U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Simple pulmonary eosinophilia

MedGen UID:
66083
•Concept ID:
C0242459
•
Disease or Syndrome
Synonyms: Loeffler Syndrome; Pulmonary Eosinophilia, Simple; Simple Pulmonary Eosinophilia; Simple Pulmonary Eosinophilias; Syndrome, Loeffler
SNOMED CT: Löffler's syndrome (64936001); PIE syndrome (64936001); Loffler's syndrome (64936001); Löffler syndrome (64936001); Simple pulmonary eosinophilia (64936001)

Definition

A transient inflammatory pulmonary disorder characterized by eosinophilia. Eosinophilic infiltration of the lungs may be secondary to parasitic infection or drug hypersensitivity. Clinical signs include dry cough, fever and dyspnea. Prognosis is favorable as the disorder follows a self-limited course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSimple pulmonary eosinophilia

Professional guidelines

PubMed

Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Chest CT Diagnosis and Clinical Management of Drug-Related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper From the Fleischner Society.
Johkoh T, Lee KS, Nishino M, Travis WD, Ryu JH, Lee HY, Ryerson CJ, Franquet T, Bankier AA, Brown KK, Goo JM, Kauczor HU, Lynch DA, Nicholson AG, Richeldi L, Schaefer-Prokop CM, Verschakelen J, Raoof S, Rubin GD, Powell C, Inoue Y, Hatabu H
Chest 2021 Mar;159(3):1107-1125. Epub 2021 Jan 12 doi: 10.1016/j.chest.2020.11.027. PMID: 33450293

Recent clinical studies

Etiology

Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Cardiopulmonary and Gastrointestinal Manifestations of Eosinophil- associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach.
Katre RS, Sunnapwar A, Restrepo CS, Katabathina VS, Mumbower A, Baxi A, Sonavane S
Radiographics 2016 Mar-Apr;36(2):433-51. doi: 10.1148/rg.2016150145. PMID: 26963455
Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients.
Kim SJ, Bista AB, Park KJ, Kang DK, Park JH, Park KJ, Sun JS
Eur J Radiol 2014 Oct;83(10):1977-82. Epub 2014 Jul 16 doi: 10.1016/j.ejrad.2014.07.004. PMID: 25082475
Pulmonary eosinophilic infiltrates.
Rossi G, Tironi A, Dore R, Nannini N, Mengoli MC, Bertolani M, Richeldi L
Pathologica 2010 Dec;102(6):537-46. PMID: 21428117
Pulmonary eosinophilia.
Campos LE, Pereira LF
J Bras Pneumol 2009 Jun;35(6):561-73. doi: 10.1590/s1806-37132009000600010. PMID: 19618037

Diagnosis

Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Chest CT Diagnosis and Clinical Management of Drug-Related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper From the Fleischner Society.
Johkoh T, Lee KS, Nishino M, Travis WD, Ryu JH, Lee HY, Ryerson CJ, Franquet T, Bankier AA, Brown KK, Goo JM, Kauczor HU, Lynch DA, Nicholson AG, Richeldi L, Schaefer-Prokop CM, Verschakelen J, Raoof S, Rubin GD, Powell C, Inoue Y, Hatabu H
Chest 2021 Mar;159(3):1107-1125. Epub 2021 Jan 12 doi: 10.1016/j.chest.2020.11.027. PMID: 33450293
Cardiopulmonary and Gastrointestinal Manifestations of Eosinophil- associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach.
Katre RS, Sunnapwar A, Restrepo CS, Katabathina VS, Mumbower A, Baxi A, Sonavane S
Radiographics 2016 Mar-Apr;36(2):433-51. doi: 10.1148/rg.2016150145. PMID: 26963455
Pulmonary eosinophilic infiltrates.
Rossi G, Tironi A, Dore R, Nannini N, Mengoli MC, Bertolani M, Richeldi L
Pathologica 2010 Dec;102(6):537-46. PMID: 21428117
Pulmonary eosinophilia.
Campos LE, Pereira LF
J Bras Pneumol 2009 Jun;35(6):561-73. doi: 10.1590/s1806-37132009000600010. PMID: 19618037

Therapy

Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Chest CT Diagnosis and Clinical Management of Drug-Related Pneumonitis in Patients Receiving Molecular Targeting Agents and Immune Checkpoint Inhibitors: A Position Paper From the Fleischner Society.
Johkoh T, Lee KS, Nishino M, Travis WD, Ryu JH, Lee HY, Ryerson CJ, Franquet T, Bankier AA, Brown KK, Goo JM, Kauczor HU, Lynch DA, Nicholson AG, Richeldi L, Schaefer-Prokop CM, Verschakelen J, Raoof S, Rubin GD, Powell C, Inoue Y, Hatabu H
Chest 2021 Mar;159(3):1107-1125. Epub 2021 Jan 12 doi: 10.1016/j.chest.2020.11.027. PMID: 33450293
Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose.
Salerno SM, Strong JS, Roth BJ, Sakata V
Am J Respir Crit Care Med 1995 Dec;152(6 Pt 1):2170-2. doi: 10.1164/ajrccm.152.6.8520792. PMID: 8520792
Loeffler's syndrome: an uncommon adverse reaction to imipramine.
Amsterdam JD
Int Clin Psychopharmacol 1986 Jul;1(3):260-2. doi: 10.1097/00004850-198607000-00009. PMID: 3559155

Prognosis

Simple pulmonary eosinophilia found on follow-up computed tomography of oncologic patients.
Kim SJ, Bista AB, Park KJ, Kang DK, Park JH, Park KJ, Sun JS
Eur J Radiol 2014 Oct;83(10):1977-82. Epub 2014 Jul 16 doi: 10.1016/j.ejrad.2014.07.004. PMID: 25082475

Clinical prediction guides

Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients.
Johkoh T, Müller NL, Akira M, Ichikado K, Suga M, Ando M, Yoshinaga T, Kiyama T, Mihara N, Honda O, Tomiyama N, Nakamura H
Radiology 2000 Sep;216(3):773-80. doi: 10.1148/radiology.216.3.r00se01773. PMID: 10966710

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...