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Oxidative Stress

MedGen UID:
66929
Concept ID:
C0242606
Cell or Molecular Dysfunction
Synonyms: Oxidative Stresses; Stress, Oxidative

Definition

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or ""normal"" aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer''s, and many others. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, Nikfar S, Tsatsakis A, Abdollahi M
Int J Mol Sci 2022 Jan 6;23(2) doi: 10.3390/ijms23020583. PMID: 35054768Free PMC Article
Koninckx PR, Fernandes R, Ussia A, Schindler L, Wattiez A, Al-Suwaidi S, Amro B, Al-Maamari B, Hakim Z, Tahlak M
Front Endocrinol (Lausanne) 2021;12:745548. Epub 2021 Nov 25 doi: 10.3389/fendo.2021.745548. PMID: 34899597Free PMC Article
Samsu N
Biomed Res Int 2021;2021:1497449. Epub 2021 Jul 8 doi: 10.1155/2021/1497449. PMID: 34307650Free PMC Article

Recent clinical studies

Etiology

Li M, Xin S, Gu R, Zheng L, Hu J, Zhang R, Dong H
Oxid Med Cell Longev 2022;2022:8917947. Epub 2022 Aug 5 doi: 10.1155/2022/8917947. PMID: 36035208Free PMC Article
Rezzani R, Franco C
Nutrients 2021 Jan 21;13(2) doi: 10.3390/nu13020301. PMID: 33494242Free PMC Article
Klaunig JE
Curr Pharm Des 2018;24(40):4771-4778. doi: 10.2174/1381612825666190215121712. PMID: 30767733
Tan BL, Norhaizan ME, Liew WP
Oxid Med Cell Longev 2018;2018:9719584. Epub 2018 Jan 31 doi: 10.1155/2018/9719584. PMID: 29643982Free PMC Article
Bisht S, Faiq M, Tolahunase M, Dada R
Nat Rev Urol 2017 Aug;14(8):470-485. Epub 2017 May 16 doi: 10.1038/nrurol.2017.69. PMID: 28508879

Diagnosis

Li M, Xin S, Gu R, Zheng L, Hu J, Zhang R, Dong H
Oxid Med Cell Longev 2022;2022:8917947. Epub 2022 Aug 5 doi: 10.1155/2022/8917947. PMID: 36035208Free PMC Article
Marchioro HZ, Silva de Castro CC, Fava VM, Sakiyama PH, Dellatorre G, Miot HA
An Bras Dermatol 2022 Jul-Aug;97(4):478-490. Epub 2022 May 25 doi: 10.1016/j.abd.2021.09.008. PMID: 35643735Free PMC Article
Chen Z, Tian R, She Z, Cai J, Li H
Free Radic Biol Med 2020 May 20;152:116-141. Epub 2020 Mar 8 doi: 10.1016/j.freeradbiomed.2020.02.025. PMID: 32156524
Luo J, Mills K, le Cessie S, Noordam R, van Heemst D
Ageing Res Rev 2020 Jan;57:100982. Epub 2019 Nov 13 doi: 10.1016/j.arr.2019.100982. PMID: 31733333
Bisht S, Faiq M, Tolahunase M, Dada R
Nat Rev Urol 2017 Aug;14(8):470-485. Epub 2017 May 16 doi: 10.1038/nrurol.2017.69. PMID: 28508879

Therapy

Johnson SA, Fang T, De Marchi F, Neel D, Van Weehaeghe D, Berry JD, Paganoni S
Drugs 2022 Sep;82(13):1367-1388. Epub 2022 Sep 19 doi: 10.1007/s40265-022-01769-1. PMID: 36121612
Paul S, Candelario-Jalil E
Exp Neurol 2021 Jan;335:113518. Epub 2020 Nov 2 doi: 10.1016/j.expneurol.2020.113518. PMID: 33144066Free PMC Article
Chai SC, Davis K, Zhang Z, Zha L, Kirschner KF
Nutrients 2019 Jan 22;11(2) doi: 10.3390/nu11020228. PMID: 30678193Free PMC Article
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R
Phytother Res 2018 Nov;32(11):2202-2213. Epub 2018 Aug 6 doi: 10.1002/ptr.6171. PMID: 30080294
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

Prognosis

Sukumar J, Gast K, Quiroga D, Lustberg M, Williams N
Expert Rev Anticancer Ther 2021 Feb;21(2):135-148. doi: 10.1080/14737140.2021.1840984. PMID: 33198517Free PMC Article
Friedenreich CM, Ryder-Burbidge C, McNeil J
Mol Oncol 2021 Mar;15(3):790-800. Epub 2020 Aug 18 doi: 10.1002/1878-0261.12772. PMID: 32741068Free PMC Article
Nair N
Rev Cardiovasc Med 2020 Dec 30;21(4):531-540. doi: 10.31083/j.rcm.2020.04.154. PMID: 33387998
Grande G, Qiu C, Fratiglioni L
Ageing Res Rev 2020 Dec;64:101045. Epub 2020 Mar 19 doi: 10.1016/j.arr.2020.101045. PMID: 32171784
Whitfield JB
Crit Rev Clin Lab Sci 2001 Aug;38(4):263-355. doi: 10.1080/20014091084227. PMID: 11563810

Clinical prediction guides

Camilleri M, Sanders KM
Gastroenterology 2022 Jan;162(1):68-87.e1. Epub 2021 Oct 27 doi: 10.1053/j.gastro.2021.10.028. PMID: 34717924Free PMC Article
Wu Z, Wang L, Wen Z, Yao J
Sci Rep 2021 Feb 8;11(1):3292. doi: 10.1038/s41598-021-82976-w. PMID: 33558567Free PMC Article
Tur JA, Bibiloni MDM
Nutrients 2019 Aug 14;11(8) doi: 10.3390/nu11081891. PMID: 31416130Free PMC Article
Leelarungrayub J, Puntumetakul R, Sriboonreung T, Pothasak Y, Klaphajone J
Int J Chron Obstruct Pulmon Dis 2018;13:3909-3921. Epub 2018 Dec 5 doi: 10.2147/COPD.S181428. PMID: 30584292Free PMC Article
Mihai S, Codrici E, Popescu ID, Enciu AM, Albulescu L, Necula LG, Mambet C, Anton G, Tanase C
J Immunol Res 2018;2018:2180373. Epub 2018 Sep 6 doi: 10.1155/2018/2180373. PMID: 30271792Free PMC Article

Recent systematic reviews

De Wolde SD, Hulskes RH, Weenink RP, Hollmann MW, Van Hulst RA
Biomolecules 2021 Aug 14;11(8) doi: 10.3390/biom11081210. PMID: 34439876Free PMC Article
Nair AR, Pillai AJ, Nair N
Curr Cardiol Rev 2021;17(4):e230421187681. doi: 10.2174/1573403X16666201106141811. PMID: 33155924Free PMC Article
Fraguas D, Díaz-Caneja CM, Ayora M, Hernández-Álvarez F, Rodríguez-Quiroga A, Recio S, Leza JC, Arango C
Schizophr Bull 2019 Jun 18;45(4):742-751. doi: 10.1093/schbul/sby125. PMID: 30169868Free PMC Article
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article
Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P, Nappi L
Oxid Med Cell Longev 2017;2017:7265238. Epub 2017 Sep 19 doi: 10.1155/2017/7265238. PMID: 29057034Free PMC Article

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