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Erectile dysfunction

MedGen UID:
66879
Concept ID:
C0242350
Disease or Syndrome
Synonyms: Dysfunction, Erectile; Erectile Dysfunction; Impotence; Impotence, Male; Impotence, Male Sexual; Male Impotence; Male Sexual Impotence; Sexual Impotence, Male
SNOMED CT: Erectile dysfunction (860914002); Failure of erection (860914002); Male erectile disorder (860914002)
 
HPO: HP:0100639
Monarch Initiative: MONDO:0005362

Definition

A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. [from HPO]

Professional guidelines

PubMed

Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Rahnema CD, Lipshultz LI, Crosnoe LE, Kovac JR, Kim ED
Fertil Steril 2014 May;101(5):1271-9. Epub 2014 Mar 14 doi: 10.1016/j.fertnstert.2014.02.002. PMID: 24636400

Recent clinical studies

Etiology

Irwin GM
Prim Care 2019 Jun;46(2):249-255. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.006. PMID: 31030826
Mobley DF, Khera M, Baum N
Postgrad Med J 2017 Nov;93(1105):679-685. Epub 2017 Jul 27 doi: 10.1136/postgradmedj-2016-134073. PMID: 28751439
Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, Maggi M, Nelson CJ, Parish S, Salonia A, Tan R, Mulhall JP, Hellstrom WJ
Nat Rev Dis Primers 2016 Feb 4;2:16003. doi: 10.1038/nrdp.2016.3. PMID: 27188339Free PMC Article
McMahon CG
Intern Med J 2014 Jan;44(1):18-26. doi: 10.1111/imj.12325. PMID: 24450519
Khera M, Goldstein I
BMJ Clin Evid 2011 Jun 29;2011 PMID: 21711956Free PMC Article

Diagnosis

Bertolotto M, Campo I, Sachs C, Ciabattoni R, Bucci S, Cova MA, Van Nieuwenhove S
Abdom Radiol (NY) 2020 Jul;45(7):1973-1989. doi: 10.1007/s00261-020-02529-z. PMID: 32285181
Irwin GM
Prim Care 2019 Jun;46(2):249-255. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.006. PMID: 31030826
Mobley DF, Khera M, Baum N
Postgrad Med J 2017 Nov;93(1105):679-685. Epub 2017 Jul 27 doi: 10.1136/postgradmedj-2016-134073. PMID: 28751439
Am Fam Physician 2016 Nov 15;94(10):Online. PMID: 27929283
Rosen RC
Urol Clin North Am 2001 May;28(2):269-78. doi: 10.1016/s0094-0143(05)70137-3. PMID: 11402580

Therapy

Traish AM
Fertil Steril 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. PMID: 32033719
Krishnappa P, Fernandez-Pascual E, Carballido J, Martinez-Salamanca JI
Int J Impot Res 2019 Mar;31(2):65-70. Epub 2019 Mar 5 doi: 10.1038/s41443-018-0099-2. PMID: 30837718
Newman CB, Preiss D, Tobert JA, Jacobson TA, Page RL 2nd, Goldstein LB, Chin C, Tannock LR, Miller M, Raghuveer G, Duell PB, Brinton EA, Pollak A, Braun LT, Welty FK; American Heart Association Clinical Lipidology, Lipoprotein, Metabolism and Thrombosis Committee, a Joint Committee of the Council on Atherosclerosis, Thrombosis and Vascular Biology and Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; and Stroke Council
Arterioscler Thromb Vasc Biol 2019 Feb;39(2):e38-e81. doi: 10.1161/ATV.0000000000000073. PMID: 30580575
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R; Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines
Endocr Pract 2016 Jul;22 Suppl 3:1-203. Epub 2016 May 24 doi: 10.4158/EP161365.GL. PMID: 27219496
Widmer RJ, Flammer AJ, Lerman LO, Lerman A
Am J Med 2015 Mar;128(3):229-38. Epub 2014 Oct 15 doi: 10.1016/j.amjmed.2014.10.014. PMID: 25447615Free PMC Article

Prognosis

Christie A, Vera PL, Higgins M, Kumar S, Lane M, Preston D
Urology 2019 Apr;126:116-120. Epub 2019 Feb 5 doi: 10.1016/j.urology.2019.01.025. PMID: 30735744
Miner M, Parish SJ, Billups KL, Paulos M, Sigman M, Blaha MJ
Sex Med Rev 2019 Jul;7(3):455-463. Epub 2018 Feb 1 doi: 10.1016/j.sxmr.2018.01.001. PMID: 29396281
Burnett AL
J Urol 2006 Mar;175(3 Pt 2):S25-31. doi: 10.1016/S0022-5347(05)00309-5. PMID: 16458737
Rhoden EL, Morgentaler A
J Long Term Eff Med Implants 2003;13(6):519-28. doi: 10.1615/jlongtermeffmedimplants.v13.i6.80. PMID: 15056069
Sehgal VN, Srivastava G
Skinmed 2003 Nov-Dec;2(6):350-6. doi: 10.1111/j.1540-9740.2003.01950.x. PMID: 14673246

Clinical prediction guides

E Brito DV, Pereira-Lourenço M, Pereira JA, Eliseu M, Rabaça C
Arch Ital Urol Androl 2022 Jun 30;94(2):232-236. doi: 10.4081/aiua.2022.2.232. PMID: 35775353
Balta S, Mikhailidis DP
Am J Mens Health 2019 Nov-Dec;13(6):1557988319893889. doi: 10.1177/1557988319893889. PMID: 31829075Free PMC Article
Dong L, Chang D, Zhang X, Li J, Yang F, Tan K, Yang Y, Yong S, Yu X
Am J Mens Health 2019 Mar-Apr;13(2):1557988319846749. doi: 10.1177/1557988319846749. PMID: 31027441Free PMC Article
Dauendorffer JN, Ly S, Beylot-Barry M
Ann Dermatol Venereol 2019 Apr;146(4):273-278. Epub 2019 Mar 28 doi: 10.1016/j.annder.2019.01.021. PMID: 30928124
Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, Buvat J, Carson CC, Cunningham GR, Goldstein I, Guay AT, Hackett G, Kloner RA, Kostis J, Montorsi P, Ramsey M, Rosen RC, Sadovsky R, Seftel AD, Vlachopoulos C, Wu FC
J Urol 2013 Jun;189(6):2031-8. Epub 2013 Jan 9 doi: 10.1016/j.juro.2012.12.107. PMID: 23313195

Recent systematic reviews

Starc A, Trampuš M, Pavan Jukić D, Rotim C, Jukić T, Polona Mivšek A
Acta Clin Croat 2019 Sep;58(3):508-515. doi: 10.20471/acc.2019.58.03.15. PMID: 31969764Free PMC Article
Ilic D, Djulbegovic M, Jung JH, Hwang EC, Zhou Q, Cleves A, Agoritsas T, Dahm P
BMJ 2018 Sep 5;362:k3519. doi: 10.1136/bmj.k3519. PMID: 30185521Free PMC Article
Burnett AL, Nehra A, Breau RH, Culkin DJ, Faraday MM, Hakim LS, Heidelbaugh J, Khera M, McVary KT, Miner MM, Nelson CJ, Sadeghi-Nejad H, Seftel AD, Shindel AW
J Urol 2018 Sep;200(3):633-641. Epub 2018 May 7 doi: 10.1016/j.juro.2018.05.004. PMID: 29746858
Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J
Int Urol Nephrol 2017 Oct;49(10):1731-1740. Epub 2017 Jul 24 doi: 10.1007/s11255-017-1644-5. PMID: 28741090Free PMC Article
Veale D, Miles S, Bramley S, Muir G, Hodsoll J
BJU Int 2015 Jun;115(6):978-86. Epub 2015 Mar 2 doi: 10.1111/bju.13010. PMID: 25487360

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