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Capillary hemangioma

MedGen UID:
64643
Concept ID:
C0206733
Neoplastic Process
Synonym: Capillary hemangiomas
SNOMED CT: Capillary nevus (83343001); Capillary hemangioma (83343001); Hemangioma simplex (83343001); Infantile hemangioma (83343001); Plexiform hemangioma (83343001); Juvenile hemangioma (83343001); Capillary hemangioma (402867006); Angiomatous nevus of skin (56975005); Congenital vascular hamartoma (254206003); Capillary angioma (195382003); Port wine stain (83343001); Congenital vascular nevus (254206003); Superficial infantile hemangioma (56975005); Strawberry birthmark (56975005); Strawberry mark (56975005); Strawberry angioma (56975005); Capillary hemangioma of skin (56975005); Strawberry nevus (56975005); Capillary nevus of skin (56975005); Strawberry nevus of skin (56975005); Strawberry hemangioma of skin (56975005); Strawberry mark of skin (56975005); Raspberry mark of skin (56975005)
 
HPO: HP:0005306
Monarch Initiative: MONDO:0002407

Definition

The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces. [from HPO]

Conditions with this feature

Craniolenticulosutural dysplasia
MedGen UID:
334671
Concept ID:
C1843042
Disease or Syndrome
Craniolenticulosutural dysplasia is characterized by facial dysmorphism, late-closing fontanels, cataract, and skeletal defects (summary by Boyadjiev et al., 2011).
Frontoocular syndrome
MedGen UID:
344278
Concept ID:
C1854405
Disease or Syndrome
Capillary infantile hemangioma
MedGen UID:
355573
Concept ID:
C1865871
Disease or Syndrome
Capillary hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births (Mulliken and Young, 1988). Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Hemangiomas are classified as distinct from vascular malformations (see, e.g., CMC1, 163000; 108010; and CCM, 116860), in that the latter are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover (Spring and Bentz, 2005; Legiehn and Heran, 2006). Legiehn and Heran (2006) noted that the term 'hemangioma' in adults is considered inaccurate and should be discarded. Most hemangiomas occur sporadically, but some families with autosomal dominant inheritance have been reported (Walter et al., 1999).
Rubinstein-Taybi syndrome due to CREBBP mutations
MedGen UID:
1639327
Concept ID:
C4551859
Disease or Syndrome
Rubinstein-Taybi syndrome (RSTS) is characterized by distinctive facial features, broad and often angulated thumbs and halluces, short stature, and moderate-to-severe intellectual disability. The characteristic craniofacial features are downslanted palpebral fissures, low-hanging columella, high palate, grimacing smile, and talon cusps. Prenatal growth is often normal, then height, weight, and head circumference percentiles rapidly drop in the first few months of life. Short stature is typical in adulthood. Obesity may develop in childhood or adolescence. Average IQ ranges between 35 and 50; however, developmental outcome varies considerably. Some individuals with EP300-RSTS have normal intellect. Additional features include ocular abnormalities, hearing loss, respiratory difficulties, congenital heart defects, renal abnormalities, cryptorchidism, feeding problems, recurrent infections, and severe constipation.
Capillary malformation-arteriovenous malformation 1
MedGen UID:
1648501
Concept ID:
C4747394
Disease or Syndrome
Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is characterized by the presence of multiple small (1-2 cm in diameter) capillary malformations mostly localized on the face and limbs. Some affected individuals also have associated arteriovenous malformations (AVMs) and/or arteriovenous fistulas (AFVs), fast-flow vascular anomalies that typically arise in the skin, muscle, bone, spine, and brain; life-threatening complications of these lesions can include bleeding, congestive heart failure, and/or neurologic consequences. Symptoms from intracranial AVMs/AVFs appear to occur early in life. Several individuals have Parkes Weber syndrome (multiple micro-AVFs associated with a cutaneous capillary stain and excessive soft-tissue and skeletal growth of an affected limb).
Neurofacioskeletal syndrome with or without renal agenesis
MedGen UID:
1778926
Concept ID:
C5543070
Disease or Syndrome
Neurofacioskeletal syndrome with or without renal agenesis (NFSRA) is characterized by developmental delay and/or intellectual disability; corpus callosum hypoplasia or agenesis; facial dysmorphism, including upslanting palpebral fissures, broad nasal tip, and wide mouth; and skeletal abnormalities, including short stature, scoliosis, and flexion contractures, with broad fingertips and/or toes. Renal agenesis, unilateral or bilateral, has also been observed in some patients (Schneeberger et al., 2020).

Professional guidelines

PubMed

Satterfield KR, Chambers CB
Surv Ophthalmol 2019 Sep-Oct;64(5):608-618. Epub 2019 Feb 14 doi: 10.1016/j.survophthal.2019.02.005. PMID: 30772366
Ni N, Guo S, Langer P
Curr Opin Ophthalmol 2011 Sep;22(5):419-25. doi: 10.1097/ICU.0b013e32834994b4. PMID: 21730838
Ni N, Wagner RS, Langer P, Guo S
J Pediatr Ophthalmol Strabismus 2011 Sep-Oct;48(5):269-76; quiz 268, 277. Epub 2010 Oct 21 doi: 10.3928/01913913-20101018-02. PMID: 20964274

Recent clinical studies

Etiology

Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, Xiang B, Qiu T, Dai S, Jiang X, Lu G, Qiu L, Kong F, Zhang Y
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):599-607. doi: 10.1001/jamaoto.2021.0454. PMID: 33856430Free PMC Article
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445

Diagnosis

Naina P, Nithya R, Eapen P
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):202-204. doi: 10.4103/ijpm.ijpm_592_21. PMID: 36656243
Luo J, He YQ
Am J Respir Crit Care Med 2022 Oct 15;206(8):1035-1036. doi: 10.1164/rccm.202202-0297IM. PMID: 35776058
Khan HA, Shahzad MA, Iqbal F, Awan MA, Khan QA, Saatci AO, Abbass A, Hussain F, Hussain SA, Ali A, Ali W
Semin Ophthalmol 2021 Oct 3;36(7):531-540. Epub 2021 Mar 29 doi: 10.1080/08820538.2021.1897851. PMID: 33780299
Marback EF, Guerra RL, Maia Junior Ode O, Marback RL
Arq Bras Oftalmol 2013 May-Jun;76(3):200-3. doi: 10.1590/s0004-27492013000300016. PMID: 23929086
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646

Therapy

Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Pope E, Lara-Corrales I, Sibbald C, Liy-Wong C, Kanigsberg N, Drolet B, Ma J
JAMA Pediatr 2022 Jan 1;176(1):34-41. doi: 10.1001/jamapediatrics.2021.4565. PMID: 34747977Free PMC Article
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, Xiang B, Qiu T, Dai S, Jiang X, Lu G, Qiu L, Kong F, Zhang Y
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):599-607. doi: 10.1001/jamaoto.2021.0454. PMID: 33856430Free PMC Article
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article

Prognosis

Sun Y, Qiu F, Hu C, Guo Y, Lei S
Ann Plast Surg 2022 Feb 1;88(2):244-249. doi: 10.1097/SAP.0000000000002835. PMID: 35023872
Satterfield KR, Chambers CB
Surv Ophthalmol 2019 Sep-Oct;64(5):608-618. Epub 2019 Feb 14 doi: 10.1016/j.survophthal.2019.02.005. PMID: 30772366
Girerd B, Lau E, Montani D, Humbert M
Curr Opin Pulm Med 2017 Sep;23(5):386-391. doi: 10.1097/MCP.0000000000000414. PMID: 28661905
Spence-Shishido AA, Good WV, Baselga E, Frieden IJ
Clin Dermatol 2015 Mar-Apr;33(2):170-82. doi: 10.1016/j.clindermatol.2014.10.009. PMID: 25704937
Lee KC, Bercovitch L
Semin Perinatol 2013 Feb;37(1):49-58. doi: 10.1053/j.semperi.2012.11.003. PMID: 23419763

Clinical prediction guides

Ji Y, Chen S, Yang K, Zhang X, Zhou J, Li L, Xiang B, Qiu T, Dai S, Jiang X, Lu G, Qiu L, Kong F, Zhang Y
JAMA Otolaryngol Head Neck Surg 2021 Jul 1;147(7):599-607. doi: 10.1001/jamaoto.2021.0454. PMID: 33856430Free PMC Article
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Ozgonul C, Besirli CG
Retin Cases Brief Rep 2018 Summer;12(3):196-199. doi: 10.1097/ICB.0000000000000485. PMID: 27930436
Marback EF, Guerra RL, Maia Junior Ode O, Marback RL
Arq Bras Oftalmol 2013 May-Jun;76(3):200-3. doi: 10.1590/s0004-27492013000300016. PMID: 23929086
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646

Recent systematic reviews

Chen T, Gudipudi R, Nguyen SA, Carroll W, Clemmens C
Ann Otol Rhinol Laryngol 2023 Mar;132(3):332-340. Epub 2022 Apr 25 doi: 10.1177/00034894221089758. PMID: 35466712
Benevello C, Laaidi A, Peeters S, Moiraghi A, Tauziede-Espariat A, Oppenheim C, Pallud J
Neurochirurgie 2022 Dec;68(6):697-701. Epub 2022 Apr 25 doi: 10.1016/j.neuchi.2022.03.004. PMID: 35477014
Lee JC, Modiri O, England RW, Shawber CJ, Wu JK
Plast Reconstr Surg 2021 Apr 1;147(4):875-885. doi: 10.1097/PRS.0000000000007699. PMID: 33776033
Novoa M, Baselga E, Beltran S, Giraldo L, Shahbaz A, Pardo-Hernandez H, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD006545. doi: 10.1002/14651858.CD006545.pub3. PMID: 29667726Free PMC Article
Chinnadurai S, Sathe NA, Surawicz T
Lasers Surg Med 2016 Mar;48(3):221-33. Epub 2015 Dec 29 doi: 10.1002/lsm.22455. PMID: 26711436

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