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Lesion

MedGen UID:
65128
•Concept ID:
C0221198
•
Finding
Synonym: Visible Lesion
SNOMED CT: Lesion (52988006)

Definition

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLesion

Professional guidelines

PubMed

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study.
Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM
Lancet Neurol 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910Free PMC Article
Dermatomyositis: Diagnosis and treatment.
Waldman R, DeWane ME, Lu J
J Am Acad Dermatol 2020 Feb;82(2):283-296. Epub 2019 Jul 4 doi: 10.1016/j.jaad.2019.05.105. PMID: 31279813
Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group.
Barkun AN, Almadi M, Kuipers EJ, Laine L, Sung J, Tse F, Leontiadis GI, Abraham NS, Calvet X, Chan FKL, Douketis J, Enns R, Gralnek IM, Jairath V, Jensen D, Lau J, Lip GYH, Loffroy R, Maluf-Filho F, Meltzer AC, Reddy N, Saltzman JR, Marshall JK, Bardou M
Ann Intern Med 2019 Dec 3;171(11):805-822. Epub 2019 Oct 22 doi: 10.7326/M19-1795. PMID: 31634917Free PMC Article

Recent clinical studies

Etiology

Lesion location and lesion creation affect outcomes after focused ultrasound thalamotomy.
Segar DJ, Lak AM, Lee S, Harary M, Chavakula V, Lauro P, McDannold N, White J, Cosgrove GR
Brain 2021 Nov 29;144(10):3089-3100. doi: 10.1093/brain/awab176. PMID: 34750621
(18)F-FDOPA-PET in pseudotumoral brain lesions.
Renard D, Collombier L, Laurent-Chabalier S, Mura T, Le Floch A, Fertit HE, Thouvenot E, Guillamo JS
J Neurol 2021 Apr;268(4):1266-1275. Epub 2020 Oct 21 doi: 10.1007/s00415-020-10269-9. PMID: 33084938
Morel-Lavallée lesion.
Riemer K, Haukenes O, Kozak A
Tidsskr Nor Laegeforen 2019 Jan 15;139(1) Epub 2019 Jan 3 doi: 10.4045/tidsskr.18.0351. PMID: 30644680
Epidemiology of athletic knee injuries: A 10-year study.
Majewski M, Susanne H, Klaus S
Knee 2006 Jun;13(3):184-8. Epub 2006 Apr 17 doi: 10.1016/j.knee.2006.01.005. PMID: 16603363
Conservative cavity preparations.
Summitt JB
Dent Clin North Am 2002 Apr;46(2):171-84, v. doi: 10.1016/s0011-8532(01)00005-2. PMID: 12014031

Diagnosis

Approach to Kidney Biopsy: Core Curriculum 2022.
Najafian B, Lusco MA, Alpers CE, Fogo AB
Am J Kidney Dis 2022 Jul;80(1):119-131. Epub 2022 Feb 4 doi: 10.1053/j.ajkd.2021.08.024. PMID: 35125261
Perio-Endo Lesions: A Guide to Diagnosis and Clinical Management.
Sonde N, Edwards M
Prim Dent J 2020 Dec;9(4):45-51. doi: 10.1177/2050168420963305. PMID: 33225855
Brachial plexopathies.
Ferrante MA
Continuum (Minneap Minn) 2014 Oct;20(5 Peripheral Nervous System Disorders):1323-42. doi: 10.1212/01.CON.0000455878.60932.37. PMID: 25299285
Morel-Lavallee lesion.
Li H, Zhang F, Lei G
Chin Med J (Engl) 2014;127(7):1351-6. PMID: 24709193
Epidemiology of athletic knee injuries: A 10-year study.
Majewski M, Susanne H, Klaus S
Knee 2006 Jun;13(3):184-8. Epub 2006 Apr 17 doi: 10.1016/j.knee.2006.01.005. PMID: 16603363

Therapy

Inebilizumab: A Review in Neuromyelitis Optica Spectrum Disorder.
Nie T, Blair HA
CNS Drugs 2022 Oct;36(10):1133-1141. Epub 2022 Sep 7 doi: 10.1007/s40263-022-00949-7. PMID: 36070074Free PMC Article
Interventions for treating oral leukoplakia to prevent oral cancer.
Lodi G, Franchini R, Warnakulasuriya S, Varoni EM, Sardella A, Kerr AR, Carrassi A, MacDonald LC, Worthington HV
Cochrane Database Syst Rev 2016 Jul 29;7(7):CD001829. doi: 10.1002/14651858.CD001829.pub4. PMID: 27471845Free PMC Article
Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.
Smart KM, Wand BM, O'Connell NE
Cochrane Database Syst Rev 2016 Feb 24;2(2):CD010853. doi: 10.1002/14651858.CD010853.pub2. PMID: 26905470Free PMC Article
Inflammation and neuroprotection in traumatic brain injury.
Corps KN, Roth TL, McGavern DB
JAMA Neurol 2015 Mar;72(3):355-62. doi: 10.1001/jamaneurol.2014.3558. PMID: 25599342Free PMC Article
Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis.
Banks JL, Marotta CA
Stroke 2007 Mar;38(3):1091-6. Epub 2007 Feb 1 doi: 10.1161/01.STR.0000258355.23810.c6. PMID: 17272767

Prognosis

Melanoma of unknown primary: New perspectives for an old story.
Boussios S, Rassy E, Samartzis E, Moschetta M, Sheriff M, Pérez-Fidalgo JA, Pavlidis N
Crit Rev Oncol Hematol 2021 Feb;158:103208. Epub 2020 Dec 28 doi: 10.1016/j.critrevonc.2020.103208. PMID: 33383207
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2005 May;21(3):308-12. doi: 10.1097/01.mog.0000159817.55661.ca. PMID: 15818151
Multiple primary melanomas.
Johnson TM, Hamilton T, Lowe L
J Am Acad Dermatol 1998 Sep;39(3):422-7. doi: 10.1016/s0190-9622(98)70318-4. PMID: 9738776
Abdominal trauma in war.
Rignault DP
World J Surg 1992 Sep-Oct;16(5):940-6. doi: 10.1007/BF02066996. PMID: 1462634
Management of solitary pulmonary nodules.
Lillington GA
Dis Mon 1991 May;37(5):271-318. doi: 10.1016/s0011-5029(05)80012-4. PMID: 2019220

Clinical prediction guides

Comparison of image quality and lesion detection between digital and analog PET/CT.
López-Mora DA, Flotats A, Fuentes-Ocampo F, Camacho V, Fernández A, Ruiz A, Duch J, Sizova M, Domènech A, Estorch M, Carrió I
Eur J Nucl Med Mol Imaging 2019 Jun;46(6):1383-1390. Epub 2019 Jan 10 doi: 10.1007/s00259-019-4260-z. PMID: 30631910
Osteochondral lesions of the talus.
Seo SG, Kim JS, Seo DK, Kim YK, Lee SH, Lee HS
Acta Orthop 2018 Aug;89(4):462-467. Epub 2018 Apr 11 doi: 10.1080/17453674.2018.1460777. PMID: 29635971Free PMC Article
Sonography of acne vulgaris.
Wortsman X, Claveria P, Valenzuela F, Molina MT, Wortsman J
J Ultrasound Med 2014 Jan;33(1):93-102. doi: 10.7863/ultra.33.1.93. PMID: 24371103
A new periapical index based on cone beam computed tomography.
Estrela C, Bueno MR, Azevedo BC, Azevedo JR, Pécora JD
J Endod 2008 Nov;34(11):1325-1331. Epub 2008 Sep 17 doi: 10.1016/j.joen.2008.08.013. PMID: 18928840
Classification of endometriosis.
Damario MA, Rock JA
Semin Reprod Endocrinol 1997;15(3):235-44. doi: 10.1055/s-2008-1068753. PMID: 9383832

Recent systematic reviews

Complement inhibitors for age-related macular degeneration.
Tzoumas N, Riding G, Williams MA, Steel DH
Cochrane Database Syst Rev 2023 Jun 14;6(6):CD009300. doi: 10.1002/14651858.CD009300.pub3. PMID: 37314061Free PMC Article
Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression.
Proschinger S, Kuhwand P, Rademacher A, Walzik D, Warnke C, Zimmer P, Joisten N
J Neurol 2022 Jun;269(6):2922-2940. Epub 2022 Jan 27 doi: 10.1007/s00415-021-10935-6. PMID: 35084560Free PMC Article
Bisphosphonate-associated osteonecrosis of the jaw.
Ferreira Jr LH Jr, Mendonça Jr KD Jr, Chaves de Souza J, Soares Dos Reis DC, do Carmo Faleiros Veloso Guedes C, de Souza Castro Filice L, Bruzadelli Macedo S, Soares Rocha F
Minerva Dent Oral Sci 2021 Feb;70(1):49-57. Epub 2020 Sep 22 doi: 10.23736/S2724-6329.20.04306-X. PMID: 32960522
A Systematic Review and Meta-Analysis of Nonvital Pulp Therapy for Primary Teeth.
Coll JA, Vargas K, Marghalani AA, Chen CY, AlShamali S, Dhar V, Crystal YO
Pediatr Dent 2020 Jul 15;42(4):256-461. PMID: 32847665
Which physical examination tests provide clinicians with the most value when examining the shoulder? Update of a systematic review with meta-analysis of individual tests.
Hegedus EJ, Goode AP, Cook CE, Michener L, Myer CA, Myer DM, Wright AA
Br J Sports Med 2012 Nov;46(14):964-78. Epub 2012 Jul 7 doi: 10.1136/bjsports-2012-091066. PMID: 22773322

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