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Granuloma, Respiratory Tract

MedGen UID:
6675
•Concept ID:
C0018200
•
Disease or Syndrome
Synonyms: Granuloma, Respiratory System; Respiratory System Granuloma; Respiratory System Granulomas; Respiratory Tract Granuloma; Respiratory Tract Granulomas

Definition

Granulomatous disorders affecting one or more sites in the respiratory tract. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranuloma, Respiratory Tract

Professional guidelines

PubMed

Diagnosis and Treatment of Benign Pediatric Lesions.
Hron TA, Kavanagh KR, Murray N
Otolaryngol Clin North Am 2019 Aug;52(4):657-668. Epub 2019 May 11 doi: 10.1016/j.otc.2019.03.010. PMID: 31088693
Update upon efficacy and safety of etanercept for the treatment of spondyloarthritis and juvenile idiopathic arthritis.
Murdaca G, Negrini S, Magnani O, Penza E, Pellecchio M, Gulli R, Mandich P, Puppo F
Mod Rheumatol 2018 May;28(3):417-431. Epub 2017 Aug 24 doi: 10.1080/14397595.2017.1366006. PMID: 28837372
Wegener's granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease.
Tarabishy AB, Schulte M, Papaliodis GN, Hoffman GS
Surv Ophthalmol 2010 Sep-Oct;55(5):429-44. Epub 2010 Jul 17 doi: 10.1016/j.survophthal.2009.12.003. PMID: 20638092

Recent clinical studies

Etiology

The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.
Lin PL, Flynn JL
J Immunol 2018 Nov 1;201(9):2541-2548. doi: 10.4049/jimmunol.1800993. PMID: 30348659Free PMC Article
A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.
Crouser ED, White P, Caceres EG, Julian MW, Papp AC, Locke LW, Sadee W, Schlesinger LS
Am J Respir Cell Mol Biol 2017 Oct;57(4):487-498. doi: 10.1165/rcmb.2016-0321OC. PMID: 28598206Free PMC Article
Lung transplantation in sarcoidosis.
Shah L
Semin Respir Crit Care Med 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339. PMID: 17330198
Epidemiology of sarcoidosis: recent advances and future prospects.
Rybicki BA, Iannuzzi MC
Semin Respir Crit Care Med 2007 Feb;28(1):22-35. doi: 10.1055/s-2007-970331. PMID: 17330190
Genetics of sarcoidosis.
Iannuzzi MC
Semin Respir Crit Care Med 2007 Feb;28(1):15-21. doi: 10.1055/s-2007-970330. PMID: 17330189

Diagnosis

Pulmonary Hyalinizing Granuloma.
Karakurt G, Duger M
Arch Bronconeumol 2022 Dec;58(12):821-822. Epub 2022 Jul 21 doi: 10.1016/j.arbres.2022.07.009. PMID: 35914957
Stimulants and the lung : review of literature.
Tseng W, Sutter ME, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):82-100. doi: 10.1007/s12016-013-8376-9. PMID: 23760760
Pulmonary affectation of vasculitis.
Martín-Suñé N, Ríos-Blanco JJ
Arch Bronconeumol 2012 Nov;48(11):410-8. Epub 2012 Jun 6 doi: 10.1016/j.arbres.2012.04.007. PMID: 22682604
Pulmonary hyalinizing granuloma.
Xu ZL, Bethune D, Manos D, Foyle A, Henteleff H, Johnston M, Cartier Y
Beijing Da Xue Xue Bao Yi Xue Ban 2009 Aug 18;41(4):463-8. PMID: 19727240
Pathology of sarcoidosis.
Rosen Y
Semin Respir Crit Care Med 2007 Feb;28(1):36-52. doi: 10.1055/s-2007-970332. PMID: 17330191

Therapy

Microparticles in the pathogenesis of TB: Novel perspectives for diagnostic and therapy management of Mycobacterium tuberculosis infection.
Dornelas Moreira J, Rodrigues Silva H, de Paulo Coelho Peixoto de Toledo V, Mara Pinto Dabés Guimarães T
Microb Pathog 2020 Jul;144:104176. Epub 2020 Mar 31 doi: 10.1016/j.micpath.2020.104176. PMID: 32244042
Stimulants and the lung : review of literature.
Tseng W, Sutter ME, Albertson TE
Clin Rev Allergy Immunol 2014 Feb;46(1):82-100. doi: 10.1007/s12016-013-8376-9. PMID: 23760760
Pulmonary affectation of vasculitis.
Martín-Suñé N, Ríos-Blanco JJ
Arch Bronconeumol 2012 Nov;48(11):410-8. Epub 2012 Jun 6 doi: 10.1016/j.arbres.2012.04.007. PMID: 22682604
Pulmonary sarcoidosis.
Lynch JP 3rd, Ma YL, Koss MN, White ES
Semin Respir Crit Care Med 2007 Feb;28(1):53-74. doi: 10.1055/s-2007-970333. PMID: 17330192
Chronic hypersensitivity pneumonitis.
Churg A, Muller NL, Flint J, Wright JL
Am J Surg Pathol 2006 Feb;30(2):201-8. doi: 10.1097/01.pas.0000184806.38037.3c. PMID: 16434894

Prognosis

Current Sarcoidosis Models and the Importance of Focusing on the Granuloma.
Locke LW, Schlesinger LS, Crouser ED
Front Immunol 2020;11:1719. Epub 2020 Aug 4 doi: 10.3389/fimmu.2020.01719. PMID: 32849608Free PMC Article
Pulmonary affectation of vasculitis.
Martín-Suñé N, Ríos-Blanco JJ
Arch Bronconeumol 2012 Nov;48(11):410-8. Epub 2012 Jun 6 doi: 10.1016/j.arbres.2012.04.007. PMID: 22682604
Lung transplantation in sarcoidosis.
Shah L
Semin Respir Crit Care Med 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339. PMID: 17330198
Pulmonary sarcoidosis.
Lynch JP 3rd, Ma YL, Koss MN, White ES
Semin Respir Crit Care Med 2007 Feb;28(1):53-74. doi: 10.1055/s-2007-970333. PMID: 17330192
Genetics of sarcoidosis.
Iannuzzi MC
Semin Respir Crit Care Med 2007 Feb;28(1):15-21. doi: 10.1055/s-2007-970330. PMID: 17330189

Clinical prediction guides

Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza.
Ohshimo S, Guzman J, Costabel U, Bonella F
Eur Respir Rev 2017 Sep 30;26(145) Epub 2017 Aug 9 doi: 10.1183/16000617.0012-2017. PMID: 28794143Free PMC Article
Clinical and pathological features of adult pulmonary tuberculosis with reversed halo sign.
Zhan X, Wang Z, Zhang L, Jin ML, Liu M, Chen WH, Dai HP
Int J Tuberc Lung Dis 2013 Dec;17(12):1621-5. doi: 10.5588/ijtld.13.0300. PMID: 24200279
A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis.
Marino S, El-Kebir M, Kirschner D
J Theor Biol 2011 Jul 7;280(1):50-62. Epub 2011 Apr 1 doi: 10.1016/j.jtbi.2011.03.022. PMID: 21443879Free PMC Article
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
J Leukoc Biol 2007 Oct;82(4):946-55. Epub 2007 Jul 5 doi: 10.1189/jlb.0307133. PMID: 17615381
Lung transplantation in sarcoidosis.
Shah L
Semin Respir Crit Care Med 2007 Feb;28(1):134-40. doi: 10.1055/s-2007-970339. PMID: 17330198

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