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Metastatic Malignant Neoplasm in the Conjunctiva

MedGen UID:
673319
•Concept ID:
C0686457
•
Neoplastic Process
Synonyms: Metastatic malignant neoplasm of conjunctiva; Metastatic malignant neoplasm to conjunctiva; Secondary malignant neoplasm of conjunctiva
SNOMED CT: Secondary malignant neoplasm of conjunctiva (94263002); Metastatic malignant neoplasm to conjunctiva (94263002); Metastatic malignant neoplasm of conjunctiva (94263002)

Definition

A malignant neoplasm that has spread to the conjunctiva from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Conjunctiva

Professional guidelines

PubMed

Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Clinical Management of Uveal and Conjunctival Melanoma.
Blum ES, Yang J, Komatsubara KM, Carvajal RD
Oncology (Williston Park) 2016 Jan;30(1):29-32, 34-43, 48. PMID: 26791842
Eyelid and ocular surface carcinoma: diagnosis and management.
Yin VT, Merritt HA, Sniegowski M, Esmaeli B
Clin Dermatol 2015 Mar-Apr;33(2):159-69. doi: 10.1016/j.clindermatol.2014.10.008. PMID: 25704936

Recent clinical studies

Etiology

The role of HPV in the etiopathogenesis of pterygium and the relationship with recurrence.
Nergiz D, Süren E, Süren D
Int Ophthalmol 2023 Oct;43(10):3793-3801. Epub 2023 Jul 9 doi: 10.1007/s10792-023-02791-2. PMID: 37422852
Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Pathology of eyelid tumors.
Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927Free PMC Article

Diagnosis

Generalized Reddish Skin Nodules.
Hamijoyo L, Yaddin DF, Wijaya I, Fianza PI, Usman HA, Hernowo BS, Ceana HY, Pangastuti M, Hartantri Y
Acta Med Indones 2023 Apr;55(2):223-225. PMID: 37524604
Cutaneous melanoma metastatic to the conjunctiva.
Lemaître S, Luthert PJ, Arora AK
J Fr Ophtalmol 2022 Mar;45(3):369-370. Epub 2022 Jan 20 doi: 10.1016/j.jfo.2021.05.021. PMID: 35067371
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341

Therapy

Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Identification of fusions with potential clinical significance in melanoma.
Moran JMT, Le LP, Nardi V, Golas J, Farahani AA, Signorelli S, Onozato ML, Foreman RK, Duncan LM, Lawrence DP, Lennerz JK, Dias-Santagata D, Hoang MP
Mod Pathol 2022 Dec;35(12):1837-1847. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01138-z. PMID: 35871080
Conjunctival Melanoma: Current Treatments and Future Options.
Grimes JM, Shah NV, Samie FH, Carvajal RD, Marr BP
Am J Clin Dermatol 2020 Jun;21(3):371-381. doi: 10.1007/s40257-019-00500-3. PMID: 31965542
Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience.
Das S, Shi C, Du L, Idrees K, Berlin J
J Gastrointest Cancer 2019 Dec;50(4):709-715. doi: 10.1007/s12029-018-0131-2. PMID: 29974346Free PMC Article
Orbital cysticercosis.
Sekhar GC, Lemke BN
Ophthalmology 1997 Oct;104(10):1599-604. doi: 10.1016/s0161-6420(97)30090-6. PMID: 9331197

Prognosis

The role of HPV in the etiopathogenesis of pterygium and the relationship with recurrence.
Nergiz D, Süren E, Süren D
Int Ophthalmol 2023 Oct;43(10):3793-3801. Epub 2023 Jul 9 doi: 10.1007/s10792-023-02791-2. PMID: 37422852
Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study.
Liu X, Yue H, Jiang S, Kong L, Xu Y, Chen Y, Wang C, Wang Y, Zhu X, Kong Y, Zhang X, Qian J, Luo Z
Cancer Med 2023 Aug;12(15):16163-16172. Epub 2023 Jul 6 doi: 10.1002/cam4.6273. PMID: 37409486Free PMC Article
Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Clinical treatment options for early-stage and advanced conjunctival melanoma.
Zeng Y, Hu C, Shu L, Pan Y, Zhao L, Pu X, Wu F
Surv Ophthalmol 2021 May-Jun;66(3):461-470. Epub 2020 Sep 25 doi: 10.1016/j.survophthal.2020.09.004. PMID: 32980421
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341

Clinical prediction guides

Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis.
Marinò M, Ionni I, Lanzolla G, Sframeli A, Latrofa F, Rocchi R, Marcocci C
J Endocrinol Invest 2020 Apr;43(4):401-411. Epub 2019 Nov 5 doi: 10.1007/s40618-019-01141-3. PMID: 31691261
Proton radiotherapy in advanced malignant melanoma of the conjunctiva.
Scholz SL, Hérault J, Stang A, Griewank KG, Meller D, Thariat J, Steuhl KP, Westekemper H, Sauerwein W
Graefes Arch Clin Exp Ophthalmol 2019 Jun;257(6):1309-1318. Epub 2019 Mar 27 doi: 10.1007/s00417-019-04286-2. PMID: 30919076
Adenocarcinoma Ex-Goblet Cell: a Retrospective Experience.
Das S, Shi C, Du L, Idrees K, Berlin J
J Gastrointest Cancer 2019 Dec;50(4):709-715. doi: 10.1007/s12029-018-0131-2. PMID: 29974346Free PMC Article
The treatment results in patients with lmphoma disease in the orbit.
Furdová A, Marková A, Kapitánová K, Zahorjanová P
Cesk Slov Oftalmol 2018 Spring;73(5-6):211-217. PMID: 30541302
Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma.
Pópulo H, Soares P, Rocha AS, Silva P, Lopes JM
Melanoma Res 2010 Apr;20(2):107-17. doi: 10.1097/CMR.0b013e32832ccd09. PMID: 20173664

Recent systematic reviews

The effect of different pterygium surgery techniques on the ocular surface parameters in different durations: a systematic review and meta-analysis.
Chang J, Cao Q, Yong J, Ling X, Zhang X, Kang Z, Xue C
Graefes Arch Clin Exp Ophthalmol 2024 May;262(5):1383-1396. Epub 2023 Aug 15 doi: 10.1007/s00417-023-06191-1. PMID: 37581652
Perforation in appendiceal well-differentiated carcinoid and goblet cell tumors: impact on prognosis? A systematic review.
Madani A, van der Bilt JD, Consten EC, Vriens MR, Borel Rinkes IH
Ann Surg Oncol 2015 Mar;22(3):959-65. Epub 2014 Sep 5 doi: 10.1245/s10434-014-4023-9. PMID: 25190118

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