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Giant cell tumor of bone

MedGen UID:
64624
Concept ID:
C0206638
Neoplastic Process
Synonym: Giant Cell Tumor of Bone
SNOMED CT: Giant cell tumor of bone (697970009); GTCT - Giant cell tumor of bone (697970009); Giant cell tumor of bone (57500000); Osteoclastoma (57500000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0011847
Monarch Initiative: MONDO:0005674
Orphanet: ORPHA363976

Definition

A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell tumor of bone

Professional guidelines

PubMed

van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Nagano A, Urakawa H, Tanaka K, Ozaki T
Jpn J Clin Oncol 2022 May 5;52(5):411-416. doi: 10.1093/jjco/hyac018. PMID: 35199172
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2023

Recent clinical studies

Etiology

Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Hess MC, Kafchinski L, Ransom E
Orthop Clin North Am 2023 Jan;54(1):75-88. Epub 2022 Oct 23 doi: 10.1016/j.ocl.2022.08.002. PMID: 36402513
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024
van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H
Eur J Cancer 2017 May;77:75-83. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.021. PMID: 28365529

Diagnosis

Errani C, Tsukamoto S, Angulo Alvarado R, Righi A, Nitta Y, Donati DM, Mavrogenis AF
Orthopedics 2023 Nov-Dec;46(6):e376-e380. Epub 2023 May 2 doi: 10.3928/01477447-20230426-05. PMID: 37126833
Tan X, Zhang Y, Wei D, Yang Y, Xiang F
Clin Exp Med 2023 Nov;23(7):3053-3075. Epub 2023 Apr 27 doi: 10.1007/s10238-023-01079-0. PMID: 37103655
Temple EW, Prusa RD
Clin Podiatr Med Surg 2021 Apr;38(2):227-233. Epub 2021 Jan 26 doi: 10.1016/j.cpm.2020.12.007. PMID: 33745653
Scotto di Carlo F, Whyte MP, Gianfrancesco F
Cancer Lett 2020 Oct 1;489:1-8. Epub 2020 Jun 2 doi: 10.1016/j.canlet.2020.05.031. PMID: 32502498
Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article

Therapy

Dhillon S
Drugs 2024 Jan;84(1):105-109. doi: 10.1007/s40265-023-01985-3. PMID: 38112898
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Wessel LE, Strike SA, Singh A, Bernthal NM, Athanasian EA
J Hand Surg Am 2023 Sep;48(9):923-930. Epub 2023 Apr 7 doi: 10.1016/j.jhsa.2023.02.013. PMID: 37032292
Basu Mallick A, Chawla SP
Curr Oncol Rep 2021 Mar 22;23(5):51. doi: 10.1007/s11912-021-01047-5. PMID: 33754215
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

Prognosis

Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Tan X, Zhang Y, Wei D, Yang Y, Xiang F
Clin Exp Med 2023 Nov;23(7):3053-3075. Epub 2023 Apr 27 doi: 10.1007/s10238-023-01079-0. PMID: 37103655
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Itkin B, Straminsky S, De Ronato G, Lewi D, Marantz A, Bardach A
Jpn J Clin Oncol 2018 Jul 1;48(7):640-652. doi: 10.1093/jjco/hyy067. PMID: 29741702
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Clinical prediction guides

Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Tahir I, Andrei V, Pollock R, Saifuddin A
Skeletal Radiol 2022 May;51(5):957-970. Epub 2021 Sep 25 doi: 10.1007/s00256-021-03913-6. PMID: 34562125
Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303Free PMC Article

Recent systematic reviews

Sun Z, Wu Z, Zhang L, Jia Q, Zhou Z, Xiao J
J Cancer Res Ther 2023 Feb;19(1):25-33. doi: 10.4103/jcrt.jcrt_1171_22. PMID: 37006039
Formica VM, Bruno V, Scotto Di Uccio A, Cocca E, Rossi B, Zoccali C
Orthop Traumatol Surg Res 2023 May;109(3):103396. Epub 2022 Sep 7 doi: 10.1016/j.otsr.2022.103396. PMID: 36087835
Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078
Itkin B, Straminsky S, De Ronato G, Lewi D, Marantz A, Bardach A
Jpn J Clin Oncol 2018 Jul 1;48(7):640-652. doi: 10.1093/jjco/hyy067. PMID: 29741702
Zheng K, Wang Z, Wu SJ, Ye ZM, Xu SF, Xu M, Hu YC, Yu XC
Orthop Surg 2015 May;7(2):102-7. doi: 10.1111/os.12174. PMID: 26033989Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2023

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