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Small Intestinal Carcinoma

MedGen UID:
65952
•Concept ID:
C0238196
•
Neoplastic Process
Synonyms: Cancer of Small Bowel; Cancer of the Small Bowel; Carcinoma of Small Bowel; Carcinoma of Small Intestine; Carcinoma of the Small Bowel; Carcinoma of the Small Intestine; Small Bowel Cancer; Small Bowel Carcinoma; Small Intestine Cancer

Definition

A carcinoma arising from the small intestine. The vast majority are adenocarcinomas. The remaining cases are adenosquamous, squamous, or undifferentiated carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Carcinoma

Professional guidelines

PubMed

Clinical practice guidelines for duodenal cancer 2021.
Nakagawa K, Sho M, Fujishiro M, Kakushima N, Horimatsu T, Okada KI, Iguchi M, Uraoka T, Kato M, Yamamoto Y, Aoyama T, Akahori T, Eguchi H, Kanaji S, Kanetaka K, Kuroda S, Nagakawa Y, Nunobe S, Higuchi R, Fujii T, Yamashita H, Yamada S, Narita Y, Honma Y, Muro K, Ushiku T, Ejima Y, Yamaue H, Kodera Y
J Gastroenterol 2022 Dec;57(12):927-941. Epub 2022 Oct 19 doi: 10.1007/s00535-022-01919-y. PMID: 36260172Free PMC Article

Recent clinical studies

Etiology

Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis.
Han Y, Chen W, Li P, Ye J
Medicine (Baltimore) 2015 Sep;94(38):e1612. doi: 10.1097/MD.0000000000001612. PMID: 26402826Free PMC Article
Loss of ARID1A expression is associated with poor prognosis in small intestinal carcinoma.
Kim MJ, Gu MJ, Chang HK, Yu E
Histopathology 2015 Mar;66(4):508-16. Epub 2015 Jan 12 doi: 10.1111/his.12566. PMID: 25400081
HER2 protein expression and HER2 gene amplification are infrequent in small intestinal carcinomas.
Gu MJ, Hong SM, Jung SJ; Korean Small Intestinal Cancer Study Group
Virchows Arch 2013 Jun;462(6):603-7. Epub 2013 May 24 doi: 10.1007/s00428-013-1425-1. PMID: 23703294
Expression of hMLH1, hMSH2 and hMSH6 in small intestinal carcinomas.
Gu MJ, Bae YK, Kim A, Hong SM, Yu E, Kim J, Jang KT, Chang HK, Jung ES, Bae HI, Yoon GS, Kim JM, Kim JY, Kim GI, Oh YH, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong SW, Jung SJ, Lee JS; Korean Small Intestinal Cancer Study Group
Hepatogastroenterology 2012 Oct;59(119):2228-32. doi: 10.5754/hge11601. PMID: 22456432
Crohn's disease and intestinal carcinoma. A report of 11 cases with emphasis on associated epithelial dysplasia.
Petras RE, Mir-Madjlessi SH, Farmer RG
Gastroenterology 1987 Dec;93(6):1307-14. PMID: 2824276

Diagnosis

Clinical practice guidelines for duodenal cancer 2021.
Nakagawa K, Sho M, Fujishiro M, Kakushima N, Horimatsu T, Okada KI, Iguchi M, Uraoka T, Kato M, Yamamoto Y, Aoyama T, Akahori T, Eguchi H, Kanaji S, Kanetaka K, Kuroda S, Nagakawa Y, Nunobe S, Higuchi R, Fujii T, Yamashita H, Yamada S, Narita Y, Honma Y, Muro K, Ushiku T, Ejima Y, Yamaue H, Kodera Y
J Gastroenterol 2022 Dec;57(12):927-941. Epub 2022 Oct 19 doi: 10.1007/s00535-022-01919-y. PMID: 36260172Free PMC Article
The application value of capsule endoscopy in diagnosing small intestinal carcinoma.
Li X, Gui Y, Shen F, Zhao CL, Yang Y, Han W
J Cancer Res Ther 2018 Jan;14(1):57-60. doi: 10.4103/jcrt.JCRT_584_17. PMID: 29516960
Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis.
Han Y, Chen W, Li P, Ye J
Medicine (Baltimore) 2015 Sep;94(38):e1612. doi: 10.1097/MD.0000000000001612. PMID: 26402826Free PMC Article
Primary undifferentiated carcinoma of the small intestine: an immunohistochemical study and review of the literature.
Namikawa T, Kobayashi M, Iwabu J, Kitagawa H, Maeda H, Okabayashi T, Iguchi M, Hiroi M, Hanazaki K
Med Mol Morphol 2010 Jun;43(2):91-5. Epub 2010 Aug 4 doi: 10.1007/s00795-009-0448-9. PMID: 20683696
Early-stage small-bowel adenocarcinoma: a review of local endoscopic therapy.
Friedrich-Rust M, Ell C
Endoscopy 2005 Aug;37(8):755-9. doi: 10.1055/s-2005-870162. PMID: 16032496

Therapy

Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis.
Han Y, Chen W, Li P, Ye J
Medicine (Baltimore) 2015 Sep;94(38):e1612. doi: 10.1097/MD.0000000000001612. PMID: 26402826Free PMC Article

Prognosis

Loss of ARID1A expression is associated with poor prognosis in small intestinal carcinoma.
Kim MJ, Gu MJ, Chang HK, Yu E
Histopathology 2015 Mar;66(4):508-16. Epub 2015 Jan 12 doi: 10.1111/his.12566. PMID: 25400081
Carbonic anhydrase IX expression is associated with favorable prognostic factors in small intestinal carcinoma.
Gu MJ, Kwon KW
J Histochem Cytochem 2014 Mar;62(3):205-10. Epub 2013 Nov 11 doi: 10.1369/0022155413512657. PMID: 24217923Free PMC Article
HER2 protein expression and HER2 gene amplification are infrequent in small intestinal carcinomas.
Gu MJ, Hong SM, Jung SJ; Korean Small Intestinal Cancer Study Group
Virchows Arch 2013 Jun;462(6):603-7. Epub 2013 May 24 doi: 10.1007/s00428-013-1425-1. PMID: 23703294
Expression of hMLH1, hMSH2 and hMSH6 in small intestinal carcinomas.
Gu MJ, Bae YK, Kim A, Hong SM, Yu E, Kim J, Jang KT, Chang HK, Jung ES, Bae HI, Yoon GS, Kim JM, Kim JY, Kim GI, Oh YH, Jang KY, Jun SY, Eom DW, Kwon KW, Kang GH, Park JB, Hong SW, Jung SJ, Lee JS; Korean Small Intestinal Cancer Study Group
Hepatogastroenterology 2012 Oct;59(119):2228-32. doi: 10.5754/hge11601. PMID: 22456432
Primary undifferentiated carcinoma of the small intestine: an immunohistochemical study and review of the literature.
Namikawa T, Kobayashi M, Iwabu J, Kitagawa H, Maeda H, Okabayashi T, Iguchi M, Hiroi M, Hanazaki K
Med Mol Morphol 2010 Jun;43(2):91-5. Epub 2010 Aug 4 doi: 10.1007/s00795-009-0448-9. PMID: 20683696

Clinical prediction guides

The application value of capsule endoscopy in diagnosing small intestinal carcinoma.
Li X, Gui Y, Shen F, Zhao CL, Yang Y, Han W
J Cancer Res Ther 2018 Jan;14(1):57-60. doi: 10.4103/jcrt.JCRT_584_17. PMID: 29516960
Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal Malignancy: A Meta-Analysis.
Han Y, Chen W, Li P, Ye J
Medicine (Baltimore) 2015 Sep;94(38):e1612. doi: 10.1097/MD.0000000000001612. PMID: 26402826Free PMC Article
Loss of ARID1A expression is associated with poor prognosis in small intestinal carcinoma.
Kim MJ, Gu MJ, Chang HK, Yu E
Histopathology 2015 Mar;66(4):508-16. Epub 2015 Jan 12 doi: 10.1111/his.12566. PMID: 25400081
Carbonic anhydrase IX expression is associated with favorable prognostic factors in small intestinal carcinoma.
Gu MJ, Kwon KW
J Histochem Cytochem 2014 Mar;62(3):205-10. Epub 2013 Nov 11 doi: 10.1369/0022155413512657. PMID: 24217923Free PMC Article
HER2 protein expression and HER2 gene amplification are infrequent in small intestinal carcinomas.
Gu MJ, Hong SM, Jung SJ; Korean Small Intestinal Cancer Study Group
Virchows Arch 2013 Jun;462(6):603-7. Epub 2013 May 24 doi: 10.1007/s00428-013-1425-1. PMID: 23703294

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