnke B, Negrini D, Al-Musawi MH, Meguid C, Ahrendt S, Schulick RD, Del Chiaro M, Oba A
Pancreatology 2020 Jul;20(5):902-909. Epub 2020 May 5 doi: 10.1016/j.pan.2020.04.015. PMID: 32418758

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