U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brucellosis

MedGen UID:
674
•Concept ID:
C0006309
•
Disease or Syndrome
Synonyms: Cyprus fever; Gibraltar fever; Malta fever; Rock fever; Undulant fever
SNOMED CT: Brucellosis (75702008); Malta fever (75702008); Mediterranean fever (75702008); Undulant fever (75702008); Cyprus fever (75702008); Rock fever (75702008); Gibraltar fever (75702008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005683
Orphanet: ORPHA1304

Definition

Brucellosis is an anthropozoonotic infection, endemic in the Mediterranean region, the Middle East, Latin America and parts of Asia and Africa, that is caused by gram-negative coccobacilli of the genus <i>Brucella</i> transmitted through consumption of unpasteurized dairy products or through direct contact with infected animals, placentas or aborted fetuses. Brucellosis is characterized by fever, fatigue, malaise, headache, anorexia, weight loss, sweating, osteomuscular pain (joint and lumbar pain), and arthritis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrucellosis
Follow this link to review classifications for Brucellosis in Orphanet.

Professional guidelines

PubMed

Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review.
Qureshi KA, Parvez A, Fahmy NA, Abdel Hady BH, Kumar S, Ganguly A, Atiya A, Elhassan GO, Alfadly SO, Parkkila S, Aspatwar A
Ann Med 2023;55(2):2295398. Epub 2024 Jan 2 doi: 10.1080/07853890.2023.2295398. PMID: 38165919Free PMC Article
Current Study of the Detection and Treatment Targets of Spinal Tuberculosis.
Wang B, Gao W, Hao D
Curr Drug Targets 2020;21(4):320-327. doi: 10.2174/1389450120666191002151637. PMID: 31577205
Brucella - Virulence Factors, Pathogenesis and Treatment.
Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A
Pol J Microbiol 2018 Jun 30;67(2):151-161. doi: 10.21307/pjm-2018-029. PMID: 30015453Free PMC Article

Recent clinical studies

Etiology

The emergence of Brucella canis as a public health threat in Europe: what we know and what we need to learn.
Djokic V, Freddi L, de Massis F, Lahti E, van den Esker MH, Whatmore A, Haughey A, Ferreira AC, Garofolo G, Melzer F, Sacchini F, Koets A, Wyllie S, Fontbonne A, Girault G, Vicente AF, McGiven J, Ponsart C
Emerg Microbes Infect 2023 Dec;12(2):2249126. Epub 2023 Aug 31 doi: 10.1080/22221751.2023.2249126. PMID: 37649455Free PMC Article
Ophthalmological findings in brucellosis.
Karakurt Y, Karakeçili F
J Fr Ophtalmol 2023 Sep;46(7):769-775. Epub 2023 Aug 2 doi: 10.1016/j.jfo.2023.02.017. PMID: 37541801
Neurobrucellosis: Brief Review.
Bouferraa Y, Bou Zerdan M, Hamouche R, Azar E, Afif C, Jabbour R
Neurologist 2021 Nov 4;26(6):248-252. doi: 10.1097/NRL.0000000000000348. PMID: 34734902
A review of the immunopathogenesis of Brucellosis.
Amjadi O, Rafiei A, Mardani M, Zafari P, Zarifian A
Infect Dis (Lond) 2019 May;51(5):321-333. Epub 2019 Feb 18 doi: 10.1080/23744235.2019.1568545. PMID: 30773082
The new global map of human brucellosis.
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV
Lancet Infect Dis 2006 Feb;6(2):91-9. doi: 10.1016/S1473-3099(06)70382-6. PMID: 16439329

Diagnosis

Research progress on complications of Brucellosis.
Jin M, Fan Z, Gao R, Li X, Gao Z, Wang Z
Front Cell Infect Microbiol 2023;13:1136674. Epub 2023 Mar 31 doi: 10.3389/fcimb.2023.1136674. PMID: 37065189Free PMC Article
Brucellosis.
Crecelius EM, Burnett MW
J Spec Oper Med 2021 Summer;21(2):98-99. doi: 10.55460/QMQR-TI7J. PMID: 34105131
Bovine brucellosis - a comprehensive review.
Khurana SK, Sehrawat A, Tiwari R, Prasad M, Gulati B, Shabbir MZ, Chhabra R, Karthik K, Patel SK, Pathak M, Iqbal Yatoo M, Gupta VK, Dhama K, Sah R, Chaicumpa W
Vet Q 2021 Jan 1;41(1):61-88. doi: 10.1080/01652176.2020.1868616. PMID: 33353489Free PMC Article
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Human brucellosis.
Franco MP, Mulder M, Gilman RH, Smits HL
Lancet Infect Dis 2007 Dec;7(12):775-86. doi: 10.1016/S1473-3099(07)70286-4. PMID: 18045560

Therapy

Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review.
Qureshi KA, Parvez A, Fahmy NA, Abdel Hady BH, Kumar S, Ganguly A, Atiya A, Elhassan GO, Alfadly SO, Parkkila S, Aspatwar A
Ann Med 2023;55(2):2295398. Epub 2024 Jan 2 doi: 10.1080/07853890.2023.2295398. PMID: 38165919Free PMC Article
The advances in brucellosis vaccines.
Hou H, Liu X, Peng Q
Vaccine 2019 Jul 9;37(30):3981-3988. Epub 2019 Jun 5 doi: 10.1016/j.vaccine.2019.05.084. PMID: 31176541
Research Progress on Brucellosis.
Deng Y, Liu X, Duan K, Peng Q
Curr Med Chem 2019;26(30):5598-5608. doi: 10.2174/0929867325666180510125009. PMID: 29745323
Brucellosis.
Harrison ER, Posada R
Pediatr Rev 2018 Apr;39(4):222-224. doi: 10.1542/pir.2017-0126. PMID: 29610436
Spinal brucellosis.
Tali ET, Koc AM, Oner AY
Neuroimaging Clin N Am 2015 May;25(2):233-45. doi: 10.1016/j.nic.2015.01.004. PMID: 25952175

Prognosis

Research progress on complications of Brucellosis.
Jin M, Fan Z, Gao R, Li X, Gao Z, Wang Z
Front Cell Infect Microbiol 2023;13:1136674. Epub 2023 Mar 31 doi: 10.3389/fcimb.2023.1136674. PMID: 37065189Free PMC Article
Neurobrucellosis: Brief Review.
Bouferraa Y, Bou Zerdan M, Hamouche R, Azar E, Afif C, Jabbour R
Neurologist 2021 Nov 4;26(6):248-252. doi: 10.1097/NRL.0000000000000348. PMID: 34734902
Pulmonary infections due to brucellosis in childhood.
Bayhan Gİ, Batur A, Ece İ
Tuberk Toraks 2020 Mar;68(1):43-47. doi: 10.5578/tt.69015. PMID: 32718139
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Musculoskeletal brucellosis.
Arkun R, Mete BD
Semin Musculoskelet Radiol 2011 Nov;15(5):470-9. Epub 2011 Nov 11 doi: 10.1055/s-0031-1293493. PMID: 22081282

Clinical prediction guides

Brucellosis-associated hepatitis.
Arslan Y, Baran Aİ, Çelik M
Ir J Med Sci 2024 Feb;193(1):149-156. Epub 2023 May 16 doi: 10.1007/s11845-023-03382-x. PMID: 37191870
Ophthalmological findings in brucellosis.
Karakurt Y, Karakeçili F
J Fr Ophtalmol 2023 Sep;46(7):769-775. Epub 2023 Aug 2 doi: 10.1016/j.jfo.2023.02.017. PMID: 37541801
Laboratory and clinical predictors of focal involvement and bacteremia in brucellosis.
Copur B, Sayili U
Eur J Clin Microbiol Infect Dis 2022 May;41(5):793-801. Epub 2022 Apr 1 doi: 10.1007/s10096-022-04436-1. PMID: 35364783
Treatment of pulmonary brucellosis: a systematic review.
Solera J, Solís García Del Pozo J
Expert Rev Anti Infect Ther 2017 Jan;15(1):33-42. Epub 2016 Nov 10 doi: 10.1080/14787210.2017.1254042. PMID: 27790937
Musculoskeletal brucellosis.
Arkun R, Mete BD
Semin Musculoskelet Radiol 2011 Nov;15(5):470-9. Epub 2011 Nov 11 doi: 10.1055/s-0031-1293493. PMID: 22081282

Recent systematic reviews

Follow-up outcomes of asymptomatic brucellosis: a systematic review and meta-analysis.
Li F, Du L, Zhen H, Li M, An S, Fan W, Yan Y, Zhao M, Han X, Li Z, Yang H, Zhang C, Guo C, Zhen Q
Emerg Microbes Infect 2023 Dec;12(1):2185464. doi: 10.1080/22221751.2023.2185464. PMID: 36849445Free PMC Article
Brucellosis in transplant recipients: A systematic review.
Rabiei MM, Imanzade F, Hatami F, Hesami H, Irvani SSN, Alavi Darazam I
Transpl Infect Dis 2021 Aug;23(4):e13604. Epub 2021 Mar 27 doi: 10.1111/tid.13604. PMID: 33743545
Congenital Brucellosis: A Systematic Review of the Literature.
Alsaif M, Dabelah K, Girim H, Featherstone R, Robinson JL
Vector Borne Zoonotic Dis 2018 Aug;18(8):393-403. Epub 2018 Jun 29 doi: 10.1089/vbz.2018.2280. PMID: 29957148
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Treatment of pulmonary brucellosis: a systematic review.
Solera J, Solís García Del Pozo J
Expert Rev Anti Infect Ther 2017 Jan;15(1):33-42. Epub 2016 Nov 10 doi: 10.1080/14787210.2017.1254042. PMID: 27790937

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...