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Hantavirus pulmonary syndrome(HARDS)

MedGen UID:
66205
Concept ID:
C0243025
Disease or Syndrome
Synonyms: Four corners hantavirus; Hantavirus-associated respiratory distress syndrome; HARDS
SNOMED CT: Hantavirus pulmonary syndrome (120639003)
 
Monarch Initiative: MONDO:0017879
Orphanet: ORPHA319247

Definition

A rare viral hemorrhagic fever characterized by virus-induced microvascular leakage rapidly leading to a severe illness with diffuse pulmonary edema and respiratory failure. These symptoms set in after a short first disease stage with fever, myalgia, and headache, followed by severe gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea. The high lethality of the disease is due to the possible development of hypotension and cardiogenic shock. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHantavirus pulmonary syndrome
Follow this link to review classifications for Hantavirus pulmonary syndrome in Orphanet.

Professional guidelines

PubMed

Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984
Jonsson CB, Hooper J, Mertz G
Antiviral Res 2008 Apr;78(1):162-9. Epub 2007 Nov 21 doi: 10.1016/j.antiviral.2007.10.012. PMID: 18093668Free PMC Article

Recent clinical studies

Etiology

Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Gutiérrez Jara JP, Muñoz Quezada MT
Medwave 2022 Apr 26;22(3):e8722. doi: 10.5867/medwave.2022.03.002526. PMID: 35507807
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Hawes S, Seabolt JP
Clin Lab Sci 2003 Winter;16(1):39-42. PMID: 12587657

Diagnosis

Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Riquelme R
Semin Respir Crit Care Med 2021 Dec;42(6):822-827. Epub 2021 Dec 16 doi: 10.1055/s-0041-1733803. PMID: 34918323
Avšič-Županc T, Saksida A, Korva M
Clin Microbiol Infect 2019 Apr;21S:e6-e16. Epub 2015 Jun 22 doi: 10.1111/1469-0691.12291. PMID: 24750436
Simpson SQ, Spikes L, Patel S, Faruqi I
Infect Dis Clin North Am 2010 Mar;24(1):159-73. doi: 10.1016/j.idc.2009.10.011. PMID: 20171551

Therapy

Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Macneil A, Nichol ST, Spiropoulou CF
Virus Res 2011 Dec;162(1-2):138-47. Epub 2011 Sep 17 doi: 10.1016/j.virusres.2011.09.017. PMID: 21945215
Schmaljohn C
Vaccine 2009 Nov 5;27 Suppl 4:D61-4. doi: 10.1016/j.vaccine.2009.07.096. PMID: 19837289
Jonsson CB, Hooper J, Mertz G
Antiviral Res 2008 Apr;78(1):162-9. Epub 2007 Nov 21 doi: 10.1016/j.antiviral.2007.10.012. PMID: 18093668Free PMC Article
Ferrés M, Vial P
Curr Opin Pediatr 2004 Feb;16(1):70-5. doi: 10.1097/00008480-200402000-00013. PMID: 14758117

Prognosis

Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Llah ST, Mir S, Sharif S, Khan S, Mir MA
J Med Virol 2018 Jun;90(6):1003-1009. Epub 2018 Mar 15 doi: 10.1002/jmv.25054. PMID: 29446472
Figueiredo LT, Souza WM, Ferrés M, Enria DA
Virus Res 2014 Jul 17;187:43-54. Epub 2014 Feb 5 doi: 10.1016/j.virusres.2014.01.015. PMID: 24508343
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984

Clinical prediction guides

Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Riquelme R, Rioseco ML, Bastidas L, Trincado D, Riquelme M, Loyola H, Valdivieso F
Emerg Infect Dis 2015 Apr;21(4):562-8. doi: 10.3201/eid2104.141437. PMID: 25816116Free PMC Article
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984
Terajima M, Ennis FA
Viruses 2011 Jul;3(7):1059-73. Epub 2011 Jul 6 doi: 10.3390/v3071059. PMID: 21994770Free PMC Article
Escutenaire S, Pastoret PP
Rev Sci Tech 2000 Apr;19(1):64-78. doi: 10.20506/rst.19.1.1209. PMID: 11189727

Recent systematic reviews

Toledo J, Haby MM, Reveiz L, Sosa Leon L, Angerami R, Aldighieri S
J Infect Dis 2022 Oct 17;226(8):1362-1371. doi: 10.1093/infdis/jiab461. PMID: 34515290Free PMC Article
Vigueras-Galván AL, López-Pérez AM, García-Peña GE, Rico-Chávez O, Sarmiento-Silva RE, Suzán G
Viruses 2019 Jul 12;11(7) doi: 10.3390/v11070642. PMID: 31336858Free PMC Article

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