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Neuroendocrine neoplasm

MedGen UID:
64652
•Concept ID:
C0206754
•
Neoplastic Process
Synonyms: Neuroendocrine Tumor; Neuroendocrine Tumors; Tumor, Neuroendocrine; Tumors, Neuroendocrine
SNOMED CT: Neuroendocrine neoplasm (128928004); Neuroendocrine tumor (55937004); Neuroendocrine tumor (255046005)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
HPO: HP:0100634
Monarch Initiative: MONDO:0019496
Orphanet: ORPHA877

Definition

A tumor that originates from a neuroendocrine cell. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine neoplasm

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
JNETS clinical practice guidelines for gastroenteropancreatic neuroendocrine neoplasms: diagnosis, treatment, and follow-up: a synopsis.
Ito T, Masui T, Komoto I, Doi R, Osamura RY, Sakurai A, Ikeda M, Takano K, Igarashi H, Shimatsu A, Nakamura K, Nakamoto Y, Hijioka S, Morita K, Ishikawa Y, Ohike N, Kasajima A, Kushima R, Kojima M, Sasano H, Hirano S, Mizuno N, Aoki T, Aoki T, Ohtsuka T, Okumura T, Kimura Y, Kudo A, Konishi T, Matsumoto I, Kobayashi N, Fujimori N, Honma Y, Morizane C, Uchino S, Horiuchi K, Yamasaki M, Matsubayashi J, Sato Y, Sekiguchi M, Abe S, Okusaka T, Kida M, Kimura W, Tanaka M, Majima Y, Jensen RT, Hirata K, Imamura M, Uemoto S
J Gastroenterol 2021 Nov;56(11):1033-1044. Epub 2021 Sep 29 doi: 10.1007/s00535-021-01827-7. PMID: 34586495Free PMC Article
Perspectives on the current pharmacotherapeutic strategies for management of functional neuroendocrine tumor syndromes.
Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345Free PMC Article

Recent clinical studies

Etiology

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: High-grade neuroendocrine neoplasm cohort.
Patel SP, Mayerson E, Chae YK, Strosberg J, Wang J, Konda B, Hayward J, McLeod CM, Chen HX, Sharon E, Othus M, Ryan CW, Plets M, Blanke CD, Kurzrock R
Cancer 2021 Sep 1;127(17):3194-3201. Epub 2021 Apr 21 doi: 10.1002/cncr.33591. PMID: 33882143Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.
Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
JNETS clinical practice guidelines for gastroenteropancreatic neuroendocrine neoplasms: diagnosis, treatment, and follow-up: a synopsis.
Ito T, Masui T, Komoto I, Doi R, Osamura RY, Sakurai A, Ikeda M, Takano K, Igarashi H, Shimatsu A, Nakamura K, Nakamoto Y, Hijioka S, Morita K, Ishikawa Y, Ohike N, Kasajima A, Kushima R, Kojima M, Sasano H, Hirano S, Mizuno N, Aoki T, Aoki T, Ohtsuka T, Okumura T, Kimura Y, Kudo A, Konishi T, Matsumoto I, Kobayashi N, Fujimori N, Honma Y, Morizane C, Uchino S, Horiuchi K, Yamasaki M, Matsubayashi J, Sato Y, Sekiguchi M, Abe S, Okusaka T, Kida M, Kimura W, Tanaka M, Majima Y, Jensen RT, Hirata K, Imamura M, Uemoto S
J Gastroenterol 2021 Nov;56(11):1033-1044. Epub 2021 Sep 29 doi: 10.1007/s00535-021-01827-7. PMID: 34586495Free PMC Article
Neuroendocrine Neoplasms of the Small Bowel and Pancreas.
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article

Therapy

Progress in immunotherapy for neuroendocrine neoplasm of the digestive system.
Pan WX, Zhang XM, Hao SL, Han W
World J Gastroenterol 2023 Jul 14;29(26):4174-4185. doi: 10.3748/wjg.v29.i26.4174. PMID: 37475845Free PMC Article
Advances in the Treatment of Gastroenteropancreatic Neuroendocrine Carcinomas: Are we Moving Forward?
Garcia-Carbonero R, Anton-Pascual B, Modrego A, Del Carmen Riesco-Martinez M, Lens-Pardo A, Carretero-Puche C, Rubio-Cuesta B, Soldevilla B
Endocr Rev 2023 Jul 11;44(4):724-736. doi: 10.1210/endrev/bnad006. PMID: 36879384Free PMC Article
A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: High-grade neuroendocrine neoplasm cohort.
Patel SP, Mayerson E, Chae YK, Strosberg J, Wang J, Konda B, Hayward J, McLeod CM, Chen HX, Sharon E, Othus M, Ryan CW, Plets M, Blanke CD, Kurzrock R
Cancer 2021 Sep 1;127(17):3194-3201. Epub 2021 Apr 21 doi: 10.1002/cncr.33591. PMID: 33882143Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Merkel cell carcinoma.
Ramahi E, Choi J, Fuller CD, Eng TY
Am J Clin Oncol 2013 Jun;36(3):299-309. doi: 10.1097/COC.0b013e318210f83c. PMID: 21422993Free PMC Article

Prognosis

The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.
Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Neuroendocrine Tumors of the Appendix, Colon, and Rectum.
Hrabe J
Surg Oncol Clin N Am 2020 Apr;29(2):267-279. doi: 10.1016/j.soc.2019.11.010. PMID: 32151360
Neuroendocrine Neoplasms of the Small Bowel and Pancreas.
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article

Clinical prediction guides

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Clinical implications of lung neuroendocrine neoplasm classification.
Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420
Neuroendocrine Neoplasms of the Small Bowel and Pancreas.
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article

Recent systematic reviews

Primary renal neuroendocrine neoplasms: A systematic literature review, report of four local cases, and original survival analysis of 63 patients from a national registry 2012-2018.
Paisey SA, Weerasuriya S, Palmer K, White BE, Srirajaskanthan R, Chandrakumaran K, Ramage JK
J Neuroendocrinol 2022 Dec;34(12):e13215. Epub 2022 Dec 16 doi: 10.1111/jne.13215. PMID: 36524462
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.
Peltrini R, Cantoni V, Green R, Lionetti R, D'Ambra M, Bartolini C, De Luca M, Bracale U, Cuocolo A, Corcione F
Surgeon 2021 Dec;19(6):e549-e558. Epub 2021 Feb 25 doi: 10.1016/j.surge.2021.01.010. PMID: 33640282
Adrenocorticotropic Hormone-Producing Pancreatic Neuroendocrine Neoplasms: A Systematic Review.
Wu Y, Xiong G, Zhang H, Wang M, Zhu F, Qin R
Endocr Pract 2021 Feb;27(2):152-157. Epub 2021 Feb 3 doi: 10.1016/j.eprac.2020.10.012. PMID: 33616046
Update Regarding Imaging of Neuroendocrine Neoplasms.
Figiel JH, Viniol SG, Görlach J, Rinke A, Librizzi D, Mahnken AH
Rofo 2020 Feb;192(2):171-182. Epub 2019 Sep 11 doi: 10.1055/a-1001-2412. PMID: 31509861

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