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Hantavirus pulmonary syndrome(HARDS)

MedGen UID:
66205
•Concept ID:
C0243025
•
Disease or Syndrome
Synonyms: Four corners hantavirus; Hantavirus-associated respiratory distress syndrome; HARDS
SNOMED CT: Hantavirus pulmonary syndrome (120639003)
 
Monarch Initiative: MONDO:0017879
Orphanet: ORPHA319247

Definition

A rare viral hemorrhagic fever characterized by virus-induced microvascular leakage rapidly leading to a severe illness with diffuse pulmonary edema and respiratory failure. These symptoms set in after a short first disease stage with fever, myalgia, and headache, followed by severe gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea. The high lethality of the disease is due to the possible development of hypotension and cardiogenic shock. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHantavirus pulmonary syndrome
Follow this link to review classifications for Hantavirus pulmonary syndrome in Orphanet.

Professional guidelines

PubMed

Progress on the Prevention and Treatment of Hantavirus Disease.
Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Hantavirus infections for the clinician: from case presentation to diagnosis and treatment.
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984
Treatment of hantavirus pulmonary syndrome.
Jonsson CB, Hooper J, Mertz G
Antiviral Res 2008 Apr;78(1):162-9. Epub 2007 Nov 21 doi: 10.1016/j.antiviral.2007.10.012. PMID: 18093668Free PMC Article

Recent clinical studies

Etiology

Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Modeling of hantavirus cardiopulmonary syndrome.
Gutiérrez Jara JP, Muñoz Quezada MT
Medwave 2022 Apr 26;22(3):e8722. doi: 10.5867/medwave.2022.03.002526. PMID: 35507807
Development of RT-qPCR and semi-nested RT-PCR assays for molecular diagnosis of hantavirus pulmonary syndrome.
Nunes BTD, de Mendonça MHR, Simith DB, Moraes AF, Cardoso CC, Prazeres ITE, de Aquino AA, Santos ADCM, Queiroz ALN, Rodrigues DSG, Andriolo RB, Travassos da Rosa ES, Martins LC, Vasconcelos PFDC, Medeiros DBA
PLoS Negl Trop Dis 2019 Dec;13(12):e0007884. Epub 2019 Dec 26 doi: 10.1371/journal.pntd.0007884. PMID: 31877142Free PMC Article
Hantavirus infections.
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Hantavirus.
Hawes S, Seabolt JP
Clin Lab Sci 2003 Winter;16(1):39-42. PMID: 12587657

Diagnosis

Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Hantavirus.
Riquelme R
Semin Respir Crit Care Med 2021 Dec;42(6):822-827. Epub 2021 Dec 16 doi: 10.1055/s-0041-1733803. PMID: 34918323
Development of RT-qPCR and semi-nested RT-PCR assays for molecular diagnosis of hantavirus pulmonary syndrome.
Nunes BTD, de Mendonça MHR, Simith DB, Moraes AF, Cardoso CC, Prazeres ITE, de Aquino AA, Santos ADCM, Queiroz ALN, Rodrigues DSG, Andriolo RB, Travassos da Rosa ES, Martins LC, Vasconcelos PFDC, Medeiros DBA
PLoS Negl Trop Dis 2019 Dec;13(12):e0007884. Epub 2019 Dec 26 doi: 10.1371/journal.pntd.0007884. PMID: 31877142Free PMC Article
Hantavirus infections.
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Hantavirus pulmonary syndrome.
Simpson SQ, Spikes L, Patel S, Faruqi I
Infect Dis Clin North Am 2010 Mar;24(1):159-73. doi: 10.1016/j.idc.2009.10.011. PMID: 20171551

Therapy

Progress on the Prevention and Treatment of Hantavirus Disease.
Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Hantavirus pulmonary syndrome.
Macneil A, Nichol ST, Spiropoulou CF
Virus Res 2011 Dec;162(1-2):138-47. Epub 2011 Sep 17 doi: 10.1016/j.virusres.2011.09.017. PMID: 21945215
Vaccines for hantaviruses.
Schmaljohn C
Vaccine 2009 Nov 5;27 Suppl 4:D61-4. doi: 10.1016/j.vaccine.2009.07.096. PMID: 19837289
Hantavirus infection in children.
Ferrés M, Vial P
Curr Opin Pediatr 2004 Feb;16(1):70-5. doi: 10.1097/00008480-200402000-00013. PMID: 14758117
Hantavirus pulmonary syndrome.
Levy H, Simpson SQ
Am J Respir Crit Care Med 1994 Jun;149(6):1710-3. doi: 10.1164/ajrccm.149.6.8004332. PMID: 8004332

Prognosis

Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Hantavirus pulmonary syndrome.
Schussler JM, Jordan H, Stokoe C, Feliciano N, Sutker W, Orr D
South Med J 1999 Feb;92(2):233-5. doi: 10.1097/00007611-199902000-00015. PMID: 10071675
Hantavirus pulmonary syndrome.
Levy H, Simpson SQ
Am J Respir Crit Care Med 1994 Jun;149(6):1710-3. doi: 10.1164/ajrccm.149.6.8004332. PMID: 8004332
Hantavirus pulmonary syndrome.
Farr RW
W V Med J 1994 Oct;90(10):422-5. PMID: 7801629

Clinical prediction guides

Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
The Syrian hamster model of hantavirus pulmonary syndrome.
Safronetz D, Ebihara H, Feldmann H, Hooper JW
Antiviral Res 2012 Sep;95(3):282-92. Epub 2012 Jun 15 doi: 10.1016/j.antiviral.2012.06.002. PMID: 22705798Free PMC Article
Hantavirus infections for the clinician: from case presentation to diagnosis and treatment.
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984
T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome.
Terajima M, Ennis FA
Viruses 2011 Jul;3(7):1059-73. Epub 2011 Jul 6 doi: 10.3390/v3071059. PMID: 21994770Free PMC Article
Hantavirus infections.
Escutenaire S, Pastoret PP
Rev Sci Tech 2000 Apr;19(1):64-78. doi: 10.20506/rst.19.1.1209. PMID: 11189727

Recent systematic reviews

Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review.
Toledo J, Haby MM, Reveiz L, Sosa Leon L, Angerami R, Aldighieri S
J Infect Dis 2022 Oct 17;226(8):1362-1371. doi: 10.1093/infdis/jiab461. PMID: 34515290Free PMC Article
Current Situation and Perspectives on Hantaviruses in Mexico.
Vigueras-Galván AL, López-Pérez AM, García-Peña GE, Rico-Chávez O, Sarmiento-Silva RE, Suzán G
Viruses 2019 Jul 12;11(7) doi: 10.3390/v11070642. PMID: 31336858Free PMC Article

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