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Clear cell adenocarcinoma

MedGen UID:
64629
•Concept ID:
C0206681
•
Neoplastic Process
Synonyms: Adenocarcinoma, Clear Cell; Adenocarcinomas, Clear Cell; Clear Cell Adenocarcinoma; Clear Cell Adenocarcinomas
SNOMED CT: Mesonephroid clear cell adenocarcinoma (30546008); Clear cell adenocarcinoma (30546008); Clear cell carcinoma (30546008)
 
Monarch Initiative: MONDO:0005004

Definition

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell adenocarcinoma

Professional guidelines

PubMed

Uncommon Cervical Lesions: A Review and Discussion of the Differential Diagnosis.
Griesinger LM, Szczepanski JM, McMullen ER, Skala SL
Arch Pathol Lab Med 2021 Jul 1;145(7):891-902. doi: 10.5858/arpa.2020-0327-RA. PMID: 33091926
Management and clinical outcomes of patients with recurrent/progressive ovarian clear cell carcinoma.
Huang HJ, Yang LY, Tung HJ, Ku FC, Wu RC, Tang YH, Chang WY, Jung SM, Wang CC, Lin CT, Liu FY, Lin G, Chen MY, Chou HH, Chang TC, Chao A, Lai CH
J Formos Med Assoc 2020 Apr;119(4):793-804. Epub 2019 Dec 6 doi: 10.1016/j.jfma.2019.11.018. PMID: 31818713
Successful surgical treatment and chemotherapy for ovarian cancer in a patient with idiopathic thrombocytopenic purpura.
Wakana K, Yasugi T, Nako Y, Nei T, Ozaki Y, Mizutani K
Int J Clin Oncol 2011 Aug;16(4):447-9. Epub 2010 Dec 4 doi: 10.1007/s10147-010-0149-3. PMID: 21132452

Recent clinical studies

Etiology

Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Endometriosis-associated Ovarian Cancers.
Anglesio MS, Yong PJ
Clin Obstet Gynecol 2017 Dec;60(4):711-727. doi: 10.1097/GRF.0000000000000320. PMID: 28990985
Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379
Diethylstilbestrol exposure.
Schrager S, Potter BE
Am Fam Physician 2004 May 15;69(10):2395-400. PMID: 15168959

Diagnosis

Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Clear cell carcinoma of testis: A review.
Lin M, Awalt H, Ayala AG, Ro JY
Ann Diagn Pathol 2019 Jun;40:26-29. Epub 2019 Mar 20 doi: 10.1016/j.anndiagpath.2019.03.002. PMID: 30921621
ARID1A gene mutation in ovarian and endometrial cancers (Review).
Takeda T, Banno K, Okawa R, Yanokura M, Iijima M, Irie-Kunitomi H, Nakamura K, Iida M, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D
Oncol Rep 2016 Feb;35(2):607-13. Epub 2015 Nov 16 doi: 10.3892/or.2015.4421. PMID: 26572704Free PMC Article
Clear cell adenocarcinoma of the urethra: review of the literature.
Venyo AK
Int J Surg Oncol 2015;2015:790235. Epub 2015 Jan 20 doi: 10.1155/2015/790235. PMID: 25685552Free PMC Article

Therapy

Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Genomics to immunotherapy of ovarian clear cell carcinoma: Unique opportunities for management.
Oda K, Hamanishi J, Matsuo K, Hasegawa K
Gynecol Oncol 2018 Nov;151(2):381-389. Epub 2018 Sep 12 doi: 10.1016/j.ygyno.2018.09.001. PMID: 30217369Free PMC Article
Clear-cell carcinoma of the ovary.
Fujiwara K, Shintani D, Nishikawa T
Ann Oncol 2016 Apr;27 Suppl 1:i50-i52. doi: 10.1093/annonc/mdw086. PMID: 27141072
ARID1A gene mutation in ovarian and endometrial cancers (Review).
Takeda T, Banno K, Okawa R, Yanokura M, Iijima M, Irie-Kunitomi H, Nakamura K, Iida M, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D
Oncol Rep 2016 Feb;35(2):607-13. Epub 2015 Nov 16 doi: 10.3892/or.2015.4421. PMID: 26572704Free PMC Article

Prognosis

Recent Trends in the Incidence of Clear Cell Adenocarcinoma and Survival Outcomes: A SEER Analysis.
Guo Y, Shrestha A, Maskey N, Dong X, Zheng Z, Yang F, Wang R, Ma W, Liu J, Li C, Zhang W, Mao S, Zhang A, Liu S, Yao X
Front Endocrinol (Lausanne) 2022;13:762589. Epub 2022 Feb 24 doi: 10.3389/fendo.2022.762589. PMID: 35282450Free PMC Article
Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population-Based Analysis.
Mukdad L, Han AY, Badran K, Alonso JE, Nasser HB, Goel AN, St John MA
Otolaryngol Head Neck Surg 2020 Apr;162(4):498-503. Epub 2020 Feb 4 doi: 10.1177/0194599820903028. PMID: 32013719
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Clear cell adenocarcinoma of the ovary: a clinical analysis and comparison with serous carcinoma.
Jenison EL, Montag AG, Griffiths CT, Welch WR, Lavin PT, Greer J, Knapp RC
Gynecol Oncol 1989 Jan;32(1):65-71. doi: 10.1016/0090-8258(89)90852-4. PMID: 2642454

Clinical prediction guides

New therapies for clear cell ovarian carcinoma.
Stewart J, Cunningham N, Banerjee S
Int J Gynecol Cancer 2023 Mar 6;33(3):385-393. doi: 10.1136/ijgc-2022-003704. PMID: 36878571
Primary Clear Cell Adenocarcinoma of the Head and Neck: A Population-Based Analysis.
Mukdad L, Han AY, Badran K, Alonso JE, Nasser HB, Goel AN, St John MA
Otolaryngol Head Neck Surg 2020 Apr;162(4):498-503. Epub 2020 Feb 4 doi: 10.1177/0194599820903028. PMID: 32013719
Management and clinical outcomes of patients with recurrent/progressive ovarian clear cell carcinoma.
Huang HJ, Yang LY, Tung HJ, Ku FC, Wu RC, Tang YH, Chang WY, Jung SM, Wang CC, Lin CT, Liu FY, Lin G, Chen MY, Chou HH, Chang TC, Chao A, Lai CH
J Formos Med Assoc 2020 Apr;119(4):793-804. Epub 2019 Dec 6 doi: 10.1016/j.jfma.2019.11.018. PMID: 31818713
Clear cell carcinoma of testis: A review.
Lin M, Awalt H, Ayala AG, Ro JY
Ann Diagn Pathol 2019 Jun;40:26-29. Epub 2019 Mar 20 doi: 10.1016/j.anndiagpath.2019.03.002. PMID: 30921621
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Recent systematic reviews

Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics.
Marchocki Z, Cusimano MC, Clarfield L, Kim SR, Fazelzad R, Espin-Garcia O, Bouchard-Fortier G, Rossi EC, Stewart KI, Soliman PT, How JA, Gotlieb WH, Holloway RW, Ianieri MM, Cabrera S, Lim YK, Ferguson SE
Am J Obstet Gynecol 2021 Oct;225(4):367.e1-367.e39. Epub 2021 May 29 doi: 10.1016/j.ajog.2021.05.034. PMID: 34058168
Clear cell carcinoma of the urinary bladder: a systematic review.
Chan EO, Chan VW, Poon JY, Chan BH, Yu CP, Chiu PK, Ng CF, Teoh JY
Int Urol Nephrol 2021 May;53(5):815-824. Epub 2021 Jan 18 doi: 10.1007/s11255-020-02725-2. PMID: 33462714
Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis.
Vera-Badillo FE, Templeton AJ, Duran I, Ocana A, de Gouveia P, Aneja P, Knox JJ, Tannock IF, Escudier B, Amir E
Eur Urol 2015 Apr;67(4):740-9. Epub 2014 Jun 2 doi: 10.1016/j.eururo.2014.05.010. PMID: 24882670

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