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Brucellosis

MedGen UID:
674
•Concept ID:
C0006309
•
Disease or Syndrome
Synonyms: Cyprus fever; Gibraltar fever; Malta fever; Rock fever; Undulant fever
SNOMED CT: Brucellosis (75702008); Malta fever (75702008); Mediterranean fever (75702008); Undulant fever (75702008); Cyprus fever (75702008); Rock fever (75702008); Gibraltar fever (75702008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0005683
Orphanet: ORPHA1304

Definition

Brucellosis is an anthropozoonotic infection, endemic in the Mediterranean region, the Middle East, Latin America and parts of Asia and Africa, that is caused by gram-negative coccobacilli of the genus <i>Brucella</i> transmitted through consumption of unpasteurized dairy products or through direct contact with infected animals, placentas or aborted fetuses. Brucellosis is characterized by fever, fatigue, malaise, headache, anorexia, weight loss, sweating, osteomuscular pain (joint and lumbar pain), and arthritis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrucellosis
Follow this link to review classifications for Brucellosis in Orphanet.

Professional guidelines

PubMed

Current Study of the Detection and Treatment Targets of Spinal Tuberculosis.
Wang B, Gao W, Hao D
Curr Drug Targets 2020;21(4):320-327. doi: 10.2174/1389450120666191002151637. PMID: 31577205
Spontaneous spondylodiscitis: review, incidence, management, and clinical outcome in 44 patients.
Waheed G, Soliman MAR, Ali AM, Aly MH
Neurosurg Focus 2019 Jan 1;46(1):E10. doi: 10.3171/2018.10.FOCUS18463. PMID: 30611166
Brucella - Virulence Factors, Pathogenesis and Treatment.
Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A
Pol J Microbiol 2018 Jun 30;67(2):151-161. doi: 10.21307/pjm-2018-029. PMID: 30015453Free PMC Article

Recent clinical studies

Etiology

Pulmonary infections due to brucellosis in childhood.
Bayhan Gİ, Batur A, Ece İ
Tuberk Toraks 2020 Mar;68(1):43-47. doi: 10.5578/tt.69015. PMID: 32718139
A review of the immunopathogenesis of Brucellosis.
Amjadi O, Rafiei A, Mardani M, Zafari P, Zarifian A
Infect Dis (Lond) 2019 May;51(5):321-333. Epub 2019 Feb 18 doi: 10.1080/23744235.2019.1568545. PMID: 30773082
Epidemiosurveillance of brucellosis.
Adone R, Pasquali P
Rev Sci Tech 2013 Apr;32(1):199-205. doi: 10.20506/rst.32.1.2202. PMID: 23837377
The new global map of human brucellosis.
Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV
Lancet Infect Dis 2006 Feb;6(2):91-9. doi: 10.1016/S1473-3099(06)70382-6. PMID: 16439329
Human brucellosis.
Sauret JM, Vilissova N
J Am Board Fam Pract 2002 Sep-Oct;15(5):401-6. PMID: 12350062

Diagnosis

Brucellosis.
Crecelius EM, Burnett MW
J Spec Oper Med 2021 Summer;21(2):98-99. doi: 10.55460/QMQR-TI7J. PMID: 34105131
Bovine brucellosis - a comprehensive review.
Khurana SK, Sehrawat A, Tiwari R, Prasad M, Gulati B, Shabbir MZ, Chhabra R, Karthik K, Patel SK, Pathak M, Iqbal Yatoo M, Gupta VK, Dhama K, Sah R, Chaicumpa W
Vet Q 2021 Jan 1;41(1):61-88. doi: 10.1080/01652176.2020.1868616. PMID: 33353489Free PMC Article
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Spinal brucellosis.
Tali ET, Koc AM, Oner AY
Neuroimaging Clin N Am 2015 May;25(2):233-45. doi: 10.1016/j.nic.2015.01.004. PMID: 25952175
Human brucellosis.
Franco MP, Mulder M, Gilman RH, Smits HL
Lancet Infect Dis 2007 Dec;7(12):775-86. doi: 10.1016/S1473-3099(07)70286-4. PMID: 18045560

Therapy

The advances in brucellosis vaccines.
Hou H, Liu X, Peng Q
Vaccine 2019 Jul 9;37(30):3981-3988. Epub 2019 Jun 5 doi: 10.1016/j.vaccine.2019.05.084. PMID: 31176541
Research Progress on Brucellosis.
Deng Y, Liu X, Duan K, Peng Q
Curr Med Chem 2019;26(30):5598-5608. doi: 10.2174/0929867325666180510125009. PMID: 29745323
Brucellosis.
Harrison ER, Posada R
Pediatr Rev 2018 Apr;39(4):222-224. doi: 10.1542/pir.2017-0126. PMID: 29610436
Alternative strategies for vaccination to brucellosis.
Pascual DW, Yang X, Wang H, Goodwin Z, Hoffman C, Clapp B
Microbes Infect 2018 Oct-Nov;20(9-10):599-605. Epub 2017 Dec 26 doi: 10.1016/j.micinf.2017.12.006. PMID: 29287984Free PMC Article
Spinal brucellosis.
Tali ET, Koc AM, Oner AY
Neuroimaging Clin N Am 2015 May;25(2):233-45. doi: 10.1016/j.nic.2015.01.004. PMID: 25952175

Prognosis

Pulmonary infections due to brucellosis in childhood.
Bayhan Gİ, Batur A, Ece İ
Tuberk Toraks 2020 Mar;68(1):43-47. doi: 10.5578/tt.69015. PMID: 32718139
Wild Boar: A Reservoir of Foodborne Zoonoses.
Fredriksson-Ahomaa M
Foodborne Pathog Dis 2019 Mar;16(3):153-165. Epub 2018 Nov 27 doi: 10.1089/fpd.2018.2512. PMID: 30481068
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Musculoskeletal brucellosis.
Arkun R, Mete BD
Semin Musculoskelet Radiol 2011 Nov;15(5):470-9. Epub 2011 Nov 11 doi: 10.1055/s-0031-1293493. PMID: 22081282
Brucella endocarditis.
Jeroudi MO, Halim MA, Harder EJ, Al-Siba'i MB, Ziady G, Mercer EN
Br Heart J 1987 Sep;58(3):279-83. doi: 10.1136/hrt.58.3.279. PMID: 3311098Free PMC Article

Clinical prediction guides

Ophthalmological findings in brucellosis.
Karakurt Y, Karakeçili F
J Fr Ophtalmol 2023 Sep;46(7):769-775. Epub 2023 Aug 2 doi: 10.1016/j.jfo.2023.02.017. PMID: 37541801
Laboratory and clinical predictors of focal involvement and bacteremia in brucellosis.
Copur B, Sayili U
Eur J Clin Microbiol Infect Dis 2022 May;41(5):793-801. Epub 2022 Apr 1 doi: 10.1007/s10096-022-04436-1. PMID: 35364783
Immunopathogenesis of Hepatic Brucellosis.
Giambartolomei GH, Delpino MV
Front Cell Infect Microbiol 2019;9:423. Epub 2019 Dec 20 doi: 10.3389/fcimb.2019.00423. PMID: 31956605Free PMC Article
Association of Brucellosis with Abortion Prevalence in Humans and Animals in Africa: A Review.
Ntirandekura JB, Matemba LE, Kimera SI, Muma JB, Karimuribo ED
Afr J Reprod Health 2018 Sep;22(3):120-136. doi: 10.29063/ajrh2018/v22i3.13. PMID: 30381939
Musculoskeletal brucellosis.
Arkun R, Mete BD
Semin Musculoskelet Radiol 2011 Nov;15(5):470-9. Epub 2011 Nov 11 doi: 10.1055/s-0031-1293493. PMID: 22081282

Recent systematic reviews

Brucellosis in transplant recipients: A systematic review.
Rabiei MM, Imanzade F, Hatami F, Hesami H, Irvani SSN, Alavi Darazam I
Transpl Infect Dis 2021 Aug;23(4):e13604. Epub 2021 Mar 27 doi: 10.1111/tid.13604. PMID: 33743545
Congenital Brucellosis: A Systematic Review of the Literature.
Alsaif M, Dabelah K, Girim H, Featherstone R, Robinson JL
Vector Borne Zoonotic Dis 2018 Aug;18(8):393-403. Epub 2018 Jun 29 doi: 10.1089/vbz.2018.2280. PMID: 29957148
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China.
Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K
Biomed Res Int 2018;2018:5712920. Epub 2018 Apr 22 doi: 10.1155/2018/5712920. PMID: 29850535Free PMC Article
Epidemiology of brucellosis in Iran: A comprehensive systematic review and meta-analysis study.
Mirnejad R, Jazi FM, Mostafaei S, Sedighi M
Microb Pathog 2017 Aug;109:239-247. Epub 2017 Jun 7 doi: 10.1016/j.micpath.2017.06.005. PMID: 28602839
Clinical manifestations of human brucellosis: a systematic review and meta-analysis.
Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J
PLoS Negl Trop Dis 2012;6(12):e1929. Epub 2012 Dec 6 doi: 10.1371/journal.pntd.0001929. PMID: 23236528Free PMC Article

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