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Mediastinal mass

MedGen UID:
66006
•Concept ID:
C0240318
•
Finding
Synonyms: Mass of mediastinum; Mediastinal Mass
SNOMED CT: Mediastinal mass (94147001); Mass of mediastinum (94147001)
 
HPO: HP:0033823

Definition

A mass in the mediastinum seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics). [from HPO]

Conditions with this feature

Neuroblastoma, susceptibility to, 1
MedGen UID:
412713
•Concept ID:
C2749485
•
Finding
See: Condition Record
Neuroblastoma, susceptibility to, 1

Professional guidelines

PubMed

Modern Classification and Management of Pediatric B-cell Leukemia and Lymphoma.
Kovach AE, Raca G
Surg Pathol Clin 2023 Jun;16(2):249-266. Epub 2023 Mar 8 doi: 10.1016/j.path.2023.01.001. PMID: 37149359
The Hematological Differential Diagnosis of Mediastinal Masses.
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
Management of Residual Mass in Germ Cell Tumors After Chemotherapy.
Albany C, Kesler K, Cary C
Curr Oncol Rep 2019 Jan 21;21(1):5. doi: 10.1007/s11912-019-0758-6. PMID: 30666469

Recent clinical studies

Etiology

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Anesthesia for children with anterior mediastinal masses.
Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Mediastinal mass.
Hamid UI, Jones JM
BMJ Case Rep 2010 Oct 4;2010 doi: 10.1136/bcr.11.2009.2471. PMID: 22778081Free PMC Article
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Diagnosis

The Hematological Differential Diagnosis of Mediastinal Masses.
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
Perioperative Cardiothoracic and Vascular Risk in Childhood Cancer and its Survivors.
Ketterl TG, Latham GJ
J Cardiothorac Vasc Anesth 2021 Jan;35(1):162-175. Epub 2020 Mar 7 doi: 10.1053/j.jvca.2020.02.052. PMID: 32360009
Fifteen-minute consultation: Obvious and not-so-obvious mediastinal masses.
Green K, Behjati S, Cheng D
Arch Dis Child Educ Pract Ed 2019 Dec;104(6):298-303. Epub 2019 May 2 doi: 10.1136/archdischild-2018-315269. PMID: 31048342
MR Imaging of Mediastinal Masses.
Ackman JB
Magn Reson Imaging Clin N Am 2015 May;23(2):141-64. doi: 10.1016/j.mric.2015.01.002. PMID: 25952512
Spinal neurosarcoidosis.
Chang BL, Kuo HC, Chu CC, Huang CC
Acta Neurol Taiwan 2011 Jun;20(2):142-8. PMID: 21739394

Therapy

Strategies for recognizing pneumonia look-alikes.
Drummond D, Hadchouel A, Petit A, Khen-Dunlop N, Lozach C, Delacourt C, Berteloot L
Eur J Pediatr 2022 Oct;181(10):3565-3575. Epub 2022 Jul 30 doi: 10.1007/s00431-022-04575-9. PMID: 35906335
Adult lymphoblastic lymphoma.
Portell CA, Sweetenham JW
Cancer J 2012 Sep-Oct;18(5):432-8. doi: 10.1097/PPO.0b013e31826b1232. PMID: 23006948
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Prognosis

Anesthesia for children with anterior mediastinal masses.
Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Mediastinal mass.
Hamid UI, Jones JM
BMJ Case Rep 2010 Oct 4;2010 doi: 10.1136/bcr.11.2009.2471. PMID: 22778081Free PMC Article
Tumors of the thymus.
Strollo DC, Rosado-de-Christenson ML
J Thorac Imaging 1999 Jul;14(3):152-71. doi: 10.1097/00005382-199907000-00002. PMID: 10404501
Posterior mediastinal masses.
Saenz NC, Schnitzer JJ, Eraklis AE, Hendren WH, Grier HE, Macklis RM, Shamberger RC
J Pediatr Surg 1993 Feb;28(2):172-6. doi: 10.1016/s0022-3468(05)80268-4. PMID: 8437074
Thymoma: radiologic-pathologic correlation.
Rosado-de-Christenson ML, Galobardes J, Moran CA
Radiographics 1992 Jan;12(1):151-68. doi: 10.1148/radiographics.12.1.1734461. PMID: 1734461

Clinical prediction guides

Clinicogenomic Landscape of Metastatic Thymic Epithelial Tumors.
Ardeshir-Larijani F, Schneider BP, Althouse SK, Radovich M, Masood A, Perna F, Salman H, Loehrer PJ
JCO Precis Oncol 2023 Feb;7:e2200465. doi: 10.1200/PO.22.00465. PMID: 36787505Free PMC Article
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Anesthesia for children with anterior mediastinal masses.
Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Recent systematic reviews

Total resection of a giant retroperitoneal and mediastinal ganglioneuroma-case report and systematic review of the literature.
Kirchweger P, Wundsam HV, Fischer I, Rösch CS, Böhm G, Tsybrovskyy O, Alibegovic V, Függer R
World J Surg Oncol 2020 Sep 18;18(1):248. doi: 10.1186/s12957-020-02016-1. PMID: 32948207Free PMC Article
Diagnostic outcome and safety of CT-guided core needle biopsy for mediastinal masses: a systematic review and meta-analysis.
Lee HN, Yun SJ, Kim JI, Ryu CW
Eur Radiol 2020 Jan;30(1):588-599. Epub 2019 Aug 15 doi: 10.1007/s00330-019-06377-4. PMID: 31418086
A systematic overview of chemotherapy effects in Hodgkin's disease.
Brandt L, Kimby E, Nygren P, Glimelius B; SBU-group. Swedish Council of Technology Assessment in Health Care
Acta Oncol 2001;40(2-3):185-97. doi: 10.1080/02841860151116240. PMID: 11441931

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