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Multiple organ dysfunction syndrome

MedGen UID:
6462
Concept ID:
C0026766
Disease or Syndrome
Synonym: Multiple organ failure
SNOMED CT: Multisystem organ failure (57653000); Multiple systems organ failure (57653000); MOF - Multiple organ failure (57653000); Multi-organ failure (57653000); MOSF - Multiple organ systems failure (57653000); Multiple organ systems failure (57653000); MSOF - Multiple systems organ failure (57653000); MODS - Multiple organ dysfunction syndrome (57653000); Multiple organ dysfunction syndrome (57653000); Multiple organ failure (57653000)
 
Monarch Initiative: MONDO:0043726

Definition

Progressive, potentially reversible physiologic dysfunction in two or more organ systems in response to severe physiologic insult. Dysregulated immunological response is the critical pathophysiologic factor in most cases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultiple organ dysfunction syndrome

Professional guidelines

PubMed

Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, Kumar A, van Laar JAM, Lachmann G, Nichols KE, Ramanan AV, Wang Y, Wang Z, Janka G, Henter JI
Blood 2019 Jun 6;133(23):2465-2477. Epub 2019 Apr 16 doi: 10.1182/blood.2018894618. PMID: 30992265
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ
Chest 1992 Jun;101(6):1644-55. doi: 10.1378/chest.101.6.1644. PMID: 1303622

Recent clinical studies

Etiology

Weiss SL, Fitzgerald JC
Pediatrics 2024 Jan 1;153(1) doi: 10.1542/peds.2023-062967. PMID: 38084084Free PMC Article
Chen X, Yuan S, Mi L, Long Y, He H
Front Immunol 2023;14:1217366. Epub 2023 Aug 30 doi: 10.3389/fimmu.2023.1217366. PMID: 37711629Free PMC Article
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

Diagnosis

Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Young JA, Pallas CR, Knovich MA
Bone Marrow Transplant 2021 Aug;56(8):1805-1817. Epub 2021 Apr 19 doi: 10.1038/s41409-021-01283-0. PMID: 33875812Free PMC Article
La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, Kumar A, van Laar JAM, Lachmann G, Nichols KE, Ramanan AV, Wang Y, Wang Z, Janka G, Henter JI
Blood 2019 Jun 6;133(23):2465-2477. Epub 2019 Apr 16 doi: 10.1182/blood.2018894618. PMID: 30992265
Varela ML, Mogildea M, Moreno I, Lopes A
Inflammation 2018 Aug;41(4):1115-1127. doi: 10.1007/s10753-018-0739-1. PMID: 29404872

Therapy

Qin S, Chan SL, Gu S, Bai Y, Ren Z, Lin X, Chen Z, Jia W, Jin Y, Guo Y, Hu X, Meng Z, Liang J, Cheng Y, Xiong J, Ren H, Yang F, Li W, Chen Y, Zeng Y, Sultanbaev A, Pazgan-Simon M, Pisetska M, Melisi D, Ponomarenko D, Osypchuk Y, Sinielnikov I, Yang TS, Liang X, Chen C, Wang L, Cheng AL, Kaseb A, Vogel A; CARES-310 Study Group
Lancet 2023 Sep 30;402(10408):1133-1146. Epub 2023 Jul 24 doi: 10.1016/S0140-6736(23)00961-3. PMID: 37499670
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Richards JE, Harris T, Dünser MW, Bouzat P, Gauss T
Anesth Analg 2021 Jul 1;133(1):68-79. doi: 10.1213/ANE.0000000000005552. PMID: 33908898
Jacob ST, Crozier I, Fischer WA 2nd, Hewlett A, Kraft CS, Vega MA, Soka MJ, Wahl V, Griffiths A, Bollinger L, Kuhn JH
Nat Rev Dis Primers 2020 Feb 20;6(1):13. doi: 10.1038/s41572-020-0147-3. PMID: 32080199Free PMC Article
Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY, Li CJ
Cell Physiol Biochem 2018;46(4):1650-1667. Epub 2018 Apr 20 doi: 10.1159/000489241. PMID: 29694958

Prognosis

Perez Ruiz de Garibay A, Kortgen A, Leonhardt J, Zipprich A, Bauer M
Crit Care 2022 Sep 26;26(1):289. doi: 10.1186/s13054-022-04163-1. PMID: 36163253Free PMC Article
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Lee EP, Wu HP, Chan OW, Lin JJ, Hsia SH
Biomed J 2022 Feb;45(1):63-73. Epub 2021 Oct 12 doi: 10.1016/j.bj.2021.10.004. PMID: 34653683Free PMC Article
Confalonieri M, Urbino R, Potena A, Piattella M, Parigi P, Puccio G, Della Porta R, Giorgio C, Blasi F, Umberger R, Meduri GU
Am J Respir Crit Care Med 2005 Feb 1;171(3):242-8. Epub 2004 Nov 19 doi: 10.1164/rccm.200406-808OC. PMID: 15557131
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

Clinical prediction guides

Zheng D, Yu GL, Zhou YP, Zhang QM, Wang CG, Zhang S
PeerJ 2024;12:e16769. Epub 2024 Jan 31 doi: 10.7717/peerj.16769. PMID: 38313014Free PMC Article
Barichello T, Generoso JS, Singer M, Dal-Pizzol F
Crit Care 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5. PMID: 34991675Free PMC Article
Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R
Chest 2007 Apr;131(4):954-63. doi: 10.1378/chest.06-2100. PMID: 17426195
Confalonieri M, Urbino R, Potena A, Piattella M, Parigi P, Puccio G, Della Porta R, Giorgio C, Blasi F, Umberger R, Meduri GU
Am J Respir Crit Care Med 2005 Feb 1;171(3):242-8. Epub 2004 Nov 19 doi: 10.1164/rccm.200406-808OC. PMID: 15557131
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

Recent systematic reviews

Shao R, Lou X, Xue J, Ning D, Chen G, Jiang L
Inflamm Res 2022 Nov;71(10-11):1191-1202. Epub 2022 Aug 15 doi: 10.1007/s00011-022-01624-9. PMID: 35969260Free PMC Article
Taneri PE, Gómez-Ochoa SA, Llanaj E, Raguindin PF, Rojas LZ, Roa-Díaz ZM, Salvador D Jr, Groothof D, Minder B, Kopp-Heim D, Hautz WE, Eisenga MF, Franco OH, Glisic M, Muka T
Eur J Epidemiol 2020 Aug;35(8):763-773. Epub 2020 Aug 20 doi: 10.1007/s10654-020-00678-5. PMID: 32816244Free PMC Article
Xiao SH, Luo L, Liu XH, Zhou YM, Liu HM, Huang ZF
Medicine (Baltimore) 2018 Jun;97(23):e10971. doi: 10.1097/MD.0000000000010971. PMID: 29879049Free PMC Article
Tang BM, Craig JC, Eslick GD, Seppelt I, McLean AS
Crit Care Med 2009 May;37(5):1594-603. doi: 10.1097/CCM.0b013e31819fb507. PMID: 19325471
Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ
Crit Care Med 1995 Oct;23(10):1638-52. doi: 10.1097/00003246-199510000-00007. PMID: 7587228

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