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Adenomyoma

MedGen UID:
64617
Concept ID:
C0206622
Neoplastic Process
Synonym: Adenomyomas
SNOMED CT: Adenomyoma (40293003)
 
Monarch Initiative: MONDO:0005635

Definition

A benign neoplasm characterized by the presence of a glandular and a mesenchymal (fibromyomatous) component. It occurs in the uterine corpus, cervix, and uterine ligaments. A variant of adenomyoma associated with glandular architectural complexity is called atypical polypoid adenomyoma. Simple polypectomy is usually curative. Atypical polypoid adenomyoma may recur following polypectomy. [from NCI]

Professional guidelines

PubMed

Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380
Soave I, Wenger JM, Pluchino N, Marci R
Curr Med Res Opin 2018 May;34(5):839-849. Epub 2017 Nov 10 doi: 10.1080/03007995.2017.1393404. PMID: 29046066
Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

Recent clinical studies

Etiology

Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Soave I, Wenger JM, Pluchino N, Marci R
Curr Med Res Opin 2018 May;34(5):839-849. Epub 2017 Nov 10 doi: 10.1080/03007995.2017.1393404. PMID: 29046066
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

Diagnosis

Kerbage Y, Dericquebourg S, Collinet P, Verpillat P, Giraudet G, Rubod C
J Gynecol Obstet Hum Reprod 2022 Mar;51(3):102313. Epub 2022 Jan 11 doi: 10.1016/j.jogoh.2022.102313. PMID: 35031510
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article

Therapy

Bourdon M, Santulli P, Maignien C, Bordonne C, Millischer AE, Chargui A, Marcellin L, Mantelet LM, Fouque Gadol L, Chapron C
Fertil Steril 2024 Mar;121(3):460-469. Epub 2023 Dec 4 doi: 10.1016/j.fertnstert.2023.11.039. PMID: 38056519
Zhang S, Wang K, Di A, Yu D, Yao T
Ann Palliat Med 2021 Nov;10(11):12003-12011. doi: 10.21037/apm-21-3133. PMID: 34872323
Osada H
Fertil Steril 2018 Mar;109(3):406-417. doi: 10.1016/j.fertnstert.2018.01.032. PMID: 29566853
Dueholm M
Best Pract Res Clin Obstet Gynaecol 2018 Aug;51:119-137. Epub 2018 Feb 15 doi: 10.1016/j.bpobgyn.2018.01.016. PMID: 29555380
Tsui KH, Lee WL, Chen CY, Sheu BC, Yen MS, Chang TC, Wang PH
Taiwan J Obstet Gynecol 2014 Dec;53(4):459-65. doi: 10.1016/j.tjog.2014.04.024. PMID: 25510683

Prognosis

Golse N, Lewin M, Rode A, Sebagh M, Mabrut JY
J Visc Surg 2017 Oct;154(5):345-353. Epub 2017 Aug 24 doi: 10.1016/j.jviscsurg.2017.06.004. PMID: 28844704
Jiang QY, Wang L, Wu RJ
Gynecol Endocrinol 2013 Jul;29(7):623-5. Epub 2013 Mar 25 doi: 10.3109/09513590.2013.777418. PMID: 23527553
Levy G, Dehaene A, Laurent N, Lernout M, Collinet P, Lucot JP, Lions C, Poncelet E
Diagn Interv Imaging 2013 Jan;94(1):3-25. Epub 2012 Dec 12 doi: 10.1016/j.diii.2012.10.012. PMID: 23246186
D'Angelo E, Prat J
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):705-18. Epub 2011 Jul 13 doi: 10.1016/j.bpobgyn.2011.05.010. PMID: 21742560
Protopapas A, Milingos S, Markaki S, Loutradis D, Haidopoulos D, Sotiropoulou M, Antsaklis A
Gynecol Obstet Invest 2008;65(4):275-80. Epub 2008 Jan 24 doi: 10.1159/000113871. PMID: 18216491

Clinical prediction guides

Vu Trung K, Heise C, Abou-Ali E, Auriemma F, Karam E, van der Wiel SE, Bruno MJ, Caillol F, Giovannini M, Masaryk V, Will U, Anderloni A, Pérez-Cuadrado-Robles E, Dugic A, Meier B, Paik WH, Petrone MC, Wichmann D, Dinis-Ribeiro M, Gonçalves TC, Wedi E, Schmidt A, Gulla A, Hoffmeister A, Rosendahl J, Ratone JP, Saadeh R, Repici A, Deprez P, Sauvanet A, Souche FR, Fabre JM, Muehldorfer S, Caca K, Löhr M, Michl P, Krug S, Regner S, Gaujoux S, Hollenbach M
Gastrointest Endosc 2024 Apr;99(4):587-595.e1. Epub 2023 Nov 10 doi: 10.1016/j.gie.2023.10.040. PMID: 37951279
Benagiano G, Brosens I, Habiba M
Hum Reprod Update 2014 May-Jun;20(3):386-402. Epub 2013 Oct 18 doi: 10.1093/humupd/dmt052. PMID: 24140719
Tahlan A, Nanda A, Mohan H
Int J Gynecol Pathol 2006 Oct;25(4):361-5. doi: 10.1097/01.pgp.0000209570.08716.b3. PMID: 16990713
Tamai K, Koyama T, Umeoka S, Saga T, Fujii S, Togashi K
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):583-602. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.009. PMID: 16564228
Benagiano G, Brosens I
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):449-63. Epub 2006 Mar 2 doi: 10.1016/j.bpobgyn.2006.01.007. PMID: 16515887

Recent systematic reviews

Giorgi M, Labanca L, Centini G, Lazzeri L, Martire FG, Sorrentino E, Mancini V, Raimondo D, Raffone A, Neola D, Aru AC, Habib N, Casadio P, Seracchioli R, Zupi E
Int J Gynaecol Obstet 2024 Mar;164(3):869-901. Epub 2023 Sep 8 doi: 10.1002/ijgo.15049. PMID: 37688388
Cozzolino M, Tartaglia S, Pellegrini L, Troiano G, Rizzo G, Petraglia F
Reprod Sci 2022 Nov;29(11):3177-3193. Epub 2022 Jan 3 doi: 10.1007/s43032-021-00818-6. PMID: 34981458
Biasioli A, Londero AP, Orsaria M, Scrimin F, Mangino FP, Bertozzi S, Mariuzzi L, Cagnacci A
Medicine (Baltimore) 2020 Jun 26;99(26):e20491. doi: 10.1097/MD.0000000000020491. PMID: 32590732Free PMC Article
Fiegel H, Gfroerer S, Rolle U
Acta Paediatr 2016 Nov;105(11):1275-1279. doi: 10.1111/apa.13567. PMID: 27588829
Grimbizis GF, Mikos T, Tarlatzis B
Fertil Steril 2014 Feb;101(2):472-87. Epub 2013 Nov 26 doi: 10.1016/j.fertnstert.2013.10.025. PMID: 24289992

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