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Adult Brain Neoplasm

MedGen UID:
65076
•Concept ID:
C0220624
•
Neoplastic Process
Synonyms: Adult Brain Tumor; Brain Neoplasms, Adult; Neoplasm of Adult Brain; Neoplasm of the Adult Brain; Tumor of Adult Brain; Tumor of the Adult Brain

Definition

A benign or malignant, primary or metastatic neoplasm of the brain occurring in adults. [from NCI]

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692. PMID: 21296991

Recent clinical studies

Etiology

Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790
Identifying brain tumours in children and young adults.
Wilne SH, Dineen RA, Dommett RM, Chu TP, Walker DA
BMJ 2013 Oct 9;347:f5844. doi: 10.1136/bmj.f5844. PMID: 24108155
Anaplastic astrocytoma in adults.
Stupp R, Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):72-80. Epub 2007 May 2 doi: 10.1016/j.critrevonc.2007.03.003. PMID: 17478095

Diagnosis

Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
Wang KY, Chen MM, Malayil Lincoln CM
Neuroimaging Clin N Am 2021 Feb;31(1):121-138. doi: 10.1016/j.nic.2020.09.011. PMID: 33220825
Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
Wang KY, Chen MM, Malayil Lincoln CM
Radiol Clin North Am 2019 Nov;57(6):1147-1162. Epub 2019 Aug 16 doi: 10.1016/j.rcl.2019.07.004. PMID: 31582041
Stereotactic Radiosurgery and Hypofractionated Radiotherapy for Glioblastoma.
Shah JL, Li G, Shaffer JL, Azoulay MI, Gibbs IC, Nagpal S, Soltys SG
Neurosurgery 2018 Jan 1;82(1):24-34. doi: 10.1093/neuros/nyx115. PMID: 28605463
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614

Therapy

Contemporary RNA Therapeutics for Glioblastoma.
Melnick K, Dastmalchi F, Mitchell D, Rahman M, Sayour EJ
Neuromolecular Med 2022 Mar;24(1):8-12. Epub 2021 Jun 8 doi: 10.1007/s12017-021-08669-9. PMID: 34101090Free PMC Article
CAR-T cells for pediatric brain tumors: Present and future.
Leruste A, Beccaria K, Doz F
Bull Cancer 2021 Oct;108(10S):S109-S116. doi: 10.1016/j.bulcan.2021.06.002. PMID: 34920793
Tumour treating fields therapy for glioblastoma: current advances and future directions.
Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y, Collis SJ
Br J Cancer 2021 Feb;124(4):697-709. Epub 2020 Nov 4 doi: 10.1038/s41416-020-01136-5. PMID: 33144698Free PMC Article
GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Response assessment criteria for brain metastases: proposal from the RANO group.
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612

Prognosis

Surveillance imaging in pediatric ependymoma.
Klawinski D, Indelicato DJ, Hossain J, Sandler E
Pediatr Blood Cancer 2020 Nov;67(11):e28622. Epub 2020 Aug 3 doi: 10.1002/pbc.28622. PMID: 32743915
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.
Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150. PMID: 31675094Free PMC Article
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.
Brown PD, Ballman KV, Cerhan JH, Anderson SK, Carrero XW, Whitton AC, Greenspoon J, Parney IF, Laack NNI, Ashman JB, Bahary JP, Hadjipanayis CG, Urbanic JJ, Barker FG 2nd, Farace E, Khuntia D, Giannini C, Buckner JC, Galanis E, Roberge D
Lancet Oncol 2017 Aug;18(8):1049-1060. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30441-2. PMID: 28687377Free PMC Article
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article
Hypofractionated stereotactic reirradiation for recurrent glioblastoma.
Yazici G, Cengiz M, Ozyigit G, Eren G, Yildiz F, Akyol F, Gurkaynak M, Zorlu F
J Neurooncol 2014 Oct;120(1):117-23. Epub 2014 Jul 11 doi: 10.1007/s11060-014-1524-0. PMID: 25012955

Clinical prediction guides

Extrachromosomal DNA: Redefining the pathogenesis of glioblastoma.
Shiras A, Mondal A
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188551. Epub 2021 Apr 20 doi: 10.1016/j.bbcan.2021.188551. PMID: 33892052
Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
Wang KY, Chen MM, Malayil Lincoln CM
Neuroimaging Clin N Am 2021 Feb;31(1):121-138. doi: 10.1016/j.nic.2020.09.011. PMID: 33220825
Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
Wang KY, Chen MM, Malayil Lincoln CM
Radiol Clin North Am 2019 Nov;57(6):1147-1162. Epub 2019 Aug 16 doi: 10.1016/j.rcl.2019.07.004. PMID: 31582041
Epidemiology and Overview of Gliomas.
Davis ME
Semin Oncol Nurs 2018 Dec;34(5):420-429. Epub 2018 Nov 2 doi: 10.1016/j.soncn.2018.10.001. PMID: 30392758
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.
Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G
Lancet Oncol 2017 Aug;18(8):1040-1048. Epub 2017 Jul 4 doi: 10.1016/S1470-2045(17)30414-X. PMID: 28687375Free PMC Article

Recent systematic reviews

Risk factors for childhood brain tumours: A systematic review and meta-analysis of observational studies from 1976 to 2022.
Onyije FM, Dolatkhah R, Olsson A, Bouaoun L, Deltour I, Erdmann F, Bonaventure A, Scheurer ME, Clavel J, Schüz J
Cancer Epidemiol 2024 Feb;88:102510. Epub 2023 Dec 5 doi: 10.1016/j.canep.2023.102510. PMID: 38056243Free PMC Article
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Epstein-Barr Virus and Astrocytoma.
Freixo C, Hermouet S, Neves AM
Crit Rev Oncog 2019;24(4):339-347. doi: 10.1615/CritRevOncog.2020032954. PMID: 32421989
Management of elderly patients with glioblastoma-multiforme-a systematic review.
Asmaa A, Dixit S, Rowland-Hill C, Achawal S, Rajaraman C, O'Reilly G, Highley R, Hussain M, Baker L, Gill L, Morris H, Hingorani M
Br J Radiol 2018 Jul;91(1088):20170271. Epub 2018 Mar 9 doi: 10.1259/bjr.20170271. PMID: 29376741Free PMC Article
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article

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