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Erectile dysfunction

MedGen UID:
66879
Concept ID:
C0242350
Disease or Syndrome
Synonyms: Dysfunction, Erectile; Erectile Dysfunction; Impotence; Impotence, Male; Impotence, Male Sexual; Male Impotence; Male Sexual Impotence; Sexual Impotence, Male
SNOMED CT: Erectile dysfunction (860914002); Failure of erection (860914002); Male erectile disorder (860914002)
 
HPO: HP:0100639
Monarch Initiative: MONDO:0005362

Definition

A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. [from HPO]

Professional guidelines

PubMed

Leisegang K, Sengupta P, Agarwal A, Henkel R
Andrologia 2021 Feb;53(1):e13617. Epub 2020 May 12 doi: 10.1111/and.13617. PMID: 32399992
Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Rahnema CD, Lipshultz LI, Crosnoe LE, Kovac JR, Kim ED
Fertil Steril 2014 May;101(5):1271-9. Epub 2014 Mar 14 doi: 10.1016/j.fertnstert.2014.02.002. PMID: 24636400

Recent clinical studies

Etiology

Irwin GM
Prim Care 2019 Jun;46(2):249-255. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.006. PMID: 31030826
Mobley DF, Khera M, Baum N
Postgrad Med J 2017 Nov;93(1105):679-685. Epub 2017 Jul 27 doi: 10.1136/postgradmedj-2016-134073. PMID: 28751439
Khera M, Goldstein I
BMJ Clin Evid 2011 Jun 29;2011 PMID: 21711956Free PMC Article
Rhoden EL, Morgentaler A
J Long Term Eff Med Implants 2003;13(6):519-28. doi: 10.1615/jlongtermeffmedimplants.v13.i6.80. PMID: 15056069
Sehgal VN, Srivastava G
Skinmed 2003 Nov-Dec;2(6):350-6. doi: 10.1111/j.1540-9740.2003.01950.x. PMID: 14673246

Diagnosis

Bertolotto M, Campo I, Sachs C, Ciabattoni R, Bucci S, Cova MA, Van Nieuwenhove S
Abdom Radiol (NY) 2020 Jul;45(7):1973-1989. doi: 10.1007/s00261-020-02529-z. PMID: 32285181
Irwin GM
Prim Care 2019 Jun;46(2):249-255. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.006. PMID: 31030826
Krzastek SC, Bopp J, Smith RP, Kovac JR
F1000Res 2019;8 Epub 2019 Jan 25 doi: 10.12688/f1000research.16576.1. PMID: 30740217Free PMC Article
Mobley DF, Khera M, Baum N
Postgrad Med J 2017 Nov;93(1105):679-685. Epub 2017 Jul 27 doi: 10.1136/postgradmedj-2016-134073. PMID: 28751439
Am Fam Physician 2016 Nov 15;94(10):Online. PMID: 27929283

Therapy

Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M
Curr Urol Rep 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544Free PMC Article
Traish AM
Fertil Steril 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. PMID: 32033719
Newman CB, Preiss D, Tobert JA, Jacobson TA, Page RL 2nd, Goldstein LB, Chin C, Tannock LR, Miller M, Raghuveer G, Duell PB, Brinton EA, Pollak A, Braun LT, Welty FK; American Heart Association Clinical Lipidology, Lipoprotein, Metabolism and Thrombosis Committee, a Joint Committee of the Council on Atherosclerosis, Thrombosis and Vascular Biology and Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; and Stroke Council
Arterioscler Thromb Vasc Biol 2019 Feb;39(2):e38-e81. doi: 10.1161/ATV.0000000000000073. PMID: 30580575
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R; Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines
Endocr Pract 2016 Jul;22 Suppl 3:1-203. Epub 2016 May 24 doi: 10.4158/EP161365.GL. PMID: 27219496
Widmer RJ, Flammer AJ, Lerman LO, Lerman A
Am J Med 2015 Mar;128(3):229-38. Epub 2014 Oct 15 doi: 10.1016/j.amjmed.2014.10.014. PMID: 25447615Free PMC Article

Prognosis

Miner M, Parish SJ, Billups KL, Paulos M, Sigman M, Blaha MJ
Sex Med Rev 2019 Jul;7(3):455-463. Epub 2018 Feb 1 doi: 10.1016/j.sxmr.2018.01.001. PMID: 29396281
Abhishek A, Doherty M
Arthritis Res Ther 2017 Aug 10;19(1):184. doi: 10.1186/s13075-017-1394-x. PMID: 28797283Free PMC Article
Dogra PN, Singh P, Nayyar R, Yadav S
Urol Clin North Am 2017 Feb;44(1):49-56. doi: 10.1016/j.ucl.2016.08.013. PMID: 27908371
Rhoden EL, Morgentaler A
J Long Term Eff Med Implants 2003;13(6):519-28. doi: 10.1615/jlongtermeffmedimplants.v13.i6.80. PMID: 15056069
Sehgal VN, Srivastava G
Skinmed 2003 Nov-Dec;2(6):350-6. doi: 10.1111/j.1540-9740.2003.01950.x. PMID: 14673246

Clinical prediction guides

Tian Y, Zhou Q, Li W, Liu M, Li Q, Chen Q
Front Endocrinol (Lausanne) 2023;14:1211720. Epub 2023 Oct 4 doi: 10.3389/fendo.2023.1211720. PMID: 37908749Free PMC Article
E Brito DV, Pereira-Lourenço M, Pereira JA, Eliseu M, Rabaça C
Arch Ital Urol Androl 2022 Jun 30;94(2):232-236. doi: 10.4081/aiua.2022.2.232. PMID: 35775353
Feng C, Yang Y, Chen L, Guo R, Liu H, Li C, Wang Y, Dong P, Li Y
Front Endocrinol (Lausanne) 2022;13:812974. Epub 2022 Feb 18 doi: 10.3389/fendo.2022.812974. PMID: 35250871Free PMC Article
Balta S, Mikhailidis DP
Am J Mens Health 2019 Nov-Dec;13(6):1557988319893889. doi: 10.1177/1557988319893889. PMID: 31829075Free PMC Article
Dauendorffer JN, Ly S, Beylot-Barry M
Ann Dermatol Venereol 2019 Apr;146(4):273-278. Epub 2019 Mar 28 doi: 10.1016/j.annder.2019.01.021. PMID: 30928124

Recent systematic reviews

Starc A, Trampuš M, Pavan Jukić D, Rotim C, Jukić T, Polona Mivšek A
Acta Clin Croat 2019 Sep;58(3):508-515. doi: 10.20471/acc.2019.58.03.15. PMID: 31969764Free PMC Article
Myers C, Smith M
Physiotherapy 2019 Jun;105(2):235-243. Epub 2019 Jan 14 doi: 10.1016/j.physio.2019.01.002. PMID: 30979506
Ilic D, Djulbegovic M, Jung JH, Hwang EC, Zhou Q, Cleves A, Agoritsas T, Dahm P
BMJ 2018 Sep 5;362:k3519. doi: 10.1136/bmj.k3519. PMID: 30185521Free PMC Article
Burnett AL, Nehra A, Breau RH, Culkin DJ, Faraday MM, Hakim LS, Heidelbaugh J, Khera M, McVary KT, Miner MM, Nelson CJ, Sadeghi-Nejad H, Seftel AD, Shindel AW
J Urol 2018 Sep;200(3):633-641. Epub 2018 May 7 doi: 10.1016/j.juro.2018.05.004. PMID: 29746858
Veale D, Miles S, Bramley S, Muir G, Hodsoll J
BJU Int 2015 Jun;115(6):978-86. Epub 2015 Mar 2 doi: 10.1111/bju.13010. PMID: 25487360

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