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Granuloma, Respiratory Tract

MedGen UID:
6675
•Concept ID:
C0018200
•
Disease or Syndrome
Synonyms: Granuloma, Respiratory System; Respiratory System Granuloma; Respiratory System Granulomas; Respiratory Tract Granuloma; Respiratory Tract Granulomas

Definition

Granulomatous disorders affecting one or more sites in the respiratory tract. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranuloma, Respiratory Tract

Professional guidelines

PubMed

Diagnosis and Treatment of Benign Pediatric Lesions.
Hron TA, Kavanagh KR, Murray N
Otolaryngol Clin North Am 2019 Aug;52(4):657-668. Epub 2019 May 11 doi: 10.1016/j.otc.2019.03.010. PMID: 31088693
Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis.
Rimoli CF, Martins RHG, Catâneo DC, Imamura R, Catâneo AJM
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):781-789. Epub 2018 Apr 14 doi: 10.1016/j.bjorl.2018.03.003. PMID: 29699879Free PMC Article
Update upon efficacy and safety of etanercept for the treatment of spondyloarthritis and juvenile idiopathic arthritis.
Murdaca G, Negrini S, Magnani O, Penza E, Pellecchio M, Gulli R, Mandich P, Puppo F
Mod Rheumatol 2018 May;28(3):417-431. Epub 2017 Aug 24 doi: 10.1080/14397595.2017.1366006. PMID: 28837372

Recent clinical studies

Etiology

The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.
Lin PL, Flynn JL
J Immunol 2018 Nov 1;201(9):2541-2548. doi: 10.4049/jimmunol.1800993. PMID: 30348659Free PMC Article
A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.
Crouser ED, White P, Caceres EG, Julian MW, Papp AC, Locke LW, Sadee W, Schlesinger LS
Am J Respir Cell Mol Biol 2017 Oct;57(4):487-498. doi: 10.1165/rcmb.2016-0321OC. PMID: 28598206Free PMC Article
Lung transplantation in sarcoidosis.
Shah L
Semin Respir Crit Care Med 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339. PMID: 17330198
Epidemiology of sarcoidosis: recent advances and future prospects.
Rybicki BA, Iannuzzi MC
Semin Respir Crit Care Med 2007 Feb;28(1):22-35. doi: 10.1055/s-2007-970331. PMID: 17330190
Genetics of sarcoidosis.
Iannuzzi MC
Semin Respir Crit Care Med 2007 Feb;28(1):15-21. doi: 10.1055/s-2007-970330. PMID: 17330189

Diagnosis

Pulmonary Hyalinizing Granuloma.
Karakurt G, Duger M
Arch Bronconeumol 2022 Dec;58(12):821-822. Epub 2022 Jul 21 doi: 10.1016/j.arbres.2022.07.009. PMID: 35914957
Stimulants and the lung : review of literature.
Tseng W, Sutter ME, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):82-100. doi: 10.1007/s12016-013-8376-9. PMID: 23760760
Pulmonary affectation of vasculitis.
Martín-Suñé N, Ríos-Blanco JJ
Arch Bronconeumol 2012 Nov;48(11):410-8. Epub 2012 Jun 6 doi: 10.1016/j.arbres.2012.04.007. PMID: 22682604
Pulmonary sarcoidosis.
Lynch JP 3rd, Ma YL, Koss MN, White ES
Semin Respir Crit Care Med 2007 Feb;28(1):53-74. doi: 10.1055/s-2007-970333. PMID: 17330192
Pathology of sarcoidosis.
Rosen Y
Semin Respir Crit Care Med 2007 Feb;28(1):36-52. doi: 10.1055/s-2007-970332. PMID: 17330191

Therapy

Stimulants and the lung : review of literature.
Tseng W, Sutter ME, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):82-100. doi: 10.1007/s12016-013-8376-9. PMID: 23760760
Common variable immunodeficiency-associated granulomatous and interstitial lung disease.
Prasse A, Kayser G, Warnatz K
Curr Opin Pulm Med 2013 Sep;19(5):503-9. doi: 10.1097/MCP.0b013e3283642c47. PMID: 23880700
Pulmonary affectation of vasculitis.
Martín-Suñé N, Ríos-Blanco JJ
Arch Bronconeumol 2012 Nov;48(11):410-8. Epub 2012 Jun 6 doi: 10.1016/j.arbres.2012.04.007. PMID: 22682604
Pulmonary sarcoidosis.
Lynch JP 3rd, Ma YL, Koss MN, White ES
Semin Respir Crit Care Med 2007 Feb;28(1):53-74. doi: 10.1055/s-2007-970333. PMID: 17330192
Chronic hypersensitivity pneumonitis.
Churg A, Muller NL, Flint J, Wright JL
Am J Surg Pathol 2006 Feb;30(2):201-8. doi: 10.1097/01.pas.0000184806.38037.3c. PMID: 16434894

Prognosis

Current Sarcoidosis Models and the Importance of Focusing on the Granuloma.
Locke LW, Schlesinger LS, Crouser ED
Front Immunol 2020;11:1719. Epub 2020 Aug 4 doi: 10.3389/fimmu.2020.01719. PMID: 32849608Free PMC Article
Common variable immunodeficiency-associated granulomatous and interstitial lung disease.
Prasse A, Kayser G, Warnatz K
Curr Opin Pulm Med 2013 Sep;19(5):503-9. doi: 10.1097/MCP.0b013e3283642c47. PMID: 23880700
Pulmonary affectation of vasculitis.
Martín-Suñé N, Ríos-Blanco JJ
Arch Bronconeumol 2012 Nov;48(11):410-8. Epub 2012 Jun 6 doi: 10.1016/j.arbres.2012.04.007. PMID: 22682604
Lung transplantation in sarcoidosis.
Shah L
Semin Respir Crit Care Med 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339. PMID: 17330198
Pulmonary sarcoidosis.
Lynch JP 3rd, Ma YL, Koss MN, White ES
Semin Respir Crit Care Med 2007 Feb;28(1):53-74. doi: 10.1055/s-2007-970333. PMID: 17330192

Clinical prediction guides

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.
Wessler T, Joslyn LR, Borish HJ, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ
PLoS Comput Biol 2020 May;16(5):e1007280. Epub 2020 May 20 doi: 10.1371/journal.pcbi.1007280. PMID: 32433646Free PMC Article
Immunological roulette: Luck or something more? Considering the connections between host and environment in TB.
Pearl JE, Das M, Cooper AM
Cell Mol Immunol 2018 Mar;15(3):226-232. Epub 2018 Jan 29 doi: 10.1038/cmi.2017.145. PMID: 29375129Free PMC Article
Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza.
Ohshimo S, Guzman J, Costabel U, Bonella F
Eur Respir Rev 2017 Sep 30;26(145) Epub 2017 Aug 9 doi: 10.1183/16000617.0012-2017. PMID: 28794143Free PMC Article
Clinical and pathological features of adult pulmonary tuberculosis with reversed halo sign.
Zhan X, Wang Z, Zhang L, Jin ML, Liu M, Chen WH, Dai HP
Int J Tuberc Lung Dis 2013 Dec;17(12):1621-5. doi: 10.5588/ijtld.13.0300. PMID: 24200279
Lung transplantation in sarcoidosis.
Shah L
Semin Respir Crit Care Med 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339. PMID: 17330198

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