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Oxidative Stress

MedGen UID:
66929
•Concept ID:
C0242606
•
Cell or Molecular Dysfunction
Synonyms: Oxidative Stresses; Stress, Oxidative

Definition

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or ""normal"" aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer''s, and many others. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOxidative Stress

Professional guidelines

PubMed

New Understanding of Diagnosis, Treatment and Prevention of Endometriosis.
Amro B, Ramirez Aristondo ME, Alsuwaidi S, Almaamari B, Hakim Z, Tahlak M, Wattiez A, Koninckx PR
Int J Environ Res Public Health 2022 May 31;19(11) doi: 10.3390/ijerph19116725. PMID: 35682310Free PMC Article
Pathogenesis Based Diagnosis and Treatment of Endometriosis.
Koninckx PR, Fernandes R, Ussia A, Schindler L, Wattiez A, Al-Suwaidi S, Amro B, Al-Maamari B, Hakim Z, Tahlak M
Front Endocrinol (Lausanne) 2021;12:745548. Epub 2021 Nov 25 doi: 10.3389/fendo.2021.745548. PMID: 34899597Free PMC Article
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.
Samsu N
Biomed Res Int 2021;2021:1497449. Epub 2021 Jul 8 doi: 10.1155/2021/1497449. PMID: 34307650Free PMC Article

Recent clinical studies

Etiology

Mechanisms of Oxidative Stress in Metabolic Syndrome.
Masenga SK, Kabwe LS, Chakulya M, Kirabo A
Int J Mol Sci 2023 Apr 26;24(9) doi: 10.3390/ijms24097898. PMID: 37175603Free PMC Article
Novel Diagnostic Biomarkers Related to Oxidative Stress and Macrophage Ferroptosis in Atherosclerosis.
Li M, Xin S, Gu R, Zheng L, Hu J, Zhang R, Dong H
Oxid Med Cell Longev 2022;2022:8917947. Epub 2022 Aug 5 doi: 10.1155/2022/8917947. PMID: 36035208Free PMC Article
Oxidative Stress and Cancer.
Klaunig JE
Curr Pharm Des 2018;24(40):4771-4778. doi: 10.2174/1381612825666190215121712. PMID: 30767733
Nutrients and Oxidative Stress: Friend or Foe?
Tan BL, Norhaizan ME, Liew WP
Oxid Med Cell Longev 2018;2018:9719584. Epub 2018 Jan 31 doi: 10.1155/2018/9719584. PMID: 29643982Free PMC Article
Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease.
Tönnies E, Trushina E
J Alzheimers Dis 2017;57(4):1105-1121. doi: 10.3233/JAD-161088. PMID: 28059794Free PMC Article

Diagnosis

Mechanisms of Oxidative Stress in Metabolic Syndrome.
Masenga SK, Kabwe LS, Chakulya M, Kirabo A
Int J Mol Sci 2023 Apr 26;24(9) doi: 10.3390/ijms24097898. PMID: 37175603Free PMC Article
Novel Diagnostic Biomarkers Related to Oxidative Stress and Macrophage Ferroptosis in Atherosclerosis.
Li M, Xin S, Gu R, Zheng L, Hu J, Zhang R, Dong H
Oxid Med Cell Longev 2022;2022:8917947. Epub 2022 Aug 5 doi: 10.1155/2022/8917947. PMID: 36035208Free PMC Article
Update on the pathogenesis of vitiligo.
Marchioro HZ, Silva de Castro CC, Fava VM, Sakiyama PH, Dellatorre G, Miot HA
An Bras Dermatol 2022 Jul-Aug;97(4):478-490. Epub 2022 May 25 doi: 10.1016/j.abd.2021.09.008. PMID: 35643735Free PMC Article
Ageing, age-related diseases and oxidative stress: What to do next?
Luo J, Mills K, le Cessie S, Noordam R, van Heemst D
Ageing Res Rev 2020 Jan;57:100982. Epub 2019 Nov 13 doi: 10.1016/j.arr.2019.100982. PMID: 31733333
Oxidative stress and male infertility.
Bisht S, Faiq M, Tolahunase M, Dada R
Nat Rev Urol 2017 Aug;14(8):470-485. Epub 2017 May 16 doi: 10.1038/nrurol.2017.69. PMID: 28508879

Therapy

GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging.
Sekhar RV
J Nutr 2021 Dec 3;151(12):3606-3616. doi: 10.1093/jn/nxab309. PMID: 34587244
Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies.
Paul S, Candelario-Jalil E
Exp Neurol 2021 Jan;335:113518. Epub 2020 Nov 2 doi: 10.1016/j.expneurol.2020.113518. PMID: 33144066Free PMC Article
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R
Phytother Res 2018 Nov;32(11):2202-2213. Epub 2018 Aug 6 doi: 10.1002/ptr.6171. PMID: 30080294
Photobiomodulation in human muscle tissue: an advantage in sports performance?
Ferraresi C, Huang YY, Hamblin MR
J Biophotonics 2016 Dec;9(11-12):1273-1299. Epub 2016 Nov 22 doi: 10.1002/jbio.201600176. PMID: 27874264Free PMC Article
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

Prognosis

Triple-negative breast cancer: promising prognostic biomarkers currently in development.
Sukumar J, Gast K, Quiroga D, Lustberg M, Williams N
Expert Rev Anticancer Ther 2021 Feb;21(2):135-148. doi: 10.1080/14737140.2021.1840984. PMID: 33198517Free PMC Article
Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms.
Friedenreich CM, Ryder-Burbidge C, McNeil J
Mol Oncol 2021 Mar;15(3):790-800. Epub 2020 Aug 18 doi: 10.1002/1878-0261.12772. PMID: 32741068Free PMC Article
Epidemiology and pathogenesis of heart failure with preserved ejection fraction.
Nair N
Rev Cardiovasc Med 2020 Dec 30;21(4):531-540. doi: 10.31083/j.rcm.2020.04.154. PMID: 33387998
Prevention of dementia in an ageing world: Evidence and biological rationale.
Grande G, Qiu C, Fratiglioni L
Ageing Res Rev 2020 Dec;64:101045. Epub 2020 Mar 19 doi: 10.1016/j.arr.2020.101045. PMID: 32171784
Gamma glutamyl transferase.
Whitfield JB
Crit Rev Clin Lab Sci 2001 Aug;38(4):263-355. doi: 10.1080/20014091084227. PMID: 11563810

Clinical prediction guides

Gastroparesis.
Camilleri M, Sanders KM
Gastroenterology 2022 Jan;162(1):68-87.e1. Epub 2021 Oct 27 doi: 10.1053/j.gastro.2021.10.028. PMID: 34717924Free PMC Article
Oxidative stress biomarkers in the perinatal period: Diagnostic and prognostic value.
Perrone S, Laschi E, Buonocore G
Semin Fetal Neonatal Med 2020 Apr;25(2):101087. Epub 2020 Jan 23 doi: 10.1016/j.siny.2020.101087. PMID: 32008959
Anthropometry, Body Composition and Resting Energy Expenditure in Human.
Tur JA, Bibiloni MDM
Nutrients 2019 Aug 14;11(8) doi: 10.3390/nu11081891. PMID: 31416130Free PMC Article
Preliminary study: comparative effects of lung volume therapy between slow and fast deep-breathing techniques on pulmonary function, respiratory muscle strength, oxidative stress, cytokines, 6-minute walking distance, and quality of life in persons with COPD.
Leelarungrayub J, Puntumetakul R, Sriboonreung T, Pothasak Y, Klaphajone J
Int J Chron Obstruct Pulmon Dis 2018;13:3909-3921. Epub 2018 Dec 5 doi: 10.2147/COPD.S181428. PMID: 30584292Free PMC Article
Saliva and oxidative stress in oral cavity and in some systemic disorders.
Buczko P, Zalewska A, Szarmach I
J Physiol Pharmacol 2015 Feb;66(1):3-9. PMID: 25716960

Recent systematic reviews

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis.
De Wolde SD, Hulskes RH, Weenink RP, Hollmann MW, Van Hulst RA
Biomolecules 2021 Aug 14;11(8) doi: 10.3390/biom11081210. PMID: 34439876Free PMC Article
Cardiovascular Changes in Menopause.
Nair AR, Pillai AJ, Nair N
Curr Cardiol Rev 2021;17(4):e230421187681. doi: 10.2174/1573403X16666201106141811. PMID: 33155924Free PMC Article
A systematic review of p53 regulation of oxidative stress in skeletal muscle.
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article
Oxidative Stress and Endometriosis: A Systematic Review of the Literature.
Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P, Nappi L
Oxid Med Cell Longev 2017;2017:7265238. Epub 2017 Sep 19 doi: 10.1155/2017/7265238. PMID: 29057034Free PMC Article
Smoking and increased Alzheimer's disease risk: a review of potential mechanisms.
Durazzo TC, Mattsson N, Weiner MW; Alzheimer's Disease Neuroimaging Initiative
Alzheimers Dement 2014 Jun;10(3 Suppl):S122-45. doi: 10.1016/j.jalz.2014.04.009. PMID: 24924665Free PMC Article

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