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Hantavirus infectious disease

MedGen UID:
67028
•Concept ID:
C0242994
•
Disease or Syndrome
Synonyms: Hantavirus Infection; Hantavirus Infections; Infections, Hantavirus; Infections, Orthohantavirus; Orthohantavirus Infection; Orthohantavirus Infections
SNOMED CT: Hantavirus infection (359761005); Disease caused by Hantanvirus (359763008); Disease caused by Hantavirus (359761005); Disease caused by Hantaanvirus (359763008); Disease due to Hantavirus (359761005); Disease due to Hantaanvirus (359763008); Disease due to Hantanvirus (359763008)
 
Monarch Initiative: MONDO:0005780

Definition

Any infection caused by a virus of the genus Hantavirus, which is transmitted by aerosolized rodent excreta or rodent bites, that can result in a variety of clinical manifestations from hemorrhagic fever with renal syndrome to a pulmonary syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHantavirus infectious disease

Professional guidelines

PubMed

Hantavirus in humans: a review of clinical aspects and management.
Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Progress on the Prevention and Treatment of Hantavirus Disease.
Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Rodent-borne infectious disease outbreaks after flooding disasters: Epidemiology, management, and prevention.
Diaz JH
J Emerg Manag 2015 Sep-Oct;13(5):459-67. doi: 10.5055/jem.2015.0255. PMID: 26537701

Recent clinical studies

Etiology

Hantavirus in humans: a review of clinical aspects and management.
Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Modeling of hantavirus cardiopulmonary syndrome.
Gutiérrez Jara JP, Muñoz Quezada MT
Medwave 2022 Apr 26;22(3):e8722. doi: 10.5867/medwave.2022.03.002526. PMID: 35507807
A Review of Hantavirus Research in Indonesia: Prevalence in Humans and Rodents, and the Discovery of Serang Virus.
Lukman N, Kosasih H, Ibrahim IN, Pradana AA, Neal A, Karyana M
Viruses 2019 Jul 31;11(8) doi: 10.3390/v11080698. PMID: 31370291Free PMC Article
Hantavirus maintenance and transmission in reservoir host populations.
Forbes KM, Sironen T, Plyusnin A
Curr Opin Virol 2018 Feb;28:1-6. Epub 2017 Nov 13 doi: 10.1016/j.coviro.2017.09.003. PMID: 29024905
Hantaviruses: an overview.
Simmons JH, Riley LK
Comp Med 2002 Apr;52(2):97-110. PMID: 12022401

Diagnosis

Hantavirus in humans: a review of clinical aspects and management.
Vial PA, Ferrés M, Vial C, Klingström J, Ahlm C, López R, Le Corre N, Mertz GJ
Lancet Infect Dis 2023 Sep;23(9):e371-e382. Epub 2023 Apr 24 doi: 10.1016/S1473-3099(23)00128-7. PMID: 37105214
Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Hantaviruses--globally emerging pathogens.
Kruger DH, Figueiredo LT, Song JW, Klempa B
J Clin Virol 2015 Mar;64:128-36. Epub 2014 Oct 20 doi: 10.1016/j.jcv.2014.08.033. PMID: 25453325
Hantavirus pulmonary syndrome.
Simpson SQ, Spikes L, Patel S, Faruqi I
Infect Dis Clin North Am 2010 Mar;24(1):159-73. doi: 10.1016/j.idc.2009.10.011. PMID: 20171551
Hantaviruses: an overview.
Simmons JH, Riley LK
Comp Med 2002 Apr;52(2):97-110. PMID: 12022401

Therapy

Defibrotide: potential for treating endothelial dysfunction related to viral and post-infectious syndromes.
Richardson E, García-Bernal D, Calabretta E, Jara R, Palomo M, Baron RM, Yanik G, Fareed J, Vlodavsky I, Iacobelli M, Díaz-Ricart M, Richardson PG, Carlo-Stella C, Moraleda JM
Expert Opin Ther Targets 2021 Jun;25(6):423-433. Epub 2021 Jun 25 doi: 10.1080/14728222.2021.1944101. PMID: 34167431
Progress on the Prevention and Treatment of Hantavirus Disease.
Brocato RL, Hooper JW
Viruses 2019 Jul 4;11(7) doi: 10.3390/v11070610. PMID: 31277410Free PMC Article
Viral-Associated GN: Hepatitis B and Other Viral Infections.
Kupin WL
Clin J Am Soc Nephrol 2017 Sep 7;12(9):1529-1533. Epub 2016 Oct 18 doi: 10.2215/CJN.09180816. PMID: 27797900Free PMC Article
Hantavirus infection: an emerging infectious disease causing acute renal failure.
Krautkrämer E, Zeier M, Plyusnin A
Kidney Int 2013 Jan;83(1):23-7. Epub 2012 Nov 14 doi: 10.1038/ki.2012.360. PMID: 23151954
Vaccines for hantaviruses.
Schmaljohn C
Vaccine 2009 Nov 5;27 Suppl 4:D61-4. doi: 10.1016/j.vaccine.2009.07.096. PMID: 19837289

Prognosis

A framework for understanding and predicting orthohantavirus functional traits.
Mull N, Seifert SN, Forbes KM
Trends Microbiol 2023 Nov;31(11):1102-1110. Epub 2023 Jun 3 doi: 10.1016/j.tim.2023.05.004. PMID: 37277284
Hantavirus Pulmonary Syndrome: 1993-2018.
Thorp L, Fullerton L, Whitesell A, Dehority W
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059352. PMID: 36855865
Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Hantavirus host assemblages and human disease in the Atlantic Forest.
Muylaert RL, Bovendorp RS, Sabino-Santos G Jr, Prist PR, Melo GL, Priante CF, Wilkinson DA, Ribeiro MC, Hayman DTS
PLoS Negl Trop Dis 2019 Aug;13(8):e0007655. Epub 2019 Aug 12 doi: 10.1371/journal.pntd.0007655. PMID: 31404077Free PMC Article
Viral-Associated GN: Hepatitis B and Other Viral Infections.
Kupin WL
Clin J Am Soc Nephrol 2017 Sep 7;12(9):1529-1533. Epub 2016 Oct 18 doi: 10.2215/CJN.09180816. PMID: 27797900Free PMC Article

Clinical prediction guides

Distribution, frequency and clinical presentation of leptospirosis and coinfections: a systematic review protocol.
Parra Barrera EL, Bello S, Gallego-Lopez GM, Atero N, Reyes Santamaría E, Bautista A
BMJ Open 2022 Dec 16;12(12):e055187. doi: 10.1136/bmjopen-2021-055187. PMID: 36526310Free PMC Article
Hantavirus Disease and COVID-19.
Joyce AK, Oliver TT, Kofman AD, Talker DL, Safaeian S, Peker Barclift D, Perricone AJ, D'Andrea SM, Whitesell AN, Yazzie D, Guarner J, Saleki M, Ingall GB, Choi MJ, Antone-Nez R
Am J Clin Pathol 2022 Mar 3;157(3):470-475. doi: 10.1093/ajcp/aqab155. PMID: 34643226
Hantavirus host assemblages and human disease in the Atlantic Forest.
Muylaert RL, Bovendorp RS, Sabino-Santos G Jr, Prist PR, Melo GL, Priante CF, Wilkinson DA, Ribeiro MC, Hayman DTS
PLoS Negl Trop Dis 2019 Aug;13(8):e0007655. Epub 2019 Aug 12 doi: 10.1371/journal.pntd.0007655. PMID: 31404077Free PMC Article
A Review of Hantavirus Research in Indonesia: Prevalence in Humans and Rodents, and the Discovery of Serang Virus.
Lukman N, Kosasih H, Ibrahim IN, Pradana AA, Neal A, Karyana M
Viruses 2019 Jul 31;11(8) doi: 10.3390/v11080698. PMID: 31370291Free PMC Article
Hantavirus infections for the clinician: from case presentation to diagnosis and treatment.
Sargianou M, Watson DC, Chra P, Papa A, Starakis I, Gogos C, Panos G
Crit Rev Microbiol 2012 Nov;38(4):317-29. Epub 2012 May 3 doi: 10.3109/1040841X.2012.673553. PMID: 22553984

Recent systematic reviews

Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review.
Toledo J, Haby MM, Reveiz L, Sosa Leon L, Angerami R, Aldighieri S
J Infect Dis 2022 Oct 17;226(8):1362-1371. doi: 10.1093/infdis/jiab461. PMID: 34515290Free PMC Article
Distribution of geographical scale, data aggregation unit and period in the correlation analysis between temperature and incidence of HFRS in mainland China: A systematic review of 27 ecological studies.
Bai XH, Peng C, Jiang T, Hu ZM, Huang DS, Guan P
PLoS Negl Trop Dis 2019 Aug;13(8):e0007688. Epub 2019 Aug 19 doi: 10.1371/journal.pntd.0007688. PMID: 31425512Free PMC Article

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