U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myofibroblastoma

MedGen UID:
66894
•Concept ID:
C0242404
•
Neoplastic Process
Synonym: Myofibroblastomas
SNOMED CT: Myofibroblastoma (128738002)
 
Monarch Initiative: MONDO:0040675

Definition

A benign, well circumscribed soft tissue neoplasm characterized by the presence of spindle shaped myofibroblasts and mast cells in a collagenous stroma. [from NCI]

Professional guidelines

PubMed

Mammary and extramammary myofibroblastoma: multimodality imaging features with clinicopathologic correlation, management and outcomes in a series of 23 patients.
Wickre M, Valencia E, Solanki M, Glazebrook K
Br J Radiol 2021 Apr 1;94(1120):20201019. Epub 2020 Dec 17 doi: 10.1259/bjr.20201019. PMID: 33332985Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Primary mesenchymal liver tumors: radiological spectrum, differential diagnosis, and pathologic correlation.
Harman M, Nart D, Acar T, Elmas N
Abdom Imaging 2015 Jun;40(5):1316-30. doi: 10.1007/s00261-014-0268-9. PMID: 25311993

Recent clinical studies

Etiology

Inflammatory Myofibroblastic Tumor in the Thyroid Gland: A Retrospective Case Series Study and Literature Review.
Shi P, Zhang L, Shi H, Wu Y
Oncol Res Treat 2022;45(6):353-365. Epub 2022 Apr 11 doi: 10.1159/000524489. PMID: 35405683Free PMC Article
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
Spindle cell lipoma.
Comunoglu N, Comunoglu C, Ekici AI, Ozkan F, Dervişoglu S
Pol J Pathol 2007;58(1):7-11. PMID: 17585537
Ethmoidal myofibroblastoma.
Samuel D, Thomas DM, Tierney PA, Levine T, Patel KS
J Otolaryngol 1995 Oct;24(5):313-6. PMID: 8537994

Diagnosis

Mammary and extramammary myofibroblastoma: multimodality imaging features with clinicopathologic correlation, management and outcomes in a series of 23 patients.
Wickre M, Valencia E, Solanki M, Glazebrook K
Br J Radiol 2021 Apr 1;94(1120):20201019. Epub 2020 Dec 17 doi: 10.1259/bjr.20201019. PMID: 33332985Free PMC Article
Clinicopathological and radiological characterization of myofibroblastoma of breast: A single institutional case review.
Yan M, Bomeisl P, Gilmore H, Sieck L, Kuchta Z, Harbhajanka A
Ann Diagn Pathol 2020 Oct;48:151591. Epub 2020 Aug 15 doi: 10.1016/j.anndiagpath.2020.151591. PMID: 32829069
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
Mesenchymal breast lesions.
Schickman R, Leibman AJ, Handa P, Kornmehl A, Abadi M
Clin Radiol 2015 Jun;70(6):567-75. Epub 2015 Jan 29 doi: 10.1016/j.crad.2014.12.015. PMID: 25638601

Therapy

A report on second neo-plasms in seven children with solid tumors.
Hu H, Zhang W, Li J, Li F, Li R, Liu Z, Huang D
Ann Ital Chir 2022;92:331-338. PMID: 36052474
Inflammatory Pseudotumors of the Skull Base: Meta-Analysis.
Alyono JC, Shi Y, Berry GJ, Recht LD, Harsh GR 4th, Jackler RK, Corrales CE
Otol Neurotol 2015 Sep;36(8):1432-8. doi: 10.1097/MAO.0000000000000818. PMID: 26164448
Vaginal myofibroblastoma with prostatic glands: is there an association with tamoxifen use? A case report.
Lorange E, Harmanli O, Cao QJ, Jones KA
J Reprod Med 2013 Jul-Aug;58(7-8):344-6. PMID: 23947086
Mammary myofibroblastoma: report of two cases with fine-needle aspiration cytology and review of the cytology literature.
Odashiro AN, Odashiro Miiji LN, Odashiro DN, Nguyen GK
Diagn Cytopathol 2004 Jun;30(6):406-10. doi: 10.1002/dc.20042. PMID: 15176028
Fine needle aspiration cytology presentation of a cellular variant of breast myofibroblastoma. Report of a case with immunohistochemical studies.
Schmitt FC, AC Mera A
Acta Cytol 1998 May-Jun;42(3):721-4. doi: 10.1159/000331833. PMID: 9622694

Prognosis

Clinicopathological and radiological characterization of myofibroblastoma of breast: A single institutional case review.
Yan M, Bomeisl P, Gilmore H, Sieck L, Kuchta Z, Harbhajanka A
Ann Diagn Pathol 2020 Oct;48:151591. Epub 2020 Aug 15 doi: 10.1016/j.anndiagpath.2020.151591. PMID: 32829069
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Lipomatous tumors of the breast: A contemporary review.
Rowe JJ, Cheah AL, Calhoun BC
Semin Diagn Pathol 2017 Sep;34(5):453-461. Epub 2017 May 29 doi: 10.1053/j.semdp.2017.05.008. PMID: 28662999
Intranodal palisaded myofibroblastoma.
Nguyen T, Eltorky MA
Arch Pathol Lab Med 2007 Feb;131(2):306-10. doi: 10.5858/2007-131-306-IPM. PMID: 17284119
Ethmoidal myofibroblastoma.
Samuel D, Thomas DM, Tierney PA, Levine T, Patel KS
J Otolaryngol 1995 Oct;24(5):313-6. PMID: 8537994

Clinical prediction guides

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Lipomatous tumors of the breast: A contemporary review.
Rowe JJ, Cheah AL, Calhoun BC
Semin Diagn Pathol 2017 Sep;34(5):453-461. Epub 2017 May 29 doi: 10.1053/j.semdp.2017.05.008. PMID: 28662999
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148

Recent systematic reviews

Superficial myofibroblastoma of the lower female genital tract: A clinicopathological analysis of 15 cases.
Zhang M, Shi P, Zhou B, Liu J, Li L
Ann Diagn Pathol 2022 Oct;60:152010. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152010. PMID: 35907316

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...