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Neuroendocrine neoplasm

MedGen UID:: 64652
•Concept ID:: C0206754
•: Neoplastic Process

Synonyms:	Neuroendocrine Tumor; Neuroendocrine Tumors; Tumor, Neuroendocrine; Tumors, Neuroendocrine
SNOMED CT:	Neuroendocrine neoplasm (128928004); Neuroendocrine tumor (55937004); Neuroendocrine tumor (255046005)
Modes of inheritance:	Unknown inheritance MedGen UID: 989040 •Concept ID: CN307042 • Finding Source: Orphanet Hereditary clinical entity whose mode of inheritance is unknown. See: This record Unknown inheritance (Orphanet)

HPO:	HP:0100634
Monarch Initiative:	MONDO:0019496
Orphanet:	ORPHA877

Definition

A tumor that originates from a neuroendocrine cell. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeuroendocrine neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of endocrine system
        Neoplasm of the endocrine system
        Neuroendocrine neoplasm
        APUdoma
        Cutaneous neuroendocrine carcinoma
        Merkel Cell Carcinoma by AJCC v7 Stage
        Merkel Cell Carcinoma by AJCC v8 Stage
        Metastatic Merkel Cell Carcinoma
        Recurrent Merkel Cell Carcinoma
        Refractory Merkel Cell Carcinoma
        Unresectable Merkel Cell Carcinoma
        Vulvar Merkel Cell Carcinoma
        Bladder Neuroendocrine Neoplasm
        Bladder Neuroendocrine Carcinoma
        Bladder Large Cell Neuroendocrine Carcinoma
        Urinary bladder small cell neuroendocrine carcinoma
        Bladder Neuroendocrine Tumor
        Bladder Paraganglioma
        Metastatic Bladder Paraganglioma
        Breast neuroendocrine neoplasm
        Breast Neuroendocrine Carcinoma
        Breast large cell neuroendocrine carcinoma
        Breast Small Cell Neuroendocrine Carcinoma
        Breast Neuroendocrine Tumor
        Breast Neuroendocrine Tumor G1
        Breast Neuroendocrine Tumor G2
        Metastatic Breast Neuroendocrine Neoplasm
        Metastatic Breast Neuroendocrine Tumor G1
        Carcinoid syndrome
        Carcinoid heart disease
        Carcinoid tumor
        Atypical carcinoid tumor
        Lung Atypical Carcinoid Tumor
        Thymic Atypical Carcinoid Tumor
        Cervical Neuroendocrine Tumor G1
        Childhood carcinoid tumor
        Digestive System Neuroendocrine Tumor G1
        Ampulla of Vater Neuroendocrine Tumor G1
        Anal Canal Neuroendocrine Tumor G1
        Appendix neuroendocrine tumor G1
        Carcinoid tumor of intestine
        Enterochromaffin-Like Cell Neuroendocrine Tumor G1
        Esophageal Neuroendocrine Tumor G1
        Extrahepatic Bile Duct Neuroendocrine Tumor G1
        Gallbladder Neuroendocrine Tumor G1
        Liver Neuroendocrine Tumor G1
        Localized Digestive System Neuroendocrine Tumor G1
        Metastatic Digestive System Neuroendocrine Tumor G1
        Pancreatic neuroendocrine tumor G1
        Recurrent Digestive System Neuroendocrine Tumor G1
        Regional Digestive System Neuroendocrine Tumor G1
        Unresectable Digestive System Neuroendocrine Tumor G1
        Foregut Neuroendocrine Tumor G1
        Duodenal Neuroendocrine Tumor G1
        Gastric neuroendocrine tumor G1
        Pulmonary carcinoid tumor
        Thymic carcinoid tumor
        Hindgut Neuroendocrine Tumor G1
        Descending Colon Neuroendocrine Tumor G1
        Rectal neuroendocrine tumor G1
        Transverse Colon Neuroendocrine Tumor G1
        Intestinal carcinoid
        Metastatic Carcinoid Tumor
        Advanced Carcinoid Tumor
        Metastatic Lung Carcinoid Tumor
        Midgut Neuroendocrine Tumor G1
        Ascending colon neuroendocrine tumor G1
        Cecum neuroendocrine tumor G1
        Ileal neuroendocrine tumor G1
        Jejunal neuroendocrine tumor G1
        Meckel Diverticulum Neuroendocrine Tumor G1
        Ovarian Carcinoid Tumor
        Testicular Neuroendocrine Tumor, Prepubertal-Type
        Unresectable Neuroendocrine Tumor G1
        Unresectable Lung Carcinoid Tumor
        Uterine Corpus Neuroendocrine Tumor G1
        Cervical Neuroendocrine Neoplasm
        Cervical Neuroendocrine Carcinoma
        Cervical large cell neuroendocrine carcinoma
        Cervical small cell carcinoma
        Cervical Neuroendocrine Tumor G2
        Chromophobe adenoma
        Digestive system neuroendocrine neoplasm
        Ampulla of Vater Neuroendocrine Neoplasm
        Ampulla of Vater Neuroendocrine Carcinoma
        Ampulla of Vater Neuroendocrine Tumor
        Anal canal neuroendocrine neoplasm
        Anal Canal Neuroendocrine Carcinoma
        Anal Canal Neuroendocrine Tumor
        Appendix neuroendocrine neoplasm
        Appendix Neuroendocrine Carcinoma
        Neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade
        Digestive System Neuroendocrine Carcinoma
        Digestive System Large Cell Neuroendocrine Carcinoma
        Digestive System Small Cell Neuroendocrine Carcinoma
        Esophageal Neuroendocrine Carcinoma
        Extrahepatic Bile Duct Neuroendocrine Carcinoma
        Gallbladder Neuroendocrine Carcinoma
        Gastric Neuroendocrine Carcinoma
        Gastroesophageal Junction Neuroendocrine Carcinoma
        Intestinal Neuroendocrine Carcinoma
        Liver neuroendocrine carcinoma
        Metastatic Digestive System Neuroendocrine Carcinoma
        Pancreatic endocrine carcinoma
        Recurrent Digestive System Neuroendocrine Carcinoma
        Refractory Digestive System Neuroendocrine Carcinoma
        Unresectable Digestive System Neuroendocrine Carcinoma
        Digestive System Neuroendocrine Tumor
        Digestive System Neuroendocrine Tumor by AJCC v7 Stage
        Digestive System Neuroendocrine Tumor G2
        Digestive System Neuroendocrine Tumor G3
        Esophageal neuroendocrine tumor
        Extrahepatic Bile Duct Neuroendocrine Tumor
        Gallbladder neuroendocrine tumor, grade 1/2
        Gastric neuroendocrine tumor, well differentiated, low or intermediate grade
        Gastrin-producing neuroendocrine tumor
        Intestinal Neuroendocrine Tumor
        L-cell glucagon-like peptide-producing neuroendocrine tumor
        Liver Neuroendocrine Tumor
        Midgut Neuroendocrine Tumor
        Neuroendocrine pancreatic tumor
        Somatostatinoma
        VIPoma
        Esophageal Neuroendocrine Neoplasm
        Extrahepatic Bile Duct Neuroendocrine Neoplasm
        Gallbladder neuroendocrine neoplasm
        Gastric neuroendocrine neoplasm
        Intestinal neuroendocrine neoplasm
        Colorectal Neuroendocrine Neoplasm
        Small intestine neuroendocrine neoplasm
        Liver Neuroendocrine Neoplasm
        Metastatic Digestive System Neuroendocrine Neoplasm
        Advanced Digestive System Neuroendocrine Neoplasm
        Locally Advanced Digestive System Neuroendocrine Neoplasm
        Metastatic Digestive System Neuroendocrine Tumor G2
        Metastatic Midgut Neuroendocrine Tumor
        Metastatic Pancreatic Neuroendocrine Neoplasm
        Pancreatic endocrine tumor
        Glucagonoma syndrome
        Pancreatic islet cell adenoma
        Unresectable Pancreatic Neuroendocrine Neoplasm
        Refractory Digestive System Neuroendocrine Neoplasm
        Unresectable Digestive System Neuroendocrine Neoplasm
        Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm
        Unresectable Midgut Neuroendocrine Tumor
        Kidney Neuroendocrine Neoplasm
        Kidney Neuroendocrine Carcinoma
        Kidney Large Cell Neuroendocrine Carcinoma
        Kidney Small Cell Neuroendocrine Carcinoma
        Kidney Neuroendocrine Tumor
        Kidney Paraganglioma
        Laryngeal neuroendocrine neoplasm
        Laryngeal Neuroendocrine Carcinoma
        Laryngeal Paraganglioma
        Lung neuroendocrine neoplasm
        Lung Neuroendocrine Carcinoma
        Combined lung carcinoma
        Pulmonary large cell neuroendocrine carcinoma
        Small cell lung carcinoma
        Metastatic Lung Neuroendocrine Neoplasm
        Advanced Lung Neuroendocrine Neoplasm
        Locally Advanced Lung Neuroendocrine Neoplasm
        Metastatic Lung Large Cell Neuroendocrine Carcinoma
        Metastatic Lung Small Cell Carcinoma
        Recurrent Lung Neuroendocrine Neoplasm
        Recurrent Lung Small Cell Carcinoma
        Unresectable Lung Neuroendocrine Neoplasm
        Unresectable Lung Small Cell Carcinoma
        Melanoma
        Amelanotic melanoma
        Amelanotic skin melanoma
        Childhood malignant melanoma
        Epithelioid cell melanoma
        Epithelioid cell uveal melanoma
        Experimental Malignant Melanoma
        B16 Malignant Melanoma
        Cloudman S91 Malignant Melanoma
        Harding-Passey Malignant Melanoma
        Lentigo Maligna
        Malignant breast melanoma
        Malignant melanoma of skin
        Acral lentiginous melanoma
        Balloon cell malignant melanoma
        Cutaneous Melanoma by AJCC v6 Stage
        Cutaneous Melanoma by AJCC v7 Stage
        Cutaneous Melanoma by AJCC v8 Stage
        Cutaneous Melanoma of the Extremity
        Familial melanoma
        High-CSD Melanoma
        Invasive Cutaneous Melanoma
        Lentigo maligna melanoma
        Malignant Melanoma in Precancerous Melanosis
        Melanoma Arising from Blue Nevus
        Melanoma in congenital melanocytic nevus
        Melanoma in Junctional Nevus
        Metastatic Cutaneous Melanoma
        Minimal Deviation Melanoma
        Nevoid Melanoma
        Nodular malignant melanoma
        Old Burn Scar-Related Cutaneous Melanoma
        Penile Cutaneous Melanoma
        Recurrent Melanoma
        Refractory Cutaneous Melanoma
        Regressing Cutaneous Melanoma
        Scrotum melanoma
        Signet Ring Melanoma
        Solar Radiation-Related Cutaneous Melanoma
        Spitz Melanoma
        Superficial spreading melanoma
        Unresectable Cutaneous Melanoma
        Melanomatosis
        Meningeal melanomatosis
        Metastatic melanoma
        Advanced Melanoma
        Locally Advanced Melanoma
        Melanoma Metastatic in the Central Nervous System
        Melanoma of Unknown Primary
        Metastatic Non-Cutaneous Melanoma
        Mixed epithelioid and spindle cell melanoma
        Mixed cell uveal melanoma
        Non-cutaneous melanoma
        Central Nervous System Melanoma
        Lung Melanoma
        Malignant conjunctival melanoma
        Malignant cornea melanoma
        Mucosal melanoma
        Ovarian Melanoma
        Prostate Melanoma
        Recurrent Non-Cutaneous Melanoma
        Refractory Non-Cutaneous Melanoma
        Regressing Non-Cutaneous Melanoma
        Retinal melanoma
        Uveal melanoma
        Ocular melanoma
        Eyelid melanoma
        Lacrimal Drainage System Melanoma
        Metastatic Ocular Melanoma
        Ocular melanoma with extraocular extension
        Recurrent Ocular Melanoma
        Refractory Ocular Melanoma
        Orbital Melanoma
        Penile Melanoma
        Penile Mucosal Melanoma
        Refractory Melanoma
        Regressing Melanoma
        Spindle cell melanoma
        Desmoplastic melanoma
        Spindle cell intraocular melanoma
        Type A Spindle Cell Melanoma
        Type B Spindle Cell Melanoma
        Unresectable Melanoma
        Unresectable Mucosal Melanoma
        Unresectable Uveal Melanoma
        Metastatic Neuroendocrine Neoplasm
        Advanced Neuroendocrine Neoplasm
        Advanced Neuroendocrine Carcinoma
        Advanced Neuroendocrine Tumor
        Advanced Paraganglioma
        Advanced Thymic Neuroendocrine Neoplasm
        Locally Advanced Neuroendocrine Neoplasm
        Locally Advanced Neuroendocrine Carcinoma
        Locally Advanced Neuroendocrine Tumor
        Locally Advanced Paraganglioma
        Metastatic Neuroendocrine Carcinoma
        Metastatic Large Cell Neuroendocrine Carcinoma
        Metastatic Prostate Neuroendocrine Carcinoma
        Metastatic Small Cell Neuroendocrine Carcinoma
        Metastatic Thyroid Gland Medullary Carcinoma
        Neuroendocrine Carcinoma of Unknown Primary
        Metastatic Neuroendocrine Tumor
        Metastatic Non-Functioning Neuroendocrine Tumor
        Metastatic Pancreatic Neuroendocrine Tumor
        Metastatic Thymic Neuroendocrine Neoplasm
        Neuroendocrine carcinoma
        Extracutaneous Merkel Cell Carcinoma
        Head and Neck Merkel Cell Carcinoma
        Head and Neck Neuroendocrine Carcinoma
        Medullary thyroid carcinoma
        Sinonasal Neuroendocrine Carcinoma
        Large cell neuroendocrine carcinoma
        Endometrial Large Cell Neuroendocrine Carcinoma
        Head and Neck Large Cell Neuroendocrine Carcinoma
        Ovarian large-cell neuroendocrine carcinoma
        Prostate Large Cell Neuroendocrine Carcinoma
        Thymic large cell neuroendocrine carcinoma
        Unresectable Large Cell Neuroendocrine Carcinoma
        Vaginal Large Cell Neuroendocrine Carcinoma
        Vulvar Large Cell Neuroendocrine Carcinoma
        Medullary Carcinoma, Not Otherwise Specified
        Neuroendocrine Carcinoma, Excluding Head and Neck
        Prostate Neuroendocrine Carcinoma
        Vaginal Neuroendocrine Carcinoma
        Vulvar neuroendocrine carcinoma
        Recurrent Neuroendocrine Carcinoma
        Recurrent Thyroid Gland Medullary Carcinoma
        Refractory Neuroendocrine Carcinoma
        Refractory Lung Small Cell Carcinoma
        Refractory Thyroid Gland Medullary Carcinoma
        Small Cell Neuroendocrine Carcinoma
        Extrapulmonary Small Cell Neuroendocrine Carcinoma
        Unresectable Neuroendocrine Carcinoma
        Unresectable Thyroid Gland Medullary Carcinoma
        Ovarian neuroendocrine neoplasm
        Ovarian Neuroendocrine Carcinoma
        Pulmonary type ovarian small cell carcinoma
        Paraganglioma
        Chemodectoma
        Benign carotid body paraganglioma
        Malignant carotid body paraganglioma
        Composite Paraganglioma
        Adrenal Gland Composite Pheochromocytoma
        Extra-Adrenal Paraganglioma
        Cardiac Paraganglioma
        Central Nervous System Paraganglioma
        Extraadrenal pheochromocytoma
        Glomus jugular tumor
        Glomus tympanicum paraganglioma
        Intra-Abdominal Paraganglioma
        Metastatic Extra-Adrenal Paraganglioma
        Paraganglioma of head and neck
        Parasympathetic paraganglioma
        Paratesticular Paraganglioma
        Prostate Paraganglioma
        Urinary System Paraganglioma
        Hereditary Paraganglioma
        Hereditary Adrenal Gland Pheochromocytoma
        Metastatic Paraganglioma
        Malignant adrenal gland pheochromocytoma
        Non-Metastatic Paraganglioma
        Benign adrenal gland pheochromocytoma
        Paragangliomas 1
        Paragangliomas with sensorineural hearing loss
        Paragangliomas 2
        Paragangliomas 3
        Paragangliomas 4
        Paragangliomas 5
        Paragangliomas 6
        Paragangliomas 7
        Pheochromocytoma
        Recurrent Paraganglioma
        Recurrent Adrenal Gland Pheochromocytoma
        Refractory Paraganglioma
        Refractory Adrenal Gland Pheochromocytoma
        Sympathetic paraganglioma
        Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage
        Adrenal pheochromocytoma
        Unresectable Paraganglioma
        Unresectable Adrenal Gland Pheochromocytoma
        Pituitary gland acidophil adenoma
        Pituitary gland basophil adenoma
        Prostate neuroendocrine neoplasm
        Prostate Adenocarcinoma with Neuroendocrine Differentiation
        Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation
        Usual Prostate Adenocarcinoma with Neuroendocrine Differentiation
        Recurrent Neuroendocrine Neoplasm
        Recurrent Abdominal Neuroendocrine Neoplasm
        Recurrent Pancreatic Neuroendocrine Carcinoma
        Refractory Neuroendocrine Neoplasm
        Refractory Abdominal Neuroendocrine Neoplasm
        Refractory Pancreatic Neuroendocrine Carcinoma
        Schwannoma
        Ancient Schwannoma
        C-P angle neurinoma
        Cellular schwannoma
        Conventional Schwannoma
        Epithelioid Schwannoma
        Microcystic/reticular schwannoma
        Peripheral nerve schwannoma
        Adrenal Gland Schwannoma
        Benign dermal neurilemmoma
        Bone Schwannoma
        Breast Schwannoma
        Cardiac Schwannoma
        Colorectal Schwannoma
        Esophageal Schwannoma
        Gastric Schwannoma
        Intraocular Schwannoma
        Kidney Schwannoma
        Mediastinal schwannoma
        Neurilemmoma of the pleura
        Paratesticular Schwannoma
        Penile Schwannoma
        Schwannoma of jugular foramen
        Schwannoma of ureter
        Sternal Intraosseous Schwannoma
        Sympathetic neurilemmoma
        Thyroid Gland Schwannoma
        Peripheral schwannoma
        Plexiform schwannoma
        Schwannoma of twelfth cranial nerve
        Schwannomatosis
        Sellar Schwannoma
        Sinonasal Schwannoma
        Trigeminal schwannoma
        Vestibular schwannoma
        Bilateral vestibular schwannoma
        Neurofibromatosis, type 2
        Unilateral vestibular schwannoma
        Thymic Neuroendocrine Neoplasm
        Thymic neuroendocrine carcinoma
        Moderately-differentiated thymic neuroendocrine carcinoma
        Poorly differentiated thymic neuroendocrine carcinoma
        Thymus small cell carcinoma
        Well-differentiated thymic neuroendocrine carcinoma
        Unresectable Thymic Neuroendocrine Neoplasm
        Unresectable Neuroendocrine Neoplasm
        Unresectable Abdominal Neuroendocrine Neoplasm
        Unresectable Neuroendocrine Tumor
        Uterine corpus neuroendocrine neoplasm
        Endometrial Neuroendocrine Carcinoma
        Endometrial small cell carcinoma

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

JNETS clinical practice guidelines for gastroenteropancreatic neuroendocrine neoplasms: diagnosis, treatment, and follow-up: a synopsis.

Ito T, Masui T, Komoto I, Doi R, Osamura RY, Sakurai A, Ikeda M, Takano K, Igarashi H, Shimatsu A, Nakamura K, Nakamoto Y, Hijioka S, Morita K, Ishikawa Y, Ohike N, Kasajima A, Kushima R, Kojima M, Sasano H, Hirano S, Mizuno N, Aoki T, Aoki T, Ohtsuka T, Okumura T, Kimura Y, Kudo A, Konishi T, Matsumoto I, Kobayashi N, Fujimori N, Honma Y, Morizane C, Uchino S, Horiuchi K, Yamasaki M, Matsubayashi J, Sato Y, Sekiguchi M, Abe S, Okusaka T, Kida M, Kimura W, Tanaka M, Majima Y, Jensen RT, Hirata K, Imamura M, Uemoto S
J Gastroenterol 2021 Nov;56(11):1033-1044. Epub 2021 Sep 29 doi: 10.1007/s00535-021-01827-7. PMID: 34586495 Free PMC Article

Perspectives on the current pharmacotherapeutic strategies for management of functional neuroendocrine tumor syndromes.

Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345 Free PMC Article

See all (45)

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Pituitary Tumors.

Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: High-grade neuroendocrine neoplasm cohort.

Patel SP, Mayerson E, Chae YK, Strosberg J, Wang J, Konda B, Hayward J, McLeod CM, Chen HX, Sharon E, Othus M, Ryan CW, Plets M, Blanke CD, Kurzrock R
Cancer 2021 Sep 1;127(17):3194-3201. Epub 2021 Apr 21 doi: 10.1002/cncr.33591. PMID: 33882143 Free PMC Article

Appendiceal cancer : a review of the literature.

Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Merkel cell carcinoma.

Ramahi E, Choi J, Fuller CD, Eng TY
Am J Clin Oncol 2013 Jun;36(3):299-309. doi: 10.1097/COC.0b013e318210f83c. PMID: 21422993 Free PMC Article

See all (314)

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.

Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028

The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.

Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341

Lung neuroendocrine neoplasms: recent progress and persistent challenges.

Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914 Free PMC Article

Appendiceal cancer : a review of the literature.

Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Neuroendocrine Neoplasms of the Small Bowel and Pancreas.

Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758 Free PMC Article

See all (435)

Therapy

A phase II basket trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART) SWOG S1609: High-grade neuroendocrine neoplasm cohort.

Appendiceal cancer : a review of the literature.

Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors.

Patel SP, Othus M, Chae YK, Giles FJ, Hansel DE, Singh PP, Fontaine A, Shah MH, Kasi A, Baghdadi TA, Matrana M, Gatalica Z, Korn WM, Hayward J, McLeod C, Chen HX, Sharon E, Mayerson E, Ryan CW, Plets M, Blanke CD, Kurzrock R
Clin Cancer Res 2020 May 15;26(10):2290-2296. Epub 2020 Jan 22 doi: 10.1158/1078-0432.CCR-19-3356. PMID: 31969335 Free PMC Article

Neuroendocrine Cancer, Therapeutic Strategies in G3 Cancers.

Rinke A, Gress TM
Digestion 2017;95(2):109-114. Epub 2017 Feb 4 doi: 10.1159/000454761. PMID: 28161703

Merkel cell carcinoma.

Ramahi E, Choi J, Fuller CD, Eng TY
Am J Clin Oncol 2013 Jun;36(3):299-309. doi: 10.1097/COC.0b013e318210f83c. PMID: 21422993 Free PMC Article

See all (123)

Prognosis

The 2021 WHO Classification of Lung Tumors: Impact of Advances Since 2015.

Lung neuroendocrine neoplasms: recent progress and persistent challenges.

Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914 Free PMC Article

Appendiceal cancer : a review of the literature.

Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Neuroendocrine Tumors of the Appendix, Colon, and Rectum.

Hrabe J
Surg Oncol Clin N Am 2020 Apr;29(2):267-279. doi: 10.1016/j.soc.2019.11.010. PMID: 32151360

Neuroendocrine Neoplasms of the Small Bowel and Pancreas.

Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758 Free PMC Article

See all (334)

Clinical prediction guides

Lung neuroendocrine neoplasms: recent progress and persistent challenges.

Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914 Free PMC Article

Clinical implications of lung neuroendocrine neoplasm classification.

Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420

Neuroendocrine neoplasm update: toward universal nomenclature.

Rindi G, Inzani F
Endocr Relat Cancer 2020 Jun;27(6):R211-R218. doi: 10.1530/ERC-20-0036. PMID: 32276263

Neuroendocrine Neoplasms of the Small Bowel and Pancreas.

Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758 Free PMC Article

Current treatment status in pancreatic neuroendocrine neoplasms.

Liu DJ, Hua R, Sun YW
Chin Clin Oncol 2019 Apr;8(2):20. doi: 10.21037/cco.2019.04.01. PMID: 31070040

See all (212)

Recent systematic reviews

Primary renal neuroendocrine neoplasms: A systematic literature review, report of four local cases, and original survival analysis of 63 patients from a national registry 2012-2018.

Paisey SA, Weerasuriya S, Palmer K, White BE, Srirajaskanthan R, Chandrakumaran K, Ramage JK
J Neuroendocrinol 2022 Dec;34(12):e13215. Epub 2022 Dec 16 doi: 10.1111/jne.13215. PMID: 36524462

Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.

Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796 Free PMC Article

Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: A systematic review and meta-analysis.

Peltrini R, Cantoni V, Green R, Lionetti R, D'Ambra M, Bartolini C, De Luca M, Bracale U, Cuocolo A, Corcione F
Surgeon 2021 Dec;19(6):e549-e558. Epub 2021 Feb 25 doi: 10.1016/j.surge.2021.01.010. PMID: 33640282

Adrenocorticotropic Hormone-Producing Pancreatic Neuroendocrine Neoplasms: A Systematic Review.

Wu Y, Xiong G, Zhang H, Wang M, Zhu F, Qin R
Endocr Pract 2021 Feb;27(2):152-157. Epub 2021 Feb 3 doi: 10.1016/j.eprac.2020.10.012. PMID: 33616046

Update Regarding Imaging of Neuroendocrine Neoplasms.

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