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Malignant Ascites

MedGen UID:
67389
•Concept ID:
C0220656
•
Neoplastic Process
Synonyms: Ascites, Malignant; Malignant ascites
SNOMED CT: Malignant ascites (236005001)

Definition

Accumulation of fluid in the peritoneal cavity resulting from the growth of primary or metastatic malignant neoplasms in the peritoneum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Ascites

Professional guidelines

PubMed

A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663
Quality assessment of the guidelines for the management of malignant pleural effusions and ascites.
Li JX, Shi YM, An LY, Yang JX, Qi YX, Yang T, Cen YY, Lin YY, Sun DL
World J Surg Oncol 2020 Dec 11;18(1):331. doi: 10.1186/s12957-020-02097-y. PMID: 33308239Free PMC Article
Malignant ascites: systematic review and guideline for treatment.
Becker G, Galandi D, Blum HE
Eur J Cancer 2006 Mar;42(5):589-97. Epub 2006 Jan 24 doi: 10.1016/j.ejca.2005.11.018. PMID: 16434188

Recent clinical studies

Etiology

A Palliative Approach to Management of Peritoneal Carcinomatosis and Malignant Ascites.
Bleicher J, Lambert LA
Surg Oncol Clin N Am 2021 Jul;30(3):475-490. doi: 10.1016/j.soc.2021.02.004. PMID: 34053663
Development and validation a simple model for identify malignant ascites.
Guo YY, Peng XL, Zhan N, Tian S, Li J, Dong WG
Int J Med Sci 2021;18(9):1966-1974. Epub 2021 Mar 3 doi: 10.7150/ijms.53743. PMID: 33850466Free PMC Article
Evaluation and treatment of malignant ascites secondary to gastric cancer.
Maeda H, Kobayashi M, Sakamoto J
World J Gastroenterol 2015 Oct 21;21(39):10936-47. doi: 10.3748/wjg.v21.i39.10936. PMID: 26494952Free PMC Article
Malignant ascites: pathophysiology and treatment.
Cavazzoni E, Bugiantella W, Graziosi L, Franceschini MS, Donini A
Int J Clin Oncol 2013 Feb;18(1):1-9. Epub 2012 Mar 31 doi: 10.1007/s10147-012-0396-6. PMID: 22460778
Malignant ascites: systematic review and guideline for treatment.
Becker G, Galandi D, Blum HE
Eur J Cancer 2006 Mar;42(5):589-97. Epub 2006 Jan 24 doi: 10.1016/j.ejca.2005.11.018. PMID: 16434188

Diagnosis

Immune Tumor Microenvironment in Ovarian Cancer Ascites.
Almeida-Nunes DL, Mendes-Frias A, Silvestre R, Dinis-Oliveira RJ, Ricardo S
Int J Mol Sci 2022 Sep 14;23(18) doi: 10.3390/ijms231810692. PMID: 36142615Free PMC Article
Integrated analysis of ascites and plasma extracellular vesicles identifies a miRNA-based diagnostic signature in ovarian cancer.
Wang W, Jo H, Park S, Kim H, Kim SI, Han Y, Lee J, Seol A, Kim J, Lee M, Lee C, Dhanasekaran DN, Ahn T, Song YS
Cancer Lett 2022 Aug 28;542:215735. Epub 2022 May 13 doi: 10.1016/j.canlet.2022.215735. PMID: 35569696
Capturing tumour heterogeneity in pre- and post-chemotherapy colorectal cancer ascites-derived cells using single-cell RNA-sequencing.
Poonpanichakul T, Shiao MS, Jiravejchakul N, Matangkasombut P, Sirachainan E, Charoensawan V, Jinawath N
Biosci Rep 2021 Dec 22;41(12) doi: 10.1042/BSR20212093. PMID: 34708245Free PMC Article
Palliation of malignant ascites.
Hodge C, Badgwell BD
J Surg Oncol 2019 Jul;120(1):67-73. Epub 2019 Mar 22 doi: 10.1002/jso.25453. PMID: 30903617
Malignant ascites.
Parsons SL, Watson SA, Steele RJ
Br J Surg 1996 Jan;83(1):6-14. doi: 10.1002/bjs.1800830104. PMID: 8653366

Therapy

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis.
Ma Q, He X, Zhang B, Guo F, Ou X, Yang Q, Shu P, Chen Y, Li K, Gao G, Zhu Y, Qin D, Tang J, Li X, Jing M, Zhao J, Mo Z, Liu N, Zeng Y, Zhou K, Feng M, Liao W, Lei W, Li Q, Li D, Wang Y
Signal Transduct Target Ther 2022 Nov 19;7(1):380. doi: 10.1038/s41392-022-01198-2. PMID: 36402752Free PMC Article
Capturing tumour heterogeneity in pre- and post-chemotherapy colorectal cancer ascites-derived cells using single-cell RNA-sequencing.
Poonpanichakul T, Shiao MS, Jiravejchakul N, Matangkasombut P, Sirachainan E, Charoensawan V, Jinawath N
Biosci Rep 2021 Dec 22;41(12) doi: 10.1042/BSR20212093. PMID: 34708245Free PMC Article
Antibody Based EpCAM Targeted Therapy of Cancer, Review and Update.
Eyvazi S, Farajnia S, Dastmalchi S, Kanipour F, Zarredar H, Bandehpour M
Curr Cancer Drug Targets 2018;18(9):857-868. doi: 10.2174/1568009618666180102102311. PMID: 29295696
Malignant ascites in ovarian cancer and the role of targeted therapeutics.
Smolle E, Taucher V, Haybaeck J
Anticancer Res 2014 Apr;34(4):1553-61. PMID: 24692682
Malignant ascites: systematic review and guideline for treatment.
Becker G, Galandi D, Blum HE
Eur J Cancer 2006 Mar;42(5):589-97. Epub 2006 Jan 24 doi: 10.1016/j.ejca.2005.11.018. PMID: 16434188

Prognosis

Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.
Fan Y, Li Y, Yao X, Jin J, Scott A, Liu B, Wang S, Huo L, Wang Y, Wang R, Pool Pizzi M, Ma L, Shao S, Sewastjanow-Silva M, Waters R, Chatterjee D, Liu B, Shanbhag N, Peng G, Calin GA, Mazur PK, Hanash SM, Ishizawa J, Hirata Y, Nagano O, Wang Z, Wang L, Xian W, McKeon F, Ajani JA, Song S
Gut 2023 Apr;72(4):624-637. Epub 2022 Aug 24 doi: 10.1136/gutjnl-2021-326581. PMID: 36002248
SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells.
Xuan Y, Wang H, Yung MM, Chen F, Chan WS, Chan YS, Tsui SK, Ngan HY, Chan KK, Chan DW
Theranostics 2022;12(7):3534-3552. Epub 2022 Apr 24 doi: 10.7150/thno.70194. PMID: 35547771Free PMC Article
Macrophage-mediated vascular permeability via VLA4/VCAM1 pathway dictates ascites development in ovarian cancer.
Zhang S, Xie B, Wang L, Yang H, Zhang H, Chen Y, Wang F, Liu C, He H
J Clin Invest 2021 Feb 1;131(3) doi: 10.1172/JCI140315. PMID: 33295887Free PMC Article
Tumor-promoting macrophages prevail in malignant ascites of advanced gastric cancer.
Eum HH, Kwon M, Ryu D, Jo A, Chung W, Kim N, Hong Y, Son DS, Kim ST, Lee J, Lee HO, Park WY
Exp Mol Med 2020 Dec;52(12):1976-1988. Epub 2020 Dec 4 doi: 10.1038/s12276-020-00538-y. PMID: 33277616Free PMC Article
Palliation of malignant ascites.
Hodge C, Badgwell BD
J Surg Oncol 2019 Jul;120(1):67-73. Epub 2019 Mar 22 doi: 10.1002/jso.25453. PMID: 30903617

Clinical prediction guides

SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells.
Xuan Y, Wang H, Yung MM, Chen F, Chan WS, Chan YS, Tsui SK, Ngan HY, Chan KK, Chan DW
Theranostics 2022;12(7):3534-3552. Epub 2022 Apr 24 doi: 10.7150/thno.70194. PMID: 35547771Free PMC Article
Capturing tumour heterogeneity in pre- and post-chemotherapy colorectal cancer ascites-derived cells using single-cell RNA-sequencing.
Poonpanichakul T, Shiao MS, Jiravejchakul N, Matangkasombut P, Sirachainan E, Charoensawan V, Jinawath N
Biosci Rep 2021 Dec 22;41(12) doi: 10.1042/BSR20212093. PMID: 34708245Free PMC Article
Mechanistic prediction of first-in-human dose for bispecific CD3/EpCAM T-cell engager antibody M701, using an integrated PK/PD modeling method.
Song L, Xue J, Zhang J, Li S, Liu D, Zhou T
Eur J Pharm Sci 2021 Mar 1;158:105584. Epub 2020 Oct 9 doi: 10.1016/j.ejps.2020.105584. PMID: 33039565
Evaluation and treatment of malignant ascites secondary to gastric cancer.
Maeda H, Kobayashi M, Sakamoto J
World J Gastroenterol 2015 Oct 21;21(39):10936-47. doi: 10.3748/wjg.v21.i39.10936. PMID: 26494952Free PMC Article
Malignant ascites in ovarian cancer and the role of targeted therapeutics.
Smolle E, Taucher V, Haybaeck J
Anticancer Res 2014 Apr;34(4):1553-61. PMID: 24692682

Recent systematic reviews

Effect of hyperthermic intrathoracic chemotherapy (HITHOC) on the malignant pleural effusion: A systematic review and meta-analysis.
Zhou H, Wu W, Tang X, Zhou J, Shen Y
Medicine (Baltimore) 2017 Jan;96(1):e5532. doi: 10.1097/MD.0000000000005532. PMID: 28072694Free PMC Article
Diagnostic value of carcinoembryonic antigen in malignancy-related ascites: systematic review and meta-analysis.
Ahadi M, Tehranian S, Memar B, Vossoughinia H, Salari M, Eskandari E, Farzanehfar M, Sadeghi R
Acta Gastroenterol Belg 2014 Dec;77(4):418-24. PMID: 25682632
Management of drainage for malignant ascites in gynaecological cancer.
Keen A, Fitzgerald D, Bryant A, Dickinson HO
Cochrane Database Syst Rev 2010 Jan 20;(1):CD007794. doi: 10.1002/14651858.CD007794.pub2. PMID: 20091648Free PMC Article
Indwelling catheters for the management of refractory malignant ascites: a systematic literature overview and retrospective chart review.
Fleming ND, Alvarez-Secord A, Von Gruenigen V, Miller MJ, Abernethy AP
J Pain Symptom Manage 2009 Sep;38(3):341-9. Epub 2009 Mar 28 doi: 10.1016/j.jpainsymman.2008.09.008. PMID: 19328648
Malignant ascites: systematic review and guideline for treatment.
Becker G, Galandi D, Blum HE
Eur J Cancer 2006 Mar;42(5):589-97. Epub 2006 Jan 24 doi: 10.1016/j.ejca.2005.11.018. PMID: 16434188

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