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Scrotum Paget disease

MedGen UID:
65959
Concept ID:
C0238330
Disease or Syndrome
Synonyms: Paget Disease of the Scrotum; Paget disease of the scrotum; Paget's Disease of Scrotum; Paget's disease of scrotum; Paget's Disease of the Scrotum; Paget's disease of the scrotum; Scrotal Paget Disease; Scrotal Paget's Disease; scrotal Paget's disease; scrotum mammary Paget's disease; scrotum Paget disease; scrotum Paget's disease
 
Monarch Initiative: MONDO:0002649

Definition

A rare form of Paget disease that arises from the scrotum. It is usually not associated with an underlying malignancy. It presents as a red plaque or raised lesion. Microscopically, it is characterized by the presence of the typical Paget cells which are large, round cells with abundant cytoplasm and prominent nuclei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVScrotum Paget disease

Professional guidelines

PubMed

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Zhu Y, Ye DW
Urol Clin North Am 2016 Nov;43(4):523-530. doi: 10.1016/j.ucl.2016.06.013. PMID: 27717438

Recent clinical studies

Etiology

Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
Piras A, Sanfratello A, Boldrini L, La Vecchia M, Venuti V, Amari ML, Orlando M, Zichichi L, Angileri T, Daidone A
Dermatol Ther 2020 Nov;33(6):e13890. Epub 2020 Jul 25 doi: 10.1111/dth.13890. PMID: 32584449
Gatalica Z, Vranic S, Krušlin B, Poorman K, Stafford P, Kacerovska D, Senarathne W, Florento E, Contreras E, Leary A, Choi A, In GK
Cancer Med 2020 Feb;9(4):1441-1450. Epub 2020 Jan 3 doi: 10.1002/cam4.2820. PMID: 31899853Free PMC Article
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Zhang N, Gong K, Zhang X, Yang Y, Na Y
Urol Oncol 2010 Jan-Feb;28(1):28-33. Epub 2008 Sep 21 doi: 10.1016/j.urolonc.2008.07.002. PMID: 18805708

Diagnosis

Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article

Therapy

Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272
Gatalica Z, Vranic S, Krušlin B, Poorman K, Stafford P, Kacerovska D, Senarathne W, Florento E, Contreras E, Leary A, Choi A, In GK
Cancer Med 2020 Feb;9(4):1441-1450. Epub 2020 Jan 3 doi: 10.1002/cam4.2820. PMID: 31899853Free PMC Article
Chen M, Chen X, Dai Y, Yang Z, Zhang X, Li D
Aging Male 2020 Dec;23(5):854-859. Epub 2019 Apr 29 doi: 10.1080/13685538.2019.1607284. PMID: 31033366
Hirai I, Tanese K, Nakamura Y, Ishii M, Kawakami Y, Funakoshi T
Oncologist 2019 Jun;24(6):e394-e396. Epub 2019 Mar 7 doi: 10.1634/theoncologist.2018-0856. PMID: 30846514Free PMC Article
Hartman R, Chu J, Patel R, Meehan S, Stein JA
Dermatol Online J 2011 Oct 15;17(10):4. PMID: 22031630

Prognosis

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Zhang N, Gong K, Zhang X, Yang Y, Na Y
Urol Oncol 2010 Jan-Feb;28(1):28-33. Epub 2008 Sep 21 doi: 10.1016/j.urolonc.2008.07.002. PMID: 18805708

Clinical prediction guides

Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Liu Y, Wang Y, Qi R, Mao X, Jin F
Medicine (Baltimore) 2020 Dec 18;99(51):e23443. doi: 10.1097/MD.0000000000023443. PMID: 33371071Free PMC Article
Piras A, Sanfratello A, Boldrini L, La Vecchia M, Venuti V, Amari ML, Orlando M, Zichichi L, Angileri T, Daidone A
Dermatol Ther 2020 Nov;33(6):e13890. Epub 2020 Jul 25 doi: 10.1111/dth.13890. PMID: 32584449
Gatalica Z, Vranic S, Krušlin B, Poorman K, Stafford P, Kacerovska D, Senarathne W, Florento E, Contreras E, Leary A, Choi A, In GK
Cancer Med 2020 Feb;9(4):1441-1450. Epub 2020 Jan 3 doi: 10.1002/cam4.2820. PMID: 31899853Free PMC Article
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904

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