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Giant cell tumor of bone

MedGen UID:
64624
•Concept ID:
C0206638
•
Neoplastic Process
Synonym: Giant Cell Tumor of Bone
SNOMED CT: Giant cell tumor of bone (697970009); GTCT - Giant cell tumor of bone (697970009); Giant cell tumor of bone (57500000); Osteoclastoma (57500000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011847
Monarch Initiative: MONDO:0005674
Orphanet: ORPHA363976

Definition

A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell tumor of bone

Professional guidelines

PubMed

Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Current management of giant-cell tumor of bone in the denosumab era.
Nagano A, Urakawa H, Tanaka K, Ozaki T
Jpn J Clin Oncol 2022 May 5;52(5):411-416. doi: 10.1093/jjco/hyac018. PMID: 35199172
Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2023

Recent clinical studies

Etiology

Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Current concepts in the treatment of giant cell tumour of bone.
van der Heijden L, Dijkstra S, van de Sande M, Gelderblom H
Curr Opin Oncol 2020 Jul;32(4):332-338. doi: 10.1097/CCO.0000000000000645. PMID: 32541321
Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024
Giant cell tumour of bone in the denosumab era.
van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H
Eur J Cancer 2017 May;77:75-83. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.021. PMID: 28365529
Giant cell tumor of bone.
Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193

Diagnosis

Calcaneal Bone Tumors.
Temple EW, Prusa RD
Clin Podiatr Med Surg 2021 Apr;38(2):227-233. Epub 2021 Jan 26 doi: 10.1016/j.cpm.2020.12.007. PMID: 33745653
The two faces of giant cell tumor of bone.
Scotto di Carlo F, Whyte MP, Gianfrancesco F
Cancer Lett 2020 Oct 1;489:1-8. Epub 2020 Jun 2 doi: 10.1016/j.canlet.2020.05.031. PMID: 32502498
Selected Giant Cell Rich Lesions of the Temporal Bone.
Martinez AP, Torres-Mora J
Head Neck Pathol 2018 Sep;12(3):367-377. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0906-6. PMID: 30069841Free PMC Article
Giant cell tumor of bone.
Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM
Orthopedics 2014 Feb;37(2):112-20. doi: 10.3928/01477447-20140124-08. PMID: 24679193
Giant cell tumor of bone.
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Therapy

Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Current management of giant-cell tumor of bone in the denosumab era.
Nagano A, Urakawa H, Tanaka K, Ozaki T
Jpn J Clin Oncol 2022 May 5;52(5):411-416. doi: 10.1093/jjco/hyac018. PMID: 35199172
Giant Cell Tumor of Bone: An Update.
Basu Mallick A, Chawla SP
Curr Oncol Rep 2021 Mar 22;23(5):51. doi: 10.1007/s11912-021-01047-5. PMID: 33754215
Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.
Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024
Giant cell tumour of bone in the denosumab era.
van der Heijden L, Dijkstra PDS, Blay JY, Gelderblom H
Eur J Cancer 2017 May;77:75-83. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.021. PMID: 28365529

Prognosis

Giant cell tumour of bone.
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis.
Itkin B, Straminsky S, De Ronato G, Lewi D, Marantz A, Bardach A
Jpn J Clin Oncol 2018 Jul 1;48(7):640-652. doi: 10.1093/jjco/hyy067. PMID: 29741702
Giant cell tumor of bone.
Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Clinical prediction guides

Giant cell tumour of bone.
Aoude A, Nikomarov D, Perera JR, Ibe IK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS
Bone Joint J 2023 May 1;105-B(5):559-567. doi: 10.1302/0301-620X.105B5.BJJ-2022-1231.R1. PMID: 37121582
Updated concepts in treatment of giant cell tumor of bone.
van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707
Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.
Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433Free PMC Article
Malignant giant cell tumour of bone: a review of clinical, pathological and imaging features.
Tahir I, Andrei V, Pollock R, Saifuddin A
Skeletal Radiol 2022 May;51(5):957-970. Epub 2021 Sep 25 doi: 10.1007/s00256-021-03913-6. PMID: 34562125
Locally Aggressive Connective Tissue Tumors.
Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303Free PMC Article

Recent systematic reviews

The giant cell tumor during pregnancy: A review of literature.
Formica VM, Bruno V, Scotto Di Uccio A, Cocca E, Rossi B, Zoccali C
Orthop Traumatol Surg Res 2023 May;109(3):103396. Epub 2022 Sep 7 doi: 10.1016/j.otsr.2022.103396. PMID: 36087835
Wide resection for giant-cell tumor of the distal radius: which reconstruction? A systematic review of the literature and pooled analysis of 176 cases.
Zoccali C, Formica VM, Sperduti I, Checcucci E, Scotto di Uccio A, Pagnotta A, Villani C
Hand Surg Rehabil 2022 Oct;41(5):552-560. Epub 2022 Jul 19 doi: 10.1016/j.hansur.2022.07.002. PMID: 35868588
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis.
Itkin B, Straminsky S, De Ronato G, Lewi D, Marantz A, Bardach A
Jpn J Clin Oncol 2018 Jul 1;48(7):640-652. doi: 10.1093/jjco/hyy067. PMID: 29741702
Giant cell tumor of the pelvis: a systematic review.
Zheng K, Wang Z, Wu SJ, Ye ZM, Xu SF, Xu M, Hu YC, Yu XC
Orthop Surg 2015 May;7(2):102-7. doi: 10.1111/os.12174. PMID: 26033989Free PMC Article
Therapeutic radiotherapy for giant cell tumor of the spine: a systemic review.
Ma Y, Xu W, Yin H, Huang Q, Liu T, Yang X, Wei H, Xiao J
Eur Spine J 2015 Aug;24(8):1754-60. Epub 2015 May 6 doi: 10.1007/s00586-015-3834-0. PMID: 25943724

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    Clinical resources

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2023

    Reviews

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