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Statin causing adverse effect in therapeutic use

MedGen UID:
654187
•Concept ID:
C0570410
•
Pathologic Function
Synonym: Statin response
SNOMED CT: 3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor adverse reaction (293432006); 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction (293432006); HMG COA reductase inhibitor adverse reaction (293432006); Statin adverse reaction (293432006)
 
Related genes: SLCO1B1, RYR1

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment.
Lampsas S, Xenou M, Oikonomou E, Pantelidis P, Lysandrou A, Sarantos S, Goliopoulou A, Kalogeras K, Tsigkou V, Kalpis A, Paschou SA, Theofilis P, Vavuranakis M, Tousoulis D, Siasos G
Molecules 2023 Jan 18;28(3) doi: 10.3390/molecules28030969. PMID: 36770634Free PMC Article
Perioperative Cardiovascular Risk Assessment and Management for Noncardiac Surgery: A Review.
Smilowitz NR, Berger JS
JAMA 2020 Jul 21;324(3):279-290. doi: 10.1001/jama.2020.7840. PMID: 32692391
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

Recent clinical studies

Etiology

Dyslipidemia.
Arvanitis M, Lowenstein CJ
Ann Intern Med 2023 Jun;176(6):ITC81-ITC96. Epub 2023 Jun 13 doi: 10.7326/AITC202306200. PMID: 37307585
Statin Intolerance: A Review and Update.
Tsushima Y, Hatipoglu B
Endocr Pract 2023 Jul;29(7):566-571. Epub 2023 Mar 22 doi: 10.1016/j.eprac.2023.03.004. PMID: 36958647
Effect of statins on atherosclerotic plaque.
Almeida SO, Budoff M
Trends Cardiovasc Med 2019 Nov;29(8):451-455. Epub 2019 Jan 7 doi: 10.1016/j.tcm.2019.01.001. PMID: 30642643
Grapefruit Juice and Statins.
Lee JW, Morris JK, Wald NJ
Am J Med 2016 Jan;129(1):26-9. Epub 2015 Aug 20 doi: 10.1016/j.amjmed.2015.07.036. PMID: 26299317
Statin-induced myopathies.
Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ
Pharmacol Rep 2011;63(4):859-66. doi: 10.1016/s1734-1140(11)70601-6. PMID: 22001973

Diagnosis

Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment.
Lampsas S, Xenou M, Oikonomou E, Pantelidis P, Lysandrou A, Sarantos S, Goliopoulou A, Kalogeras K, Tsigkou V, Kalpis A, Paschou SA, Theofilis P, Vavuranakis M, Tousoulis D, Siasos G
Molecules 2023 Jan 18;28(3) doi: 10.3390/molecules28030969. PMID: 36770634Free PMC Article
Statins Neuromuscular Adverse Effects.
Attardo S, Musumeci O, Velardo D, Toscano A
Int J Mol Sci 2022 Jul 28;23(15) doi: 10.3390/ijms23158364. PMID: 35955495Free PMC Article
Diagnosis and Management of Statin Intolerance.
Alonso R, Cuevas A, Cafferata A
J Atheroscler Thromb 2019 Mar 1;26(3):207-215. Epub 2019 Jan 19 doi: 10.5551/jat.RV17030. PMID: 30662020Free PMC Article
Safety and efficacy of statin therapy.
Adhyaru BB, Jacobson TA
Nat Rev Cardiol 2018 Dec;15(12):757-769. doi: 10.1038/s41569-018-0098-5. PMID: 30375494
Statin-Associated Side Effects.
Thompson PD, Panza G, Zaleski A, Taylor B
J Am Coll Cardiol 2016 May 24;67(20):2395-2410. doi: 10.1016/j.jacc.2016.02.071. PMID: 27199064

Therapy

Statin Intolerance: A Review and Update.
Tsushima Y, Hatipoglu B
Endocr Pract 2023 Jul;29(7):566-571. Epub 2023 Mar 22 doi: 10.1016/j.eprac.2023.03.004. PMID: 36958647
Effect of statins on atherosclerotic plaque.
Almeida SO, Budoff M
Trends Cardiovasc Med 2019 Nov;29(8):451-455. Epub 2019 Jan 7 doi: 10.1016/j.tcm.2019.01.001. PMID: 30642643
Grapefruit Juice and Statins.
Lee JW, Morris JK, Wald NJ
Am J Med 2016 Jan;129(1):26-9. Epub 2015 Aug 20 doi: 10.1016/j.amjmed.2015.07.036. PMID: 26299317
The pharmacology of statins.
Sirtori CR
Pharmacol Res 2014 Oct;88:3-11. Epub 2014 Mar 20 doi: 10.1016/j.phrs.2014.03.002. PMID: 24657242
Statin-induced myopathies.
Tomaszewski M, Stępień KM, Tomaszewska J, Czuczwar SJ
Pharmacol Rep 2011;63(4):859-66. doi: 10.1016/s1734-1140(11)70601-6. PMID: 22001973

Prognosis

Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults : Real-World Evidence From a Target Trial Emulation Study.
Xu W, Lee AL, Lam CLK, Danaei G, Wan EYF
Ann Intern Med 2024 Jun;177(6):701-710. Epub 2024 May 28 doi: 10.7326/M24-0004. PMID: 38801776
Statins Neuromuscular Adverse Effects.
Attardo S, Musumeci O, Velardo D, Toscano A
Int J Mol Sci 2022 Jul 28;23(15) doi: 10.3390/ijms23158364. PMID: 35955495Free PMC Article
Statin therapy is not warranted for a person with high LDL-cholesterol on a low-carbohydrate diet.
Diamond DM, Bikman BT, Mason P
Curr Opin Endocrinol Diabetes Obes 2022 Oct 1;29(5):497-511. Epub 2022 Aug 4 doi: 10.1097/MED.0000000000000764. PMID: 35938780
PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis.
Khan SU, Yedlapati SH, Lone AN, Hao Q, Guyatt G, Delvaux N, Bekkering GET, Vandvik PO, Riaz IB, Li S, Aertgeerts B, Rodondi N
BMJ 2022 May 4;377:e069116. doi: 10.1136/bmj-2021-069116. PMID: 35508321
Statins for the primary prevention of cardiovascular disease.
Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD004816. doi: 10.1002/14651858.CD004816.pub5. PMID: 23440795Free PMC Article

Clinical prediction guides

Statins Neuromuscular Adverse Effects.
Attardo S, Musumeci O, Velardo D, Toscano A
Int J Mol Sci 2022 Jul 28;23(15) doi: 10.3390/ijms23158364. PMID: 35955495Free PMC Article
Statin therapy is not warranted for a person with high LDL-cholesterol on a low-carbohydrate diet.
Diamond DM, Bikman BT, Mason P
Curr Opin Endocrinol Diabetes Obes 2022 Oct 1;29(5):497-511. Epub 2022 Aug 4 doi: 10.1097/MED.0000000000000764. PMID: 35938780
PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis.
Khan SU, Yedlapati SH, Lone AN, Hao Q, Guyatt G, Delvaux N, Bekkering GET, Vandvik PO, Riaz IB, Li S, Aertgeerts B, Rodondi N
BMJ 2022 May 4;377:e069116. doi: 10.1136/bmj-2021-069116. PMID: 35508321
Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults.
Zhou Z, Ryan J, Ernst ME, Zoungas S, Tonkin AM, Woods RL, McNeil JJ, Reid CM, Curtis AJ, Wolfe R, Wrigglesworth J, Shah RC, Storey E, Murray A, Orchard SG, Nelson MR; ASPREE Investigator Group
J Am Coll Cardiol 2021 Jun 29;77(25):3145-3156. doi: 10.1016/j.jacc.2021.04.075. PMID: 34167639Free PMC Article
Statin-induced myopathy: a review and update.
Abd TT, Jacobson TA
Expert Opin Drug Saf 2011 May;10(3):373-87. Epub 2011 Feb 23 doi: 10.1517/14740338.2011.540568. PMID: 21342078

Recent systematic reviews

PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis.
Khan SU, Yedlapati SH, Lone AN, Hao Q, Guyatt G, Delvaux N, Bekkering GET, Vandvik PO, Riaz IB, Li S, Aertgeerts B, Rodondi N
BMJ 2022 May 4;377:e069116. doi: 10.1136/bmj-2021-069116. PMID: 35508321
Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies.
Olmastroni E, Molari G, De Beni N, Colpani O, Galimberti F, Gazzotti M, Zambon A, Catapano AL, Casula M
Eur J Prev Cardiol 2022 May 5;29(5):804-814. doi: 10.1093/eurjpc/zwab208. PMID: 34871380
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis.
Navarese EP, Robinson JG, Kowalewski M, Kolodziejczak M, Andreotti F, Bliden K, Tantry U, Kubica J, Raggi P, Gurbel PA
JAMA 2018 Apr 17;319(15):1566-1579. doi: 10.1001/jama.2018.2525. PMID: 29677301Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118

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