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Multiple organ dysfunction syndrome

MedGen UID:
6462
•Concept ID:
C0026766
•
Disease or Syndrome
Synonym: Multiple organ failure
SNOMED CT: Multisystem organ failure (57653000); Multiple systems organ failure (57653000); MOF - Multiple organ failure (57653000); Multi-organ failure (57653000); MOSF - Multiple organ systems failure (57653000); Multiple organ systems failure (57653000); MSOF - Multiple systems organ failure (57653000); MODS - Multiple organ dysfunction syndrome (57653000); Multiple organ dysfunction syndrome (57653000); Multiple organ failure (57653000)
 
Monarch Initiative: MONDO:0043726

Definition

Progressive, potentially reversible physiologic dysfunction in two or more organ systems in response to severe physiologic insult. Dysregulated immunological response is the critical pathophysiologic factor in most cases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple organ dysfunction syndrome

Professional guidelines

PubMed

Hemodynamic monitoring and management of pediatric septic shock.
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults.
La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, Kumar A, van Laar JAM, Lachmann G, Nichols KE, Ramanan AV, Wang Y, Wang Z, Janka G, Henter JI
Blood 2019 Jun 6;133(23):2465-2477. Epub 2019 Apr 16 doi: 10.1182/blood.2018894618. PMID: 30992265
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ
Chest 1992 Jun;101(6):1644-55. doi: 10.1378/chest.101.6.1644. PMID: 1303622

Recent clinical studies

Etiology

Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial.
Karakike E, Scicluna BP, Roumpoutsou M, Mitrou I, Karampela N, Karageorgos A, Psaroulis K, Massa E, Pitsoulis A, Chaloulis P, Pappa E, Schrijver IT, Frantzeskaki F, Lada M, Dauby N, De Bels D, Floros I, Anisoglou S, Antoniadou E, Patrani M, Vlachogianni G, Mouloudi E, Antoniadou A, Grimaldi D, Roger T, Wiersinga WJ, Tsangaris I, Giamarellos-Bourboulis EJ
Crit Care 2022 Jun 18;26(1):183. doi: 10.1186/s13054-022-04055-4. PMID: 35717241Free PMC Article
Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Hemodynamic monitoring and management of pediatric septic shock.
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
The Critical Roles and Mechanisms of Immune Cell Death in Sepsis.
Cheng Z, Abrams ST, Toh J, Wang SS, Wang Z, Yu Q, Yu W, Toh CH, Wang G
Front Immunol 2020;11:1918. Epub 2020 Aug 25 doi: 10.3389/fimmu.2020.01918. PMID: 32983116Free PMC Article
Multiple organ dysfunction syndrome.
Ramírez M
Curr Probl Pediatr Adolesc Health Care 2013 Nov-Dec;43(10):273-7. doi: 10.1016/j.cppeds.2013.10.003. PMID: 24295608

Diagnosis

Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Role of gut microbiota on intestinal barrier function in acute pancreatitis.
Li XY, He C, Zhu Y, Lu NH
World J Gastroenterol 2020 May 14;26(18):2187-2193. doi: 10.3748/wjg.v26.i18.2187. PMID: 32476785Free PMC Article
Ebola virus disease.
Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults.
La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, Kumar A, van Laar JAM, Lachmann G, Nichols KE, Ramanan AV, Wang Y, Wang Z, Janka G, Henter JI
Blood 2019 Jun 6;133(23):2465-2477. Epub 2019 Apr 16 doi: 10.1182/blood.2018894618. PMID: 30992265
Acute Inflammation and Metabolism.
Varela ML, Mogildea M, Moreno I, Lopes A
Inflammation 2018 Aug;41(4):1115-1127. doi: 10.1007/s10753-018-0739-1. PMID: 29404872

Therapy

Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Vasopressors in Trauma: A Never Event?
Richards JE, Harris T, Dünser MW, Bouzat P, Gauss T
Anesth Analg 2021 Jul 1;133(1):68-79. doi: 10.1213/ANE.0000000000005552. PMID: 33908898
Ebola virus disease.
Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Surgery, neuroinflammation and cognitive impairment.
Alam A, Hana Z, Jin Z, Suen KC, Ma D
EBioMedicine 2018 Nov;37:547-556. Epub 2018 Oct 19 doi: 10.1016/j.ebiom.2018.10.021. PMID: 30348620Free PMC Article
Current Mechanistic Concepts in Ischemia and Reperfusion Injury.
Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY, Li CJ
Cell Physiol Biochem 2018;46(4):1650-1667. Epub 2018 Apr 20 doi: 10.1159/000489241. PMID: 29694958

Prognosis

Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients.
Perez Ruiz de Garibay A, Kortgen A, Leonhardt J, Zipprich A, Bauer M
Crit Care 2022 Sep 26;26(1):289. doi: 10.1186/s13054-022-04163-1. PMID: 36163253Free PMC Article
Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Hemodynamic monitoring and management of pediatric septic shock.
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Pathogenetic mechanisms of septic cardiomyopathy.
Wang R, Xu Y, Fang Y, Wang C, Xue Y, Wang F, Cheng J, Ren H, Wang J, Guo W, Liu L, Zhang M
J Cell Physiol 2022 Jan;237(1):49-58. Epub 2021 Jul 18 doi: 10.1002/jcp.30527. PMID: 34278573
Multiple organ dysfunction syndrome.
Ramírez M
Curr Probl Pediatr Adolesc Health Care 2013 Nov-Dec;43(10):273-7. doi: 10.1016/j.cppeds.2013.10.003. PMID: 24295608

Clinical prediction guides

Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review.
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Clinical characteristics and management of 1572 patients with pyogenic liver abscess: A 12-year retrospective study.
Yin D, Ji C, Zhang S, Wang J, Lu Z, Song X, Jiang H, Lau WY, Liu L
Liver Int 2021 Apr;41(4):810-818. Epub 2020 Dec 28 doi: 10.1111/liv.14760. PMID: 33314531Free PMC Article
Multiple organ dysfunction after trauma.
Cole E, Gillespie S, Vulliamy P, Brohi K; Organ Dysfunction in Trauma (ORDIT) study collaborators
Br J Surg 2020 Mar;107(4):402-412. Epub 2019 Nov 6 doi: 10.1002/bjs.11361. PMID: 31691956Free PMC Article
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial.
Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R
Chest 2007 Apr;131(4):954-63. doi: 10.1378/chest.06-2100. PMID: 17426195
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

Recent systematic reviews

Review: the role of GSDMD in sepsis.
Shao R, Lou X, Xue J, Ning D, Chen G, Jiang L
Inflamm Res 2022 Nov;71(10-11):1191-1202. Epub 2022 Aug 15 doi: 10.1007/s00011-022-01624-9. PMID: 35969260Free PMC Article
Is restrictive fluid resuscitation beneficial not only for hemorrhagic shock but also for septic shock?: A meta-analysis.
Jiang S, Wu M, Lu X, Zhong Y, Kang X, Song Y, Fan Z
Medicine (Baltimore) 2021 Mar 26;100(12):e25143. doi: 10.1097/MD.0000000000025143. PMID: 33761680Free PMC Article
Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis.
Taneri PE, Gómez-Ochoa SA, Llanaj E, Raguindin PF, Rojas LZ, Roa-Díaz ZM, Salvador D Jr, Groothof D, Minder B, Kopp-Heim D, Hautz WE, Eisenga MF, Franco OH, Glisic M, Muka T
Eur J Epidemiol 2020 Aug;35(8):763-773. Epub 2020 Aug 20 doi: 10.1007/s10654-020-00678-5. PMID: 32816244Free PMC Article
A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome.
Dare AJ, Phillips AR, Hickey AJ, Mittal A, Loveday B, Thompson N, Windsor JA
Free Radic Biol Med 2009 Dec 1;47(11):1517-25. Epub 2009 Aug 26 doi: 10.1016/j.freeradbiomed.2009.08.019. PMID: 19715753
Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome.
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

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