U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lymphangitic Carcinomatosis

MedGen UID:
65954
•Concept ID:
C0238258
•
Neoplastic Process
Synonym: Lymphangitis carcinomatosa
SNOMED CT: Lymphangitis carcinomatosa (255119002)

Definition

Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination. The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphangitic Carcinomatosis

Professional guidelines

PubMed

Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413
Pulmonary toxicity related to systemic treatment of nonsmall cell lung cancer.
De Sanctis A, Taillade L, Vignot S, Novello S, Conforti R, Spano JP, Scagliotti GV, Khayat D
Cancer 2011 Jul 15;117(14):3069-80. Epub 2011 Jan 31 doi: 10.1002/cncr.25894. PMID: 21283982
Effects of radiation therapy on the lung: radiologic appearances and differential diagnosis.
Choi YW, Munden RF, Erasmus JJ, Park KJ, Chung WK, Jeon SC, Park CK
Radiographics 2004 Jul-Aug;24(4):985-97; discussion 998. doi: 10.1148/rg.244035160. PMID: 15256622

Recent clinical studies

Etiology

The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review.
Hui D, Yennurajalingam S
Curr Opin Support Palliat Care 2023 Dec 1;17(4):270-276. Epub 2023 Sep 29 doi: 10.1097/SPC.0000000000000677. PMID: 37773042
Lymphangitic Carcinomatosis From Prostate Cancer Identified With Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography Imaging.
Tang VD, Campbell P, Pattison DA
Urology 2018 Apr;114:e1-e2. Epub 2017 Dec 29 doi: 10.1016/j.urology.2017.12.010. PMID: 29291425
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Tighe D, Cavilla S, Simcock R
Int J Oral Maxillofac Surg 2014 Jul;43(7):806-10. Epub 2014 Mar 4 doi: 10.1016/j.ijom.2013.12.003. PMID: 24612960
Pulmonary toxicity related to systemic treatment of nonsmall cell lung cancer.
De Sanctis A, Taillade L, Vignot S, Novello S, Conforti R, Spano JP, Scagliotti GV, Khayat D
Cancer 2011 Jul 15;117(14):3069-80. Epub 2011 Jan 31 doi: 10.1002/cncr.25894. PMID: 21283982
Lymphangitic carcinomatosis of the lung: pathologic, diagnostic and therapeutic considerations.
Green N, Kern W, Levis R, Schleiter W, Bonorris J, Berne CJ
Int J Radiat Oncol Biol Phys 1977 Jan-Feb;2(1-2):149-53. doi: 10.1016/0360-3016(77)90021-9. PMID: 849895

Diagnosis

Corticosteroids for pulmonary lymphangitic carcinomatosis.
Takimoto T
BMJ Support Palliat Care 2024 Jan 8;13(e3):e951-e952. doi: 10.1136/spcare-2022-003983. PMID: 36302614
Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413
Atypical pulmonary metastases in children: pictorial review of imaging patterns.
Gagnon MH, Wallace AB, Yedururi S, Khanna G
Pediatr Radiol 2021 Jan;51(1):131-139. Epub 2020 Sep 23 doi: 10.1007/s00247-020-04821-y. PMID: 32965564
Pulmonary lymphangitic carcinomatosis.
Lin WR, Lai RS
QJM 2014 Nov;107(11):935-6. Epub 2014 Apr 8 doi: 10.1093/qjmed/hcu076. PMID: 24713225
Tropical pulmonary eosinophilia.
Enzenauer RJ, Underwood GH Jr, Ribbing J
South Med J 1990 Jan;83(1):69-72. doi: 10.1097/00007611-199001000-00022. PMID: 2405502

Therapy

Corticosteroids for pulmonary lymphangitic carcinomatosis.
Takimoto T
BMJ Support Palliat Care 2024 Jan 8;13(e3):e951-e952. doi: 10.1136/spcare-2022-003983. PMID: 36302614
The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review.
Hui D, Yennurajalingam S
Curr Opin Support Palliat Care 2023 Dec 1;17(4):270-276. Epub 2023 Sep 29 doi: 10.1097/SPC.0000000000000677. PMID: 37773042
Micronodular lung disease on high-resolution CT: patterns and differential diagnosis.
Kim J, Dabiri B, Hammer MM
Clin Radiol 2021 Jun;76(6):399-406. Epub 2021 Feb 7 doi: 10.1016/j.crad.2020.12.025. PMID: 33563413
Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review.
Zhuang L, Liu X, Hu C, Zhang L, Jiang G, Wu J, Zheng S
World J Surg Oncol 2014 Mar 27;12:66. doi: 10.1186/1477-7819-12-66. PMID: 24669948Free PMC Article
Pulmonary toxicity related to systemic treatment of nonsmall cell lung cancer.
De Sanctis A, Taillade L, Vignot S, Novello S, Conforti R, Spano JP, Scagliotti GV, Khayat D
Cancer 2011 Jul 15;117(14):3069-80. Epub 2011 Jan 31 doi: 10.1002/cncr.25894. PMID: 21283982

Prognosis

Pulmonary lymphangitic carcinomatosis.
Lin WR, Lai RS
QJM 2014 Nov;107(11):935-6. Epub 2014 Apr 8 doi: 10.1093/qjmed/hcu076. PMID: 24713225
Pulmonary lymphangitic carcinomatosis in liver carcinoma: a rare case report and literature review.
Zhuang L, Liu X, Hu C, Zhang L, Jiang G, Wu J, Zheng S
World J Surg Oncol 2014 Mar 27;12:66. doi: 10.1186/1477-7819-12-66. PMID: 24669948Free PMC Article
Pulmonary lymphangitic carcinomatosis from head and neck squamous cell carcinoma.
Tighe D, Cavilla S, Simcock R
Int J Oral Maxillofac Surg 2014 Jul;43(7):806-10. Epub 2014 Mar 4 doi: 10.1016/j.ijom.2013.12.003. PMID: 24612960
Lymphangitic carcinomatosis of colon carcinoma: a sign of poor prognosis.
Jaeger T, Zirbs M, Andres C, Gutermuth J, Ring J, Rodriguez R, Jochum W, Anliker MD
Clin Exp Dermatol 2012 Dec;37(8):937-9. Epub 2012 Jun 8 doi: 10.1111/j.1365-2230.2012.04412.x. PMID: 22681561
Endobronchial metastasis from stomach carcinoma.
Scala R, Aronne D, Del Prato B, Montella L, Giacobbe R, Galloro R, Palumbo U
Monaldi Arch Chest Dis 2000 Feb;55(1):6-8. PMID: 10786416

Clinical prediction guides

The role of corticosteroids in the palliation of dyspnea in cancer patients: an evidence-based review.
Hui D, Yennurajalingam S
Curr Opin Support Palliat Care 2023 Dec 1;17(4):270-276. Epub 2023 Sep 29 doi: 10.1097/SPC.0000000000000677. PMID: 37773042
Fluorodeoxyglucose Uptake in Advanced Non-small Cell Lung Cancer With and Without Pulmonary Lymphangitic Carcinomatosis.
Ooi H, Chen CY, Hsiao YC, Huang WS, Hsieh BT
Anticancer Res 2016 Aug;36(8):4313-20. PMID: 27466550
Lobar extent of pulmonary lymphangitic carcinomatosis. Tl-201 chloride and Tc-99m MIBI scintigraphic findings.
Kashitani N, Eda R, Masayoshi T, Takeyama H, Makihara S, Kitamura Y, Yamamoto Y, Hiraki Y
Clin Nucl Med 1996 Sep;21(9):726-9. doi: 10.1097/00003072-199609000-00011. PMID: 8879875
CT of pulmonary metastases with pathological correlation.
Hirakata K, Nakata H, Nakagawa T
Semin Ultrasound CT MR 1995 Oct;16(5):379-94. doi: 10.1016/0887-2171(95)90027-6. PMID: 8527171
Resolution of pulmonary lymphangitic carcinoma of the breast.
Schimmel DH, Julien PJ, Gamsu G
Chest 1976 Jan;69(1):106-8. doi: 10.1378/chest.69.1.106. PMID: 1244262

Recent systematic reviews

CT Characteristics of Non-Small Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangement: A Systematic Review and Meta-Analysis.
Kim TH, Woo S, Yoon SH, Halpenny DF, Han S, Suh CH
AJR Am J Roentgenol 2019 Nov;213(5):1059-1072. Epub 2019 Aug 15 doi: 10.2214/AJR.19.21485. PMID: 31414902Free PMC Article
Computed Tomography Imaging Characteristics of Non-Small-Cell Lung Cancer With Anaplastic Lymphoma Kinase Rearrangements: A Systematic Review and Meta-Analysis.
Mendoza DP, Stowell J, Muzikansky A, Shepard JO, Shaw AT, Digumarthy SR
Clin Lung Cancer 2019 Sep;20(5):339-349. Epub 2019 May 11 doi: 10.1016/j.cllc.2019.05.006. PMID: 31164317

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...