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Neurological symptom

MedGen UID:
66714
•Concept ID:
C0235031
•
Sign or Symptom
Synonyms: Neurologic Symptom; Neurologic Symptoms; Symptom, Neurologic; Symptoms, Neurologic
SNOMED CT: Neurological symptom (308921004); Symptom of nervous system (308921004)

Definition

A term that refers to the clinical manifestations resulting from pathologic processes that affect the central and peripheral nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurological symptom

Professional guidelines

PubMed

Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Consensus clinical management guidelines for Niemann-Pick disease type C.
Geberhiwot T, Moro A, Dardis A, Ramaswami U, Sirrs S, Marfa MP, Vanier MT, Walterfang M, Bolton S, Dawson C, Héron B, Stampfer M, Imrie J, Hendriksz C, Gissen P, Crushell E, Coll MJ, Nadjar Y, Klünemann H, Mengel E, Hrebicek M, Jones SA, Ory D, Bembi B, Patterson M; International Niemann-Pick Disease Registry (INPDR)
Orphanet J Rare Dis 2018 Apr 6;13(1):50. doi: 10.1186/s13023-018-0785-7. PMID: 29625568Free PMC Article
Conversion Disorder, Functional Neurological Symptom Disorder, and Chronic Pain: Comorbidity, Assessment, and Treatment.
Tsui P, Deptula A, Yuan DY
Curr Pain Headache Rep 2017 Jun;21(6):29. doi: 10.1007/s11916-017-0627-7. PMID: 28434123

Recent clinical studies

Etiology

Functional Neurological Symptom Disorder in Williams Syndrome: Case Series and Review of Relevant Literature.
Thom RP, Balaj K, Keary CJ, Pober BR, McDougle CJ
J Acad Consult Liaison Psychiatry 2022 Mar-Apr;63(2):170-179. Epub 2021 Oct 5 doi: 10.1016/j.jaclp.2021.09.007. PMID: 34619410
Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study.
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19.
Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT
Brain 2021 May 7;144(4):1263-1276. doi: 10.1093/brain/awab009. PMID: 33822001Free PMC Article
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
A review of functional neurological symptom disorder etiology and the integrated etiological summary model.
Fobian AD, Elliott L
J Psychiatry Neurosci 2019 Jan 1;44(1):8-18. doi: 10.1503/jpn.170190. PMID: 30565902Free PMC Article

Diagnosis

Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19.
Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT
Brain 2021 May 7;144(4):1263-1276. doi: 10.1093/brain/awab009. PMID: 33822001Free PMC Article
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Conversion, Factitious Disorder and Malingering: A Distinct Pattern or a Continuum?
Galli S, Tatu L, Bogousslavsky J, Aybek S
Front Neurol Neurosci 2018;42:72-80. Epub 2017 Nov 17 doi: 10.1159/000475699. PMID: 29151092
Conversion Disorder, Functional Neurological Symptom Disorder, and Chronic Pain: Comorbidity, Assessment, and Treatment.
Tsui P, Deptula A, Yuan DY
Curr Pain Headache Rep 2017 Jun;21(6):29. doi: 10.1007/s11916-017-0627-7. PMID: 28434123
Dissociative disorders in DSM-5.
Spiegel D, Lewis-Fernández R, Lanius R, Vermetten E, Simeon D, Friedman M
Annu Rev Clin Psychol 2013;9:299-326. Epub 2013 Feb 1 doi: 10.1146/annurev-clinpsy-050212-185531. PMID: 23394228

Therapy

Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study.
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Collantes MEV, Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG
Can J Neurol Sci 2021 Jan;48(1):66-76. Epub 2020 Jul 15 doi: 10.1017/cjn.2020.146. PMID: 32665054Free PMC Article
Spectrum of Neurological Manifestations in Covid-19: A Review.
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article

Prognosis

Functional Neurological Symptom Disorder in Williams Syndrome: Case Series and Review of Relevant Literature.
Thom RP, Balaj K, Keary CJ, Pober BR, McDougle CJ
J Acad Consult Liaison Psychiatry 2022 Mar-Apr;63(2):170-179. Epub 2021 Oct 5 doi: 10.1016/j.jaclp.2021.09.007. PMID: 34619410
Management of breast cancer brain metastases.
Takahashi H, Isogawa M
Chin Clin Oncol 2018 Jun;7(3):30. doi: 10.21037/cco.2018.05.06. PMID: 30056732
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Consensus clinical management guidelines for Niemann-Pick disease type C.
Geberhiwot T, Moro A, Dardis A, Ramaswami U, Sirrs S, Marfa MP, Vanier MT, Walterfang M, Bolton S, Dawson C, Héron B, Stampfer M, Imrie J, Hendriksz C, Gissen P, Crushell E, Coll MJ, Nadjar Y, Klünemann H, Mengel E, Hrebicek M, Jones SA, Ory D, Bembi B, Patterson M; International Niemann-Pick Disease Registry (INPDR)
Orphanet J Rare Dis 2018 Apr 6;13(1):50. doi: 10.1186/s13023-018-0785-7. PMID: 29625568Free PMC Article
Sturge-Weber syndrome.
Nabbout R, Juhász C
Handb Clin Neurol 2013;111:315-21. doi: 10.1016/B978-0-444-52891-9.00037-3. PMID: 23622182

Clinical prediction guides

Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19.
Hosp JA, Dressing A, Blazhenets G, Bormann T, Rau A, Schwabenland M, Thurow J, Wagner D, Waller C, Niesen WD, Frings L, Urbach H, Prinz M, Weiller C, Schroeter N, Meyer PT
Brain 2021 May 7;144(4):1263-1276. doi: 10.1093/brain/awab009. PMID: 33822001Free PMC Article
Spectrum of Neurological Manifestations in Covid-19: A Review.
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study.
El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA
Endocr Metab Immune Disord Drug Targets 2020;20(9):1531-1534. doi: 10.2174/1871530320666200506081407. PMID: 32370731
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders.
Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, Hallett M, LaFaver K, LaFrance WC Jr, Lang AE, Nicholson T, Nielsen G, Reuber M, Voon V, Stone J, Morgante F
JAMA Neurol 2018 Sep 1;75(9):1132-1141. doi: 10.1001/jamaneurol.2018.1264. PMID: 29868890Free PMC Article
Consensus clinical management guidelines for Niemann-Pick disease type C.
Geberhiwot T, Moro A, Dardis A, Ramaswami U, Sirrs S, Marfa MP, Vanier MT, Walterfang M, Bolton S, Dawson C, Héron B, Stampfer M, Imrie J, Hendriksz C, Gissen P, Crushell E, Coll MJ, Nadjar Y, Klünemann H, Mengel E, Hrebicek M, Jones SA, Ory D, Bembi B, Patterson M; International Niemann-Pick Disease Registry (INPDR)
Orphanet J Rare Dis 2018 Apr 6;13(1):50. doi: 10.1186/s13023-018-0785-7. PMID: 29625568Free PMC Article

Recent systematic reviews

Surgical treatment of type A acute aortic dissection with cerebral malperfusion: a systematic review.
Wang C, Zhang L, Li T, Xi Z, Wu H, Li D
J Cardiothorac Surg 2022 Jun 3;17(1):140. doi: 10.1186/s13019-022-01894-8. PMID: 35659278Free PMC Article
Structural neuroimaging of somatoform disorders: A systematic review.
Rossetti MG, Delvecchio G, Calati R, Perlini C, Bellani M, Brambilla P
Neurosci Biobehav Rev 2021 Mar;122:66-78. Epub 2020 Dec 20 doi: 10.1016/j.neubiorev.2020.12.017. PMID: 33359097
Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis.
Collantes MEV, Espiritu AI, Sy MCC, Anlacan VMM, Jamora RDG
Can J Neurol Sci 2021 Jan;48(1):66-76. Epub 2020 Jul 15 doi: 10.1017/cjn.2020.146. PMID: 32665054Free PMC Article
Risk factors for the onset and progression of Huntington disease.
Chao TK, Hu J, Pringsheim T
Neurotoxicology 2017 Jul;61:79-99. Epub 2017 Jan 20 doi: 10.1016/j.neuro.2017.01.005. PMID: 28111121
'Non-neuronopathic' Gaucher disease reconsidered. Prevalence of neurological manifestations in a Dutch cohort of type I Gaucher disease patients and a systematic review of the literature.
Biegstraaten M, van Schaik IN, Aerts JM, Hollak CE
J Inherit Metab Dis 2008 Jun;31(3):337-49. Epub 2008 Apr 4 doi: 10.1007/s10545-008-0832-y. PMID: 18404411

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