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Neoplasm of male breast

MedGen UID:
66983
•Concept ID:
C0242788
•
Neoplastic Process
Synonyms: Breast Neoplasm, Male; Breast Neoplasms, Male; Breast Tumor, Male; Breast Tumors, Male; Male Breast Neoplasm; Male Breast Neoplasms; Male Breast Tumor; Male Breast Tumors; Neoplasm, Male Breast; Neoplasms, Breast, Male; Neoplasms, Male Breast; Tumor, Male Breast; Tumors, Breast, Male; Tumors, Male Breast
SNOMED CT: Neoplasm of male breast (126937006)

Definition

Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of male breast

Professional guidelines

PubMed

EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937
Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Aug 1;30(8):1194-1220. doi: 10.1093/annonc/mdz173. PMID: 31161190

Recent clinical studies

Etiology

Treatment of male breast cancer: meta-analysis of real-world evidence.
Lin AP, Huang TW, Tam KW
Br J Surg 2021 Sep 27;108(9):1034-1042. doi: 10.1093/bjs/znab279. PMID: 34476472
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Male breast cancer: a disease distinct from female breast cancer.
Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F
Breast Cancer Res Treat 2019 Jan;173(1):37-48. Epub 2018 Sep 28 doi: 10.1007/s10549-018-4921-9. PMID: 30267249Free PMC Article
Male Breast Cancer: Epidemiology and Risk Factors.
Abdelwahab Yousef AJ
Semin Oncol 2017 Aug;44(4):267-272. Epub 2017 Nov 9 doi: 10.1053/j.seminoncol.2017.11.002. PMID: 29526255
Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship.
Ruddy KJ, Winer EP
Ann Oncol 2013 Jun;24(6):1434-43. Epub 2013 Feb 20 doi: 10.1093/annonc/mdt025. PMID: 23425944

Diagnosis

Breast cancer-specific mortality in early breast cancer as defined by high-risk clinical and pathologic characteristics.
Nelson DR, Brown J, Morikawa A, Method M
PLoS One 2022;17(2):e0264637. Epub 2022 Feb 25 doi: 10.1371/journal.pone.0264637. PMID: 35213669Free PMC Article
Treatment of male breast cancer: meta-analysis of real-world evidence.
Lin AP, Huang TW, Tam KW
Br J Surg 2021 Sep 27;108(9):1034-1042. doi: 10.1093/bjs/znab279. PMID: 34476472
An updated review of epidemiology, risk factors, and management of male breast cancer.
Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Breast Cancer in Men.
Giordano SH
N Engl J Med 2018 Jun 14;378(24):2311-2320. doi: 10.1056/NEJMra1707939. PMID: 29897847

Therapy

An updated review of epidemiology, risk factors, and management of male breast cancer.
Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Management of Male Breast Cancer: ASCO Guideline.
Hassett MJ, Somerfield MR, Baker ER, Cardoso F, Kansal KJ, Kwait DC, Plichta JK, Ricker C, Roshal A, Ruddy KJ, Safer JD, Van Poznak C, Yung RL, Giordano SH
J Clin Oncol 2020 Jun 1;38(16):1849-1863. Epub 2020 Feb 14 doi: 10.1200/JCO.19.03120. PMID: 32058842
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Male breast cancer: a disease distinct from female breast cancer.
Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F
Breast Cancer Res Treat 2019 Jan;173(1):37-48. Epub 2018 Sep 28 doi: 10.1007/s10549-018-4921-9. PMID: 30267249Free PMC Article
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.
Razavi P, Chang MT, Xu G, Bandlamudi C, Ross DS, Vasan N, Cai Y, Bielski CM, Donoghue MTA, Jonsson P, Penson A, Shen R, Pareja F, Kundra R, Middha S, Cheng ML, Zehir A, Kandoth C, Patel R, Huberman K, Smyth LM, Jhaveri K, Modi S, Traina TA, Dang C, Zhang W, Weigelt B, Li BT, Ladanyi M, Hyman DM, Schultz N, Robson ME, Hudis C, Brogi E, Viale A, Norton L, Dickler MN, Berger MF, Iacobuzio-Donahue CA, Chandarlapaty S, Scaltriti M, Reis-Filho JS, Solit DB, Taylor BS, Baselga J
Cancer Cell 2018 Sep 10;34(3):427-438.e6. doi: 10.1016/j.ccell.2018.08.008. PMID: 30205045Free PMC Article

Prognosis

An updated review of epidemiology, risk factors, and management of male breast cancer.
Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Aug 1;30(8):1194-1220. doi: 10.1093/annonc/mdz173. PMID: 31161190
Breast Cancer in Men.
Giordano SH
N Engl J Med 2018 Jun 14;378(24):2311-2320. doi: 10.1056/NEJMra1707939. PMID: 29897847
Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship.
Ruddy KJ, Winer EP
Ann Oncol 2013 Jun;24(6):1434-43. Epub 2013 Feb 20 doi: 10.1093/annonc/mdt025. PMID: 23425944

Clinical prediction guides

An updated review of epidemiology, risk factors, and management of male breast cancer.
Khan NAJ, Tirona M
Med Oncol 2021 Mar 15;38(4):39. doi: 10.1007/s12032-021-01486-x. PMID: 33721121
Management of Male Breast Cancer: ASCO Guideline.
Hassett MJ, Somerfield MR, Baker ER, Cardoso F, Kansal KJ, Kwait DC, Plichta JK, Ricker C, Roshal A, Ruddy KJ, Safer JD, Van Poznak C, Yung RL, Giordano SH
J Clin Oncol 2020 Jun 1;38(16):1849-1863. Epub 2020 Feb 14 doi: 10.1200/JCO.19.03120. PMID: 32058842
Bioinformatics analysis of prognostic significance of COL10A1 in breast cancer.
Zhang M, Chen H, Wang M, Bai F, Wu K
Biosci Rep 2020 Feb 28;40(2) doi: 10.1042/BSR20193286. PMID: 32043519Free PMC Article
Genetic Factors, Adherence to Healthy Lifestyle Behavior, and Risk of Invasive Breast Cancer Among Women in the UK Biobank.
Arthur RS, Wang T, Xue X, Kamensky V, Rohan TE
J Natl Cancer Inst 2020 Sep 1;112(9):893-901. doi: 10.1093/jnci/djz241. PMID: 31899501Free PMC Article
Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer.
Bardia A, Mayer IA, Diamond JR, Moroose RL, Isakoff SJ, Starodub AN, Shah NC, O'Shaughnessy J, Kalinsky K, Guarino M, Abramson V, Juric D, Tolaney SM, Berlin J, Messersmith WA, Ocean AJ, Wegener WA, Maliakal P, Sharkey RM, Govindan SV, Goldenberg DM, Vahdat LT
J Clin Oncol 2017 Jul 1;35(19):2141-2148. Epub 2017 Mar 14 doi: 10.1200/JCO.2016.70.8297. PMID: 28291390Free PMC Article

Recent systematic reviews

Ultra-processed food consumption and cancer risk: A systematic review and meta-analysis.
Isaksen IM, Dankel SN
Clin Nutr 2023 Jun;42(6):919-928. Epub 2023 Mar 30 doi: 10.1016/j.clnu.2023.03.018. PMID: 37087831
Serum 25-Hydroxyvitamin D and Cancer Risk: A Systematic Review of Mendelian Randomization Studies.
Lawler T, Warren Andersen S
Nutrients 2023 Jan 13;15(2) doi: 10.3390/nu15020422. PMID: 36678292Free PMC Article
Plant-Based Diets and Cancer Prognosis: a Review of Recent Research.
Hardt L, Mahamat-Saleh Y, Aune D, Schlesinger S
Curr Nutr Rep 2022 Dec;11(4):695-716. Epub 2022 Sep 23 doi: 10.1007/s13668-022-00440-1. PMID: 36138327Free PMC Article
The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis.
De Nys L, Anderson K, Ofosu EF, Ryde GC, Connelly J, Whittaker AC
Psychoneuroendocrinology 2022 Sep;143:105843. Epub 2022 Jun 24 doi: 10.1016/j.psyneuen.2022.105843. PMID: 35777076
Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D
Diabetes Care 2012 Nov;35(11):2402-11. doi: 10.2337/dc12-0336. PMID: 23093685Free PMC Article

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