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Pain of prostate

MedGen UID:
66016
•Concept ID:
C0240812
•
Sign or Symptom
Synonyms: Prostatalgia; Prostate pain; Prostatic Pain; Prostatic pain; Prostatodynia
SNOMED CT: Pain of prostate (36729000); Prostate pain (36729000); Prostatic pain (36729000); Prostatalgia (36729000); Prostatodynia (36729000)

Definition

Pain in the prostate gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPain of prostate

Professional guidelines

PubMed

Management of chronic primary pelvic pain syndromes.
Parsons BA, Baranowski AP, Berghmans B, Borovicka J, Cottrell AM, Dinis-Oliveira P, Elneil S, Hughes J, Messelink BEJ, de C Williams AC, Abreu-Mendes P, Zumstein V, Engeler DS
BJU Int 2022 May;129(5):572-581. Epub 2021 Oct 27 doi: 10.1111/bju.15609. PMID: 34617386
Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.
Cicero AFG, Allkanjari O, Busetto GM, Cai T, Larganà G, Magri V, Perletti G, Robustelli Della Cuna FS, Russo GI, Stamatiou K, Trinchieri A, Vitalone A
Arch Ital Urol Androl 2019 Oct 2;91(3) doi: 10.4081/aiua.2019.3.139. PMID: 31577095
Acute Bacterial Prostatitis: Diagnosis and Management.
Coker TJ, Dierfeldt DM
Am Fam Physician 2016 Jan 15;93(2):114-20. PMID: 26926407

Recent clinical studies

Etiology

Multidisciplinary approach to prostatitis.
Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, Giuberti R, Granatieri CM, Latino MA, Larganà G, Leli C, Maierna G, Marchese V, Massa E, Matteelli A, Montanari E, Morgia G, Naber KG, Papadouli V, Perletti G, Rekleiti N, Russo GI, Sensini A, Stamatiou K, Trinchieri A, Wagenlehner FME
Arch Ital Urol Androl 2019 Jan 18;90(4):227-248. doi: 10.4081/aiua.2018.4.227. PMID: 30655633
Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.
Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, Harte SE, Kutch JJ, Lai HH, Martucci KT, Moldwin R, Naliboff BD, Pontari MA, Sutcliffe S, Landis JR; MAPP Research Network Study Group
Nat Rev Urol 2019 Mar;16(3):187-200. doi: 10.1038/s41585-018-0135-5. PMID: 30560936Free PMC Article
The microbiome in prostate inflammation and prostate cancer.
Porter CM, Shrestha E, Peiffer LB, Sfanos KS
Prostate Cancer Prostatic Dis 2018 Sep;21(3):345-354. Epub 2018 May 23 doi: 10.1038/s41391-018-0041-1. PMID: 29795140
Comprehensive overview of prostatitis.
Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783
Acute Bacterial Prostatitis: Diagnosis and Management.
Coker TJ, Dierfeldt DM
Am Fam Physician 2016 Jan 15;93(2):114-20. PMID: 26926407

Diagnosis

Prostatitis: A Review.
Yebes A, Toribio-Vazquez C, Martinez-Perez S, Quesada-Olarte JM, Rodriguez-Serrano A, Álvarez-Maestro M, Martinez-Piñeiro L
Curr Urol Rep 2023 May;24(5):241-251. Epub 2023 Mar 7 doi: 10.1007/s11934-023-01150-z. PMID: 36881349
Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.
Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, Harte SE, Kutch JJ, Lai HH, Martucci KT, Moldwin R, Naliboff BD, Pontari MA, Sutcliffe S, Landis JR; MAPP Research Network Study Group
Nat Rev Urol 2019 Mar;16(3):187-200. doi: 10.1038/s41585-018-0135-5. PMID: 30560936Free PMC Article
Comprehensive overview of prostatitis.
Khan FU, Ihsan AU, Khan HU, Jana R, Wazir J, Khongorzul P, Waqar M, Zhou X
Biomed Pharmacother 2017 Oct;94:1064-1076. Epub 2017 Aug 16 doi: 10.1016/j.biopha.2017.08.016. PMID: 28813783
Acute Bacterial Prostatitis: Diagnosis and Management.
Coker TJ, Dierfeldt DM
Am Fam Physician 2016 Jan 15;93(2):114-20. PMID: 26926407
Treatment of bacterial prostatitis.
Lipsky BA, Byren I, Hoey CT
Clin Infect Dis 2010 Jun 15;50(12):1641-52. doi: 10.1086/652861. PMID: 20459324

Therapy

Prostatitis: A Review.
Yebes A, Toribio-Vazquez C, Martinez-Perez S, Quesada-Olarte JM, Rodriguez-Serrano A, Álvarez-Maestro M, Martinez-Piñeiro L
Curr Urol Rep 2023 May;24(5):241-251. Epub 2023 Mar 7 doi: 10.1007/s11934-023-01150-z. PMID: 36881349
Multidisciplinary approach to prostatitis.
Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, Giuberti R, Granatieri CM, Latino MA, Larganà G, Leli C, Maierna G, Marchese V, Massa E, Matteelli A, Montanari E, Morgia G, Naber KG, Papadouli V, Perletti G, Rekleiti N, Russo GI, Sensini A, Stamatiou K, Trinchieri A, Wagenlehner FME
Arch Ital Urol Androl 2019 Jan 18;90(4):227-248. doi: 10.4081/aiua.2018.4.227. PMID: 30655633
Chronic prostatitis/chronic pelvic pain syndrome: a review of evaluation and therapy.
Polackwich AS, Shoskes DA
Prostate Cancer Prostatic Dis 2016 Jun;19(2):132-8. Epub 2016 Mar 8 doi: 10.1038/pcan.2016.8. PMID: 26951713
Acute Bacterial Prostatitis: Diagnosis and Management.
Coker TJ, Dierfeldt DM
Am Fam Physician 2016 Jan 15;93(2):114-20. PMID: 26926407
Treatment of bacterial prostatitis.
Lipsky BA, Byren I, Hoey CT
Clin Infect Dis 2010 Jun 15;50(12):1641-52. doi: 10.1086/652861. PMID: 20459324

Prognosis

Time of metastatic disease presentation and volume of disease are prognostic for metastatic hormone sensitive prostate cancer (mHSPC).
Francini E, Gray KP, Xie W, Shaw GK, Valença L, Bernard B, Albiges L, Harshman LC, Kantoff PW, Taplin ME, Sweeney CJ
Prostate 2018 Sep;78(12):889-895. Epub 2018 Apr 29 doi: 10.1002/pros.23645. PMID: 29707790Free PMC Article
The Urinary Tract Microbiome in Health and Disease.
Aragón IM, Herrera-Imbroda B, Queipo-Ortuño MI, Castillo E, Del Moral JS, Gómez-Millán J, Yucel G, Lara MF
Eur Urol Focus 2018 Jan;4(1):128-138. Epub 2016 Nov 14 doi: 10.1016/j.euf.2016.11.001. PMID: 28753805
Pharmacotherapy of prostatitis.
Snow DC, Shoskes DA
Expert Opin Pharmacother 2010 Oct;11(14):2319-30. doi: 10.1517/14656566.2010.495946. PMID: 20569089
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708
Chronic prostatitis.
Batstone GR, Doble A
Curr Opin Urol 2003 Jan;13(1):23-9. doi: 10.1097/00042307-200301000-00005. PMID: 12490812

Clinical prediction guides

Gut Microflora Modulates Th17/Treg Cell Differentiation in Experimental Autoimmune Prostatitis via the Short-Chain Fatty Acid Propionate.
Du HX, Yue SY, Niu D, Liu C, Zhang LG, Chen J, Chen Y, Guan Y, Hua XL, Li C, Chen XG, Zhang L, Liang CZ
Front Immunol 2022;13:915218. Epub 2022 Jul 4 doi: 10.3389/fimmu.2022.915218. PMID: 35860242Free PMC Article
Multidisciplinary approach to prostatitis.
Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, Giuberti R, Granatieri CM, Latino MA, Larganà G, Leli C, Maierna G, Marchese V, Massa E, Matteelli A, Montanari E, Morgia G, Naber KG, Papadouli V, Perletti G, Rekleiti N, Russo GI, Sensini A, Stamatiou K, Trinchieri A, Wagenlehner FME
Arch Ital Urol Androl 2019 Jan 18;90(4):227-248. doi: 10.4081/aiua.2018.4.227. PMID: 30655633
Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.
Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, Harte SE, Kutch JJ, Lai HH, Martucci KT, Moldwin R, Naliboff BD, Pontari MA, Sutcliffe S, Landis JR; MAPP Research Network Study Group
Nat Rev Urol 2019 Mar;16(3):187-200. doi: 10.1038/s41585-018-0135-5. PMID: 30560936Free PMC Article
Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.
Franco JV, Turk T, Jung JH, Xiao YT, Iakhno S, Garrote V, Vietto V
Cochrane Database Syst Rev 2018 May 12;5(5):CD012551. doi: 10.1002/14651858.CD012551.pub3. PMID: 29757454Free PMC Article
Chronic prostatitis.
Erickson BA, Schaeffer AJ, Van Le B
BMJ Clin Evid 2008 May 22;2008 PMID: 19450305Free PMC Article

Recent systematic reviews

Adverse Events and Androgen Receptor Signaling Inhibitors in the Treatment of Prostate Cancer: A Systematic Review and Multivariate Network Meta-analysis.
Cao B, Kim M, Reizine NM, Moreira DM
Eur Urol Oncol 2023 Jun;6(3):237-250. Epub 2023 Jan 20 doi: 10.1016/j.euo.2023.01.001. PMID: 36682938
Effectiveness of Myofascial Manual Therapies in Chronic Pelvic Pain Syndrome: A Systematic Review and Meta-Analysis.
Dal Farra F, Aquino A, Tarantino AG, Origo D
Int Urogynecol J 2022 Nov;33(11):2963-2976. Epub 2022 Apr 7 doi: 10.1007/s00192-022-05173-x. PMID: 35389057
Pelvic Floor Physical Therapy for Pelvic Floor Hypertonicity: A Systematic Review of Treatment Efficacy.
van Reijn-Baggen DA, Han-Geurts IJM, Voorham-van der Zalm PJ, Pelger RCM, Hagenaars-van Miert CHAC, Laan ETM
Sex Med Rev 2022 Apr;10(2):209-230. Epub 2021 Jun 12 doi: 10.1016/j.sxmr.2021.03.002. PMID: 34127429
PROSPECT guidelines update for evidence-based pain management after prostatectomy for cancer.
Lemoine A, Witdouck A, Beloeil H, Bonnet F; PROSPECT Working Group Of The European Society Of Regional Anaesthesia And Pain Therapy (ESRA)
Anaesth Crit Care Pain Med 2021 Aug;40(4):100922. Epub 2021 Jun 29 doi: 10.1016/j.accpm.2021.100922. PMID: 34197976
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.
Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH
BMC Public Health 2009 Mar 25;9:88. doi: 10.1186/1471-2458-9-88. PMID: 19320986Free PMC Article

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