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Appendix adenocarcinoma

MedGen UID:
65942
Concept ID:
C0238003
Neoplastic Process
Synonym: Appendiceal adenocarcinoma
SNOMED CT: Adenocarcinoma of appendix (413445002)
 
Monarch Initiative: MONDO:0006087

Definition

A malignant neoplasm arising from the glandular epithelium of the appendix with invasion of the appendiceal wall beyond the muscularis mucosa. The majority of cases are well differentiated adenocarcinomas with mucinous stroma formation. Clinically, it may present as an abdominal mass or with symptoms of acute appendicitis. Patients with chronic ulcerative colitis are at a higher risk in developing appendiceal adenocarcinomas compared to the general population. [from NCI]

Professional guidelines

PubMed

Govaerts K, Lurvink RJ, De Hingh IHJT, Van der Speeten K, Villeneuve L, Kusamura S, Kepenekian V, Deraco M, Glehen O, Moran BJ; PSOGI
Eur J Surg Oncol 2021 Jan;47(1):11-35. Epub 2020 Feb 28 doi: 10.1016/j.ejso.2020.02.012. PMID: 32199769
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023

Recent clinical studies

Etiology

Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article
Villanueva Saenz E, Pérez-Aguirre J, Belmonte MC, Martínez PH, Márquez RM, Carranza RJ
Tech Coloproctol 2006 Mar;10(1):54-6. Epub 2006 Mar 15 doi: 10.1007/s10151-006-0252-7. PMID: 16528481

Diagnosis

Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Cakir U, Kirimlioglu H, Basdemir G
Eur Rev Med Pharmacol Sci 2014;18(17):2424-7. PMID: 25268085
Wang W, Wang L, Xu J, Shi S, Tian Y, Zhang Y
J Xray Sci Technol 2014;22(4):493-501. doi: 10.3233/XST-140440. PMID: 25080116
Ozakyol AH, Sariçam T, Kabukçuoğlu S, Cağa T, Erenoğlu E
Am J Clin Oncol 1999 Oct;22(5):458-9. doi: 10.1097/00000421-199910000-00007. PMID: 10521058

Therapy

Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article

Prognosis

Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article
Elias D, Glehen O, Pocard M, Quenet F, Goéré D, Arvieux C, Rat P, Gilly F; Association Française de Chirurgie
Ann Surg 2010 May;251(5):896-901. doi: 10.1097/SLA.0b013e3181d9765d. PMID: 20395843
Ozakyol AH, Sariçam T, Kabukçuoğlu S, Cağa T, Erenoğlu E
Am J Clin Oncol 1999 Oct;22(5):458-9. doi: 10.1097/00000421-199910000-00007. PMID: 10521058

Clinical prediction guides

Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023

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