Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Giant cell tumor

MedGen UID:: 6598
•Concept ID:: C0017525
•: Neoplastic Process

Synonyms:	Cell Tumor, Giant; Cell Tumors, Giant; Giant Cell Tumor; Giant Cell Tumors; Tumor, Giant Cell; Tumors, Giant Cell
SNOMED CT:	Giant cell tumor (115238001); Giant cell tumor (443790001)

Monarch Initiative:	MONDO:0002171

Definition

A benign, intermediate, or malignant neoplasm characterized by the presence of neoplastic giant cells. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGiant cell tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Connective and Soft Tissue Disorder
        Connective and soft tissue neoplasm
        Giant cell tumor
        Giant cell tumor of bone
        Giant cell tumor of soft tissue
        Malignant giant cell tumor
        Giant Cell Carcinoma
        Gallbladder Undifferentiated Carcinoma, Spindle and Giant Cell Type
        Laryngeal Giant Cell Carcinoma
        Lung giant cell carcinoma
        Giant cell glioblastoma
        Adult Giant Cell Glioblastoma
        Childhood Giant Cell Glioblastoma
        Recurrent Giant Cell Glioblastoma
        Refractory Giant Cell Glioblastoma
        Malignant giant cell tumor of soft parts
        Malignant Osteoclastic Giant Cell-Rich Tumor of Bone
        Malignancy in giant cell tumor of bone
        Malignant tenosynovial giant cell tumor
        Osteoclastic Giant Cell-Rich Tumor of Bone
        Benign Osteoclastic Giant Cell-Rich Tumor of Bone
        Giant Cell Lesion of Small Bones
        Intermediate Osteoclastic Giant Cell-Rich Tumor of Bone
        Tenosynovial giant cell tumor
        Tenosynovial giant cell tumor, diffuse type
        Tenosynovial giant cell tumor, localized type

Professional guidelines

PubMed

Treatment updates on tenosynovial giant cell tumor.

Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703

Management of Pigmented Villonodular Synovitis (PVNS): an Orthopedic Surgeon's Perspective.

Bernthal NM, Ishmael CR, Burke ZDC
Curr Oncol Rep 2020 Jun 4;22(6):63. doi: 10.1007/s11912-020-00926-7. PMID: 32494892

Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.

Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

See all (149)

Recent clinical studies

Etiology

Tenosynovial giant cell tumor.

Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897

Updated concepts in treatment of giant cell tumor of bone.

van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707

Giant Cell Tumor of Soft Tissue: A Rare Entity.

Mavrogenis AF, Tsukamoto S, Antoniadou T, Righi A, Errani C
Orthopedics 2019 Jul 1;42(4):e364-e369. doi: 10.3928/01477447-20190624-04. PMID: 31323108

Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.

Lipplaa A, Dijkstra S, Gelderblom H
Curr Opin Oncol 2019 Jul;31(4):329-335. doi: 10.1097/CCO.0000000000000529. PMID: 30844887 Free PMC Article

Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.

Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

See all (1154)

Diagnosis

Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.

Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187

Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.

Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298 Free PMC Article

Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis).

Gouin F, Noailles T
Orthop Traumatol Surg Res 2017 Feb;103(1S):S91-S97. Epub 2017 Jan 2 doi: 10.1016/j.otsr.2016.11.002. PMID: 28057477

Giant cell tumor of bone.

Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Giant-cell tumor.

Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

See all (1688)

Therapy

Tenosynovial giant cell tumor.

Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897

Treatment updates on tenosynovial giant cell tumor.

Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703

Giant Cell Tumor of Bone: An Update.

Basu Mallick A, Chawla SP
Curr Oncol Rep 2021 Mar 22;23(5):51. doi: 10.1007/s11912-021-01047-5. PMID: 33754215

Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options.

Montgomery C, Couch C, Emory CL, Nicholas R
J Knee Surg 2019 Apr;32(4):331-336. Epub 2018 Nov 16 doi: 10.1055/s-0038-1675815. PMID: 30449024

Pigmented villonodular synovitis.

Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604

See all (585)

Prognosis

Updated concepts in treatment of giant cell tumor of bone.

van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707

Malignancy in giant cell tumor of bone: analysis of an open-label phase 2 study of denosumab.

Palmerini E, Seeger LL, Gambarotti M, Righi A, Reichardt P, Bukata S, Blay JY, Dai T, Jandial D, Picci P
BMC Cancer 2021 Jan 22;21(1):89. doi: 10.1186/s12885-020-07739-8. PMID: 33482769 Free PMC Article

Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.

Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298 Free PMC Article

Giant cell tumor of bone.

Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ
J Am Acad Orthop Surg 2013 Feb;21(2):118-26. doi: 10.5435/JAAOS-21-02-118. PMID: 23378375

Giant-cell tumor.

Gruenwald N, Demos TC, Lomasney LM, Rapp T
Orthopedics 2006 Feb;29(2):94, 167-71. doi: 10.3928/01477447-20060201-04. PMID: 16485448

See all (894)

Clinical prediction guides

Updated concepts in treatment of giant cell tumor of bone.

van der Heijden L, Lipplaa A, van Langevelde K, Bovée JVMG, van de Sande MAJ, Gelderblom H
Curr Opin Oncol 2022 Jul 1;34(4):371-378. doi: 10.1097/CCO.0000000000000852. PMID: 35837707

Secondary Malignancy in Giant Cell Tumor: A Single-Center Study.

Joo MW, Lee YS, Park HS, Chung YG, Yoon C
Curr Oncol 2022 Jun 2;29(6):4068-4080. doi: 10.3390/curroncol29060324. PMID: 35735433 Free PMC Article

Malignant giant cell tumour of bone: a review of clinical, pathological and imaging features.

Tahir I, Andrei V, Pollock R, Saifuddin A
Skeletal Radiol 2022 May;51(5):957-970. Epub 2021 Sep 25 doi: 10.1007/s00256-021-03913-6. PMID: 34562125

Malignancy in giant cell tumor of bone: analysis of an open-label phase 2 study of denosumab.

Benign tumors of the spine.

Thakur NA, Daniels AH, Schiller J, Valdes MA, Czerwein JK, Schiller A, Esmende S, Terek RM
J Am Acad Orthop Surg 2012 Nov;20(11):715-24. doi: 10.5435/JAAOS-20-11-715. PMID: 23118137

See all (790)

Recent systematic reviews

The giant cell tumor during pregnancy: A review of literature.

Formica VM, Bruno V, Scotto Di Uccio A, Cocca E, Rossi B, Zoccali C
Orthop Traumatol Surg Res 2023 May;109(3):103396. Epub 2022 Sep 7 doi: 10.1016/j.otsr.2022.103396. PMID: 36087835

Management of giant cell tumors of the distal radius: a systematic review and meta-analysis.

Koucheki R, Gazendam A, Perera J, Griffin A, Ferguson P, Wunder J, Tsoi K
Eur J Orthop Surg Traumatol 2023 May;33(4):759-772. Epub 2022 Mar 30 doi: 10.1007/s00590-022-03252-9. PMID: 35377078

Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.

Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298 Free PMC Article

Giant cell tumor of the pelvis: a systematic review.

Zheng K, Wang Z, Wu SJ, Ye ZM, Xu SF, Xu M, Hu YC, Yu XC
Orthop Surg 2015 May;7(2):102-7. doi: 10.1111/os.12174. PMID: 26033989 Free PMC Article

Therapeutic radiotherapy for giant cell tumor of the spine: a systemic review.

Ma Y, Xu W, Yin H, Huang Q, Liu T, Yang X, Wei H, Xiao J
Eur Spine J 2015 Aug;24(8):1754-60. Epub 2015 May 6 doi: 10.1007/s00586-015-3834-0. PMID: 25943724

See all (41)

MedGen

National Center for Biotechnology Information

Send to:

Giant cell tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity