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Referred pain

MedGen UID:
65869
•Concept ID:
C0234250
•
Sign or Symptom
Synonyms: Pain, Referred; Referred Pain
SNOMED CT: Referred pain (6617009)

Definition

A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReferred pain

Professional guidelines

PubMed

Hip Pain in Adults: Evaluation and Differential Diagnosis.
Chamberlain R
Am Fam Physician 2021 Jan 15;103(2):81-89. PMID: 33448767
Treatment and management of myofascial pain syndrome.
Urits I, Charipova K, Gress K, Schaaf AL, Gupta S, Kiernan HC, Choi PE, Jung JW, Cornett E, Kaye AD, Viswanath O
Best Pract Res Clin Anaesthesiol 2020 Sep;34(3):427-448. Epub 2020 Aug 8 doi: 10.1016/j.bpa.2020.08.003. PMID: 33004157
Low Back Pain, a Comprehensive Review: Pathophysiology, Diagnosis, and Treatment.
Urits I, Burshtein A, Sharma M, Testa L, Gold PA, Orhurhu V, Viswanath O, Jones MR, Sidransky MA, Spektor B, Kaye AD
Curr Pain Headache Rep 2019 Mar 11;23(3):23. doi: 10.1007/s11916-019-0757-1. PMID: 30854609

Recent clinical studies

Etiology

Electrical dry needling versus conventional physiotherapy in the treatment of active and latent myofascial trigger points in patients with nonspecific chronic low back pain.
Lara-Palomo IC, Gil-Martínez E, Antequera-Soler E, Castro-Sánchez AM, Fernández-Sánchez M, García-López H
Trials 2022 Mar 28;23(1):238. doi: 10.1186/s13063-022-06179-y. PMID: 35346331Free PMC Article
Treatment and management of myofascial pain syndrome.
Urits I, Charipova K, Gress K, Schaaf AL, Gupta S, Kiernan HC, Choi PE, Jung JW, Cornett E, Kaye AD, Viswanath O
Best Pract Res Clin Anaesthesiol 2020 Sep;34(3):427-448. Epub 2020 Aug 8 doi: 10.1016/j.bpa.2020.08.003. PMID: 33004157
Cholelithiasis: Presentation and Management.
Littlefield A, Lenahan C
J Midwifery Womens Health 2019 May;64(3):289-297. Epub 2019 Mar 25 doi: 10.1111/jmwh.12959. PMID: 30908805
Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials.
Rubinstein SM, de Zoete A, van Middelkoop M, Assendelft WJJ, de Boer MR, van Tulder MW
BMJ 2019 Mar 13;364:l689. doi: 10.1136/bmj.l689. PMID: 30867144Free PMC Article
Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Group†.
Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A, Brooks SL, Ceusters W, Drangsholt M, Ettlin D, Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF; International RDC/TMD Consortium Network, International association for Dental Research; Orofacial Pain Special Interest Group, International Association for the Study of Pain
J Oral Facial Pain Headache 2014 Winter;28(1):6-27. doi: 10.11607/jop.1151. PMID: 24482784Free PMC Article

Diagnosis

Musculoskeletal mimics of cervical radiculopathy.
Chiou-Tan FY
Muscle Nerve 2022 Jul;66(1):6-14. Epub 2022 Apr 24 doi: 10.1002/mus.27553. PMID: 35466429
Hip Pain in Adults: Evaluation and Differential Diagnosis.
Chamberlain R
Am Fam Physician 2021 Jan 15;103(2):81-89. PMID: 33448767
Cholelithiasis: Presentation and Management.
Littlefield A, Lenahan C
J Midwifery Womens Health 2019 May;64(3):289-297. Epub 2019 Mar 25 doi: 10.1111/jmwh.12959. PMID: 30908805
Low Back Pain, a Comprehensive Review: Pathophysiology, Diagnosis, and Treatment.
Urits I, Burshtein A, Sharma M, Testa L, Gold PA, Orhurhu V, Viswanath O, Jones MR, Sidransky MA, Spektor B, Kaye AD
Curr Pain Headache Rep 2019 Mar 11;23(3):23. doi: 10.1007/s11916-019-0757-1. PMID: 30854609
Sciatica.
Valat JP, Genevay S, Marty M, Rozenberg S, Koes B
Best Pract Res Clin Rheumatol 2010 Apr;24(2):241-52. doi: 10.1016/j.berh.2009.11.005. PMID: 20227645

Therapy

Electrical dry needling versus conventional physiotherapy in the treatment of active and latent myofascial trigger points in patients with nonspecific chronic low back pain.
Lara-Palomo IC, Gil-Martínez E, Antequera-Soler E, Castro-Sánchez AM, Fernández-Sánchez M, García-López H
Trials 2022 Mar 28;23(1):238. doi: 10.1186/s13063-022-06179-y. PMID: 35346331Free PMC Article
Treatment and management of myofascial pain syndrome.
Urits I, Charipova K, Gress K, Schaaf AL, Gupta S, Kiernan HC, Choi PE, Jung JW, Cornett E, Kaye AD, Viswanath O
Best Pract Res Clin Anaesthesiol 2020 Sep;34(3):427-448. Epub 2020 Aug 8 doi: 10.1016/j.bpa.2020.08.003. PMID: 33004157
The pharmacological management of dental pain.
Pergolizzi JV, Magnusson P, LeQuang JA, Gharibo C, Varrassi G
Expert Opin Pharmacother 2020 Apr;21(5):591-601. Epub 2020 Feb 6 doi: 10.1080/14656566.2020.1718651. PMID: 32027199
Recent advances in understanding and managing phantom limb pain.
Aternali A, Katz J
F1000Res 2019;8 Epub 2019 Jul 23 doi: 10.12688/f1000research.19355.1. PMID: 31354940Free PMC Article
Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials.
Rubinstein SM, de Zoete A, van Middelkoop M, Assendelft WJJ, de Boer MR, van Tulder MW
BMJ 2019 Mar 13;364:l689. doi: 10.1136/bmj.l689. PMID: 30867144Free PMC Article

Prognosis

The pharmacological management of dental pain.
Pergolizzi JV, Magnusson P, LeQuang JA, Gharibo C, Varrassi G
Expert Opin Pharmacother 2020 Apr;21(5):591-601. Epub 2020 Feb 6 doi: 10.1080/14656566.2020.1718651. PMID: 32027199
Tooth-Related Pain or Not?
Renton T
Headache 2020 Jan;60(1):235-246. Epub 2019 Nov 1 doi: 10.1111/head.13689. PMID: 31675112
Diagnosis of myofascial pain syndrome.
Gerwin RD
Phys Med Rehabil Clin N Am 2014 May;25(2):341-55. Epub 2014 Mar 18 doi: 10.1016/j.pmr.2014.01.011. PMID: 24787337
Diagnosis and prognosis of acute hamstring injuries in athletes.
Kerkhoffs GM, van Es N, Wieldraaijer T, Sierevelt IN, Ekstrand J, van Dijk CN
Knee Surg Sports Traumatol Arthrosc 2013 Feb;21(2):500-9. Epub 2012 May 24 doi: 10.1007/s00167-012-2055-x. PMID: 22622781Free PMC Article
Sciatica.
Valat JP, Genevay S, Marty M, Rozenberg S, Koes B
Best Pract Res Clin Rheumatol 2010 Apr;24(2):241-52. doi: 10.1016/j.berh.2009.11.005. PMID: 20227645

Clinical prediction guides

Electrical dry needling versus conventional physiotherapy in the treatment of active and latent myofascial trigger points in patients with nonspecific chronic low back pain.
Lara-Palomo IC, Gil-Martínez E, Antequera-Soler E, Castro-Sánchez AM, Fernández-Sánchez M, García-López H
Trials 2022 Mar 28;23(1):238. doi: 10.1186/s13063-022-06179-y. PMID: 35346331Free PMC Article
The pharmacological management of dental pain.
Pergolizzi JV, Magnusson P, LeQuang JA, Gharibo C, Varrassi G
Expert Opin Pharmacother 2020 Apr;21(5):591-601. Epub 2020 Feb 6 doi: 10.1080/14656566.2020.1718651. PMID: 32027199
Co-occurrence of pain syndromes.
Affaitati G, Costantini R, Tana C, Cipollone F, Giamberardino MA
J Neural Transm (Vienna) 2020 Apr;127(4):625-646. Epub 2019 Nov 29 doi: 10.1007/s00702-019-02107-8. PMID: 31784821
Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials.
Rubinstein SM, de Zoete A, van Middelkoop M, Assendelft WJJ, de Boer MR, van Tulder MW
BMJ 2019 Mar 13;364:l689. doi: 10.1136/bmj.l689. PMID: 30867144Free PMC Article
Physical examination techniques for the assessment of pelvic floor myofascial pain: a systematic review.
Meister MR, Shivakumar N, Sutcliffe S, Spitznagle T, Lowder JL
Am J Obstet Gynecol 2018 Nov;219(5):497.e1-497.e13. Epub 2018 Jun 28 doi: 10.1016/j.ajog.2018.06.014. PMID: 29959930Free PMC Article

Recent systematic reviews

Effect of ischemic compression on myofascial pain syndrome: a systematic review and meta-analysis.
Lu W, Li J, Tian Y, Lu X
Chiropr Man Therap 2022 Sep 1;30(1):34. doi: 10.1186/s12998-022-00441-5. PMID: 36050701Free PMC Article
Sensory Innervation of the Hip Joint and Referred Pain: A Systematic Review of the Literature.
Laumonerie P, Dalmas Y, Tibbo ME, Robert S, Durant T, Caste T, Vialla T, Tiercelin J, Gracia G, Chaynes P
Pain Med 2021 May 21;22(5):1149-1157. doi: 10.1093/pm/pnab061. PMID: 33565587
Benefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trials.
Rubinstein SM, de Zoete A, van Middelkoop M, Assendelft WJJ, de Boer MR, van Tulder MW
BMJ 2019 Mar 13;364:l689. doi: 10.1136/bmj.l689. PMID: 30867144Free PMC Article
Physical examination techniques for the assessment of pelvic floor myofascial pain: a systematic review.
Meister MR, Shivakumar N, Sutcliffe S, Spitznagle T, Lowder JL
Am J Obstet Gynecol 2018 Nov;219(5):497.e1-497.e13. Epub 2018 Jun 28 doi: 10.1016/j.ajog.2018.06.014. PMID: 29959930Free PMC Article
What Is Evidence-Based About Myofascial Chains: A Systematic Review.
Wilke J, Krause F, Vogt L, Banzer W
Arch Phys Med Rehabil 2016 Mar;97(3):454-61. Epub 2015 Aug 14 doi: 10.1016/j.apmr.2015.07.023. PMID: 26281953

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