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Lyme arthritis

MedGen UID:
66074
•Concept ID:
C0242381
•
Disease or Syndrome
Synonyms: Arthritis, Lyme; Lyme Arthritis
SNOMED CT: Arthritis in Lyme disease (33937009); Lyme arthritis (33937009)

Definition

Joint inflammation, most often affecting large joints, associated with Lyme disease, presenting months after infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLyme arthritis

Professional guidelines

PubMed

Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Diagnosis and treatment of Lyme arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2015 Jun;29(2):269-80. doi: 10.1016/j.idc.2015.02.004. PMID: 25999223Free PMC Article

Recent clinical studies

Etiology

Forty Years of Evidence on the Efficacy and Safety of Oral and Injectable Antibiotics for Treating Lyme Disease of Adults and Children: A Network Meta-Analysis.
Yang J, Wen S, Kong J, Yue P, Cao W, Xu X, Zhang Y, Chen J, Liu M, Fan Y, Luo L, Chen T, Li L, Li B, Dong Y, Luo S, Zhou G, Liu A, Bao F
Microbiol Spectr 2021 Dec 22;9(3):e0076121. Epub 2021 Nov 10 doi: 10.1128/Spectrum.00761-21. PMID: 34756070Free PMC Article
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Lyme disease.
Evans J
Curr Opin Rheumatol 2000 Jul;12(4):311-7. doi: 10.1097/00002281-200007000-00014. PMID: 10910185
Lyme disease.
Evans J
Curr Opin Rheumatol 1999 Jul;11(4):281-8. doi: 10.1097/00002281-199907000-00010. PMID: 10411382

Diagnosis

Lyme Arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2022 Sep;36(3):563-577. doi: 10.1016/j.idc.2022.03.006. PMID: 36116835Free PMC Article
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Diagnosis and treatment of Lyme arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2015 Jun;29(2):269-80. doi: 10.1016/j.idc.2015.02.004. PMID: 25999223Free PMC Article

Therapy

Lyme Arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2022 Sep;36(3):563-577. doi: 10.1016/j.idc.2022.03.006. PMID: 36116835Free PMC Article
Lyme disease: diagnosis and treatment.
Schoen RT
Curr Opin Rheumatol 2020 May;32(3):247-254. doi: 10.1097/BOR.0000000000000698. PMID: 32141956
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease.
Chomel B
Rev Sci Tech 2015 Aug;34(2):569-76. doi: 10.20506/rst.34.2.2380. PMID: 26601457
Diagnosis and treatment of Lyme arthritis.
Arvikar SL, Steere AC
Infect Dis Clin North Am 2015 Jun;29(2):269-80. doi: 10.1016/j.idc.2015.02.004. PMID: 25999223Free PMC Article

Prognosis

Trauma-related Lyme arthritis.
Roberts J 4th, Merchant E
BMJ Case Rep 2023 Jul 5;16(7) doi: 10.1136/bcr-2023-255532. PMID: 37407232Free PMC Article
Challenges in the Diagnosis and Treatment of Lyme Disease.
Schoen RT
Curr Rheumatol Rep 2020 Jan 7;22(1):3. doi: 10.1007/s11926-019-0857-2. PMID: 31912251
Clinical spectrum of Lyme disease.
Cardenas-de la Garza JA, De la Cruz-Valadez E, Ocampo-Candiani J, Welsh O
Eur J Clin Microbiol Infect Dis 2019 Feb;38(2):201-208. Epub 2018 Nov 19 doi: 10.1007/s10096-018-3417-1. PMID: 30456435
Lyme disease and the orthopaedic implications of lyme arthritis.
Smith BG, Cruz AI Jr, Milewski MD, Shapiro ED
J Am Acad Orthop Surg 2011 Feb;19(2):91-100. doi: 10.5435/00124635-201102000-00004. PMID: 21292932Free PMC Article
Lyme disease.
Evans J
Curr Opin Rheumatol 1999 Jul;11(4):281-8. doi: 10.1097/00002281-199907000-00010. PMID: 10411382

Clinical prediction guides

Forty Years of Evidence on the Efficacy and Safety of Oral and Injectable Antibiotics for Treating Lyme Disease of Adults and Children: A Network Meta-Analysis.
Yang J, Wen S, Kong J, Yue P, Cao W, Xu X, Zhang Y, Chen J, Liu M, Fan Y, Luo L, Chen T, Li L, Li B, Dong Y, Luo S, Zhou G, Liu A, Bao F
Microbiol Spectr 2021 Dec 22;9(3):e0076121. Epub 2021 Nov 10 doi: 10.1128/Spectrum.00761-21. PMID: 34756070Free PMC Article
A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis.
Brouwer MAE, van de Schoor FR, Vrijmoeth HD, Netea MG, Joosten LAB
Immunol Rev 2020 Mar;294(1):63-79. Epub 2020 Jan 13 doi: 10.1111/imr.12837. PMID: 31930745Free PMC Article
Lyme disease: a rigorous review of diagnostic criteria and treatment.
Borchers AT, Keen CL, Huntley AC, Gershwin ME
J Autoimmun 2015 Feb;57:82-115. Epub 2014 Oct 16 doi: 10.1016/j.jaut.2014.09.004. PMID: 25451629
Lyme arthritis: pathogenesis, clinical presentation, and management.
Puius YA, Kalish RA
Infect Dis Clin North Am 2008 Jun;22(2):289-300, vi-vii. doi: 10.1016/j.idc.2007.12.014. PMID: 18452802
Lyme arthritis.
Kahan A, Amor B, Menkes CJ
Biomed Pharmacother 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9. PMID: 2686765

Recent systematic reviews

Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015-2017.
Geebelen L, Van Cauteren D, Devleesschauwer B, Moreels S, Tersago K, Van Oyen H, Speybroeck N, Lernout T
Ticks Tick Borne Dis 2019 Apr;10(3):598-605. Epub 2018 Dec 28 doi: 10.1016/j.ttbdis.2018.12.007. PMID: 30772196
Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution.
Jarosz AC, Badawi A
Inflamm Res 2019 Jan;68(1):7-17. Epub 2018 Aug 18 doi: 10.1007/s00011-018-1180-5. PMID: 30121835Free PMC Article

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