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Lung cancer

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
Synonyms: Lung cancer, somatic; Malignant tumor of lung
SNOMED CT: Malignant tumor of lung (363358000); Lung cancer (363358000)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); SLC22A18 (11p15.4)
 
Monarch Initiative: MONDO:0008903
OMIM®: 211980

Definition

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

Clinical features

From HPO
Alveolar cell carcinoma
MedGen UID:
2871
Concept ID:
C0007120
Neoplastic Process
Adenocarcinoma of the Bronchus.
Non-small cell lung carcinoma
MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
Lung adenocarcinoma
MedGen UID:
57744
Concept ID:
C0152013
Neoplastic Process
A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Rolfo C, Mack P, Scagliotti GV, Aggarwal C, Arcila ME, Barlesi F, Bivona T, Diehn M, Dive C, Dziadziuszko R, Leighl N, Malapelle U, Mok T, Peled N, Raez LE, Sequist L, Sholl L, Swanton C, Abbosh C, Tan D, Wakelee H, Wistuba I, Bunn R, Freeman-Daily J, Wynes M, Belani C, Mitsudomi T, Gandara D
J Thorac Oncol 2021 Oct;16(10):1647-1662. Epub 2021 Jul 8 doi: 10.1016/j.jtho.2021.06.017. PMID: 34246791
Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236

Curated

UK NICE guideline NG122, Lung cancer: diagnosis and management

Recent clinical studies

Etiology

Oliver AL
Surg Clin North Am 2022 Jun;102(3):335-344. Epub 2022 Apr 21 doi: 10.1016/j.suc.2021.12.001. PMID: 35671760
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Bade BC, Dela Cruz CS
Clin Chest Med 2020 Mar;41(1):1-24. doi: 10.1016/j.ccm.2019.10.001. PMID: 32008623
Mao Y, Yang D, He J, Krasna MJ
Surg Oncol Clin N Am 2016 Jul;25(3):439-45. doi: 10.1016/j.soc.2016.02.001. PMID: 27261907
Rivera GA, Wakelee H
Adv Exp Med Biol 2016;893:43-57. doi: 10.1007/978-3-319-24223-1_3. PMID: 26667338

Diagnosis

Oliver AL
Surg Clin North Am 2022 Jun;102(3):335-344. Epub 2022 Apr 21 doi: 10.1016/j.suc.2021.12.001. PMID: 35671760
Wadowska K, Bil-Lula I, Trembecki Ł, Śliwińska-Mossoń M
Int J Mol Sci 2020 Jun 27;21(13) doi: 10.3390/ijms21134569. PMID: 32604993Free PMC Article
Jones GS, Baldwin DR
Clin Med (Lond) 2018 Apr 1;18(Suppl 2):s41-s46. doi: 10.7861/clinmedicine.18-2-s41. PMID: 29700092Free PMC Article
Rodriguez-Canales J, Parra-Cuentas E, Wistuba II
Cancer Treat Res 2016;170:25-46. doi: 10.1007/978-3-319-40389-2_2. PMID: 27535388
Mao Y, Yang D, He J, Krasna MJ
Surg Oncol Clin N Am 2016 Jul;25(3):439-45. doi: 10.1016/j.soc.2016.02.001. PMID: 27261907

Therapy

Ronk H, Rosenblum JS, Kung T, Zhuang Z
Cancer Biol Med 2022 Nov 1;19(10):1428-39. doi: 10.20892/j.issn.2095-3941.2022.0330. PMID: 36342229Free PMC Article
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Ma SC, Bai X, Guo XJ, Liu L, Xiao LS, Lin Y, Tan JL, Cai XT, Wen YX, Ma H, Fu QJ, Leng MX, Zhang YP, Long LL, Guo ZQ, Wu DH, Zhou JG, Dong ZY
BMC Med 2022 Apr 12;20(1):120. doi: 10.1186/s12916-022-02315-2. PMID: 35410334Free PMC Article
Majeed U, Manochakian R, Zhao Y, Lou Y
J Hematol Oncol 2021 Jul 8;14(1):108. doi: 10.1186/s13045-021-01121-2. PMID: 34238332Free PMC Article
Guerra-Martín MD, Tejedor-Bueno MS, Correa-Casado M
Int J Environ Res Public Health 2021 Jan 24;18(3) doi: 10.3390/ijerph18031017. PMID: 33498883Free PMC Article

Prognosis

Siegel RL, Miller KD, Fuchs HE, Jemal A
CA Cancer J Clin 2021 Jan;71(1):7-33. Epub 2021 Jan 12 doi: 10.3322/caac.21654. PMID: 33433946
Siegel RL, Miller KD, Jemal A
CA Cancer J Clin 2020 Jan;70(1):7-30. Epub 2020 Jan 8 doi: 10.3322/caac.21590. PMID: 31912902
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A
CA Cancer J Clin 2018 Nov;68(6):394-424. Epub 2018 Sep 12 doi: 10.3322/caac.21492. PMID: 30207593
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

Chen Y, Zitello E, Guo R, Deng Y
Clin Transl Med 2021 Apr;11(4):e367. doi: 10.1002/ctm2.367. PMID: 33931980Free PMC Article
Marquette CH, Boutros J, Benzaquen J, Ferreira M, Pastre J, Pison C, Padovani B, Bettayeb F, Fallet V, Guibert N, Basille D, Ilie M, Hofman V, Hofman P; AIR project Study Group
Lancet Respir Med 2020 Jul;8(7):709-716. doi: 10.1016/S2213-2600(20)30081-3. PMID: 32649919
Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
Cancer Cytopathol 2019 May;127(5):325-339. Epub 2019 May 3 doi: 10.1002/cncy.22137. PMID: 31050216Free PMC Article
McLaughlin J, Han G, Schalper KA, Carvajal-Hausdorf D, Pelekanou V, Rehman J, Velcheti V, Herbst R, LoRusso P, Rimm DL
JAMA Oncol 2016 Jan;2(1):46-54. doi: 10.1001/jamaoncol.2015.3638. PMID: 26562159Free PMC Article
Brunelli A, Kim AW, Berger KI, Addrizzo-Harris DJ
Chest 2013 May;143(5 Suppl):e166S-e190S. doi: 10.1378/chest.12-2395. PMID: 23649437

Recent systematic reviews

Komici K, Bencivenga L, Navani N, D'Agnano V, Guerra G, Bianco A, Rengo G, Perrotta F
Chest 2022 Aug;162(2):485-497. Epub 2022 Feb 22 doi: 10.1016/j.chest.2022.02.027. PMID: 35217002
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Chu GCW, Lazare K, Sullivan F
BMC Cancer 2018 Feb 13;18(1):181. doi: 10.1186/s12885-018-4024-3. PMID: 29439651Free PMC Article
Usman Ali M, Miller J, Peirson L, Fitzpatrick-Lewis D, Kenny M, Sherifali D, Raina P
Prev Med 2016 Aug;89:301-314. Epub 2016 Apr 26 doi: 10.1016/j.ypmed.2016.04.015. PMID: 27130532
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P, Forastiere F, Saldiva P, Yorifuji T, Loomis D
Environ Health Perspect 2014 Sep;122(9):906-11. Epub 2014 Jun 6 doi: 10.1289/ehp/1408092. PMID: 24911630Free PMC Article

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