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Measurable Residual Disease

MedGen UID:
66115
•Concept ID:
C0242596
•
Neoplastic Process
Synonyms: Minimal Disease, Residual; Minimal Residual Disease; Minimal Residual Diseases; Neoplasm, Residual; Residual Disease, Minimal; Residual Minimal Disease; Residual Minimal Diseases; Residual Neoplasm; Residual Neoplasms

Definition

Evidence for remaining tumor following primary treatment that is only apparent using highly sensitive techniques. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeasurable Residual Disease

Professional guidelines

PubMed

Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Acute myeloid leukemia: 2019 update on risk-stratification and management.
Estey EH
Am J Hematol 2018 Oct;93(10):1267-1291. doi: 10.1002/ajh.25214. PMID: 30328165

Recent clinical studies

Etiology

Acute myeloid leukaemia.
DiNardo CD, Erba HP, Freeman SD, Wei AH
Lancet 2023 Jun 17;401(10393):2073-2086. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00108-3. PMID: 37068505
Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Roadmap to cure multiple myeloma.
Rodriguez-Otero P, Paiva B, San-Miguel JF
Cancer Treat Rev 2021 Nov;100:102284. Epub 2021 Aug 31 doi: 10.1016/j.ctrv.2021.102284. PMID: 34597912
Acute myeloid leukemia: 2019 update on risk-stratification and management.
Estey EH
Am J Hematol 2018 Oct;93(10):1267-1291. doi: 10.1002/ajh.25214. PMID: 30328165

Diagnosis

Acute myeloid leukaemia.
DiNardo CD, Erba HP, Freeman SD, Wei AH
Lancet 2023 Jun 17;401(10393):2073-2086. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00108-3. PMID: 37068505
Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Roadmap to cure multiple myeloma.
Rodriguez-Otero P, Paiva B, San-Miguel JF
Cancer Treat Rev 2021 Nov;100:102284. Epub 2021 Aug 31 doi: 10.1016/j.ctrv.2021.102284. PMID: 34597912
Acute myeloid leukemia: 2019 update on risk-stratification and management.
Estey EH
Am J Hematol 2018 Oct;93(10):1267-1291. doi: 10.1002/ajh.25214. PMID: 30328165

Therapy

Acute myeloid leukaemia.
DiNardo CD, Erba HP, Freeman SD, Wei AH
Lancet 2023 Jun 17;401(10393):2073-2086. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00108-3. PMID: 37068505
Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Venetoclax Combined With FLAG-IDA Induction and Consolidation in Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia.
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Acute myeloid leukemia: 2019 update on risk-stratification and management.
Estey EH
Am J Hematol 2018 Oct;93(10):1267-1291. doi: 10.1002/ajh.25214. PMID: 30328165

Prognosis

Acute myeloid leukaemia.
DiNardo CD, Erba HP, Freeman SD, Wei AH
Lancet 2023 Jun 17;401(10393):2073-2086. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00108-3. PMID: 37068505
Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463
Venetoclax Combined With FLAG-IDA Induction and Consolidation in Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia.
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Acute myeloid leukemia: 2019 update on risk-stratification and management.
Estey EH
Am J Hematol 2018 Oct;93(10):1267-1291. doi: 10.1002/ajh.25214. PMID: 30328165

Clinical prediction guides

The present and future of measurable residual disease testing in acute myeloid leukemia.
Blachly JS, Walter RB, Hourigan CS
Haematologica 2022 Dec 1;107(12):2810-2822. doi: 10.3324/haematol.2022.282034. PMID: 36453518Free PMC Article
Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients.
Saygin C, Cannova J, Stock W, Muffly L
Haematologica 2022 Dec 1;107(12):2783-2793. doi: 10.3324/haematol.2022.280638. PMID: 36453516Free PMC Article
MRD in ALL: Optimization and Innovations.
Pierce E, Mautner B, Mort J, Blewett A, Morris A, Keng M, El Chaer F
Curr Hematol Malig Rep 2022 Aug;17(4):69-81. Epub 2022 May 26 doi: 10.1007/s11899-022-00664-6. PMID: 35616771
Measurable Residual Disease Response and Prognosis in Treatment-Naïve Acute Myeloid Leukemia With Venetoclax and Azacitidine.
Pratz KW, Jonas BA, Pullarkat V, Recher C, Schuh AC, Thirman MJ, Garcia JS, DiNardo CD, Vorobyev V, Fracchiolla NS, Yeh SP, Jang JH, Ozcan M, Yamamoto K, Illes A, Zhou Y, Dail M, Chyla B, Potluri J, Döhner H
J Clin Oncol 2022 Mar 10;40(8):855-865. Epub 2021 Dec 15 doi: 10.1200/JCO.21.01546. PMID: 34910556Free PMC Article
2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party.
Heuser M, Freeman SD, Ossenkoppele GJ, Buccisano F, Hourigan CS, Ngai LL, Tettero JM, Bachas C, Baer C, Béné MC, Bücklein V, Czyz A, Denys B, Dillon R, Feuring-Buske M, Guzman ML, Haferlach T, Han L, Herzig JK, Jorgensen JL, Kern W, Konopleva MY, Lacombe F, Libura M, Majchrzak A, Maurillo L, Ofran Y, Philippe J, Plesa A, Preudhomme C, Ravandi F, Roumier C, Subklewe M, Thol F, van de Loosdrecht AA, van der Reijden BA, Venditti A, Wierzbowska A, Valk PJM, Wood BL, Walter RB, Thiede C, Döhner K, Roboz GJ, Cloos J
Blood 2021 Dec 30;138(26):2753-2767. doi: 10.1182/blood.2021013626. PMID: 34724563Free PMC Article

Recent systematic reviews

Association of hematologic response and assay sensitivity on the prognostic impact of measurable residual disease in acute myeloid leukemia: a systematic review and meta-analysis.
Short NJ, Fu C, Berry DA, Walter RB, Freeman SD, Hourigan CS, Huang X, Gonzalez GN, Hwang H, Qi X, Kantarjian H, Zhou S, Ravandi F
Leukemia 2022 Dec;36(12):2817-2826. Epub 2022 Oct 19 doi: 10.1038/s41375-022-01692-0. PMID: 36261575
Measurable residual disease in pediatric acute myeloid leukemia: a systematic review.
Segerink WH, de Haas V, Kaspers GJL
Expert Rev Anticancer Ther 2021 Apr;21(4):451-459. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1860763. PMID: 33706635
Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy.
Dholaria B, Savani BN, Hamilton BK, Oran B, Liu HD, Tallman MS, Ciurea SO, Holtzman NG, Ii GLP, Devine SM, Mannis G, Grunwald MR, Appelbaum F, Rodriguez C, El Chaer F, Shah N, Hashmi SK, Kharfan-Dabaja MA, DeFilipp Z, Aljurf M, AlShaibani A, Inamoto Y, Jain T, Majhail N, Perales MA, Mohty M, Hamadani M, Carpenter PA, Nagler A
Transplant Cell Ther 2021 Jan;27(1):6-20. Epub 2020 Sep 20 doi: 10.1016/j.bbmt.2020.09.020. PMID: 32966881
Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.
Short NJ, Zhou S, Fu C, Berry DA, Walter RB, Freeman SD, Hourigan CS, Huang X, Nogueras Gonzalez G, Hwang H, Qi X, Kantarjian H, Ravandi F
JAMA Oncol 2020 Dec 1;6(12):1890-1899. doi: 10.1001/jamaoncol.2020.4600. PMID: 33030517Free PMC Article
A systematic literature review and meta-analysis of minimal residual disease as a prognostic indicator in adult B-cell acute lymphoblastic leukemia.
Bassan R, Brüggemann M, Radcliffe HS, Hartfield E, Kreuzbauer G, Wetten S
Haematologica 2019 Oct;104(10):2028-2039. Epub 2019 Mar 19 doi: 10.3324/haematol.2018.201053. PMID: 30890593Free PMC Article

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