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Appendix adenocarcinoma

MedGen UID:
65942
•Concept ID:
C0238003
•
Neoplastic Process
Synonym: Appendiceal adenocarcinoma
SNOMED CT: Adenocarcinoma of appendix (413445002)
 
Monarch Initiative: MONDO:0006087

Definition

A malignant neoplasm arising from the glandular epithelium of the appendix with invasion of the appendiceal wall beyond the muscularis mucosa. The majority of cases are well differentiated adenocarcinomas with mucinous stroma formation. Clinically, it may present as an abdominal mass or with symptoms of acute appendicitis. Patients with chronic ulcerative colitis are at a higher risk in developing appendiceal adenocarcinomas compared to the general population. [from NCI]

Professional guidelines

PubMed

Guideline No. 408: Management of Gestational Trophoblastic Diseases.
Eiriksson L, Dean E, Sebastianelli A, Salvador S, Comeau R, Jang JH, Bouchard-Fortier G, Osborne R, Sauthier P
J Obstet Gynaecol Can 2021 Jan;43(1):91-105.e1. doi: 10.1016/j.jogc.2020.03.001. PMID: 33384141
Appendiceal tumours and pseudomyxoma peritonei: Literature review with PSOGI/EURACAN clinical practice guidelines for diagnosis and treatment.
Govaerts K, Lurvink RJ, De Hingh IHJT, Van der Speeten K, Villeneuve L, Kusamura S, Kepenekian V, Deraco M, Glehen O, Moran BJ; PSOGI
Eur J Surg Oncol 2021 Jan;47(1):11-35. Epub 2020 Feb 28 doi: 10.1016/j.ejso.2020.02.012. PMID: 32199769
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023

Recent clinical studies

Etiology

Defining a role for systemic chemotherapy in local and advanced appendix adenocarcinoma.
Strach MC, Chakrabarty B, Nagaraju RT, Mullamitha S, Braun M, O'Dwyer ST, Aziz O, Barriuso J
ESMO Open 2023 Oct;8(5):101619. Epub 2023 Aug 24 doi: 10.1016/j.esmoop.2023.101619. PMID: 37625193Free PMC Article
Impact of high-risk features for stage II adenocarcinoma of the appendix.
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Predicting Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Appendix Adenocarcinoma.
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Impact of molecular alterations and targeted therapy in appendiceal adenocarcinomas.
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article
Appendix adenocarcinoma associated with ulcerative colitis: a case report and literature review.
Villanueva Saenz E, Pérez-Aguirre J, Belmonte MC, Martínez PH, Márquez RM, Carranza RJ
Tech Coloproctol 2006 Mar;10(1):54-6. Epub 2006 Mar 15 doi: 10.1007/s10151-006-0252-7. PMID: 16528481

Diagnosis

Sufficient Regional Lymph Node Examination for Staging Adenocarcinoma of the Appendix.
Lopez-Ramirez F, Sardi A, King MC, Nikiforchin A, Falla-Zuniga LF, Barakat P, Nieroda C, Gushchin V
Ann Surg Oncol 2024 Mar;31(3):1773-1782. Epub 2023 Dec 28 doi: 10.1245/s10434-023-14683-x. PMID: 38153641
Is the measurement of sarcopenia associated with oncological disease in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?
Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Impact of high-risk features for stage II adenocarcinoma of the appendix.
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Combination of CT imaging and endoscopy in diagnosis of appendicovesical fistula caused by appendiceal adenocarcinoma.
Wang W, Wang L, Xu J, Shi S, Tian Y, Zhang Y
J Xray Sci Technol 2014;22(4):493-501. doi: 10.3233/XST-140440. PMID: 25080116
Primary appendiceal adenocarcinoma.
Ozakyol AH, Sariçam T, Kabukçuoğlu S, Cağa T, Erenoğlu E
Am J Clin Oncol 1999 Oct;22(5):458-9. doi: 10.1097/00000421-199910000-00007. PMID: 10521058

Therapy

Is the measurement of sarcopenia associated with oncological disease in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?
Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Impact of high-risk features for stage II adenocarcinoma of the appendix.
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Predicting Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Appendix Adenocarcinoma.
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Impact of molecular alterations and targeted therapy in appendiceal adenocarcinomas.
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article

Prognosis

Defining a role for systemic chemotherapy in local and advanced appendix adenocarcinoma.
Strach MC, Chakrabarty B, Nagaraju RT, Mullamitha S, Braun M, O'Dwyer ST, Aziz O, Barriuso J
ESMO Open 2023 Oct;8(5):101619. Epub 2023 Aug 24 doi: 10.1016/j.esmoop.2023.101619. PMID: 37625193Free PMC Article
Impact of high-risk features for stage II adenocarcinoma of the appendix.
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Predicting Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Appendix Adenocarcinoma.
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Impact of molecular alterations and targeted therapy in appendiceal adenocarcinomas.
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article
Primary appendiceal adenocarcinoma.
Ozakyol AH, Sariçam T, Kabukçuoğlu S, Cağa T, Erenoğlu E
Am J Clin Oncol 1999 Oct;22(5):458-9. doi: 10.1097/00000421-199910000-00007. PMID: 10521058

Clinical prediction guides

Defining a role for systemic chemotherapy in local and advanced appendix adenocarcinoma.
Strach MC, Chakrabarty B, Nagaraju RT, Mullamitha S, Braun M, O'Dwyer ST, Aziz O, Barriuso J
ESMO Open 2023 Oct;8(5):101619. Epub 2023 Aug 24 doi: 10.1016/j.esmoop.2023.101619. PMID: 37625193Free PMC Article
Is the measurement of sarcopenia associated with oncological disease in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?
Siu AHY, Holyland M, Carey S, Steffens D, Ansari N, Koh CE
ANZ J Surg 2023 Sep;93(9):2186-2191. Epub 2023 Jul 31 doi: 10.1111/ans.18645. PMID: 37525364
Impact of high-risk features for stage II adenocarcinoma of the appendix.
Akce M, Zakka K, Penley M, Jiang R, Khalil L, Alese OB, Shaib WL, Wu C, Behera M, El-Rayes BF
Cancer Treat Res Commun 2021;27:100329. Epub 2021 Feb 4 doi: 10.1016/j.ctarc.2021.100329. PMID: 33609973
Predicting Survival After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Appendix Adenocarcinoma.
Aziz O, Jaradat I, Chakrabarty B, Selvasekar CR, Fulford PE, Saunders MP, Renehan AG, Wilson MS, O'Dwyer ST
Dis Colon Rectum 2018 Jul;61(7):795-802. doi: 10.1097/DCR.0000000000001076. PMID: 29771808
Impact of molecular alterations and targeted therapy in appendiceal adenocarcinomas.
Raghav KP, Shetty AV, Kazmi SM, Zhang N, Morris J, Taggart M, Fournier K, Royal R, Mansfield P, Eng C, Wolff RA, Overman MJ
Oncologist 2013;18(12):1270-7. Epub 2013 Oct 22 doi: 10.1634/theoncologist.2013-0186. PMID: 24149137Free PMC Article

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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023

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