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Abnormal vaginal bleeding

MedGen UID:
661931
Concept ID:
C0578503
Finding
SNOMED CT: Abnormal vaginal bleeding (301822002)
 
HPO: HP:0034263

Definition

Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal. [from HPO]

Professional guidelines

PubMed

Wang X, Yang J, Wan X, Feng F, Zhao J, Ren T, Xiang Y
Orphanet J Rare Dis 2021 Nov 18;16(1):480. doi: 10.1186/s13023-021-02111-w. PMID: 34794477Free PMC Article
Szpera-Goździewicz A, Gruca-Stryjak K, Bręborowicz GH, Ropacka-Lesiak M
Ginekol Pol 2018;89(5):276-279. doi: 10.5603/GP.a2018.0047. PMID: 30084480
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Recent clinical studies

Etiology

Dash SS, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, Deodhar KK
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):148-151. doi: 10.4103/ijpm.ijpm_212_22. PMID: 36656227
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Emmanuel I, Ochigbo A, Philip A, Nyam EY
West Afr J Med 2019 Jan-Apr;36(1):88-92. PMID: 30924123
Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T
Ultrasound Obstet Gynecol 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. PMID: 28944985
Ip PP, Irving JA, McCluggage WG, Clement PB, Young RH
Am J Surg Pathol 2013 Feb;37(2):167-77. doi: 10.1097/PAS.0b013e318272d428. PMID: 23211295

Diagnosis

Emmanuel I, Ochigbo A, Philip A, Nyam EY
West Afr J Med 2019 Jan-Apr;36(1):88-92. PMID: 30924123
Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T
Ultrasound Obstet Gynecol 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. PMID: 28944985
Caserta MP, Bolan C, Clingan MJ
Abdom Radiol (NY) 2016 Dec;41(12):2312-2329. doi: 10.1007/s00261-016-0930-5. PMID: 27734113
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Deligeoroglou E, Creatsas G
Endocr Dev 2012;22:160-170. Epub 2012 Jul 25 doi: 10.1159/000331697. PMID: 22846527

Therapy

Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Yuan Z, Cao D, Yang J, Keng S, Huang H
Int J Gynecol Cancer 2017 Sep;27(7):1489-1493. doi: 10.1097/IGC.0000000000001020. PMID: 30814243
Capuano A, Scavone C, Vitale C, Sportiello L, Rossi F, Rosano GM, Coats AJ
Int J Cardiol 2015 Dec 1;200:15-9. doi: 10.1016/j.ijcard.2015.07.038. PMID: 26404747
Saha PK, Rakshit BM, Jana N, Dutta S, Roy SB, Sengupta G
J Indian Med Assoc 2011 Dec;109(12):908-11. PMID: 23469574
Miller C, Murtagh J
Aust Fam Physician 1992 Dec;21(12):1787-8. PMID: 1476509

Prognosis

Yuan Z, Cao D, Yang J, Keng S, Huang H
Int J Gynecol Cancer 2017 Sep;27(7):1489-1493. doi: 10.1097/IGC.0000000000001020. PMID: 30814243
Motilal Nehru V, Garcia G, Ding J, Kong F, Dai Q
Am J Case Rep 2017 Jan 6;18:22-25. doi: 10.12659/ajcr.900088. PMID: 28057913Free PMC Article
Kärrberg C, Rådberg T, Holmberg E, Norström A
Acta Obstet Gynecol Scand 2015 Jun;94(6):654-9. Epub 2015 Apr 29 doi: 10.1111/aogs.12645. PMID: 25845736
McCann MF, Potter LS
Contraception 1994 Dec;50(6 Suppl 1):S1-195. PMID: 10226677
Huntsman DG, Clement PB, Gilks CB, Scully RE
Am J Surg Pathol 1994 Apr;18(4):364-75. doi: 10.1097/00000478-199404000-00005. PMID: 7511354

Clinical prediction guides

Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Epstein E, Fischerova D, Valentin L, Testa AC, Franchi D, Sladkevicius P, Frühauf F, Lindqvist PG, Mascilini F, Fruscio R, Haak LA, Opolskiene G, Pascual MA, Alcazar JL, Chiappa V, Guerriero S, Carlson JW, Van Holsbeke C, Leone FPG, De Moor B, Bourne T, van Calster B, Installe A, Timmerman D, Verbakel JY, Van den Bosch T
Ultrasound Obstet Gynecol 2018 Jun;51(6):818-828. doi: 10.1002/uog.18909. PMID: 28944985
Vaezi A, Haghighi L, Beigmohammadi F, Nojomi M
Iran J Allergy Asthma Immunol 2017 Apr;16(2):92-98. PMID: 28601048
Saha PK, Rakshit BM, Jana N, Dutta S, Roy SB, Sengupta G
J Indian Med Assoc 2011 Dec;109(12):908-11. PMID: 23469574
McCann MF, Potter LS
Contraception 1994 Dec;50(6 Suppl 1):S1-195. PMID: 10226677

Recent systematic reviews

Genovese F, Schiattarella A, D'Urso G, Vitale SG, Carugno J, Verzì G, D'Urso V, Iacono E, Siringo S, Leanza V, Palumbo M
Gynecol Obstet Invest 2023;88(2):81-90. Epub 2023 Feb 1 doi: 10.1159/000528144. PMID: 36724750
Romero SA, Young K, Hickey M, Su HI
Cochrane Database Syst Rev 2020 Dec 21;12(12):CD007245. doi: 10.1002/14651858.CD007245.pub4. PMID: 33348436Free PMC Article
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Cheewakriangkrai C, Kietpeerakool C, Charoenkwan K, Pattanittum P, John D, Aue-Aungkul A, Lumbiganon P
Cochrane Database Syst Rev 2020 Mar 13;3(3):CD013253. doi: 10.1002/14651858.CD013253.pub2. PMID: 32168393Free PMC Article
Lu T, Qi L, Ma Y, Lu G, Zhang X, Liu P
Arch Gynecol Obstet 2019 Nov;300(5):1177-1187. Epub 2019 Sep 23 doi: 10.1007/s00404-019-05309-3. PMID: 31549219

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