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Halothane hepatitis

MedGen UID:
66842
•Concept ID:
C0241913
•
Disease or Syndrome
Synonym: Halothane Hepatitis
SNOMED CT: Halothane hepatitis (235873001); HH - Halothane hepatitis (235873001)
 
Monarch Initiative: MONDO:0009323
OMIM®: 234350

Professional guidelines

PubMed

Emergency liver transplantation for acute liver failure. Evaluation of London and Clichy criteria.
Pauwels A, Mostefa-Kara N, Florent C, Lévy VG
J Hepatol 1993 Jan;17(1):124-7. doi: 10.1016/s0168-8278(05)80532-x. PMID: 8445211
Management of acute liver failure.
O'Grady JG, Williams R
Schweiz Med Wochenschr 1986 Apr 26;116(17):541-4. PMID: 3086971
Hepatitis and operating-room personnel: an approach to diagnosis and management.
Naulty JS, Reves JG, Tobey RE, Schultz WW
Anesth Analg 1977 May-Jun;56(3):366-72. doi: 10.1213/00000539-197705000-00011. PMID: 559436

Recent clinical studies

Etiology

Halothane: how should it be used in a developing country?
Mahboobi N, Esmaeili S, Safari S, Habibollahi P, Dabbagh A, Alavian SM
East Mediterr Health J 2012 Feb;18(2):159-64. doi: 10.26719/2012.18.2.159. PMID: 22571093
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.
Gut J, Christen U, Frey N, Koch V, Stoffler D
Toxicology 1995 Mar 31;97(1-3):199-224. doi: 10.1016/0300-483x(94)03010-y. PMID: 7716787
Halothane hepatitis.
Ray DC, Drummond GB
Br J Anaesth 1991 Jul;67(1):84-99. doi: 10.1093/bja/67.1.84. PMID: 1859766
Halothane and hepatitis. Incidence, predisposing factors and exposure guidelines.
Neuberger JM
Drug Saf 1990 Jan-Feb;5(1):28-38. doi: 10.2165/00002018-199005010-00004. PMID: 2178633
Halothane hepatitis.
Neuberger J, Williams R
Dig Dis 1988;6(1):52-64. doi: 10.1159/000171184. PMID: 3349642

Diagnosis

Halothane hepatitis.
Neuberger J, Williams R
Dig Dis 1988;6(1):52-64. doi: 10.1159/000171184. PMID: 3349642
Halothane hepatitis in children.
Kenna JG, Neuberger J, Mieli-Vergani G, Mowat AP, Williams R
Br Med J (Clin Res Ed) 1987 May 9;294(6581):1209-11. doi: 10.1136/bmj.294.6581.1209. PMID: 3109584Free PMC Article
Halothane hepatitis and the anaesthesiologist.
Shipton EA, Kruger AE
S Afr Med J 1984 Jan 21;65(3):86-9. PMID: 6364393
Halothane hepatitis: a critical review.
Carney FM, Van Dyke RA
Anesth Analg 1972 Jan-Feb;51(1):135-60. PMID: 4399967
Halothane hepatitis.
Sherlock S
Gut 1971 Apr;12(4):324-9. doi: 10.1136/gut.12.4.324. PMID: 4930157Free PMC Article

Therapy

Halothane: how should it be used in a developing country?
Mahboobi N, Esmaeili S, Safari S, Habibollahi P, Dabbagh A, Alavian SM
East Mediterr Health J 2012 Feb;18(2):159-64. doi: 10.26719/2012.18.2.159. PMID: 22571093
Halothane hepatitis.
Ray DC, Drummond GB
Br J Anaesth 1991 Jul;67(1):84-99. doi: 10.1093/bja/67.1.84. PMID: 1859766
Halothane hepatitis.
Neuberger J, Williams R
Dig Dis 1988;6(1):52-64. doi: 10.1159/000171184. PMID: 3349642
Halothane hepatitis revisited.
Brown BR Jr
N Engl J Med 1985 Nov 21;313(21):1347-8. doi: 10.1056/NEJM198511213132108. PMID: 4058525
Halothane hepatitis.
Qizilbash AH
Can Med Assoc J 1973 Jan 20;108(2):171-7. PMID: 4684624Free PMC Article

Prognosis

Acute liver failure caused by occupational exposure to HCFC-123: Two case reports.
Choe HJ, Ahn S, Jung K, Kim JW
Medicine (Baltimore) 2019 Mar;98(9):e14522. doi: 10.1097/MD.0000000000014522. PMID: 30817569Free PMC Article
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.
Gut J, Christen U, Frey N, Koch V, Stoffler D
Toxicology 1995 Mar 31;97(1-3):199-224. doi: 10.1016/0300-483x(94)03010-y. PMID: 7716787
Adverse effects of general anaesthetics.
Berthoud MC, Reilly CS
Drug Saf 1992 Nov-Dec;7(6):434-59. doi: 10.2165/00002018-199207060-00005. PMID: 1418699
Halothane and hepatitis. Incidence, predisposing factors and exposure guidelines.
Neuberger JM
Drug Saf 1990 Jan-Feb;5(1):28-38. doi: 10.2165/00002018-199005010-00004. PMID: 2178633
Halothane hepatitis.
Qizilbash AH
Can Med Assoc J 1973 Jan 20;108(2):171-7. PMID: 4684624Free PMC Article

Clinical prediction guides

Halothane hepatitis in Iran: a review of 59 cases.
Eghtesadi-Araghi P, Sohrabpour A, Vahedi H, Saberi-Firoozi M
World J Gastroenterol 2008 Sep 14;14(34):5322-6. doi: 10.3748/wjg.14.5322. PMID: 18785286Free PMC Article
Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis.
Kitteringham NR, Kenna JG, Park BK
Br J Clin Pharmacol 1995 Oct;40(4):379-86. doi: 10.1111/j.1365-2125.1995.tb04560.x. PMID: 8554940Free PMC Article
Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane.
Ilyin GP, Rissel M, Malledant Y, Tanguy M, Guillouzo A
Biochem Pharmacol 1994 Aug 3;48(3):561-7. doi: 10.1016/0006-2952(94)90286-0. PMID: 8068043
Adverse effects of general anaesthetics.
Berthoud MC, Reilly CS
Drug Saf 1992 Nov-Dec;7(6):434-59. doi: 10.2165/00002018-199207060-00005. PMID: 1418699
Identification by immunoblotting of three halothane-induced liver microsomal polypeptide antigens recognized by antibodies in sera from patients with halothane-associated hepatitis.
Kenna JG, Neuberger J, Williams R
J Pharmacol Exp Ther 1987 Aug;242(2):733-40. PMID: 3302210

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